JP2014503548A5 - - Google Patents
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- Publication number
- JP2014503548A5 JP2014503548A5 JP2013546460A JP2013546460A JP2014503548A5 JP 2014503548 A5 JP2014503548 A5 JP 2014503548A5 JP 2013546460 A JP2013546460 A JP 2013546460A JP 2013546460 A JP2013546460 A JP 2013546460A JP 2014503548 A5 JP2014503548 A5 JP 2014503548A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- compound
- soluble non
- peptide polymer
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 49
- 229920000642 polymer Polymers 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 125000006850 spacer group Chemical group 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims description 8
- 125000003277 amino group Chemical group 0.000 claims description 8
- 125000005647 linker group Chemical group 0.000 claims description 8
- 229920000768 polyamine Polymers 0.000 claims description 8
- 229920005862 polyol Polymers 0.000 claims description 8
- 150000003077 polyols Chemical class 0.000 claims description 8
- 229920006295 polythiol Polymers 0.000 claims description 8
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical group CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims description 8
- 229960001796 sunitinib Drugs 0.000 claims description 8
- 150000003573 thiols Chemical class 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000178 monomer Substances 0.000 claims description 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000003568 thioethers Chemical class 0.000 claims description 2
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 CCN(CC)CCNC(c1c(C)[n]c(C(**)C(c2cc(F)ccc2N2)C2=O)c1C)=O Chemical compound CCN(CC)CCNC(c1c(C)[n]c(C(**)C(c2cc(F)ccc2N2)C2=O)c1C)=O 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426919P | 2010-12-23 | 2010-12-23 | |
| US61/426,919 | 2010-12-23 | ||
| PCT/US2011/067259 WO2012088529A1 (en) | 2010-12-23 | 2011-12-23 | Polymer-sunitinib conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016136547A Division JP2016185978A (ja) | 2010-12-23 | 2016-07-11 | ポリマー−スニチニブコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503548A JP2014503548A (ja) | 2014-02-13 |
| JP2014503548A5 true JP2014503548A5 (enExample) | 2014-12-25 |
| JP6002149B2 JP6002149B2 (ja) | 2016-10-05 |
Family
ID=45529206
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546460A Active JP6002149B2 (ja) | 2010-12-23 | 2011-12-23 | ポリマー−スニチニブコンジュゲート |
| JP2016136547A Withdrawn JP2016185978A (ja) | 2010-12-23 | 2016-07-11 | ポリマー−スニチニブコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016136547A Withdrawn JP2016185978A (ja) | 2010-12-23 | 2016-07-11 | ポリマー−スニチニブコンジュゲート |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9827326B2 (enExample) |
| EP (1) | EP2654799B1 (enExample) |
| JP (2) | JP6002149B2 (enExample) |
| WO (1) | WO2012088529A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9827326B2 (en) | 2010-12-23 | 2017-11-28 | Nektar Therapeutics | Polymer-sunitinib conjugates |
| WO2012088506A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-semaxanib moiety conjugates |
| EP2654797B1 (en) | 2010-12-23 | 2017-11-08 | Nektar Therapeutics | Polymer-des-ethyl sunitinib conjugates |
| ES2910659T3 (es) * | 2014-12-04 | 2022-05-13 | Delta Fly Pharma Inc | Nuevo derivado de PEG |
| CN104610231B (zh) * | 2015-01-28 | 2016-08-17 | 广州葳澜生物科技有限公司 | 一种舒尼替尼前药 |
| MA42953A (fr) | 2015-09-22 | 2018-08-01 | Graybug Vision Inc | Composés et compositions pour le traitement de troubles oculaires |
| WO2018175922A1 (en) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| MX2019013363A (es) | 2017-05-10 | 2020-01-13 | Graybug Vision Inc | Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica. |
| KR102849949B1 (ko) * | 2019-03-08 | 2025-08-22 | 어플라이드 머티어리얼스, 인코포레이티드 | 프로세싱 챔버를 위한 다공성 샤워헤드 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4992540A (en) | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US5028703A (en) | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4810646A (en) | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| MXPA02006263A (es) | 1999-12-22 | 2004-02-26 | Sugen Inc | Metodos de modulacion de la funcion de la cinasa de tirosina c-kit de la proteina con compuestos de indolinona. |
| BRPI0117360B8 (pt) | 2000-02-15 | 2021-07-06 | Upjohn Co | inibidores de proteína de quinase de 2-indolinona de pirrol substituído, seus sais e composições farmacêuticas compreendendo os mesmos |
| EP1299355A2 (en) | 2000-05-02 | 2003-04-09 | Sugen, Inc. | (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| TWI259081B (en) | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| CA2466027C (en) | 2001-11-07 | 2013-01-08 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
| US7053144B1 (en) | 2002-06-13 | 2006-05-30 | Cmi Rubber Company, Inc. | High density rubber compounds |
| US20050079155A1 (en) | 2003-03-20 | 2005-04-14 | Xencor, Inc. | Generating protein pro-drugs using reversible PPG linkages |
| US7887789B2 (en) | 2003-05-23 | 2011-02-15 | Nektar Therapeutics | Polymer derivatives having particular atom arrangements |
| JP5632119B2 (ja) | 2003-09-17 | 2014-11-26 | ウェルズ ファーゴ バンク ナショナル アソシエイション | 多分岐ポリマーのプロドラッグ |
| WO2005107815A2 (en) | 2004-05-03 | 2005-11-17 | Nektar Therapeutics Al, Corporation | Polymer derivatives comprising an imide branching point |
| WO2005108463A2 (en) | 2004-05-03 | 2005-11-17 | Nektar Therapeutics Al, Corporation | Branched polyethylen glycol derivates comprising an acetal or ketal branching point |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| HUE025208T2 (en) | 2005-06-16 | 2016-03-29 | Nektar Therapeutics | Conjugates with degradable binding and polymer reagents useful in the preparation of such conjugates |
| JP5312050B2 (ja) | 2006-02-21 | 2013-10-09 | ネクター セラピューティクス | 分割型の分解性重合体とそれから生成される複合体 |
| US20080044438A1 (en) | 2006-03-17 | 2008-02-21 | Ostroff Gary R | Yeast Cell Particles As Oral Delivery Vehicles For Antigens |
| CA2671676C (en) | 2006-12-27 | 2014-04-22 | Baxter Healthcare Sa | Von willebrand factor-and factor viii-polymer conjugates having a releasable linkage |
| AU2008331868B2 (en) | 2007-11-28 | 2015-02-12 | Nektar Therapeutics | Oligomer-tricyclic conjugates |
| EP2254601B1 (en) | 2008-02-08 | 2019-05-29 | Nektar Therapeutics | Oligomer-cannabinoid conjugates |
| CN101998866A (zh) | 2008-04-11 | 2011-03-30 | 尼克塔治疗公司 | 低聚物-芳氧基-取代的丙胺共轭物 |
| US8658149B2 (en) | 2008-05-22 | 2014-02-25 | Ramot At Tel-Aviv University Ltd. | Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases |
| KR101671537B1 (ko) * | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| US20120052041A1 (en) | 2009-02-04 | 2012-03-01 | The Brigham And Women's Hospital, Inc. | Polymeric nanoparticles with enhanced drug-loading and methods of use thereof |
| US8816077B2 (en) * | 2009-04-17 | 2014-08-26 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| WO2010120387A1 (en) * | 2009-04-17 | 2010-10-21 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| EP2654797B1 (en) | 2010-12-23 | 2017-11-08 | Nektar Therapeutics | Polymer-des-ethyl sunitinib conjugates |
| US9827326B2 (en) | 2010-12-23 | 2017-11-28 | Nektar Therapeutics | Polymer-sunitinib conjugates |
-
2011
- 2011-12-23 US US13/996,834 patent/US9827326B2/en active Active
- 2011-12-23 JP JP2013546460A patent/JP6002149B2/ja active Active
- 2011-12-23 WO PCT/US2011/067259 patent/WO2012088529A1/en not_active Ceased
- 2011-12-23 EP EP11811620.1A patent/EP2654799B1/en active Active
-
2016
- 2016-07-11 JP JP2016136547A patent/JP2016185978A/ja not_active Withdrawn
-
2017
- 2017-10-24 US US15/792,060 patent/US10682418B2/en active Active
-
2020
- 2020-05-07 US US16/869,458 patent/US11419943B2/en active Active
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