SI2231639T1 - Kristalinična oblika n-(terc-butoksikarbonil)-3-metil-l-valil-(4r)-4-((7-kloro-4-metoksi-1- izokinolinil)oksi)-n-((1r,2s)-1-((ciklopropilsufonil)karbamoil)-2-vinil) ciklopropil)-l-prolinamid - Google Patents

Kristalinična oblika n-(terc-butoksikarbonil)-3-metil-l-valil-(4r)-4-((7-kloro-4-metoksi-1- izokinolinil)oksi)-n-((1r,2s)-1-((ciklopropilsufonil)karbamoil)-2-vinil) ciklopropil)-l-prolinamid

Info

Publication number
SI2231639T1
SI2231639T1 SI200831432T SI200831432T SI2231639T1 SI 2231639 T1 SI2231639 T1 SI 2231639T1 SI 200831432 T SI200831432 T SI 200831432T SI 200831432 T SI200831432 T SI 200831432T SI 2231639 T1 SI2231639 T1 SI 2231639T1
Authority
SI
Slovenia
Prior art keywords
vinylcyclopropyl
prolinamide
cyclopropylsulfonyl
valyl
isoquinolinyl
Prior art date
Application number
SI200831432T
Other languages
English (en)
Inventor
Robert Kevin Perrone
Chenchi Wang
William Ying
Anne I. Song
Original Assignee
Bristol-Myers Squibb Holdings Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40467309&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2231639(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Holdings Ireland filed Critical Bristol-Myers Squibb Holdings Ireland
Publication of SI2231639T1 publication Critical patent/SI2231639T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200831432T 2007-12-21 2008-12-12 Kristalinična oblika n-(terc-butoksikarbonil)-3-metil-l-valil-(4r)-4-((7-kloro-4-metoksi-1- izokinolinil)oksi)-n-((1r,2s)-1-((ciklopropilsufonil)karbamoil)-2-vinil) ciklopropil)-l-prolinamid SI2231639T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1579507P 2007-12-21 2007-12-21
EP08866514.6A EP2231639B1 (en) 2007-12-21 2008-12-12 Crystalline forms of n-(tert-butoxycarbonyl)-3-methyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-l-prolinamide
PCT/US2008/086587 WO2009085659A1 (en) 2007-12-21 2008-12-12 Crystalline forms of n-(tert-butoxycarbonyl)-3-methyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-l-prolinamide

Publications (1)

Publication Number Publication Date
SI2231639T1 true SI2231639T1 (sl) 2015-11-30

Family

ID=40467309

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200831432T SI2231639T1 (sl) 2007-12-21 2008-12-12 Kristalinična oblika n-(terc-butoksikarbonil)-3-metil-l-valil-(4r)-4-((7-kloro-4-metoksi-1- izokinolinil)oksi)-n-((1r,2s)-1-((ciklopropilsufonil)karbamoil)-2-vinil) ciklopropil)-l-prolinamid

Country Status (18)

Country Link
US (2) US8202996B2 (sl)
EP (1) EP2231639B1 (sl)
JP (1) JP5566907B2 (sl)
KR (1) KR101560428B1 (sl)
CN (3) CN103755784B (sl)
AR (2) AR069886A1 (sl)
AU (1) AU2008343423B2 (sl)
CL (1) CL2008003849A1 (sl)
DK (1) DK2231639T3 (sl)
ES (1) ES2536409T3 (sl)
HR (1) HRP20150458T1 (sl)
MX (1) MX336329B (sl)
PE (3) PE20091217A1 (sl)
PL (1) PL2231639T3 (sl)
PT (1) PT2231639E (sl)
SI (1) SI2231639T1 (sl)
TW (1) TWI496573B (sl)
WO (1) WO2009085659A1 (sl)

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US8202996B2 (en) 2012-06-19
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US20090202476A1 (en) 2009-08-13
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AU2008343423A1 (en) 2009-07-09
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