YU48453B - Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje - Google Patents

Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje

Info

Publication number
YU48453B
YU48453B YU154690A YU154690A YU48453B YU 48453 B YU48453 B YU 48453B YU 154690 A YU154690 A YU 154690A YU 154690 A YU154690 A YU 154690A YU 48453 B YU48453 B YU 48453B
Authority
YU
Yugoslavia
Prior art keywords
alkyl
chem
formula
nhr9
compounds
Prior art date
Application number
YU154690A
Other languages
English (en)
Other versions
YU154690A (sh
Inventor
Slavko prof. dr. dipl. farm. Pečar
Danijel Dr. Dipl. Farm. Kikelj
Uroš dipl. farm. Urleb
Marija dipl. ing. farm. Sollner
Gašper dipl. ing. farm. Marc
Aleš prof. dr. dipl. ing. Krbavčič
Vlado dr. Kotnik
Branka mag. dipl. biol. Wraber-Herzog
Saša dipl. ing. kem. Simčič
Alojz Dr. Ihan
Lidija Mag. Dipl. Biol. Klamfer
Lučka dipl. biol. Povšič
Zdravko Prof. Dr. Dipl. Farm. Kopitar
Anton dr. dipl. ing. farm. Štalc
Original Assignee
Univerza V Ljubljani Fakulteta Za Naravoslovlje In Tehnologijo, Odesek Za Farmacijo
LEK, Tovarna farmacevtskih izdelkov in kemičkih izdelkov, p.o.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univerza V Ljubljani Fakulteta Za Naravoslovlje In Tehnologijo, Odesek Za Farmacijo, LEK, Tovarna farmacevtskih izdelkov in kemičkih izdelkov, p.o. filed Critical Univerza V Ljubljani Fakulteta Za Naravoslovlje In Tehnologijo, Odesek Za Farmacijo
Priority to SI9011546A priority Critical patent/SI9011546B/sl
Priority to YU154690A priority patent/YU48453B/sh
Priority to AT91113276T priority patent/ATE144990T1/de
Priority to EP91113276A priority patent/EP0471280B1/en
Priority to DE69123005T priority patent/DE69123005D1/de
Priority to JP3223576A priority patent/JPH09309898A/ja
Priority to US07/743,233 priority patent/US5231216A/en
Publication of YU154690A publication Critical patent/YU154690A/sh
Publication of YU48453B publication Critical patent/YU48453B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Trans-2-acilaminocikloheksiloksiacildipeptidi, formule I u kojoj označavaju R1 grupu -CO-R6, -SO2-R7 ili ; pri čemu je R6 prava ili razgranata, alkil ili alkoksi grupa, sa 1 do 18 atoma ugljenika; R7 prava ili razgranata, alkil ili alkoksi grupa, sa 1 do 18 atoma ugljenika, fenil, ili fenil grupa supstituisana, sa pravom ili razgranatom niži-alkil grupom, sa 1 do 6 atoma ugljenika, ili sa halogenom; Y je =O, =S ili =NH; R2 i R3, koji su jednaki, -H, ili, pravu ili razgranatu, alkil grupu, sa 1 do 12 atoma ugljenika; R4 grupu -OR8 ili -NHR9, pri čemu je R8 -H, prava ili razgranata, alkil grupa, sa 1 do 8 atoma ugljenika ili benzil grupa; R9 -H, prava ili razgranata, alkil grupa, sa 1 do 18 atoma ugljenika ili benzil grupa; R5 grupu -OR9 ili -NHR9; i njihove farmaceutski prihvatljive alkalne soli. 2. (1R,2R)-trans-2-acilaminocikloheksiloksiacetildipeptidi, formule Ia u kojima označavaju R1 grupu -COR6, pri čemu je R6 prava ili razgranata, alkil grupa, sa 1 do 18 atoma ugljenika; R2 vodonik; R3 -H ili, pravu ili razgranatu, alkil grupu, sa 1 do 12 atoma ugljenika; R4 grupu -OR8 ili -NHR9, pri čemu je R8 -H, prava ili razgranata, alkil grupa, sa 1 do 8 atoma ugljenika ili benzil grupa; R9 -H, prava ili razgranata, alkil grupa, sa 1 do 18 atoma ugljenika ili benzil grupa; R5 grupu -OR9 ili -NHR9, i njihove farmaceutski prihvatljive alkalne soli. 3. (1S,2S)-trans-2-acilaminocikloheksiloksiacetildipeptidi, u kojoj R1, R2, R3, R4 i R5 imaju isto značenje kao u formuli la; i njihove farmaceutski prihvatljive alkalne soli. Prijava sadrži još 6 nezavisnih zahteva.
YU154690A 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje YU48453B (sh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
SI9011546A SI9011546B (sl) 1990-08-09 1990-08-09 Novi trans-2-acilaminocikloheksiloksiacildipeptidi v obliki zmesi njihovih diastereoizomerov in v obliki čistih diastereoizomerov, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo
YU154690A YU48453B (sh) 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje
AT91113276T ATE144990T1 (de) 1990-08-09 1991-08-07 Trans-2-acylaminocyclohexyloxyacyldipeptide
EP91113276A EP0471280B1 (en) 1990-08-09 1991-08-07 Trans-2-acylaminocyclohexyloxyacyldipeptides
DE69123005T DE69123005D1 (de) 1990-08-09 1991-08-07 Trans-2-Acylaminocyclohexyloxyacyldipeptide
JP3223576A JPH09309898A (ja) 1990-08-09 1991-08-09 新規なトランス−２−アシルアミノシクロヘキシルオキシアシルジペプチド、その製造方法及びこれを含む医薬組成物。
US07/743,233 US5231216A (en) 1990-08-09 1991-08-19 Trans-2-acylaminocyclohexyloxyacyldipeptides in the form of mixtures of diastereoisomers thereof and in the form of pure diasteredisomers, process for the preparation thereof and pharmaceutical compositions containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU154690A YU48453B (sh) 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje

Publications (2)

Publication Number Publication Date
YU154690A YU154690A (sh) 1992-12-21
YU48453B true YU48453B (sh) 1998-08-14

Family

ID=25554612

Family Applications (1)

Application Number Title Priority Date Filing Date
YU154690A YU48453B (sh) 1990-08-09 1990-08-09 Novi trans-2-acilaminociklo heksiloksiacildipeptidi u obliku smeša svojih dijastereoizomera i u obliku čistih dijastereoizomera, postupci za njihovo dobijanje

Country Status (7)

Country Link
US (1) US5231216A (sh)
EP (1) EP0471280B1 (sh)
JP (1) JPH09309898A (sh)
AT (1) ATE144990T1 (sh)
DE (1) DE69123005D1 (sh)
SI (1) SI9011546B (sh)
YU (1) YU48453B (sh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004228028B2 (en) * 2003-04-03 2009-12-10 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
CA2559665A1 (en) 2004-03-16 2005-09-29 The Regents Of The University Of California Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids
EP1814875A4 (en) * 2004-10-20 2010-02-17 Univ California IMPROVED INHIBITORS OF SOLUBLE HYDROLASE EPOXYDE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3634013A1 (de) * 1986-10-06 1988-04-14 Stephane Gero Dipeptide und deren herstellung

Also Published As

Publication number Publication date
EP0471280A2 (en) 1992-02-19
JPH09309898A (ja) 1997-12-02
EP0471280B1 (en) 1996-11-06
DE69123005D1 (de) 1996-12-12
US5231216A (en) 1993-07-27
SI9011546A (en) 1997-10-31
SI9011546B (sl) 1998-12-31
ATE144990T1 (de) 1996-11-15
YU154690A (sh) 1992-12-21
EP0471280A3 (en) 1992-09-16

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