SI2280962T1 - Derivati piridazinona - Google Patents

Derivati piridazinona

Info

Publication number
SI2280962T1
SI2280962T1 SI200930411T SI200930411T SI2280962T1 SI 2280962 T1 SI2280962 T1 SI 2280962T1 SI 200930411 T SI200930411 T SI 200930411T SI 200930411 T SI200930411 T SI 200930411T SI 2280962 T1 SI2280962 T1 SI 2280962T1
Authority
SI
Slovenia
Prior art keywords
pyridazinone derivatives
pyridazinone
derivatives
Prior art date
Application number
SI200930411T
Other languages
English (en)
Slovenian (sl)
Inventor
Dieter Dorsch
Oliver Schadt
Frank Stieber
Andree Blaukat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SI2280962T1 publication Critical patent/SI2280962T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200930411T 2008-04-21 2009-03-24 Derivati piridazinona SI2280962T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008019907A DE102008019907A1 (de) 2008-04-21 2008-04-21 Pyridazinonderivate
PCT/EP2009/002137 WO2009129905A1 (de) 2008-04-21 2009-03-24 Pyridazinonderivate
EP09734854A EP2280962B1 (de) 2008-04-21 2009-03-24 Pyridazinonderivate

Publications (1)

Publication Number Publication Date
SI2280962T1 true SI2280962T1 (sl) 2013-01-31

Family

ID=40639931

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200930411T SI2280962T1 (sl) 2008-04-21 2009-03-24 Derivati piridazinona

Country Status (22)

Country Link
US (1) US8604036B2 (OSRAM)
EP (1) EP2280962B1 (OSRAM)
JP (1) JP5576358B2 (OSRAM)
KR (1) KR20100137564A (OSRAM)
CN (1) CN102015694A (OSRAM)
AR (1) AR071208A1 (OSRAM)
AU (1) AU2009240346B2 (OSRAM)
BR (1) BRPI0911161B8 (OSRAM)
CA (1) CA2721858C (OSRAM)
CY (1) CY1113443T1 (OSRAM)
DE (1) DE102008019907A1 (OSRAM)
DK (1) DK2280962T5 (OSRAM)
EA (1) EA018362B1 (OSRAM)
ES (1) ES2394147T3 (OSRAM)
HR (1) HRP20120884T1 (OSRAM)
IL (1) IL208336A (OSRAM)
MX (1) MX2010011454A (OSRAM)
PL (1) PL2280962T3 (OSRAM)
PT (1) PT2280962E (OSRAM)
SI (1) SI2280962T1 (OSRAM)
WO (1) WO2009129905A1 (OSRAM)
ZA (1) ZA201008330B (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007038957A1 (de) * 2007-08-17 2009-02-19 Merck Patent Gmbh 6-Thioxo-pyridazinderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) * 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
DE102008037790A1 (de) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
UA103646C2 (ru) 2008-12-22 2013-11-11 Мерк Патент Гмбх Полиморфные формы 6-(1-метил-1h-пиразол-4-ил)-2-{3-[5-(2-морфолин-4-илетокси)-пиримидин-2-ил]-бензил}-2h-пиридазин-3-она и способ их получения (варианты)
CN102532126B (zh) * 2012-02-10 2014-06-18 贵州大学 2-取代-4-氯-5-[5-取代胺基-2-(1,3,4-噻二唑基)-巯基]-3(2h)-哒嗪酮类衍生物及其制备方法和用途
WO2018081381A1 (en) * 2016-10-26 2018-05-03 Proteostasis Therapeutics, Inc Pyridazine derivatives, compositions and methods for modulating cftr
EP3697776B1 (en) 2017-10-17 2023-04-19 Palau Pharma, S.L.U. Synthesis of 4-aminopyrimidine compounds
CN108752322A (zh) * 2018-09-12 2018-11-06 广州新民培林医药科技有限公司 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用
JP7671245B2 (ja) 2018-11-06 2025-05-01 エッジワイズ セラピューティクス， インコーポレイテッド ピリダジノン化合物およびその使用
CA3118908A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
SMT202300355T1 (it) 2018-11-06 2024-01-10 Edgewise Therapeutics Inc Composti di piridazinone e loro usi
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN114502551B (zh) 2019-11-01 2023-08-22 优迈特株式会社 含氟嘧啶化合物及其制备方法

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5795964A (en) 1980-12-04 1982-06-15 Morishita Seiyaku Kk Preparation of 2-substituted-3(2h)-pyridazinone derivative
US4397854A (en) 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
AU691673B2 (en) 1994-11-14 1998-05-21 Dow Agrosciences Llc Pyridazinones and their use as fungicides
US5635494A (en) 1995-04-21 1997-06-03 Rohm And Haas Company Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
DE19604388A1 (de) 1996-02-07 1997-08-14 Merck Patent Gmbh Arylalkyl-diazinone
PL194689B1 (pl) 1996-02-13 2007-06-29 Astrazeneca Uk Ltd Pochodne chinazoliny, ich kompozycje farmaceutyczne oraz ich zastosowania
EP0885198B1 (en) 1996-03-05 2001-12-19 AstraZeneca AB 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
JPH10259176A (ja) 1997-03-17 1998-09-29 Japan Tobacco Inc 血管新生阻害作用を有する新規アミド誘導体及びその用途
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
RU2209813C2 (ru) 1997-11-19 2003-08-10 Кова Ко., Лтд. Производные пиридазина, лекарственные средства на их основе и способ лечения артрита
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
KR100657189B1 (ko) * 1998-08-14 2006-12-14 니혼노야쿠가부시키가이샤 피리다지논 유도체 및 이를 함유하는 의약 조성물
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
AUPQ462299A0 (en) * 1999-12-13 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. Pyrazolopyridine compound and pharmaceutical use thereof
US6242461B1 (en) 2000-01-25 2001-06-05 Pfizer Inc. Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases
EP1289952A1 (en) 2000-05-31 2003-03-12 AstraZeneca AB Indole derivatives with vascular damaging activity
CN1255391C (zh) 2000-07-07 2006-05-10 安吉奥金尼药品有限公司 作为血管破坏剂的colchinol衍生物
WO2002008213A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
CN1578665A (zh) 2001-10-31 2005-02-09 默克专利股份公司 4型磷酸二脂酶抑制剂及其应用
CA2510298A1 (en) 2002-12-20 2004-07-15 Pharmacia Corporation Acyclic pyrazole compounds
CA2530589A1 (en) 2003-07-02 2005-01-20 Sugen Inc. Arylmethyl triazolo and imidazopyrazines as c-met inhibitors
US7959919B2 (en) * 2003-11-19 2011-06-14 Novelmed Therapeutics, Inc. Method of inhibiting factor B-mediated complement activation
TW200612918A (en) 2004-07-29 2006-05-01 Threshold Pharmaceuticals Inc Lonidamine analogs
US20070015771A1 (en) 2004-07-29 2007-01-18 Threshold Pharmaceuticals, Inc. Lonidamine analogs
US20070043057A1 (en) 2005-02-09 2007-02-22 Threshold Pharmaceuticals, Inc. Lonidamine analogs
WO2007044796A2 (en) 2005-10-11 2007-04-19 Nps Pharmaceuticals, Inc. Pyridazinone compounds as calcilytics
AU2006320580B2 (en) 2005-11-30 2011-06-23 Vertex Pharmaceuticals Incorporated Inhibitors of c-Met and uses thereof
DE102005057924A1 (de) * 2005-12-05 2007-06-06 Merck Patent Gmbh Pyridazinonderivate
EP1966214B9 (en) 2005-12-21 2017-09-13 Janssen Pharmaceutica N.V. Triazolopyridazines as tyrosine kinase modulators
WO2007130383A2 (en) 2006-04-28 2007-11-15 Northwestern University Compositions and treatments using pyridazine compounds and secretases
NL2000613C2 (nl) 2006-05-11 2007-11-20 Pfizer Prod Inc Triazoolpyrazinederivaten.
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
PE20121506A1 (es) 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
DE102006037478A1 (de) * 2006-08-10 2008-02-14 Merck Patent Gmbh 2-(Heterocyclylbenzyl)-pyridazinonderivate
US7737149B2 (en) 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
US8314087B2 (en) * 2007-02-16 2012-11-20 Amgen Inc. Nitrogen-containing heterocyclyl ketones and methods of use
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
WO2009050197A2 (en) 2007-10-16 2009-04-23 Novartis Ag Substituted piperazines and piperidines as modulators of the neuropeptide y2 receptor
JP2011500778A (ja) 2007-10-25 2011-01-06 アストラゼネカ・アクチエボラーグ ピリジン及びピラジン誘導体−０８３
US8440666B2 (en) 2007-10-31 2013-05-14 Nissan Chemical Industries, Ltd. Pyridazinone compounds and P2X7 receptor inhibitors
TW200927115A (en) 2007-11-16 2009-07-01 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
EP2072506A1 (de) 2007-12-21 2009-06-24 Bayer CropScience AG Thiazolyloxyphenylamidine oder Thiadiazolyloxyphenylamidine und deren Verwendung als Fungizide
CN101952286A (zh) 2007-12-21 2011-01-19 阿斯利康(瑞典)有限公司 用于治疗和雄激素受体有关的病症的双环衍生物
US7816540B2 (en) 2007-12-21 2010-10-19 Hoffmann-La Roche Inc. Carboxyl- or hydroxyl-substituted benzimidazole derivatives
PE20091339A1 (es) 2007-12-21 2009-09-26 Glaxo Group Ltd Derivados de oxadiazol con actividad sobre receptores s1p1
EP2242483B1 (en) 2007-12-21 2013-02-20 Synthon B.V. Raloxifene composition
ES2526649T3 (es) 2007-12-21 2015-01-14 F. Hoffmann-La Roche Ag Compuestos heterocíclicos antivíricos
PE20091669A1 (es) 2007-12-21 2009-12-06 Exelixis Inc Benzofuropirimidinonas
CL2008003785A1 (es) 2007-12-21 2009-10-09 Du Pont Compuestos derivados de piridazina; composiciones herbicidas que comprenden a dichos compuestos; y método para controlar el crecimiento de la vegetación indeseada.
BRPI0821141A2 (pt) 2007-12-21 2015-06-16 Hoffmann La Roche Derivados de heteroarila como antagonistas do receptor de orexina
PT2235012E (pt) 2007-12-21 2013-08-28 Palau Pharma Sa Derivados de 4-aminopirimidina como antagonistas de receptor h4 de histamina
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
GB0725059D0 (en) 2007-12-21 2008-01-30 Syngenta Participations Ag Novel pyridazine derivatives
CN101538245B (zh) 2008-03-18 2011-02-16 中国科学院上海药物研究所 一类哒嗪酮类化合物及其制备方法和制备药物的用途
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
EP2328586A2 (en) 2008-05-20 2011-06-08 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
EP2323994A1 (en) 2008-07-25 2011-05-25 Boehringer Ingelheim International GmbH Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
US20120028988A1 (en) 2009-03-30 2012-02-02 Sumitomo Chemical Company, Limited Use of pyridazinone compound for control of harmful arthropod pests
AR082590A1 (es) 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton

Also Published As

Publication number Publication date
CA2721858A1 (en) 2009-10-29
DE102008019907A1 (de) 2009-10-22
PT2280962E (pt) 2012-12-17
EP2280962A1 (de) 2011-02-09
IL208336A (en) 2016-07-31
EA018362B1 (ru) 2013-07-30
JP2011518202A (ja) 2011-06-23
BRPI0911161B8 (pt) 2021-05-25
KR20100137564A (ko) 2010-12-30
HRP20120884T1 (hr) 2012-11-30
JP5576358B2 (ja) 2014-08-20
BRPI0911161B1 (pt) 2020-02-11
AU2009240346A1 (en) 2009-10-29
BRPI0911161A2 (pt) 2015-10-06
IL208336A0 (en) 2010-12-30
DK2280962T5 (da) 2013-09-16
US8604036B2 (en) 2013-12-10
WO2009129905A1 (de) 2009-10-29
ZA201008330B (en) 2011-09-28
AU2009240346B2 (en) 2013-10-10
EA201001648A1 (ru) 2011-06-30
CN102015694A (zh) 2011-04-13
PL2280962T3 (pl) 2013-02-28
AR071208A1 (es) 2010-06-02
CY1113443T1 (el) 2016-06-22
EP2280962B1 (de) 2012-10-03
MX2010011454A (es) 2010-12-21
DK2280962T3 (da) 2012-11-19
CA2721858C (en) 2016-07-19
ES2394147T3 (es) 2013-01-22
US20110034474A1 (en) 2011-02-10

Similar Documents

Publication Publication Date Title
ZA201105440B (en) Pyridazinone derivatives
IL212636A0 (en) Pyridazinone derivatives
LT2754660T (lt) Piridazinono dariniai
IL202376A0 (en) Pyridazinone derivatives
ZA201008330B (en) Pyridazinone derivatives
IL210548A0 (en) Spiroaminodihydrothiazine derivatives
ZA201100799B (en) Imidazopyridin-2-one derivatives
SG10201506608RA (en) 3-deazaneplanocin derivatives
ZA201100876B (en) Pyrrolopyridinylpyrimidin-2-ylamine derivatives
ZA201102449B (en) Morpholinopurine derivatives
IL210869A0 (en) Imidazothiadiazoles derivatives
ZA201100948B (en) Acylaminobenzamide derivatives
IL210164A0 (en) Thiazolylpiperidine derivatives
IL207192A0 (en) Substituted heteroarylamide diazepinopyrimidone derivatives
ZA201105050B (en) Quinazolinamide derivatives
IL213828A0 (en) Pyridazinone derivatives
IL207191A0 (en) Substituted heteroaylamide oxazepyrimidone derivatives
ZA201008052B (en) 2-phenyl-4-cyclopropyl-pyrimidine derivatives
GB0800762D0 (en) Novel pyridazine derivatives
ZA201105781B (en) Pyridazinone derivatives
IL213051A0 (en) Difluorophenyldiacylhydrazide derivatives
GB0821711D0 (en) Dihydroindolone derivatives
GB0816145D0 (en) a-Galactosylceramide derivatives
HU0800376D0 (en) Sulfonyl-quinoline derivatives