YU154690A - Novitrans-2-acilaminocikloheksiloksiacildi peptidi v obliki smesi njihovih diasteroizomerov in v obliki čistih diasteoizomerov postopki za njihovo pripravo in farmacevtski pripra vki, ki jih vsebujejo - Google Patents

Novitrans-2-acilaminocikloheksiloksiacildi peptidi v obliki smesi njihovih diasteroizomerov in v obliki čistih diasteoizomerov postopki za njihovo pripravo in farmacevtski pripra vki, ki jih vsebujejo

Info

Publication number
YU154690A
YU154690A YU154690A YU154690A YU154690A YU 154690 A YU154690 A YU 154690A YU 154690 A YU154690 A YU 154690A YU 154690 A YU154690 A YU 154690A YU 154690 A YU154690 A YU 154690A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
chem
formula
nhr9
compounds
Prior art date
Application number
YU154690A
Other languages
English (en)
Other versions
YU48453B (sh
Inventor
S. Opečar
D. Kikelj
U. Urleb
M. Sollner
G. Marc
A. Krbavčič
V. Kotnik
B. Wraber-Herzog
S. Simčič
A. Ihan
L. Klamfer
L. Povšič
Z. Kopitar
A. Štalc
Original Assignee
Univerza E. Kardelja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univerza E. Kardelja filed Critical Univerza E. Kardelja
Priority to SI9011546A priority Critical patent/SI9011546B/sl
Priority to YU154690A priority patent/YU48453B/sh
Priority to DE69123005T priority patent/DE69123005D1/de
Priority to AT91113276T priority patent/ATE144990T1/de
Priority to EP91113276A priority patent/EP0471280B1/en
Priority to JP3223576A priority patent/JPH09309898A/ja
Priority to US07/743,233 priority patent/US5231216A/en
Publication of YU154690A publication Critical patent/YU154690A/sh
Publication of YU48453B publication Critical patent/YU48453B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

NOVITRANS-2-ACILAMINOCIKLOHEKSILOKSIACILDI PEPTIDI V OBLIKI SMESI NJIHOVIH DIASTEROIZOMEROV IN V OBLIKI ČISTIH DIASTEOIZOMEROV POSTOPKI ZA NJIHOVO PRIPRAVO IN FARMACEVTSKI PRIPRA VKI, KI JIH VSEBUJEJO. Opisani so novi trans-2-aminocikloheksiloksiacildipeptidie s formulo I v kateri pomenijo R1 skupino-CO-R6, -S)2-R7 ali R6(1-18C)-alkil ali (1-18C)-alkoksi, R7(1-18C)-alkil, v danem primeru substituiran fenil; Y = O, = S ali = NH; R2 = R3 in pomeni-H ali (1-12C)alkil; R4 -OR8 ali -NHR9, R8-H,(1-8C)alkil ali benzil; R9-H,(1-18C)alkil ali benzil; R5-OR9 ali-NHR9; in novi(1R,2R)-oziroma(1S,2S)-trans-2-acilaminocikloheksiloksiacet ildipeptidi s formulo Ia oz. Ib v kateri pomenijo R1-COR6; R6(1-18C)alkil; R2-H; R3-H ali (1-12C)alkil; R4-OR8 ali -NHR9; R8-H,(1-18C)alkil ali benzil; R9-H,(1-18C)alkil ali benzil; R5-OR9 ali -NHR9. Spojine s formulo I dobimo s presnovo karboksilnih kislin s formulo II z dipeptidi s formulo III kjer imajo substituenti gornje pomene. Spojine s formulo Ia oz. Ib dobimo s presnovo ustrezne (1 R,2 R)-oz. (1 S,2 S)-trans-2-(2-acilaminocikloheksiloksi)ocetne kisline s formulo IIa oz. IIb z dipeptidi s formulo III kjer imajo substituenti gornje pomene. Spojine s formulama Ia oz. Ib lahko dobimo tudi z ločenjem diastereoizomerne zmesi spojin s formulo I s kolonsko kromatografijo na silikagelu. Spojine s formulami I, Ia in Ib in njihove farmacevtsko sprejemljive alkalijske soli imajo imunomodulatoren in antitumorni učinek in so uporabne za izdelavo zdravil.
YU154690A 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje YU48453B (sh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
SI9011546A SI9011546B (sl) 1990-08-09 1990-08-09 Novi trans-2-acilaminocikloheksiloksiacildipeptidi v obliki zmesi njihovih diastereoizomerov in v obliki čistih diastereoizomerov, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo
YU154690A YU48453B (sh) 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje
DE69123005T DE69123005D1 (de) 1990-08-09 1991-08-07 Trans-2-Acylaminocyclohexyloxyacyldipeptide
AT91113276T ATE144990T1 (de) 1990-08-09 1991-08-07 Trans-2-acylaminocyclohexyloxyacyldipeptide
EP91113276A EP0471280B1 (en) 1990-08-09 1991-08-07 Trans-2-acylaminocyclohexyloxyacyldipeptides
JP3223576A JPH09309898A (ja) 1990-08-09 1991-08-09 新規なトランス−２−アシルアミノシクロヘキシルオキシアシルジペプチド、その製造方法及びこれを含む医薬組成物。
US07/743,233 US5231216A (en) 1990-08-09 1991-08-19 Trans-2-acylaminocyclohexyloxyacyldipeptides in the form of mixtures of diastereoisomers thereof and in the form of pure diasteredisomers, process for the preparation thereof and pharmaceutical compositions containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU154690A YU48453B (sh) 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje

Publications (2)

Publication Number Publication Date
YU154690A true YU154690A (sh) 1992-12-21
YU48453B YU48453B (sh) 1998-08-14

Family

ID=25554612

Family Applications (1)

Application Number Title Priority Date Filing Date
YU154690A YU48453B (sh) 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje

Country Status (7)

Country Link
US (1) US5231216A (sh)
EP (1) EP0471280B1 (sh)
JP (1) JPH09309898A (sh)
AT (1) ATE144990T1 (sh)
DE (1) DE69123005D1 (sh)
SI (1) SI9011546B (sh)
YU (1) YU48453B (sh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4943837B2 (ja) * 2003-04-03 2012-05-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 可溶性エポキシド加水分解酵素の改良インヒビター
US20090018092A1 (en) 2004-03-16 2009-01-15 The Regents Of The University Of California Reducing Nephropathy with Inhibitors of Soluble Epoxide Hydrolase and Epoxyeicosanoids
WO2006045119A2 (en) * 2004-10-20 2006-04-27 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3634013A1 (de) * 1986-10-06 1988-04-14 Stephane Gero Dipeptide und deren herstellung

Also Published As

Publication number Publication date
ATE144990T1 (de) 1996-11-15
JPH09309898A (ja) 1997-12-02
EP0471280B1 (en) 1996-11-06
YU48453B (sh) 1998-08-14
EP0471280A3 (en) 1992-09-16
US5231216A (en) 1993-07-27
EP0471280A2 (en) 1992-02-19
DE69123005D1 (de) 1996-12-12
SI9011546B (sl) 1998-12-31
SI9011546A (en) 1997-10-31

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