SI2109608T1 - Amid substituirani indazoli kot poli(adp-ribozna)polimeraza (parp) inhibitorjev - Google Patents

Amid substituirani indazoli kot poli(adp-ribozna)polimeraza (parp) inhibitorjev

Info

Publication number
SI2109608T1
SI2109608T1 SI200830240T SI200830240T SI2109608T1 SI 2109608 T1 SI2109608 T1 SI 2109608T1 SI 200830240 T SI200830240 T SI 200830240T SI 200830240 T SI200830240 T SI 200830240T SI 2109608 T1 SI2109608 T1 SI 2109608T1
Authority
SI
Slovenia
Prior art keywords
parp
adp
ribose
polymerase
inhibitors
Prior art date
Application number
SI200830240T
Other languages
English (en)
Slovenian (sl)
Inventor
Philip Jones
Ontoria Jesus Maria Ontoria
Rita Scarpelli
Carsten Schultz-Fademrecht
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2109608(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Priority claimed from PCT/GB2008/050018 external-priority patent/WO2008084261A1/en
Publication of SI2109608T1 publication Critical patent/SI2109608T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI200830240T 2007-01-10 2008-01-08 Amid substituirani indazoli kot poli(adp-ribozna)polimeraza (parp) inhibitorjev SI2109608T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
US92131007P 2007-04-02 2007-04-02
PCT/GB2008/050018 WO2008084261A1 (en) 2007-01-10 2008-01-08 Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
EP08702101A EP2109608B1 (en) 2007-01-10 2008-01-08 Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors

Publications (1)

Publication Number Publication Date
SI2109608T1 true SI2109608T1 (sl) 2011-07-29

Family

ID=37809722

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200831266T SI2336120T1 (sl) 2007-01-10 2008-01-08 Kombinacija, ki vsebuje z amidom substituirane indazole kot poli(adp-riboza)polimerazne (parp) inhibitorje
SI200830240T SI2109608T1 (sl) 2007-01-10 2008-01-08 Amid substituirani indazoli kot poli(adp-ribozna)polimeraza (parp) inhibitorjev

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200831266T SI2336120T1 (sl) 2007-01-10 2008-01-08 Kombinacija, ki vsebuje z amidom substituirane indazole kot poli(adp-riboza)polimerazne (parp) inhibitorje

Country Status (21)

Country Link
CN (1) CN101578279B (es)
AT (1) ATE502933T1 (es)
CR (1) CR10910A (es)
DE (1) DE602008005711D1 (es)
DK (2) DK2336120T3 (es)
ES (3) ES2362214T3 (es)
GB (1) GB0700432D0 (es)
HN (1) HN2009001260A (es)
HU (1) HUE044513T2 (es)
LT (1) LT2805945T (es)
LU (1) LUC00072I2 (es)
ME (1) ME03481B (es)
MY (1) MY147789A (es)
NI (1) NI200900135A (es)
NZ (1) NZ578256A (es)
PE (1) PE20081558A1 (es)
PT (3) PT2805945T (es)
SI (2) SI2336120T1 (es)
TW (1) TWI528961B (es)
UA (1) UA97658C2 (es)
ZA (1) ZA200903898B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106496187A (zh) * 2016-09-14 2017-03-15 陕西科技大学 一种制备PARP抑制剂Niraparib的合成方法
CN106432188A (zh) * 2016-09-17 2017-02-22 青岛辰达生物科技有限公司 一种抗癌药2‑[4‑((3s)‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的制备方法
CN106432187A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 2‑[4‑(‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的手性拆分方法
CN106467513A (zh) * 2016-09-30 2017-03-01 陕西科技大学 一种制备Niraparib的合成方法
CN106632244A (zh) * 2016-09-30 2017-05-10 陕西科技大学 一种制备抗癌药物Niraparib的新型合成方法
CN108201537A (zh) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 一种尼拉帕尼缓控释药物组合物及其用途
WO2018183349A1 (en) * 2017-03-27 2018-10-04 Tesaro, Inc. Niraparib formulations
CN109081828B (zh) * 2017-06-14 2021-03-26 上海时莱生物技术有限公司 聚(adp-核糖)聚合酶抑制剂、制备方法及用途
BR112020006039A2 (pt) 2017-09-26 2020-10-06 Tesaro, Inc. formulações de niraparibe
CN108084157A (zh) * 2018-02-12 2018-05-29 安庆奇创药业有限公司 一种尼拉帕尼的合成方法
CN108203404A (zh) * 2018-03-02 2018-06-26 上海博邦医药科技有限公司 (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法
US20240016775A1 (en) 2020-02-24 2024-01-18 Fukang (Shanghai) Health Technology Co., Ltd Anti-coronavirus application of poly adp ribose polymerase inhibitor
CN115611860B (zh) * 2021-07-13 2024-06-11 上海博璞诺科技发展有限公司 合成尼拉帕尼的方法

Also Published As

Publication number Publication date
ZA200903898B (en) 2010-04-28
ATE502933T1 (de) 2011-04-15
HUE044513T2 (hu) 2019-10-28
DK2336120T3 (da) 2014-10-06
TW200836731A (en) 2008-09-16
CR10910A (es) 2010-01-19
GB0700432D0 (en) 2007-02-21
MY147789A (en) 2013-01-31
LUC00072I2 (fr) 2018-07-04
ES2509115T3 (es) 2014-10-17
PT2336120E (pt) 2014-10-01
HN2009001260A (es) 2012-03-26
ES2362214T3 (es) 2011-06-29
ME03481B (me) 2020-01-20
UA97658C2 (ru) 2012-03-12
PT2805945T (pt) 2019-06-06
SI2336120T1 (sl) 2014-10-30
TWI528961B (zh) 2016-04-11
NZ578256A (en) 2011-12-22
DK2109608T3 (da) 2011-07-11
CN101578279A (zh) 2009-11-11
PT2109608E (pt) 2011-05-30
NI200900135A (es) 2010-08-30
DE602008005711D1 (de) 2011-05-05
CN101578279B (zh) 2013-07-17
LT2805945T (lt) 2019-06-25
PE20081558A1 (es) 2008-10-30
ES2728199T3 (es) 2019-10-22

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