MX336329B - Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r) -4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopr opilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamida. - Google Patents
Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r) -4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopr opilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamida.Info
- Publication number
- MX336329B MX336329B MX2010006489A MX2010006489A MX336329B MX 336329 B MX336329 B MX 336329B MX 2010006489 A MX2010006489 A MX 2010006489A MX 2010006489 A MX2010006489 A MX 2010006489A MX 336329 B MX336329 B MX 336329B
- Authority
- MX
- Mexico
- Prior art keywords
- crystalline forms
- vinylcyclopropyl
- valyl
- isoquinolinyl
- butoxycarbonyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La presente invención se refiere de forma general a formas cristalinas de N-(terc-butoxicarbonil)-3-metil-L-valil-(4R)-4-((7- cloro-4-metoxi-1-isoquinolinil)oxi)-N-((1R,2S)-1-((ciclopropilsul fonil)carbamoil)-2-vinilciclopropil)-L-prolinamida. La presente descripción también se refiere de forma general a una composición farmacéutica que comprende una o más de las formas cristalinas, así como métodos de usar las formas cristalinas en el tratamiento del virus de la hepatitis C (VHC) y métodos para obtener las formas cristalinas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1579507P | 2007-12-21 | 2007-12-21 | |
PCT/US2008/086587 WO2009085659A1 (en) | 2007-12-21 | 2008-12-12 | Crystalline forms of n-(tert-butoxycarbonyl)-3-methyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-l-prolinamide |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2010006489A MX2010006489A (es) | 2010-07-05 |
MX336329B true MX336329B (es) | 2016-01-15 |
Family
ID=40467309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010006489A MX336329B (es) | 2007-12-21 | 2008-12-12 | Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r) -4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopr opilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamida. |
Country Status (18)
Country | Link |
---|---|
US (2) | US8202996B2 (es) |
EP (1) | EP2231639B1 (es) |
JP (1) | JP5566907B2 (es) |
KR (1) | KR101560428B1 (es) |
CN (3) | CN101903371B (es) |
AR (2) | AR069886A1 (es) |
AU (1) | AU2008343423B2 (es) |
CL (1) | CL2008003849A1 (es) |
DK (1) | DK2231639T3 (es) |
ES (1) | ES2536409T3 (es) |
HR (1) | HRP20150458T1 (es) |
MX (1) | MX336329B (es) |
PE (3) | PE20091217A1 (es) |
PL (1) | PL2231639T3 (es) |
PT (1) | PT2231639E (es) |
SI (1) | SI2231639T1 (es) |
TW (1) | TWI496573B (es) |
WO (1) | WO2009085659A1 (es) |
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US8202996B2 (en) * | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
US8163921B2 (en) | 2008-04-16 | 2012-04-24 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US20090285774A1 (en) | 2008-05-15 | 2009-11-19 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20090285773A1 (en) | 2008-05-15 | 2009-11-19 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
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-
2008
- 2008-12-08 US US12/329,969 patent/US8202996B2/en not_active Expired - Fee Related
- 2008-12-12 AU AU2008343423A patent/AU2008343423B2/en not_active Ceased
- 2008-12-12 ES ES08866514.6T patent/ES2536409T3/es active Active
- 2008-12-12 EP EP08866514.6A patent/EP2231639B1/en not_active Not-in-force
- 2008-12-12 CN CN200880121915.0A patent/CN101903371B/zh not_active Expired - Fee Related
- 2008-12-12 JP JP2010539659A patent/JP5566907B2/ja not_active Expired - Fee Related
- 2008-12-12 SI SI200831432T patent/SI2231639T1/sl unknown
- 2008-12-12 WO PCT/US2008/086587 patent/WO2009085659A1/en active Application Filing
- 2008-12-12 DK DK08866514.6T patent/DK2231639T3/en active
- 2008-12-12 KR KR1020107013461A patent/KR101560428B1/ko active IP Right Grant
- 2008-12-12 CN CN201410043331.3A patent/CN103755784B/zh not_active Expired - Fee Related
- 2008-12-12 PL PL08866514T patent/PL2231639T3/pl unknown
- 2008-12-12 PT PT88665146T patent/PT2231639E/pt unknown
- 2008-12-12 MX MX2010006489A patent/MX336329B/es unknown
- 2008-12-12 CN CN201610420780.4A patent/CN106146613A/zh active Pending
- 2008-12-19 PE PE2008002161A patent/PE20091217A1/es not_active Application Discontinuation
- 2008-12-19 PE PE2013000341A patent/PE20131130A1/es not_active Application Discontinuation
- 2008-12-19 TW TW097149847A patent/TWI496573B/zh not_active IP Right Cessation
- 2008-12-19 PE PE2017000076A patent/PE20170534A1/es unknown
- 2008-12-19 AR ARP080105639A patent/AR069886A1/es not_active Application Discontinuation
- 2008-12-19 CL CL2008003849A patent/CL2008003849A1/es unknown
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2012
- 2012-05-16 US US13/472,720 patent/US8338606B2/en not_active Expired - Fee Related
-
2015
- 2015-04-28 HR HRP20150458TT patent/HRP20150458T1/hr unknown
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HRP20150458T1 (hr) | 2015-06-05 |
US20120230949A1 (en) | 2012-09-13 |
AU2008343423A1 (en) | 2009-07-09 |
PE20131130A1 (es) | 2013-10-05 |
JP2011507869A (ja) | 2011-03-10 |
EP2231639B1 (en) | 2015-04-01 |
PL2231639T3 (pl) | 2015-09-30 |
AU2008343423B2 (en) | 2013-10-10 |
WO2009085659A1 (en) | 2009-07-09 |
US20090202476A1 (en) | 2009-08-13 |
SI2231639T1 (sl) | 2015-11-30 |
EP2231639A1 (en) | 2010-09-29 |
CN103755784A (zh) | 2014-04-30 |
MX2010006489A (es) | 2010-07-05 |
CN101903371A (zh) | 2010-12-01 |
US8338606B2 (en) | 2012-12-25 |
ES2536409T3 (es) | 2015-05-25 |
CN106146613A (zh) | 2016-11-23 |
KR101560428B1 (ko) | 2015-10-15 |
DK2231639T3 (en) | 2015-07-06 |
AR106338A2 (es) | 2018-01-03 |
CN101903371B (zh) | 2014-03-19 |
PE20091217A1 (es) | 2009-08-14 |
PE20170534A1 (es) | 2017-05-11 |
TW200932214A (en) | 2009-08-01 |
KR20100099703A (ko) | 2010-09-13 |
TWI496573B (zh) | 2015-08-21 |
CN103755784B (zh) | 2017-04-12 |
JP5566907B2 (ja) | 2014-08-06 |
CL2008003849A1 (es) | 2009-05-29 |
US8202996B2 (en) | 2012-06-19 |
AR069886A1 (es) | 2010-02-24 |
PT2231639E (pt) | 2015-06-03 |
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