JP2014503548A5 - - Google Patents
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- Publication number
- JP2014503548A5 JP2014503548A5 JP2013546460A JP2013546460A JP2014503548A5 JP 2014503548 A5 JP2014503548 A5 JP 2014503548A5 JP 2013546460 A JP2013546460 A JP 2013546460A JP 2013546460 A JP2013546460 A JP 2013546460A JP 2014503548 A5 JP2014503548 A5 JP 2014503548A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- compound
- soluble non
- peptide polymer
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 49
- 229920000642 polymer Polymers 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 125000006850 spacer group Chemical group 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims description 8
- 125000003277 amino group Chemical group 0.000 claims description 8
- 125000005647 linker group Chemical group 0.000 claims description 8
- 229920000768 polyamine Polymers 0.000 claims description 8
- 229920005862 polyol Polymers 0.000 claims description 8
- 150000003077 polyols Chemical class 0.000 claims description 8
- 229920006295 polythiol Polymers 0.000 claims description 8
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical group CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims description 8
- 229960001796 sunitinib Drugs 0.000 claims description 8
- 150000003573 thiols Chemical class 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000178 monomer Substances 0.000 claims description 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000003568 thioethers Chemical class 0.000 claims description 2
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 CCN(CC)CCNC(c1c(C)[n]c(C(**)C(c2cc(F)ccc2N2)C2=O)c1C)=O Chemical compound CCN(CC)CCNC(c1c(C)[n]c(C(**)C(c2cc(F)ccc2N2)C2=O)c1C)=O 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426919P | 2010-12-23 | 2010-12-23 | |
| US61/426,919 | 2010-12-23 | ||
| PCT/US2011/067259 WO2012088529A1 (en) | 2010-12-23 | 2011-12-23 | Polymer-sunitinib conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016136547A Division JP2016185978A (ja) | 2010-12-23 | 2016-07-11 | ポリマー−スニチニブコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503548A JP2014503548A (ja) | 2014-02-13 |
| JP2014503548A5 true JP2014503548A5 (enExample) | 2014-12-25 |
| JP6002149B2 JP6002149B2 (ja) | 2016-10-05 |
Family
ID=45529206
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546460A Active JP6002149B2 (ja) | 2010-12-23 | 2011-12-23 | ポリマー−スニチニブコンジュゲート |
| JP2016136547A Withdrawn JP2016185978A (ja) | 2010-12-23 | 2016-07-11 | ポリマー−スニチニブコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016136547A Withdrawn JP2016185978A (ja) | 2010-12-23 | 2016-07-11 | ポリマー−スニチニブコンジュゲート |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9827326B2 (enExample) |
| EP (1) | EP2654799B1 (enExample) |
| JP (2) | JP6002149B2 (enExample) |
| WO (1) | WO2012088529A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6009457B2 (ja) | 2010-12-23 | 2016-10-19 | ネクター セラピューティクス | ポリマー−デスエチルスニチニブコンジュゲート |
| WO2012088529A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-sunitinib conjugates |
| WO2012088506A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-semaxanib moiety conjugates |
| CN107001617B (zh) * | 2014-12-04 | 2019-08-27 | 德鲁塔负富莱制药股份有限公司 | Peg衍生物 |
| CN104610231B (zh) * | 2015-01-28 | 2016-08-17 | 广州葳澜生物科技有限公司 | 一种舒尼替尼前药 |
| KR20180058758A (ko) | 2015-09-22 | 2018-06-01 | 그레이버그 비젼, 인크. | 안구 장애의 치료를 위한 화합물 및 조성물 |
| JP7217022B2 (ja) | 2017-03-23 | 2023-02-02 | グレイバグ ビジョン インコーポレイテッド | 眼障害の治療のための薬物及び組成物 |
| CA3057875A1 (en) | 2017-05-10 | 2018-11-15 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| SG11202108196QA (en) * | 2019-03-08 | 2021-09-29 | Applied Materials Inc | Porous showerhead for a processing chamber |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028703A (en) | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4810646A (en) | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US4992540A (en) | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US20020010203A1 (en) | 1999-12-22 | 2002-01-24 | Ken Lipson | Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds |
| DK1255752T3 (da) * | 2000-02-15 | 2007-11-26 | Sugen Inc | Pyrrolsubstituerede 2-indolinonproteinkinaseinhibitorer |
| EP1299355A2 (en) | 2000-05-02 | 2003-04-09 | Sugen, Inc. | (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| TWI259081B (en) | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| EP1446438A2 (en) | 2001-11-07 | 2004-08-18 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
| US7053144B1 (en) | 2002-06-13 | 2006-05-30 | Cmi Rubber Company, Inc. | High density rubber compounds |
| US20050079155A1 (en) | 2003-03-20 | 2005-04-14 | Xencor, Inc. | Generating protein pro-drugs using reversible PPG linkages |
| KR101128320B1 (ko) | 2003-05-23 | 2012-04-12 | 넥타르 테라퓨틱스 | 아미도카르보네이트 연결기를 갖는 ｐｅｇ 유도체 |
| KR101200729B1 (ko) | 2003-09-17 | 2012-11-13 | 넥타르 테라퓨틱스 | 다분지형 고분자 전구약물 |
| US9085659B2 (en) | 2004-05-03 | 2015-07-21 | Nektar Therapeutics | Polymer derivatives comprising an imide branching point |
| WO2005108463A2 (en) | 2004-05-03 | 2005-11-17 | Nektar Therapeutics Al, Corporation | Branched polyethylen glycol derivates comprising an acetal or ketal branching point |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| WO2006138572A2 (en) | 2005-06-16 | 2006-12-28 | Nektar Therapeutics Al, Corporation | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
| MX2008010841A (es) | 2006-02-21 | 2008-10-27 | Nektar Therapeutics Al Corp | Polimeros degradables segmentados y conjugados hechos de los mismos. |
| US20080044438A1 (en) | 2006-03-17 | 2008-02-21 | Ostroff Gary R | Yeast Cell Particles As Oral Delivery Vehicles For Antigens |
| WO2008082669A2 (en) | 2006-12-27 | 2008-07-10 | Nektar Therapeutics Al, Corporation | Von willebrand factor- and factor viii-polymer conjugates having a releasable linkage |
| CN101878042B (zh) | 2007-11-28 | 2013-06-19 | 尼克塔治疗公司 | 低聚物-三环共轭物 |
| US8829043B2 (en) | 2008-02-08 | 2014-09-09 | Nektar Therapeutics | Oligome-cannabinoid conjugates |
| KR101680385B1 (ko) | 2008-04-11 | 2016-11-28 | 넥타르 테라퓨틱스 | 올리고머-아릴옥시-치환된 프로판아민 컨쥬게이트 |
| US8658149B2 (en) | 2008-05-22 | 2014-02-25 | Ramot At Tel-Aviv University Ltd. | Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases |
| CN102159250B (zh) * | 2008-08-11 | 2014-08-06 | 尼克塔治疗公司 | 多臂的聚合烷酸酯偶联物 |
| US20120052041A1 (en) | 2009-02-04 | 2012-03-01 | The Brigham And Women's Hospital, Inc. | Polymeric nanoparticles with enhanced drug-loading and methods of use thereof |
| US8816077B2 (en) * | 2009-04-17 | 2014-08-26 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| US20120094998A1 (en) | 2009-04-17 | 2012-04-19 | Nektar Therapeutics | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates |
| WO2012088529A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-sunitinib conjugates |
| JP6009457B2 (ja) | 2010-12-23 | 2016-10-19 | ネクター セラピューティクス | ポリマー−デスエチルスニチニブコンジュゲート |
-
2011
- 2011-12-23 WO PCT/US2011/067259 patent/WO2012088529A1/en not_active Ceased
- 2011-12-23 EP EP11811620.1A patent/EP2654799B1/en active Active
- 2011-12-23 US US13/996,834 patent/US9827326B2/en active Active
- 2011-12-23 JP JP2013546460A patent/JP6002149B2/ja active Active
-
2016
- 2016-07-11 JP JP2016136547A patent/JP2016185978A/ja not_active Withdrawn
-
2017
- 2017-10-24 US US15/792,060 patent/US10682418B2/en active Active
-
2020
- 2020-05-07 US US16/869,458 patent/US11419943B2/en active Active
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