DE69123005D1 - Trans-2-Acylaminocyclohexyloxyacyldipeptide - Google Patents

Trans-2-Acylaminocyclohexyloxyacyldipeptide

Info

Publication number
DE69123005D1
DE69123005D1 DE69123005T DE69123005T DE69123005D1 DE 69123005 D1 DE69123005 D1 DE 69123005D1 DE 69123005 T DE69123005 T DE 69123005T DE 69123005 T DE69123005 T DE 69123005T DE 69123005 D1 DE69123005 D1 DE 69123005D1
Authority
DE
Germany
Prior art keywords
alkyl
chem
formula
trans
nhr9
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69123005T
Other languages
English (en)
Inventor
Slavko Prof Dr Pecar
Danijel Dr Kikelj
Uros Dr Urleb
Marija Sollner
Gasper Marc
Ales Prof Dr Krbavcic
Vlado Dr Kotnik
Branka Wraber-Herzog
Sasa Simcic
Alojz Dr Ihan
Lidija Klamfer
Lucka Povsic
Zdravko Prof Dr Kopitar
Anton Dr Stalc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNIVERZA EDVARDA KARDELJA V LJUBLJANI VDO FAKULTETA ZA NARAVOSLOVJE IN TEHNOLOGIJO LJUBLJANA SI
LJUBLJANI, University of
Lek Pharmaceuticals dd
Original Assignee
UNIVERZA EDVARDA KARDELJA V LJUBLJANI VDO FAKULTETA ZA NARAVOSLOVJE IN TEHNOLOGIJO LJUBLJANA SI
LJUBLJANI, University of
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNIVERZA EDVARDA KARDELJA V LJUBLJANI VDO FAKULTETA ZA NARAVOSLOVJE IN TEHNOLOGIJO LJUBLJANA SI, LJUBLJANI, University of, Lek Pharmaceuticals and Chemical Co dd filed Critical UNIVERZA EDVARDA KARDELJA V LJUBLJANI VDO FAKULTETA ZA NARAVOSLOVJE IN TEHNOLOGIJO LJUBLJANA SI
Application granted granted Critical
Publication of DE69123005D1 publication Critical patent/DE69123005D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DE69123005T 1990-08-09 1991-08-07 Trans-2-Acylaminocyclohexyloxyacyldipeptide Expired - Lifetime DE69123005D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU154690A YU48453B (sh) 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje

Publications (1)

Publication Number Publication Date
DE69123005D1 true DE69123005D1 (de) 1996-12-12

Family

ID=25554612

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69123005T Expired - Lifetime DE69123005D1 (de) 1990-08-09 1991-08-07 Trans-2-Acylaminocyclohexyloxyacyldipeptide

Country Status (7)

Country Link
US (1) US5231216A (de)
EP (1) EP0471280B1 (de)
JP (1) JPH09309898A (de)
AT (1) ATE144990T1 (de)
DE (1) DE69123005D1 (de)
SI (1) SI9011546B (de)
YU (1) YU48453B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026844A1 (en) * 2003-04-03 2005-02-03 Regents Of The University Of California Inhibitors for the soluble epoxide hydrolase
JP2007532484A (ja) 2004-03-16 2007-11-15 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 可溶性エポキシド加水分解酵素の阻害剤およびエポキシエイコサノイドを用いて腎症を緩和する方法
CN101084216B (zh) * 2004-10-20 2011-09-14 加利福尼亚大学董事会 可溶性环氧化物水解酶的改进抑制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3634013A1 (de) * 1986-10-06 1988-04-14 Stephane Gero Dipeptide und deren herstellung

Also Published As

Publication number Publication date
YU48453B (sh) 1998-08-14
EP0471280A3 (en) 1992-09-16
EP0471280B1 (de) 1996-11-06
SI9011546B (sl) 1998-12-31
ATE144990T1 (de) 1996-11-15
EP0471280A2 (de) 1992-02-19
US5231216A (en) 1993-07-27
JPH09309898A (ja) 1997-12-02
SI9011546A (en) 1997-10-31
YU154690A (sh) 1992-12-21

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Legal Events

Date Code Title Description
8332 No legal effect for de