SI9011546B - Novi trans-2-acilaminocikloheksiloksiacildipeptidi v obliki zmesi njihovih diastereoizomerov in v obliki čistih diastereoizomerov, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo - Google Patents

Novi trans-2-acilaminocikloheksiloksiacildipeptidi v obliki zmesi njihovih diastereoizomerov in v obliki čistih diastereoizomerov, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo Download PDF

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Publication number
SI9011546B
SI9011546B SI9011546A SI9011546A SI9011546B SI 9011546 B SI9011546 B SI 9011546B SI 9011546 A SI9011546 A SI 9011546A SI 9011546 A SI9011546 A SI 9011546A SI 9011546 B SI9011546 B SI 9011546B
Authority
SI
Slovenia
Prior art keywords
group
straight
carbon atoms
branched alkyl
alkyl group
Prior art date
Application number
SI9011546A
Other languages
English (en)
Slovenian (sl)
Other versions
SI9011546A (en
Inventor
Slavko Pe�ar
Danijel Kikelj
Uro� Urleb
Marija Sollner
Ga�per Marc
Ale� Krbav�i�
Branka Wraber-Herzog
Sa�a Sim�i�
Alojz Ihan
Lidija Klamfer
Lu�ka Pov�i�
Zdravko Kopitar
Anton �talc
Vlado Kotnik
Original Assignee
Univerza V Ljubljani
Lek,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univerza V Ljubljani, Lek, filed Critical Univerza V Ljubljani
Publication of SI9011546A publication Critical patent/SI9011546A/sl
Publication of SI9011546B publication Critical patent/SI9011546B/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
SI9011546A 1990-08-09 1990-08-09 Novi trans-2-acilaminocikloheksiloksiacildipeptidi v obliki zmesi njihovih diastereoizomerov in v obliki čistih diastereoizomerov, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo SI9011546B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU154690A YU48453B (sh) 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje

Publications (2)

Publication Number Publication Date
SI9011546A SI9011546A (en) 1997-10-31
SI9011546B true SI9011546B (sl) 1998-12-31

Family

ID=25554612

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9011546A SI9011546B (sl) 1990-08-09 1990-08-09 Novi trans-2-acilaminocikloheksiloksiacildipeptidi v obliki zmesi njihovih diastereoizomerov in v obliki čistih diastereoizomerov, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo

Country Status (7)

Country Link
US (1) US5231216A (de)
EP (1) EP0471280B1 (de)
JP (1) JPH09309898A (de)
AT (1) ATE144990T1 (de)
DE (1) DE69123005D1 (de)
SI (1) SI9011546B (de)
YU (1) YU48453B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1608319A4 (de) * 2003-04-03 2007-02-28 Univ California Verbesserte hemmer für lösliche epoxidhydrolase
JP2007532484A (ja) 2004-03-16 2007-11-15 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 可溶性エポキシド加水分解酵素の阻害剤およびエポキシエイコサノイドを用いて腎症を緩和する方法
CA2584342C (en) * 2004-10-20 2013-04-30 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3634013A1 (de) * 1986-10-06 1988-04-14 Stephane Gero Dipeptide und deren herstellung

Also Published As

Publication number Publication date
DE69123005D1 (de) 1996-12-12
EP0471280A2 (de) 1992-02-19
US5231216A (en) 1993-07-27
SI9011546A (en) 1997-10-31
YU48453B (sh) 1998-08-14
JPH09309898A (ja) 1997-12-02
YU154690A (sh) 1992-12-21
EP0471280A3 (en) 1992-09-16
ATE144990T1 (de) 1996-11-15
EP0471280B1 (de) 1996-11-06

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