JP2007504169A5 - - Google Patents
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- Publication number
- JP2007504169A5 JP2007504169A5 JP2006524951A JP2006524951A JP2007504169A5 JP 2007504169 A5 JP2007504169 A5 JP 2007504169A5 JP 2006524951 A JP2006524951 A JP 2006524951A JP 2006524951 A JP2006524951 A JP 2006524951A JP 2007504169 A5 JP2007504169 A5 JP 2007504169A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- poly
- amino acid
- composition
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 16
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 12
- 229920001223 polyethylene glycol Polymers 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000003827 glycol group Chemical group 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- -1 ketal Chemical compound 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 150000007970 thio esters Chemical class 0.000 claims 2
- 101000984722 Bos taurus Pancreatic trypsin inhibitor Proteins 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 102000016387 Pancreatic elastase Human genes 0.000 claims 1
- 108010067372 Pancreatic elastase Proteins 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 150000001241 acetals Chemical class 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 150000002466 imines Chemical class 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 229920001427 mPEG Polymers 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 150000002905 orthoesters Chemical class 0.000 claims 1
- 150000003014 phosphoric acid esters Chemical class 0.000 claims 1
- 229920001484 poly(alkylene) Polymers 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- 150000003673 urethanes Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49884503P | 2003-08-29 | 2003-08-29 | |
| PCT/US2004/028256 WO2005021556A2 (en) | 2003-08-29 | 2004-08-30 | Modified protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007504169A JP2007504169A (ja) | 2007-03-01 |
| JP2007504169A5 true JP2007504169A5 (enExample) | 2007-09-13 |
Family
ID=34272739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006524951A Withdrawn JP2007504169A (ja) | 2003-08-29 | 2004-08-30 | 修飾されたプロテアーゼインヒビター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070020252A1 (enExample) |
| EP (1) | EP1663279A4 (enExample) |
| JP (1) | JP2007504169A (enExample) |
| AU (1) | AU2004268144A1 (enExample) |
| CA (1) | CA2537113A1 (enExample) |
| WO (1) | WO2005021556A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| PT2298278E (pt) | 2002-06-07 | 2016-02-25 | Dyax Corp | Prevenção e redução da perda de sangue e resposta inflamatória |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| CA3050564A1 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| WO2006070012A1 (en) * | 2004-12-30 | 2006-07-06 | Ingenium Pharmaceuticals Ag | Agents useful in treating inflammatory bowel disease |
| EP1981519B1 (en) * | 2005-12-29 | 2017-12-27 | Dyax Corp. | Protease inhibition |
| DK1854477T3 (en) * | 2006-03-16 | 2016-11-28 | Dyax Corp | Peptide inhibitors of plasma kallikrein for use in the treatment of eye disorders |
| JP2012502906A (ja) * | 2008-09-17 | 2012-02-02 | ネクター セラピューティックス | オリゴマー−プロテアーゼ阻害剤コンジュゲート |
| JP2013516389A (ja) | 2009-01-06 | 2013-05-13 | ダイアックス コーポレーション | カリクレイン阻害剤による粘膜炎治療 |
| EP2440249A2 (en) * | 2009-06-12 | 2012-04-18 | Nektar Therapeutics | Covalent conjugates comprising a protease inhibitor, a water-soluble, non-peptidic oligomer and a lipophilic moiety |
| US20110094080A1 (en) * | 2009-10-27 | 2011-04-28 | William Karales | Bar soap support mat |
| ES2905545T3 (es) | 2010-01-06 | 2022-04-11 | Takeda Pharmaceuticals Co | Proteínas de unión a calicreína plasmática |
| KR102011156B1 (ko) | 2011-01-06 | 2019-08-16 | 다이액스 코포레이션 | 혈장 칼리크레인 결합 단백질 |
| IL247942B (en) | 2014-03-27 | 2022-09-01 | Dyax Corp | Compositions and methods for drops in macular edema as a result of diabetes |
| US11286307B2 (en) | 2015-12-11 | 2022-03-29 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| AU2021209045A1 (en) | 2020-01-13 | 2022-07-28 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| EP0737207B1 (en) * | 1994-01-11 | 2004-09-22 | Dyax Corporation | Inhibitors of human plasmin derived from the kunitz domains |
| US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| AU690986B2 (en) * | 1994-06-02 | 1998-05-07 | Merrell Pharmaceuticals Inc. | Perfluoroalkyl ketone inhibitors of elastase and processes for making the same |
| US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| US5990237A (en) * | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
| JP2002531089A (ja) * | 1998-11-30 | 2002-09-24 | イーライ・リリー・アンド・カンパニー | 赤血球産生性化合物 |
| JP2003513681A (ja) * | 1999-11-12 | 2003-04-15 | マキシゲン・ホールディングス・リミテッド | インターフェロンガンマ・コンジュゲート |
| US6544760B2 (en) * | 1999-12-22 | 2003-04-08 | Zymogenetics, Inc. | Kunitz domain polypeptide Zkun11 |
| US20020168323A1 (en) * | 2001-05-11 | 2002-11-14 | Igor Gonda | Optimization of the molecular properties and formulation of proteins delivered by inhalation |
| KR20030097876A (ko) * | 2001-05-21 | 2003-12-31 | 넥타르 테라퓨틱스 | 화학적으로 개질된 인슐린의 폐 투여 |
| BR0312889A (pt) * | 2002-07-24 | 2005-06-14 | Hoffmann La Roche | Polipeptìdeo t20 peguilado |
| CN100337689C (zh) * | 2002-07-24 | 2007-09-19 | 弗·哈夫曼-拉罗切有限公司 | 聚亚烷基二醇酸加合物 |
| US7314613B2 (en) * | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| CA3050564A1 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
| US20060228331A1 (en) * | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
-
2004
- 2004-08-30 CA CA002537113A patent/CA2537113A1/en not_active Abandoned
- 2004-08-30 EP EP04782687A patent/EP1663279A4/en not_active Ceased
- 2004-08-30 WO PCT/US2004/028256 patent/WO2005021556A2/en not_active Ceased
- 2004-08-30 JP JP2006524951A patent/JP2007504169A/ja not_active Withdrawn
- 2004-08-30 AU AU2004268144A patent/AU2004268144A1/en not_active Abandoned
- 2004-08-30 US US10/570,186 patent/US20070020252A1/en not_active Abandoned
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