JP2014503548A5 - - Google Patents
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- Publication number
- JP2014503548A5 JP2014503548A5 JP2013546460A JP2013546460A JP2014503548A5 JP 2014503548 A5 JP2014503548 A5 JP 2014503548A5 JP 2013546460 A JP2013546460 A JP 2013546460A JP 2013546460 A JP2013546460 A JP 2013546460A JP 2014503548 A5 JP2014503548 A5 JP 2014503548A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- compound
- soluble non
- peptide polymer
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 49
- 229920000642 polymer Polymers 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 125000006850 spacer group Chemical group 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims description 8
- 125000003277 amino group Chemical group 0.000 claims description 8
- 125000005647 linker group Chemical group 0.000 claims description 8
- 229920000768 polyamine Polymers 0.000 claims description 8
- 229920005862 polyol Polymers 0.000 claims description 8
- 150000003077 polyols Chemical class 0.000 claims description 8
- 229920006295 polythiol Polymers 0.000 claims description 8
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical group CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims description 8
- 229960001796 sunitinib Drugs 0.000 claims description 8
- 150000003573 thiols Chemical class 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000178 monomer Substances 0.000 claims description 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000003568 thioethers Chemical class 0.000 claims description 2
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 CCN(CC)CCNC(c1c(C)[n]c(C(**)C(c2cc(F)ccc2N2)C2=O)c1C)=O Chemical compound CCN(CC)CCNC(c1c(C)[n]c(C(**)C(c2cc(F)ccc2N2)C2=O)c1C)=O 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426919P | 2010-12-23 | 2010-12-23 | |
| US61/426,919 | 2010-12-23 | ||
| PCT/US2011/067259 WO2012088529A1 (en) | 2010-12-23 | 2011-12-23 | Polymer-sunitinib conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016136547A Division JP2016185978A (ja) | 2010-12-23 | 2016-07-11 | ポリマー−スニチニブコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503548A JP2014503548A (ja) | 2014-02-13 |
| JP2014503548A5 true JP2014503548A5 (enExample) | 2014-12-25 |
| JP6002149B2 JP6002149B2 (ja) | 2016-10-05 |
Family
ID=45529206
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546460A Active JP6002149B2 (ja) | 2010-12-23 | 2011-12-23 | ポリマー−スニチニブコンジュゲート |
| JP2016136547A Withdrawn JP2016185978A (ja) | 2010-12-23 | 2016-07-11 | ポリマー−スニチニブコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016136547A Withdrawn JP2016185978A (ja) | 2010-12-23 | 2016-07-11 | ポリマー−スニチニブコンジュゲート |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9827326B2 (enExample) |
| EP (1) | EP2654799B1 (enExample) |
| JP (2) | JP6002149B2 (enExample) |
| WO (1) | WO2012088529A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088529A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-sunitinib conjugates |
| WO2012088506A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-semaxanib moiety conjugates |
| JP6009457B2 (ja) | 2010-12-23 | 2016-10-19 | ネクター セラピューティクス | ポリマー−デスエチルスニチニブコンジュゲート |
| EP3228650B1 (en) * | 2014-12-04 | 2022-03-09 | Delta-Fly Pharma, Inc. | Novel peg derivative |
| CN104610231B (zh) * | 2015-01-28 | 2016-08-17 | 广州葳澜生物科技有限公司 | 一种舒尼替尼前药 |
| MX2018003462A (es) | 2015-09-22 | 2018-09-06 | Graybug Vision Inc | Compuestos y composiciones para el tratamiento de trastornos oculares. |
| MX2019011242A (es) | 2017-03-23 | 2020-01-21 | Graybug Vision Inc | Farmacos y composiciones para el tratamiento de trastornos oculares. |
| MX2019013363A (es) | 2017-05-10 | 2020-01-13 | Graybug Vision Inc | Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica. |
| CN113490765A (zh) * | 2019-03-08 | 2021-10-08 | 应用材料公司 | 用于处理腔室的多孔喷头 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810646A (en) | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US4992540A (en) | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US5028703A (en) | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| DK1255536T3 (da) | 1999-12-22 | 2006-10-30 | Sugen Inc | Indolinonderivater til modulation af c-kit-tyrosinproteinkinase |
| CN1329390C (zh) | 2000-02-15 | 2007-08-01 | 苏根公司 | 吡咯取代的2－二氢吲哚酮蛋白激酶抑制剂 |
| US20020028828A1 (en) | 2000-05-02 | 2002-03-07 | Chung-Chen Wei | (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| TWI259081B (en) | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| MXPA04004336A (es) | 2001-11-07 | 2005-05-16 | Nektar Therapeutics Al Corp | Polimeros ramificados y sus conjugados. |
| US7053144B1 (en) | 2002-06-13 | 2006-05-30 | Cmi Rubber Company, Inc. | High density rubber compounds |
| US20050079155A1 (en) | 2003-03-20 | 2005-04-14 | Xencor, Inc. | Generating protein pro-drugs using reversible PPG linkages |
| LT2644206T (lt) | 2003-05-23 | 2019-05-27 | Nektar Therapeutics | Peg dariniai, susidedantys iš dviejų peg grandinių |
| PT1675622T (pt) | 2003-09-17 | 2017-09-19 | Nektar Therapeutics | Pró-fármacos de polímeros de múltiplos braços |
| US8562965B2 (en) | 2004-05-03 | 2013-10-22 | Nektar Therapeutics | Polymer derivatives comprising an acetal or ketal branching point |
| WO2005107815A2 (en) | 2004-05-03 | 2005-11-17 | Nektar Therapeutics Al, Corporation | Polymer derivatives comprising an imide branching point |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| CA2611823C (en) | 2005-06-16 | 2013-07-30 | Nektar Therapeutics Al, Corporation | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
| CN103030801B (zh) | 2006-02-21 | 2015-07-22 | 尼克塔治疗公司 | 嵌段可降解聚合物及由其制备的轭合物 |
| WO2007109564A2 (en) | 2006-03-17 | 2007-09-27 | University Of Massachusetts | Yeast cell particles as oral delivery vehicles for antigens |
| WO2008082669A2 (en) | 2006-12-27 | 2008-07-10 | Nektar Therapeutics Al, Corporation | Von willebrand factor- and factor viii-polymer conjugates having a releasable linkage |
| WO2009073154A1 (en) | 2007-11-28 | 2009-06-11 | Nektar Therapeutics Al, Corporation | Oligomer-tricyclic conjugates |
| EP2254601B1 (en) | 2008-02-08 | 2019-05-29 | Nektar Therapeutics | Oligomer-cannabinoid conjugates |
| WO2009126333A1 (en) | 2008-04-11 | 2009-10-15 | Nektar Therapeutics | Oligomer-aryloxy-substituted propanamine conjugates |
| CN102131509B (zh) | 2008-05-22 | 2015-01-07 | 特拉维夫大学拉莫特有限公司 | 聚合物、二膦酸盐和抗血管生成剂的缀合物及其在治疗和监测骨相关疾病中的用途 |
| AU2009282413B2 (en) | 2008-08-11 | 2014-07-17 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
| WO2010091187A2 (en) | 2009-02-04 | 2010-08-12 | The Brigham And Women's Hospital, Inc. | Polymeric nanoparticles with enhanced drug-loading and methods of use thereof |
| US8816077B2 (en) * | 2009-04-17 | 2014-08-26 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| WO2010120387A1 (en) * | 2009-04-17 | 2010-10-21 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| JP6009457B2 (ja) | 2010-12-23 | 2016-10-19 | ネクター セラピューティクス | ポリマー−デスエチルスニチニブコンジュゲート |
| WO2012088529A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-sunitinib conjugates |
-
2011
- 2011-12-23 WO PCT/US2011/067259 patent/WO2012088529A1/en not_active Ceased
- 2011-12-23 US US13/996,834 patent/US9827326B2/en active Active
- 2011-12-23 JP JP2013546460A patent/JP6002149B2/ja active Active
- 2011-12-23 EP EP11811620.1A patent/EP2654799B1/en active Active
-
2016
- 2016-07-11 JP JP2016136547A patent/JP2016185978A/ja not_active Withdrawn
-
2017
- 2017-10-24 US US15/792,060 patent/US10682418B2/en active Active
-
2020
- 2020-05-07 US US16/869,458 patent/US11419943B2/en active Active