JP2014503548A5 - - Google Patents

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Publication number
JP2014503548A5
JP2014503548A5 JP2013546460A JP2013546460A JP2014503548A5 JP 2014503548 A5 JP2014503548 A5 JP 2014503548A5 JP 2013546460 A JP2013546460 A JP 2013546460A JP 2013546460 A JP2013546460 A JP 2013546460A JP 2014503548 A5 JP2014503548 A5 JP 2014503548A5
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JP
Japan
Prior art keywords
water
compound
soluble non
peptide polymer
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013546460A
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English (en)
Japanese (ja)
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JP6002149B2 (ja
JP2014503548A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/067259 external-priority patent/WO2012088529A1/en
Publication of JP2014503548A publication Critical patent/JP2014503548A/ja
Publication of JP2014503548A5 publication Critical patent/JP2014503548A5/ja
Application granted granted Critical
Publication of JP6002149B2 publication Critical patent/JP6002149B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2013546460A 2010-12-23 2011-12-23 ポリマー−スニチニブコンジュゲート Active JP6002149B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061426919P 2010-12-23 2010-12-23
US61/426,919 2010-12-23
PCT/US2011/067259 WO2012088529A1 (en) 2010-12-23 2011-12-23 Polymer-sunitinib conjugates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016136547A Division JP2016185978A (ja) 2010-12-23 2016-07-11 ポリマー−スニチニブコンジュゲート

Publications (3)

Publication Number Publication Date
JP2014503548A JP2014503548A (ja) 2014-02-13
JP2014503548A5 true JP2014503548A5 (enExample) 2014-12-25
JP6002149B2 JP6002149B2 (ja) 2016-10-05

Family

ID=45529206

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013546460A Active JP6002149B2 (ja) 2010-12-23 2011-12-23 ポリマー−スニチニブコンジュゲート
JP2016136547A Withdrawn JP2016185978A (ja) 2010-12-23 2016-07-11 ポリマー−スニチニブコンジュゲート

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016136547A Withdrawn JP2016185978A (ja) 2010-12-23 2016-07-11 ポリマー−スニチニブコンジュゲート

Country Status (4)

Country Link
US (3) US9827326B2 (enExample)
EP (1) EP2654799B1 (enExample)
JP (2) JP6002149B2 (enExample)
WO (1) WO2012088529A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088506A1 (en) 2010-12-23 2012-06-28 Nektar Therapeutics Polymer-semaxanib moiety conjugates
US9827326B2 (en) 2010-12-23 2017-11-28 Nektar Therapeutics Polymer-sunitinib conjugates
US10220020B2 (en) 2010-12-23 2019-03-05 Nektar Therapeutics Polymer-des-ethyl sunitinib conjugates
EP3228650B1 (en) * 2014-12-04 2022-03-09 Delta-Fly Pharma, Inc. Novel peg derivative
CN104610231B (zh) * 2015-01-28 2016-08-17 广州葳澜生物科技有限公司 一种舒尼替尼前药
KR20180058758A (ko) 2015-09-22 2018-06-01 그레이버그 비젼, 인크. 안구 장애의 치료를 위한 화합물 및 조성물
MX2019011242A (es) 2017-03-23 2020-01-21 Graybug Vision Inc Farmacos y composiciones para el tratamiento de trastornos oculares.
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
WO2020185360A1 (en) * 2019-03-08 2020-09-17 Applied Materials, Inc. Porous showerhead for a processing chamber

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US4992540A (en) 1984-11-28 1991-02-12 Massachusetts Institute Of Technology Glucan composition and process for preparation thereof
US5028703A (en) 1988-03-11 1991-07-02 Massachusetts Institute Of Technology Glucan composition and process for preparation thereof
US5032401A (en) 1989-06-15 1991-07-16 Alpha Beta Technology Glucan drug delivery system and adjuvant
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
CA2395461C (en) 1999-12-22 2010-05-25 Sugen, Inc. Methods of modulating c-kit tyrosine kinase function with indolinone compounds
HRP20020751B1 (hr) 2000-02-15 2011-01-31 Sugen Pirolom supstituirani 2-indolinoni kao inhibitori protein kinaze
WO2001083450A2 (en) 2000-05-02 2001-11-08 Sugen, Inc. (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors
MY128449A (en) 2000-05-24 2007-02-28 Sugen Inc Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
TWI259081B (en) 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
EP1446438A2 (en) 2001-11-07 2004-08-18 Nektar Therapeutics Al, Corporation Branched polymers and their conjugates
US7053144B1 (en) 2002-06-13 2006-05-30 Cmi Rubber Company, Inc. High density rubber compounds
US20050079155A1 (en) 2003-03-20 2005-04-14 Xencor, Inc. Generating protein pro-drugs using reversible PPG linkages
PT2644206T (pt) 2003-05-23 2019-07-10 Nektar Therapeutics Derivados de peg contendo duas cadeias de peg
CN1852740B (zh) * 2003-09-17 2011-05-11 耐科塔医药公司 多支链聚合物的药物前体
US9085659B2 (en) 2004-05-03 2015-07-21 Nektar Therapeutics Polymer derivatives comprising an imide branching point
WO2005108463A2 (en) 2004-05-03 2005-11-17 Nektar Therapeutics Al, Corporation Branched polyethylen glycol derivates comprising an acetal or ketal branching point
US7740861B2 (en) 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
CA2611823C (en) 2005-06-16 2013-07-30 Nektar Therapeutics Al, Corporation Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
EP2319542B1 (en) 2006-02-21 2018-03-21 Nektar Therapeutics Segmented degradable polymers and conjugates made therefrom
US20080044438A1 (en) 2006-03-17 2008-02-21 Ostroff Gary R Yeast Cell Particles As Oral Delivery Vehicles For Antigens
MX2009007145A (es) 2006-12-27 2009-08-27 Nektar Therapeutics Al Corp Conjugados de polimero con factor viii y factor de von willebrand que tienen una ligadura liberable.
AU2008331868B2 (en) 2007-11-28 2015-02-12 Nektar Therapeutics Oligomer-tricyclic conjugates
US8829043B2 (en) 2008-02-08 2014-09-09 Nektar Therapeutics Oligome-cannabinoid conjugates
EP2265290B1 (en) 2008-04-11 2014-06-04 Nektar Therapeutics Poly(alkylene oxide)-aryloxy-substituted propanamine conjugates
WO2009141823A2 (en) * 2008-05-22 2009-11-26 Ramot At Tel Aviv University Ltd. Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
WO2010091187A2 (en) 2009-02-04 2010-08-12 The Brigham And Women's Hospital, Inc. Polymeric nanoparticles with enhanced drug-loading and methods of use thereof
WO2010120387A1 (en) * 2009-04-17 2010-10-21 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
WO2010120388A1 (en) * 2009-04-17 2010-10-21 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
US10220020B2 (en) 2010-12-23 2019-03-05 Nektar Therapeutics Polymer-des-ethyl sunitinib conjugates
US9827326B2 (en) 2010-12-23 2017-11-28 Nektar Therapeutics Polymer-sunitinib conjugates

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