SI2457920T1 - Oligosaccharides containing the amino acid group and their conjugates - Google Patents
Oligosaccharides containing the amino acid group and their conjugates Download PDFInfo
- Publication number
- SI2457920T1 SI2457920T1 SI200831908T SI200831908T SI2457920T1 SI 2457920 T1 SI2457920 T1 SI 2457920T1 SI 200831908 T SI200831908 T SI 200831908T SI 200831908 T SI200831908 T SI 200831908T SI 2457920 T1 SI2457920 T1 SI 2457920T1
- Authority
- SI
- Slovenia
- Prior art keywords
- oligosaccharide
- protein
- group
- conjugate
- formula
- Prior art date
Links
- 229920001542 oligosaccharide Polymers 0.000 title claims abstract 23
- 150000002482 oligosaccharides Chemical class 0.000 title claims abstract 19
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 title abstract 4
- 238000000034 method Methods 0.000 claims abstract 10
- 102000003886 Glycoproteins Human genes 0.000 claims abstract 4
- 108090000288 Glycoproteins Proteins 0.000 claims abstract 4
- 230000008878 coupling Effects 0.000 claims abstract 3
- 238000010168 coupling process Methods 0.000 claims abstract 3
- 238000005859 coupling reaction Methods 0.000 claims abstract 3
- 102000004169 proteins and genes Human genes 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 230000002132 lysosomal effect Effects 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- -1 oligosaccharide oligosaccharide Chemical class 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 102000005840 alpha-Galactosidase Human genes 0.000 claims 2
- 108010030291 alpha-Galactosidase Proteins 0.000 claims 2
- 102000004627 Iduronidase Human genes 0.000 claims 1
- 108010003381 Iduronidase Proteins 0.000 claims 1
- 102100024295 Maltase-glucoamylase Human genes 0.000 claims 1
- 102000011971 Sphingomyelin Phosphodiesterase Human genes 0.000 claims 1
- 108010061312 Sphingomyelin Phosphodiesterase Proteins 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 108010028144 alpha-Glucosidases Proteins 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 125000003544 oxime group Chemical group 0.000 claims 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 208000015439 Lysosomal storage disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/738—Cross-linked polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04012—Sphingomyelin phosphodiesterase (3.1.4.12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0102—Alpha-glucosidase (3.2.1.20)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01022—Alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01076—L-Iduronidase (3.2.1.76)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88547107P | 2007-01-18 | 2007-01-18 | |
| EP11188506.7A EP2457920B1 (en) | 2007-01-18 | 2008-01-18 | Oligosaccharides comprising an aminooxy group and conjugates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2457920T1 true SI2457920T1 (en) | 2018-02-28 |
Family
ID=39473250
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200831908T SI2457920T1 (en) | 2007-01-18 | 2008-01-18 | Oligosaccharides containing the amino acid group and their conjugates |
| SI200832088T SI2457919T1 (sl) | 2007-01-18 | 2008-01-18 | Oligosaharidi, ki vsebujejo skupino aminooksi in njihovi konjugati |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200832088T SI2457919T1 (sl) | 2007-01-18 | 2008-01-18 | Oligosaharidi, ki vsebujejo skupino aminooksi in njihovi konjugati |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US8759501B2 (enExample) |
| EP (5) | EP3597655B1 (enExample) |
| JP (7) | JP5999867B2 (enExample) |
| CN (2) | CN102978185B (enExample) |
| CA (1) | CA2675968C (enExample) |
| CY (2) | CY1119954T1 (enExample) |
| DK (3) | DK2457920T3 (enExample) |
| ES (3) | ES2744574T3 (enExample) |
| FI (1) | FIC20220047I1 (enExample) |
| FR (1) | FR22C1061I2 (enExample) |
| HR (3) | HRP20130744T1 (enExample) |
| HU (3) | HUE045046T2 (enExample) |
| IL (3) | IL243117B2 (enExample) |
| LT (3) | LT2457919T (enExample) |
| LU (1) | LUC00290I2 (enExample) |
| NL (1) | NL301210I2 (enExample) |
| NO (2) | NO2457920T3 (enExample) |
| PL (3) | PL2457920T3 (enExample) |
| PT (3) | PT2121713E (enExample) |
| SI (2) | SI2457920T1 (enExample) |
| WO (1) | WO2008089403A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| US8795680B2 (en) * | 2006-07-21 | 2014-08-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for conjugation of oligosaccharides or polysaccharides to protein carriers through oxime linkages via 3-deoxy-D-manno-octulsonic acid |
| CN102978185B (zh) * | 2007-01-18 | 2015-02-11 | 建新公司 | 包含氨基氧基基团的寡糖及其轭合物 |
| US8742079B2 (en) | 2007-08-20 | 2014-06-03 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
| EP3608330B1 (en) | 2008-12-16 | 2022-11-09 | Genzyme Corporation | Synthetic intermediates for preparing oligosaccharide-protein conjugates |
| EP2448600B1 (en) | 2009-07-03 | 2016-03-30 | INSERM - Institut National de la Santé et de la Recherche Médicale | Compounds targeting the cation-independent mannose 6-phosphate receptor |
| EP3081233B1 (en) * | 2009-07-27 | 2020-12-23 | Baxalta GmbH | Glycopolysialylation of proteins other than blood coagulation proteins |
| RU2744370C2 (ru) | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| WO2011163568A1 (en) * | 2010-06-24 | 2011-12-29 | University Of Kansas | Conjugates comprising an n-oxime bond and associated methods |
| WO2012082635A1 (en) * | 2010-12-13 | 2012-06-21 | Ancora Pharmaceuticals, Inc. | Synthetic oligosaccharide group a streptococcus |
| EP2665814B1 (en) | 2011-01-20 | 2017-05-17 | Protalix Ltd. | Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells |
| JP2016514096A (ja) | 2013-02-20 | 2016-05-19 | バレリオン セラピューティクス， エルエルシー | ポンぺ病の処置のための方法および組成物 |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| IL299470B2 (en) | 2015-12-30 | 2026-05-01 | Amicus Therapeutics Inc | Improved acid alpha-glucosidase for the treatment of Pompe disease |
| KR102618519B1 (ko) | 2016-03-30 | 2023-12-28 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 재조합 산 알파-글루코시다제를 포함하는 제형 |
| CA3019354A1 (en) | 2016-03-30 | 2017-10-05 | Amicus Therapeutics, Inc. | Method for selection of high m6p recombinant proteins |
| CN119113091A (zh) | 2017-05-15 | 2024-12-13 | 阿米库斯治疗学公司 | 重组人类酸性α-葡萄糖苷酶 |
| TWI821227B (zh) | 2017-12-22 | 2023-11-11 | 美商健臻公司 | 胺甲喋呤誘發的免疫耐受性之生物標記 |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| EP3830259A4 (en) | 2018-08-02 | 2022-05-04 | Dyne Therapeutics, Inc. | MUSCLE TARGETED COMPLEXES AND THEIR USES IN THE TREATMENT OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY |
| EP3877424A2 (en) * | 2018-11-08 | 2021-09-15 | Kaleido Biosciences, Inc. | Oligosaccharide compositions and methods of use thereof |
| EP4100064A1 (en) | 2020-02-07 | 2022-12-14 | Novartis AG | Targeted plasma protein degradation |
| EP4100120A1 (en) * | 2020-02-08 | 2022-12-14 | Genzyme Corporation | Compositions and methods for treating pompe disease |
| BR112022025314A2 (pt) | 2020-06-14 | 2023-01-03 | Genzyme Corp | Composições e métodos para tratamento de doença de pompe de início tardio |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4701521A (en) * | 1978-07-17 | 1987-10-20 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
| DE2940845B1 (de) | 1979-10-09 | 1980-06-26 | Ford Werke Ag | Kreiselpumpendichtung,insbesondere fuer Kuehlwasserpumpen in Kraftfahrzeugen |
| US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| US5066789A (en) * | 1988-09-30 | 1991-11-19 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages |
| US5206370A (en) * | 1989-02-24 | 1993-04-27 | Johnson Matthey, Inc. | Certain pyridyl hydrazines and hydrazides useful for protein labeling |
| IL93432A (en) | 1989-02-24 | 1994-02-27 | Johnson Mathey Inc | Hydrazines and hydrazides, their conjugates with macromolecules and such conjugates labelled with metal ions |
| US5212298A (en) * | 1989-08-16 | 1993-05-18 | Monsanto Company | Method for producing synthetic N-linked glycoconjugates |
| US5280113A (en) * | 1989-08-16 | 1994-01-18 | Monsanto Company | Method for producing synthetic N-linked glycoconjugates |
| US5324663A (en) * | 1990-02-14 | 1994-06-28 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
| US5583042A (en) * | 1990-04-16 | 1996-12-10 | Neose Pharmaceuticals, Inc. | Apparatus for the synthesis of saccharide compositions |
| US5153312A (en) * | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| CA2073511A1 (en) * | 1990-11-14 | 1992-05-29 | Matthew R. Callstrom | Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins |
| AU1580292A (en) * | 1991-03-13 | 1992-10-21 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Increasing the therapeutic efficiency of macrophage-targeted therapeutic agents by up-regulating the mannose lectin on macrophages |
| AU1676992A (en) | 1991-03-18 | 1992-10-21 | Enzon, Inc. | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
| FR2721612B1 (fr) * | 1994-06-23 | 1996-08-09 | Idm | Nouveaux dérivés d'oligosides, leur procédé de préparation et leurs applications. |
| US6132764A (en) * | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US6071890A (en) | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| US6118045A (en) * | 1995-08-02 | 2000-09-12 | Pharming B.V. | Lysosomal proteins produced in the milk of transgenic animals |
| AUPO190596A0 (en) * | 1996-08-26 | 1996-09-19 | Alchemia Pty Ltd | Oligosaccharide synthesis |
| NZ331578A (en) * | 1997-01-21 | 2000-05-26 | Pasteur Merieux Serums Vacc | Polysaccharide-peptide-conjugates |
| US5952516A (en) | 1997-05-08 | 1999-09-14 | Genzyme Corporation | Cationic amphiphiles containing multiplesteroid lipophilic groups |
| EP1027069B1 (en) | 1997-10-29 | 2006-07-26 | Genzyme Corporation | Gene therapy for gaucher disease |
| US6287857B1 (en) | 1998-02-09 | 2001-09-11 | Genzyme Corporation | Nucleic acid delivery vehicles |
| US6538117B1 (en) * | 1999-08-10 | 2003-03-25 | The Scripps Research Institute | Programmable one-pot oligosaccharide synthesis |
| CN1263510C (zh) * | 1998-08-19 | 2006-07-12 | 巴克斯特健康护理股份有限公司 | 多糖－蛋白质缀合物或寡糖－蛋白质缀合物、其制备方法及其应用 |
| US6399575B1 (en) * | 1998-11-10 | 2002-06-04 | Auburn University | Methods and compositions for targeting compounds to the central nervous system |
| EP1035137A1 (en) * | 1999-03-12 | 2000-09-13 | Pasteur Merieux Serums Et Vaccins | Method for the reductive amination of polysaccharides |
| CA2376057A1 (en) * | 1999-06-08 | 2000-12-14 | La Jolla Pharmaceutical Company | Valency platform molecules comprising aminooxy groups |
| US6534300B1 (en) * | 1999-09-14 | 2003-03-18 | Genzyme Glycobiology Research Institute, Inc. | Methods for producing highly phosphorylated lysosomal hydrolases |
| US6770468B1 (en) * | 1999-09-14 | 2004-08-03 | Genzyme Glycobiology Research Institute, Inc. | Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway |
| EP1263472A2 (en) | 2000-02-15 | 2002-12-11 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
| US6749865B2 (en) * | 2000-02-15 | 2004-06-15 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
| US20040067527A1 (en) | 2000-07-26 | 2004-04-08 | Sara Lavi | Intracellular delivery system for protein phosphatases and other polypeptides |
| DE60110094T2 (de) * | 2000-08-18 | 2009-10-01 | Massachusetts Institute Of Technology, Cambridge | Vorrichtung und verfahren zur automatisierten synthese von oligosacchariden |
| US6676963B1 (en) * | 2000-10-27 | 2004-01-13 | Barnes-Jewish Hospital | Ligand-targeted emulsions carrying bioactive agents |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| US7001994B2 (en) | 2001-01-18 | 2006-02-21 | Genzyme Corporation | Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins |
| EP1436316B1 (en) * | 2001-04-30 | 2008-01-23 | ZyStor Therapeutics , Inc. | Subcellular targeting of therapeutic proteins |
| US7629309B2 (en) * | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US7560424B2 (en) * | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| JP2004514410A (ja) | 2001-05-07 | 2004-05-20 | スプラテック ファーマ インコーポレイティド | 生物剤の経口およびｃｎｓ供給を強化するためのリガンド |
| US6855830B2 (en) * | 2001-07-16 | 2005-02-15 | Genzyme Corporation | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| US7265084B2 (en) * | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| EP2292273A3 (en) | 2001-10-10 | 2011-11-23 | BioGeneriX AG | Remodeling and glycoconjugation of peptides |
| WO2003045928A1 (en) | 2001-11-26 | 2003-06-05 | Genzyme Corporation | Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors |
| US6905856B2 (en) * | 2001-12-21 | 2005-06-14 | Genzyme Glycobiology Research Institute, Inc. | Soluble GlcNAc phosphotransferase |
| US6800472B2 (en) * | 2001-12-21 | 2004-10-05 | Genzyme Glycobiology Research Institute, Inc. | Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase |
| WO2003057179A2 (en) | 2002-01-11 | 2003-07-17 | Biomarin Pharmaceutical, Inc. | Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes |
| TWI295483B (en) | 2002-01-31 | 2008-04-01 | Sumitomo Chemical Co | 3-5 group compound semiconductor, process for producing the same, and compound semiconductor element using the same |
| WO2003070823A2 (en) * | 2002-02-20 | 2003-08-28 | The General Hospital Corporation | Conjugates comprising a biodegradable polymer and uses therefor |
| US6916802B2 (en) | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| MXPA05002594A (es) | 2002-09-11 | 2005-05-27 | Fresenius Kabi Gmbh | Derivados de polipeptidos con hidroxialquilalmidon, especialmente derivados de eritropoyetina con hidroxialquilalmidon. |
| DE02020425T1 (de) * | 2002-09-11 | 2004-07-15 | Fresenius Kabi Deutschland Gmbh | Hasylierte Polypeptide, besonders hasyliertes Erythropoietin |
| WO2005002515A2 (en) | 2003-06-20 | 2005-01-13 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| US20050026823A1 (en) * | 2003-06-20 | 2005-02-03 | Biomarin Pharmaceutical Inc. | Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues |
| WO2005014035A2 (en) | 2003-08-08 | 2005-02-17 | Novo Nordisk Health Care Ag | Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest |
| ES2294535T3 (es) | 2003-08-12 | 2008-04-01 | Lipoxen Technologies Limited | Derivados del acido polisialico. |
| US7442372B2 (en) * | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| EP1525890A1 (en) | 2003-10-02 | 2005-04-27 | Complex Biosystems GmbH | Protein-Proteophore complexes |
| US7176185B2 (en) * | 2003-11-25 | 2007-02-13 | Tsrl, Inc. | Short peptide carrier system for cellular delivery of agent |
| CA2556169C (en) * | 2004-01-29 | 2011-11-22 | Andrew Lees | Use of amino-oxy functional groups in the preparation of vaccines |
| US20080014188A1 (en) | 2004-02-06 | 2008-01-17 | Zankel Todd C | Manufacture of Highly Phosphorylated Lysosomal Enzymes and Uses Thereof |
| PL1740204T3 (pl) | 2004-04-01 | 2018-08-31 | Chiesi Farmaceutici S.P.A. | Lecznicze zastosowanie alfa-mannozydazy |
| US8017151B2 (en) * | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
| JP5137814B2 (ja) * | 2005-04-06 | 2013-02-06 | ジェンザイム・コーポレーション | 治療ターゲティングのための酸不安定リンカーを介するｐｅｇおよびポリシアルリソソーム酵素のコンジュゲート |
| WO2008089339A2 (en) | 2007-01-18 | 2008-07-24 | Genzyme Corporation | Oligosaccharide conjugates for cellular targeting |
| CN102978185B (zh) | 2007-01-18 | 2015-02-11 | 建新公司 | 包含氨基氧基基团的寡糖及其轭合物 |
| EP3608330B1 (en) * | 2008-12-16 | 2022-11-09 | Genzyme Corporation | Synthetic intermediates for preparing oligosaccharide-protein conjugates |
-
2008
- 2008-01-18 CN CN201210469389.5A patent/CN102978185B/zh active Active
- 2008-01-18 SI SI200831908T patent/SI2457920T1/en unknown
- 2008-01-18 EP EP19177425.6A patent/EP3597655B1/en active Active
- 2008-01-18 HU HUE11188504A patent/HUE045046T2/hu unknown
- 2008-01-18 ES ES11188504T patent/ES2744574T3/es active Active
- 2008-01-18 EP EP08727910.5A patent/EP2121713B1/en active Active
- 2008-01-18 WO PCT/US2008/051429 patent/WO2008089403A2/en not_active Ceased
- 2008-01-18 ES ES08727910T patent/ES2417146T3/es active Active
- 2008-01-18 EP EP11188506.7A patent/EP2457920B1/en active Active
- 2008-01-18 HR HRP20130744AT patent/HRP20130744T1/hr unknown
- 2008-01-18 CA CA2675968A patent/CA2675968C/en not_active Expired - Fee Related
- 2008-01-18 EP EP23187944.6A patent/EP4293112A3/en active Pending
- 2008-01-18 HU HUE11188506A patent/HUE036140T2/hu unknown
- 2008-01-18 CN CN2008800076802A patent/CN101631794B/zh active Active
- 2008-01-18 DK DK11188506.7T patent/DK2457920T3/en active
- 2008-01-18 NO NO11188506A patent/NO2457920T3/no unknown
- 2008-01-18 PT PT87279105T patent/PT2121713E/pt unknown
- 2008-01-18 PT PT11188504T patent/PT2457919T/pt unknown
- 2008-01-18 LT LTEP11188504.2T patent/LT2457919T/lt unknown
- 2008-01-18 JP JP2009546533A patent/JP5999867B2/ja active Active
- 2008-01-18 DK DK11188504.2T patent/DK2457919T3/da active
- 2008-01-18 PL PL11188506T patent/PL2457920T3/pl unknown
- 2008-01-18 PL PL08727910T patent/PL2121713T3/pl unknown
- 2008-01-18 PT PT111885067T patent/PT2457920T/pt unknown
- 2008-01-18 SI SI200832088T patent/SI2457919T1/sl unknown
- 2008-01-18 US US12/523,631 patent/US8759501B2/en active Active
- 2008-01-18 IL IL243117A patent/IL243117B2/en unknown
- 2008-01-18 LT LTEP11188506.7T patent/LT2457920T/lt unknown
- 2008-01-18 DK DK08727910.5T patent/DK2121713T3/da active
- 2008-01-18 PL PL11188504T patent/PL2457919T3/pl unknown
- 2008-01-18 EP EP11188504.2A patent/EP2457919B1/en active Active
- 2008-01-18 ES ES11188506.7T patent/ES2656314T3/es active Active
-
2009
- 2009-07-16 IL IL199925A patent/IL199925A/en active IP Right Grant
-
2012
- 2012-11-01 IL IL222792A patent/IL222792A0/en active IP Right Grant
-
2014
- 2014-05-08 US US14/272,960 patent/US9469850B2/en active Active
- 2014-10-03 JP JP2014204593A patent/JP6039625B2/ja active Active
-
2016
- 2016-09-29 US US15/280,864 patent/US20170014520A1/en not_active Abandoned
- 2016-11-02 JP JP2016214773A patent/JP6309592B2/ja active Active
-
2018
- 2018-01-16 HR HRP20180076TT patent/HRP20180076T1/hr unknown
- 2018-01-24 CY CY20181100094T patent/CY1119954T1/el unknown
- 2018-03-13 JP JP2018044959A patent/JP2018109194A/ja active Pending
-
2019
- 2019-02-06 US US16/268,989 patent/US10907142B2/en active Active
- 2019-08-30 HR HRP20191562 patent/HRP20191562T1/hr unknown
- 2019-09-04 CY CY20191100928T patent/CY1122452T1/el unknown
-
2020
- 2020-08-07 JP JP2020134331A patent/JP2020185011A/ja active Pending
-
2021
- 2021-09-10 US US17/472,367 patent/US20220204963A1/en not_active Abandoned
-
2022
- 2022-07-15 JP JP2022113593A patent/JP2022137232A/ja active Pending
- 2022-12-09 NO NO2022056C patent/NO2022056I1/no unknown
- 2022-12-12 FI FIC20220047C patent/FIC20220047I1/fi unknown
- 2022-12-13 LU LU00290C patent/LUC00290I2/fr unknown
- 2022-12-14 LT LTPA2022528C patent/LTC2121713I2/lt unknown
- 2022-12-15 FR FR22C1061C patent/FR22C1061I2/fr active Active
- 2022-12-16 NL NL301210C patent/NL301210I2/nl unknown
- 2022-12-19 HU HUS2200055C patent/HUS2200055I1/hu unknown
-
2024
- 2024-09-26 US US18/897,864 patent/US20250263685A1/en active Pending
- 2024-11-29 JP JP2024207922A patent/JP2025029023A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20180076T1 (hr) | Oligosaharidi koji sadrže aminoksi skupinu i njihovi konjugati | |
| JP2012017342A5 (enExample) | ||
| CA2462085A1 (en) | Cytotoxic agents | |
| JP2009520017A5 (enExample) | ||
| US20080015263A1 (en) | Compositions for delivery of therapeutics and other materials | |
| CN109415353A (zh) | 聚乙二醇化卡非佐米化合物 | |
| AU2015200791A1 (en) | Compositions and methods for treatment of autoimmune and other diseases | |
| BRPI0608853A8 (pt) | Composições farmacêuticas e processo para a fabricação de microgrânulos de rifaximina gastrorresistentes | |
| CA2548654A1 (en) | Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication | |
| KR102498068B1 (ko) | 분기형 헤테로 단분산 폴리에틸렌 글리콜, 그 제조 방법, 및 그 결합체 | |
| CN106132970B (zh) | 硼酸酯和其药物制剂 | |
| BR0207294A (pt) | Composto, processo para a preparação de um composto ou de um sal farmaceuticamente aceitável ou um éster hidrolisável in vivo dos mesmos, composição farmacêutica, uso de um composto ou de um sal farmaceuticamente aceitável ou um éster hidrolisável in vivo dos mesmos, e, método para a produção de um efeito inibitório do ciclo celular (antiproliferação celular) em um animal de sangue quente | |
| TNSN06377A1 (en) | Combinations of glycopyrrolate and beta2 adrenoceptor agonists | |
| WO2018033719A1 (en) | Compounds | |
| AU2022381111A1 (en) | Epsilon-poly-l-lysine-based drug conjugate, intermediate thereof, and application thereof | |
| Nawaz et al. | Essential insights on advancing biomedical innovations with tragacanth gum nanocomposites: A review | |
| EP1631545A2 (de) | Reagenzien zur modifikation von biopharmazeutika, deren herstellung und anwendung | |
| CA2338000A1 (en) | Water-soluble 4-thio-maleimido derivatives and methods for their production | |
| CA2868343A1 (en) | Vancomycin derivatives | |
| JP2002520288A5 (enExample) | ||
| BRPI0923324A2 (pt) | Composto, uso de um composto, método para inibição da dna girase e/ou topoisomerase iv bacteriana em um animal de sangue quente, e, processo para preparar um composto. | |
| WO2006117211A3 (en) | Urea derivatives methods for their manufacture and uses thereof | |
| AR060690A1 (es) | Polimeros que contienen magnesio para la hiperfosfatemia | |
| CA2548666A1 (en) | Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication | |
| SG10201902820UA (en) | A polymer composition and preparation method thereof |