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Application filed by Lek Pharmaceuticals D.D.,filedCriticalLek Pharmaceuticals D.D.,
Priority to YUP-479/01ApriorityCriticalpatent/RS50301B/sr
Publication of YU47901ApublicationCriticalpatent/YU47901A/sh
Publication of RS50301BpublicationCriticalpatent/RS50301B/sr
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Hydrogenated Pyridines
(AREA)
Abstract
Postupak za dobijanje 3-etil 5-metil (+/-) 2-[(2-aminoetoksi)metil]-4-(2-hlorofenil)-l,4-dihidro-6-metil-3,5-piridindikarboksilat benzensulfonata (amlodipin benzensulfonata) prevođenjem supstance 3-(etil 5-metil (+/-) 2-[2-(N-tritilamino)etoksimetil]-4-(2-hlorofenil)-l,4-dihidro-6-metil-3,5-piridinkarboksilata i benzensul fonske kiseline, gde se prevođenje supstance vrši u etanolu, na temperaturi izmedju 20°C i temperature refluksa, uz izolovanje i prečišćavanje amiodipin benzensulfonata. Prijava sadrži 2 patentna zahteva
YUP-479/01A2001-07-062001-07-06Postupak za dobijanje amlodipin benzensulfonata visoke čistoće
RS50301B
(sr)
Foerfarande foer framstaellning av 2(n-bensyl-n-metylamino)-etylmetyl-2,6-dimetyl-4-(m-nitrofenyl) -1,4-dihydropyridin-3,5-dikarboxylat och dess hydrokloridsalt.