SI8510811A8 - PROCESS FOR PREPARATION OF STABILE SULPHO-ADENOSYL-L-METHIONINIC (SAMe) SALTS - Google Patents
PROCESS FOR PREPARATION OF STABILE SULPHO-ADENOSYL-L-METHIONINIC (SAMe) SALTS Download PDFInfo
- Publication number
- SI8510811A8 SI8510811A8 SI8510811A SI8510811A SI8510811A8 SI 8510811 A8 SI8510811 A8 SI 8510811A8 SI 8510811 A SI8510811 A SI 8510811A SI 8510811 A SI8510811 A SI 8510811A SI 8510811 A8 SI8510811 A8 SI 8510811A8
- Authority
- SI
- Slovenia
- Prior art keywords
- same
- solution
- column
- acid
- resin
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims description 4
- 150000003839 salts Chemical class 0.000 title abstract description 26
- 239000002253 acid Substances 0.000 claims abstract description 40
- 229920005989 resin Polymers 0.000 claims abstract description 26
- 239000011347 resin Substances 0.000 claims abstract description 26
- 239000006166 lysate Substances 0.000 claims abstract description 15
- 238000001223 reverse osmosis Methods 0.000 claims abstract description 8
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 8
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 6
- 239000003456 ion exchange resin Substances 0.000 claims abstract description 5
- 229920003303 ion-exchange polymer Polymers 0.000 claims abstract description 5
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000013592 cell lysate Substances 0.000 claims abstract description 4
- 229960004452 methionine Drugs 0.000 claims abstract description 4
- FVSFGYXQNHBRHP-TWBCTODHSA-N (2S)-2-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-sulfoamino]-4-methylsulfanylbutanoic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CN([C@@H](CCSC)C(O)=O)S(O)(=O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 FVSFGYXQNHBRHP-TWBCTODHSA-N 0.000 claims description 68
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
- 229920001429 chelating resin Polymers 0.000 claims description 8
- 230000002378 acidificating effect Effects 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 241000235646 Cyberlindnera jadinii Species 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 229910000831 Steel Inorganic materials 0.000 claims description 4
- 239000002250 absorbent Substances 0.000 claims description 4
- 230000002745 absorbent Effects 0.000 claims description 4
- 239000010959 steel Substances 0.000 claims description 4
- 239000004952 Polyamide Substances 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 229920002647 polyamide Polymers 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- 238000010612 desalination reaction Methods 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 230000008929 regeneration Effects 0.000 claims description 2
- 238000011069 regeneration method Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims 2
- 238000000889 atomisation Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 8
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract description 2
- 230000002934 lysing effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 43
- 239000000047 product Substances 0.000 description 32
- 239000000203 mixture Substances 0.000 description 13
- 239000012535 impurity Substances 0.000 description 12
- 239000012153 distilled water Substances 0.000 description 11
- 239000000843 powder Substances 0.000 description 11
- 239000000872 buffer Substances 0.000 description 8
- 239000003960 organic solvent Substances 0.000 description 8
- 238000000921 elemental analysis Methods 0.000 description 7
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 241000282553 Macaca Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 6
- 238000002211 ultraviolet spectrum Methods 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000004809 thin layer chromatography Methods 0.000 description 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- VERAMNDAEAQRGS-UHFFFAOYSA-N butane-1,4-disulfonic acid Chemical compound OS(=O)(=O)CCCCS(O)(=O)=O VERAMNDAEAQRGS-UHFFFAOYSA-N 0.000 description 4
- LEUIUWYZAHKPSE-UHFFFAOYSA-L disodium;butane-1,4-disulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)CCCCS([O-])(=O)=O LEUIUWYZAHKPSE-UHFFFAOYSA-L 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
- 239000004472 Lysine Substances 0.000 description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000012466 permeate Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 3
- 239000003929 acidic solution Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- VSYYDIKSLHPSDQ-UHFFFAOYSA-N octane-1,8-disulfonic acid Chemical compound OS(=O)(=O)CCCCCCCCS(O)(=O)=O VSYYDIKSLHPSDQ-UHFFFAOYSA-N 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GTQHJCOHNAFHRE-UHFFFAOYSA-N 1,10-dibromodecane Chemical compound BrCCCCCCCCCCBr GTQHJCOHNAFHRE-UHFFFAOYSA-N 0.000 description 1
- ULTHEAFYOOPTTB-UHFFFAOYSA-N 1,4-dibromobutane Chemical compound BrCCCCBr ULTHEAFYOOPTTB-UHFFFAOYSA-N 0.000 description 1
- FINUUDAOCYEWBV-UHFFFAOYSA-N 1,5-dibromohexane Chemical compound CC(Br)CCCCBr FINUUDAOCYEWBV-UHFFFAOYSA-N 0.000 description 1
- DKEGCUDAFWNSSO-UHFFFAOYSA-N 1,8-dibromooctane Chemical compound BrCCCCCCCCBr DKEGCUDAFWNSSO-UHFFFAOYSA-N 0.000 description 1
- WUUGFSXJNOTRMR-IOSLPCCCSA-N 5'-S-methyl-5'-thioadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CSC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 WUUGFSXJNOTRMR-IOSLPCCCSA-N 0.000 description 1
- WUUGFSXJNOTRMR-UHFFFAOYSA-N 5alpha-Hydroxy-3abeta,5beta,8-trimethyl-1-(1,5-dimethyl-hexen-(4)-yl)-4abetaH,7abetaH-dicyclopentano[a.d]cyclooctaen-(8) Natural products OC1C(O)C(CSC)OC1N1C2=NC=NC(N)=C2N=C1 WUUGFSXJNOTRMR-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- -1 SAMe ion Chemical class 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 229940101006 anhydrous sodium sulfite Drugs 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- BYSPXROQMZCYJY-UHFFFAOYSA-N butane-1,4-disulfonic acid;hydrate Chemical compound O.OS(=O)(=O)CCCCS(O)(=O)=O BYSPXROQMZCYJY-UHFFFAOYSA-N 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- PBARJOQXHJCTKK-UHFFFAOYSA-L disodium;dibromide Chemical compound [Na+].[Na+].[Br-].[Br-] PBARJOQXHJCTKK-UHFFFAOYSA-L 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- MHYCRLGKOZWVEF-UHFFFAOYSA-N ethyl acetate;hydrate Chemical compound O.CCOC(C)=O MHYCRLGKOZWVEF-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- FEVYVSQHKFKUEZ-UHFFFAOYSA-N hexane-1,6-disulfonic acid Chemical compound OS(=O)(=O)CCCCCCS(O)(=O)=O FEVYVSQHKFKUEZ-UHFFFAOYSA-N 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- WAIFNKJFSAECAT-UHFFFAOYSA-N pentane-1,5-disulfonic acid Chemical compound OS(=O)(=O)CCCCCS(O)(=O)=O WAIFNKJFSAECAT-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 229940001482 sodium sulfite Drugs 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cephalosporin Compounds (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT20938/84A IT1173990B (it) | 1984-05-16 | 1984-05-16 | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale |
YU811/85A YU44499B (en) | 1984-05-16 | 1985-05-15 | Process for obtaining stable sulphoadenozyil-l-methioninic salts |
Publications (1)
Publication Number | Publication Date |
---|---|
SI8510811A8 true SI8510811A8 (en) | 1996-10-31 |
Family
ID=11174338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI8510811A SI8510811A8 (en) | 1984-05-16 | 1985-05-15 | PROCESS FOR PREPARATION OF STABILE SULPHO-ADENOSYL-L-METHIONINIC (SAMe) SALTS |
Country Status (25)
Country | Link |
---|---|
US (2) | US5102791A (de) |
EP (1) | EP0162323B1 (de) |
JP (1) | JPH0630607B2 (de) |
AT (1) | ATE41157T1 (de) |
AU (1) | AU576577B2 (de) |
CA (1) | CA1241285A (de) |
DE (1) | DE3568581D1 (de) |
DK (1) | DK167283B1 (de) |
EG (1) | EG17392A (de) |
ES (1) | ES8608045A1 (de) |
FI (1) | FI81381C (de) |
GE (1) | GEP19960324B (de) |
GR (1) | GR851182B (de) |
HR (1) | HRP921151B1 (de) |
IE (1) | IE58693B1 (de) |
IN (1) | IN162199B (de) |
IT (1) | IT1173990B (de) |
MX (2) | MX7661E (de) |
NO (1) | NO163743C (de) |
PT (1) | PT80452B (de) |
SI (1) | SI8510811A8 (de) |
SU (1) | SU1530100A3 (de) |
UA (1) | UA7079A1 (de) |
YU (1) | YU44499B (de) |
ZA (1) | ZA853295B (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1173992B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale |
IT1177373B (it) * | 1984-12-06 | 1987-08-26 | Bioresearch Spa | Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica |
US20040208875A1 (en) * | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
US6492349B1 (en) * | 1993-03-31 | 2002-12-10 | Nutramax Laboratories, Inc. | Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue |
DE4425280C2 (de) * | 1994-07-16 | 1997-05-07 | Knoll Ag | Verwendung von (S)-Adenosyl-L-methionin und dessen physiologisch verträglichen Salzen zur Behandlung von Reperfusionsschäden, die nach temporärer fokaler Ischämie ausgelöst werden |
US6255295B1 (en) | 1996-12-23 | 2001-07-03 | Nutramax Laboratories, Inc. | Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue |
US6635615B1 (en) | 1999-11-17 | 2003-10-21 | Rolland F. Hebert | Stable salts of S-adenosyl-l-methionine |
IT1318535B1 (it) * | 2000-05-25 | 2003-08-27 | Chementecno Srl | Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina. |
IT1317920B1 (it) * | 2000-10-20 | 2003-07-15 | Univ Roma | S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer. |
US20050272687A1 (en) * | 2004-06-08 | 2005-12-08 | Hebert Rolland F | Stable S-adenosyl-l-methionine |
DE102005009751A1 (de) | 2005-03-03 | 2006-09-07 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von S-Adenosyl-Methionin |
TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
US20090012036A1 (en) * | 2005-05-24 | 2009-01-08 | Hebert Rolland F | Stable S-adenosyl-L-methionine |
CA2634871A1 (en) * | 2005-12-22 | 2007-11-08 | Neurochem (International) Limited | Treatment of renal disorders, diabetic nephopathy and dyslipidemias |
US8148348B2 (en) | 2006-01-17 | 2012-04-03 | Mitsubishi Gas Chemical Company, Inc. | Method of stabilizing S-adenosyl-L-methionine and stabilized composition |
ITMI20060629A1 (it) | 2006-03-31 | 2007-10-01 | Daniele Giovannone | Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento |
US9080158B2 (en) | 2006-05-16 | 2015-07-14 | Mitsubishi Gas Chemical Company, Inc. | Method of producing S-adenosyl-L-methionine-containing dry yeast having excellent storage stability, the product thereof and composition for oral intake |
JP2010529947A (ja) * | 2006-12-22 | 2010-09-02 | ベラス ヘルス(インターナショナル)リミテッド | 代謝性疾患および糖尿病を治療するための方法、化合物、および組成物 |
CN101589136B (zh) | 2007-01-25 | 2012-06-06 | 三菱瓦斯化学株式会社 | 储存稳定性优良的含s-腺苷-l-甲硫氨酸的干燥酵母的制备方法及其产品以及由该产品成型而得到的组合物 |
US20100004191A1 (en) * | 2008-07-01 | 2010-01-07 | Rolland F Hebert | Compositions of S-adenosyl-L-methionine. |
CN101985458A (zh) * | 2010-09-30 | 2011-03-16 | 无锡好芳德药业有限公司 | 一种新的制备s-腺苷蛋氨酸1,4-丁二磺酸盐的方法 |
CN102660611A (zh) * | 2012-04-27 | 2012-09-12 | 国药集团川抗制药有限公司 | 1,4—丁二磺酸腺苷蛋氨酸的制备方法 |
ES2824807T3 (es) | 2013-01-16 | 2021-05-13 | Hebert Sam E Llc | Sales de indol-3-propionato estables de S-adenosil-L-metionina |
ITMI20130426A1 (it) * | 2013-03-20 | 2014-09-21 | Gnosis Spa | S-adenosilmetionina sterile ad alto contenuto di isomero attivo per soluzioni iniettabili e procedimento per ottenerla |
CN103265595B (zh) * | 2013-05-21 | 2015-12-23 | 南京基准生物科技有限公司 | 一种酿酒酵母发酵液中提取s-腺苷甲硫氨酸的方法 |
RU2537556C1 (ru) * | 2013-07-30 | 2015-01-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ получения соли адеметионина с хондроитинсульфокислотой |
CN104418928B (zh) * | 2013-08-27 | 2017-03-29 | 上海医药工业研究院 | 一种1,4‑丁二磺酸腺苷蛋氨酸的制备方法 |
CN104086463B (zh) * | 2014-07-14 | 2016-05-11 | 河南豫辰药业股份有限公司 | 一种1,4-丁二磺酸精品及其溶液的制备方法 |
CN113416156B (zh) * | 2021-06-23 | 2022-04-22 | 深圳市铭泉盛催化剂有限公司 | 一种1,4-丁二磺酸钠的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE37913B1 (en) * | 1972-08-02 | 1977-11-09 | Bioresearch Sas | Salt of s-adenosyl-l-methionine |
IE39517B1 (en) * | 1973-06-27 | 1978-10-25 | Bioresearch Sas | Double salts of s-adenosyl-l-methhionine |
AR221676A1 (es) * | 1974-07-12 | 1981-03-13 | Bioresearch Sas | Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico |
JPS53107485A (en) * | 1977-02-28 | 1978-09-19 | Yamasa Shoyu Co Ltd | Preparation of s-adenosyl-l-methionine salt |
JPS5826899B2 (ja) * | 1979-11-28 | 1983-06-06 | 三菱瓦斯化学株式会社 | トリメリツト酸の製造法 |
GB2064523B (en) * | 1979-12-04 | 1983-06-29 | Kanegafuchi Chemical Ind | Stable composition of s-adenosyl-l-methionine |
GB2116172B (en) * | 1982-02-25 | 1986-07-09 | Nippon Zeon Co | Microbial cells containing s-adenosyl methionine in high concentrations and process for production of s adenosyl methionine |
JPS5929700A (ja) * | 1982-08-13 | 1984-02-16 | Nippon Zeon Co Ltd | S−アデノシル−l−メチオニンの精製法 |
IT1169773B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Processo per la produzione di sali stabili della solfo-adenosil-l-metionina |
JPS60102795A (ja) * | 1983-11-09 | 1985-06-06 | 株式会社日立製作所 | 固定部材を備えた電子部品 |
IT1173992B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale |
IT1177373B (it) * | 1984-12-06 | 1987-08-26 | Bioresearch Spa | Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica |
-
1984
- 1984-05-16 IT IT20938/84A patent/IT1173990B/it active Protection Beyond IP Right Term
-
1985
- 1985-04-25 AT AT85105000T patent/ATE41157T1/de not_active IP Right Cessation
- 1985-04-25 DE DE8585105000T patent/DE3568581D1/de not_active Expired
- 1985-04-25 EP EP85105000A patent/EP0162323B1/de not_active Expired
- 1985-05-02 ZA ZA853295A patent/ZA853295B/xx unknown
- 1985-05-06 IN IN345/CAL/85A patent/IN162199B/en unknown
- 1985-05-08 MX MX8511548U patent/MX7661E/es unknown
- 1985-05-09 US US06/732,287 patent/US5102791A/en not_active Expired - Lifetime
- 1985-05-13 CA CA000481416A patent/CA1241285A/en not_active Expired
- 1985-05-13 PT PT80452A patent/PT80452B/pt unknown
- 1985-05-13 IE IE118785A patent/IE58693B1/en not_active IP Right Cessation
- 1985-05-15 DK DK215585A patent/DK167283B1/da not_active IP Right Cessation
- 1985-05-15 SI SI8510811A patent/SI8510811A8/sl not_active IP Right Cessation
- 1985-05-15 UA UA3898654A patent/UA7079A1/uk unknown
- 1985-05-15 GR GR851182A patent/GR851182B/el unknown
- 1985-05-15 AU AU42519/85A patent/AU576577B2/en not_active Ceased
- 1985-05-15 YU YU811/85A patent/YU44499B/xx unknown
- 1985-05-15 NO NO851962A patent/NO163743C/no not_active IP Right Cessation
- 1985-05-15 SU SU853898654A patent/SU1530100A3/ru active
- 1985-05-16 ES ES543199A patent/ES8608045A1/es not_active Expired
- 1985-05-16 EG EG304/85A patent/EG17392A/xx active
- 1985-05-16 FI FI851952A patent/FI81381C/fi not_active IP Right Cessation
- 1985-05-16 JP JP60102796A patent/JPH0630607B2/ja not_active Expired - Fee Related
-
1990
- 1990-05-30 US US07/530,784 patent/US4990606A/en not_active Expired - Lifetime
-
1992
- 1992-06-26 MX MX9203625A patent/MX9203625A/es unknown
- 1992-10-30 HR HRP-811/85A patent/HRP921151B1/xx not_active IP Right Cessation
-
1993
- 1993-05-19 GE GEAP1993762A patent/GEP19960324B/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI8510811A8 (en) | PROCESS FOR PREPARATION OF STABILE SULPHO-ADENOSYL-L-METHIONINIC (SAMe) SALTS | |
DE2430999C2 (de) | Neue Doppelsalze von S-Adenosyl-L-methionin mit Schwefel- und p-Toluolsulfonsäure, Verfahren zu ihrer Herstellung und Arzneimittel | |
FI85288B (fi) | Foerfarande foer framstaellning av stabila sulfoadenosyl-l-metionin (same)-salter. | |
AU2001265848B8 (en) | Process for the preparation of pharmaceutically acceptable salts of (SS,RS)-S-adenosyl-L-methionine | |
US4621056A (en) | Process for producing stable sulpho-adenosyl-L-methionine salts | |
AU2001265848A1 (en) | Process for the preparation of pharmaceutically acceptable salts of (SS,RS)-S-adenosyl-L-methionine | |
US20020188116A1 (en) | Chemical synthesis of S-adenosyl-L-methionine with enrichment of ( S,S)-isomer | |
EP1091001B1 (de) | Verfahren zur Reinigung von S-Adenosyl-L-Methionin und zur Herstellung von pharmazeutisch verträglichen Salzen davon | |
JPS62249956A (ja) | カルニチンの精製方法 | |
JPH07113024B2 (ja) | ピロロキノリンキノンの精製方法 | |
US20080103303A1 (en) | Chemical Synthesis Of S-Adenosyl-L-Methionine With Enrichment Of (S,S)-Isomer | |
JPS6337635B2 (de) | ||
JPS634555B2 (de) | ||
JPS63122698A (ja) | 7−ヒドロキシグアニン誘導体及びその製造方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KO00 | Lapse of patent |
Effective date: 20050225 |