SI21123A - Nepeptidni CCR1 receptor-antagonisti v kombinaciji s ciklosporinom A za zdravljenje zavrnitve srčnega presadka - Google Patents

Nepeptidni CCR1 receptor-antagonisti v kombinaciji s ciklosporinom A za zdravljenje zavrnitve srčnega presadka Download PDF

Info

Publication number
SI21123A
SI21123A SI200120045A SI200120045A SI21123A SI 21123 A SI21123 A SI 21123A SI 200120045 A SI200120045 A SI 200120045A SI 200120045 A SI200120045 A SI 200120045A SI 21123 A SI21123 A SI 21123A
Authority
SI
Slovenia
Prior art keywords
methyl
chloro
piperazine
phenoxy
carbonyl
Prior art date
Application number
SI200120045A
Other languages
English (en)
Slovenian (sl)
Inventor
Richard Horuk
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of SI21123A publication Critical patent/SI21123A/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200120045A 2000-07-31 2001-07-31 Nepeptidni CCR1 receptor-antagonisti v kombinaciji s ciklosporinom A za zdravljenje zavrnitve srčnega presadka SI21123A (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22205300P 2000-07-31 2000-07-31
US23128200P 2000-09-08 2000-09-08
US09/915,411 US6740636B2 (en) 2000-07-31 2001-07-25 Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
PCT/US2001/023862 WO2002009762A2 (en) 2000-07-31 2001-07-31 Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection

Publications (1)

Publication Number Publication Date
SI21123A true SI21123A (sl) 2003-08-31

Family

ID=27397025

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200120045A SI21123A (sl) 2000-07-31 2001-07-31 Nepeptidni CCR1 receptor-antagonisti v kombinaciji s ciklosporinom A za zdravljenje zavrnitve srčnega presadka

Country Status (28)

Country Link
US (1) US6740636B2 (no)
EP (1) EP1305047B1 (no)
JP (1) JP2004530630A (no)
KR (1) KR20030048000A (no)
CN (1) CN1655818A (no)
AT (1) ATE330634T1 (no)
AU (2) AU7807301A (no)
BG (1) BG107502A (no)
BR (1) BR0113140A (no)
CA (1) CA2417636A1 (no)
CY (1) CY1105321T1 (no)
DE (1) DE60120986T2 (no)
DK (1) DK1305047T3 (no)
EE (1) EE200300047A (no)
ES (1) ES2261447T3 (no)
HR (1) HRP20030121A2 (no)
HU (1) HUP0300686A3 (no)
IL (1) IL153933A0 (no)
LV (1) LV13033B (no)
MX (1) MXPA03000836A (no)
NO (1) NO20030475L (no)
NZ (1) NZ523688A (no)
PL (1) PL364521A1 (no)
PT (1) PT1305047E (no)
SI (1) SI21123A (no)
SK (1) SK1222003A3 (no)
WO (1) WO2002009762A2 (no)
YU (1) YU6703A (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018642A1 (en) * 2003-08-22 2005-03-03 Schering Aktiengesellschaft Chemokine inhibiting piperazine derivatives and their use to treat myocarditis
US10499828B2 (en) * 2004-03-05 2019-12-10 Lifescience Solutions, Llc System and method for heart monitoring
US7917195B2 (en) 2004-03-05 2011-03-29 Lifesciences Solutions LLC Systems, methods and computer program products for heart monitoring
US8103065B2 (en) * 2006-01-05 2012-01-24 Lifescience Solutions Llc Assessment of medical conditions
US20110009758A1 (en) * 2009-07-10 2011-01-13 Lifescience Solutions Llc System and method for heart monitoring

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
KR100447553B1 (ko) 1997-02-26 2004-09-08 화이자 인코포레이티드 헤테로아릴-헥사노산 아미드 유도체, 그의 제조 방법 및 ｍｉｐ-1 알파의 ｃｃｒ1 수용체로의 결합에 대한 선택적 저해제로서의 용도
US6207665B1 (en) * 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
CA2319077A1 (en) 1998-01-21 1999-07-29 Yoshisuke Nakasato Chemokine receptor antagonists and methods of use therefor
US6433165B1 (en) 1998-01-21 2002-08-13 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1177834C (zh) 1998-02-05 2004-12-01 辉瑞产品公司 二羟基己酸衍生物
EP1000626A1 (en) 1998-09-18 2000-05-17 Applied Research Systems ARS Holding N.V. Chemokine receptor antagonist and cyclosporin in combined therapy
JP2002535358A (ja) 1999-01-29 2002-10-22 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 移植片拒絶反応及び虚血−再灌流障害の予防方法

Also Published As

Publication number Publication date
JP2004530630A (ja) 2004-10-07
EP1305047B1 (en) 2006-06-21
CN1655818A (zh) 2005-08-17
HUP0300686A2 (hu) 2003-08-28
BG107502A (en) 2003-07-31
SK1222003A3 (en) 2003-09-11
CY1105321T1 (el) 2010-03-03
BR0113140A (pt) 2003-06-24
LV13033B (en) 2004-02-20
IL153933A0 (en) 2003-07-31
EP1305047A2 (en) 2003-05-02
NZ523688A (en) 2005-04-29
CA2417636A1 (en) 2002-02-07
ES2261447T3 (es) 2006-11-16
HRP20030121A2 (en) 2005-02-28
PT1305047E (pt) 2006-11-30
ATE330634T1 (de) 2006-07-15
DK1305047T3 (da) 2006-10-23
YU6703A (sh) 2006-05-25
MXPA03000836A (es) 2003-06-06
AU2001278073B2 (en) 2005-06-30
AU7807301A (en) 2002-02-13
EE200300047A (et) 2004-10-15
US6740636B2 (en) 2004-05-25
DE60120986T2 (de) 2006-11-23
US20020039997A1 (en) 2002-04-04
NO20030475L (no) 2003-03-28
WO2002009762A2 (en) 2002-02-07
NO20030475D0 (no) 2003-01-30
KR20030048000A (ko) 2003-06-18
WO2002009762A3 (en) 2003-01-09
DE60120986D1 (de) 2006-08-03
HUP0300686A3 (en) 2005-03-29
PL364521A1 (en) 2004-12-13

Similar Documents

Publication Publication Date Title
Kopp et al. Cellular and molecular mechanisms of cyclosporin nephrotoxicity.
Kim et al. Reactive oxygen species, but not Ca2+ overloading, trigger pH-and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion
Vergnolle et al. A role for proteinase-activated receptor–1 in inflammatory bowel diseases
Fuggle et al. sequential analysis of hla-class II antigen expression in human renal allografts Induction of Tubular class II Antigens and Correlation with Clinical Parameters
Chong et al. In vivo activity of leflunomide: pharmacokinetic analyses and mechanism of immunosuppression
Asai et al. Magnesium supplementation prevents experimental chronic cyclosporine a nephrotoxicity via renin-angiotensin system independent mechanism.
JP2021046432A (ja) 急性放射線症候群を治療するための組成物及び方法
Rovira et al. Tofacitinib halts progression of graft dysfunction in a rat model of mixed cellular and humoral rejection
Faist et al. Immune consequences of trauma, shock, and sepsis: mechanisms and therapeutic approaches
KR20040007485A (ko) 알레르기성 질환과 같은 비만세포계 질병에 대한ｎ-페닐-2-피리미딘아민의 용도
Noris et al. Combined treatment with mycophenolate mofetil and an angiotensin II receptor antagonist fully protects from chronic rejection in a rat model of renal allograft
SI21123A (sl) Nepeptidni CCR1 receptor-antagonisti v kombinaciji s ciklosporinom A za zdravljenje zavrnitve srčnega presadka
AU2001278073A1 (en) Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection
AU2003234642B2 (en) Anti-inflammatory compositions and methods of use
US6812230B2 (en) Non-peptide CCR1 receptor antagonists for the treatment of progressive renal fibrosis
US20110229433A1 (en) Use of modified interleukin-8 proteins for treating reperfusion injury or transplant rejection
Yin et al. Inhibition of chronic rejection of aortic allografts by dietary glycine
JP2004510694A (ja) 免疫抑制性組成物
Pupure et al. Distinct Influence of Atypical 1, 4‐Dihydropyridine Compounds in Azidothymidine‐Induced Neuro‐and Cardiotoxicity in Mice Ex Vivo
ZA200301642B (en) Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection.
LT5132B (lt) Nepeptidiniai ccr1 receptorių antagonistai derinyje su ciklosporinu a širdies transplanto atmetimui gydyti
US20230167155A1 (en) Compositions and methods
KR20050054119A (ko) 잔소리졸을 함유하는 면역억제제
Versluis The use of cyclosporin A and azathioprine in clinical kidney transplantation.
Corella Graft-versus-host disease prophylaxis

Legal Events

Date Code Title Description
IF Valid on the event date
KO00 Lapse of patent

Effective date: 20060410