SI20305A - Kristali natrijeve soli pravastatina - Google Patents
Kristali natrijeve soli pravastatina Download PDFInfo
- Publication number
- SI20305A SI20305A SI9900191A SI9900191A SI20305A SI 20305 A SI20305 A SI 20305A SI 9900191 A SI9900191 A SI 9900191A SI 9900191 A SI9900191 A SI 9900191A SI 20305 A SI20305 A SI 20305A
- Authority
- SI
- Slovenia
- Prior art keywords
- sodium salt
- pravastatin sodium
- pravastatin
- ethyl acetate
- crystals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9900191A SI20305A (sl) | 1999-08-06 | 1999-08-06 | Kristali natrijeve soli pravastatina |
KR1020077015051A KR20070086847A (ko) | 1999-08-06 | 2000-08-04 | 결정형의 프라바스타틴 소듐염 |
ES00946239T ES2235911T5 (es) | 1999-08-06 | 2000-08-04 | Procedimiento para la preparación de cristales de la sal sódica de pravastatina. |
HU0202536A HUP0202536A3 (en) | 1999-08-06 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
DE60017568T DE60017568T2 (de) | 1999-08-06 | 2000-08-04 | Kristalle des natriumsalzes von pravastatin |
IL14805000A IL148050A0 (en) | 1999-08-06 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
CNB008113653A CN1205172C (zh) | 1999-08-06 | 2000-08-04 | 普伐他汀钠盐晶体 |
US10/049,093 US7078558B1 (en) | 1999-08-06 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
NZ516685A NZ516685A (en) | 1999-08-06 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
YU5402A YU5402A (sh) | 1999-08-06 | 2000-08-04 | Kristali natrijumove soli pravastatina |
EP00946239A EP1200385B2 (en) | 1999-08-06 | 2000-08-04 | Process for the preparation of crystals of the sodium salt of pravastatin |
SI200030653T SI1200385T2 (sl) | 1999-08-06 | 2000-08-04 | Kristali natrijeve soli pravastatina |
SK174-2002A SK1742002A3 (en) | 1999-08-06 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
CZ2002414A CZ2002414A3 (cs) | 1999-08-06 | 2000-08-04 | Krystaly sodné soli pravastatinu |
KR1020027001231A KR100766928B1 (ko) | 1999-08-06 | 2000-08-04 | 결정형의 프라바스타틴 소듐염 |
JP2001515281A JP2003506424A (ja) | 1999-08-06 | 2000-08-04 | プラバスタチンナトリウムの結晶 |
AU60109/00A AU782143B2 (en) | 1998-09-18 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
AT00946239T ATE287389T1 (de) | 1999-08-06 | 2000-08-04 | Kristalle des natriumsalzes von pravastatin |
PCT/IB2000/001103 WO2001010813A1 (en) | 1999-08-06 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
DK00946239T DK1200385T3 (da) | 1999-08-06 | 2000-08-04 | Krystaller af natriumsalt af pravastatin |
CA002379335A CA2379335A1 (en) | 1999-08-06 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
RU2002102862/04A RU2247711C2 (ru) | 1999-08-06 | 2000-08-04 | Кристаллическая форма натриевой соли правастатина |
PL00365850A PL365850A1 (en) | 1999-08-06 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
PT00946239T PT1200385E (pt) | 1999-08-06 | 2000-08-04 | Cristais do sal de sodio de pravastatina |
ZA200200437A ZA200200437B (en) | 1999-08-06 | 2002-01-17 | Crystals of the sodium salt of pravastatin. |
HR20020106A HRP20020106A2 (en) | 1999-08-06 | 2002-02-04 | Crystals of the sodium salt of pravastatin |
BG106389A BG65368B1 (bg) | 1999-08-06 | 2002-02-05 | Кристали на натриевата сол на правастатин |
IL148050A IL148050A (en) | 1999-08-06 | 2002-02-06 | Crystals of pravastatin sodium salt |
US10/408,012 US6740775B1 (en) | 1999-08-06 | 2003-04-04 | Crystalline sodium salt of pravastatin |
US11/400,872 US20060183929A1 (en) | 1999-08-06 | 2006-04-10 | Crystals of the sodium salt of pravastatin |
IL187261A IL187261A0 (en) | 1999-08-06 | 2007-11-08 | Crystals of the sodium salt of pravastatin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9900191A SI20305A (sl) | 1999-08-06 | 1999-08-06 | Kristali natrijeve soli pravastatina |
Publications (1)
Publication Number | Publication Date |
---|---|
SI20305A true SI20305A (sl) | 2001-02-28 |
Family
ID=20432515
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9900191A SI20305A (sl) | 1998-09-18 | 1999-08-06 | Kristali natrijeve soli pravastatina |
SI200030653T SI1200385T2 (sl) | 1999-08-06 | 2000-08-04 | Kristali natrijeve soli pravastatina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200030653T SI1200385T2 (sl) | 1999-08-06 | 2000-08-04 | Kristali natrijeve soli pravastatina |
Country Status (24)
Country | Link |
---|---|
US (3) | US7078558B1 (ko) |
EP (1) | EP1200385B2 (ko) |
JP (1) | JP2003506424A (ko) |
KR (2) | KR20070086847A (ko) |
CN (1) | CN1205172C (ko) |
AT (1) | ATE287389T1 (ko) |
BG (1) | BG65368B1 (ko) |
CA (1) | CA2379335A1 (ko) |
CZ (1) | CZ2002414A3 (ko) |
DE (1) | DE60017568T2 (ko) |
DK (1) | DK1200385T3 (ko) |
ES (1) | ES2235911T5 (ko) |
HR (1) | HRP20020106A2 (ko) |
HU (1) | HUP0202536A3 (ko) |
IL (3) | IL148050A0 (ko) |
NZ (1) | NZ516685A (ko) |
PL (1) | PL365850A1 (ko) |
PT (1) | PT1200385E (ko) |
RU (1) | RU2247711C2 (ko) |
SI (2) | SI20305A (ko) |
SK (1) | SK1742002A3 (ko) |
WO (1) | WO2001010813A1 (ko) |
YU (1) | YU5402A (ko) |
ZA (1) | ZA200200437B (ko) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
SI20070A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
KR20020062340A (ko) * | 1999-12-14 | 2002-07-25 | 비오갈 기오기스제르갸르 알티. | 신규 형태의 프라바스타틴 나트륨 |
JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
JP2002121172A (ja) * | 2000-10-16 | 2002-04-23 | Sankyo Co Ltd | プラバスタチン又はその薬理上許容される塩の精製方法 |
WO2002057229A1 (en) | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
US6716615B2 (en) | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
ATE452871T1 (de) | 2002-03-18 | 2010-01-15 | Biocon Ltd | Amorphe hmg-coa-reduktase-inhibitoren mit gewünschter teilchengrösse |
WO2004110585A1 (ja) * | 2003-06-10 | 2004-12-23 | Taisho Pharmaceutical Co., Ltd. | 放射球状晶析物およびその製造方法並びにこれを利用するドライパウダー製剤 |
CN1293874C (zh) * | 2003-08-18 | 2007-01-10 | 李朝晖 | 以洛伐他汀盐为主要活性成分的中药红曲及其制剂 |
JP2007512366A (ja) | 2003-11-24 | 2007-05-17 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | プラバスタチンの精製方法 |
US20080242725A1 (en) * | 2004-03-01 | 2008-10-02 | Janez Kerc | Pharmaceutical Composition |
WO2006017698A2 (en) | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel statin pharmaceutical compositions and related methods of treatment |
JP2008516890A (ja) * | 2004-08-06 | 2008-05-22 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | 新規なフェノフィブラート製剤および関連治療方法 |
US20090042979A1 (en) * | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
EP1833780A1 (en) * | 2005-02-09 | 2007-09-19 | Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság | Methods of making pravastatin sodium |
JP4895510B2 (ja) * | 2005-02-23 | 2012-03-14 | 株式会社トクヤマ | バリオールアミンの製造方法 |
JP4813841B2 (ja) * | 2005-07-25 | 2011-11-09 | キユーピー株式会社 | プラバスタチンナトリウムの製造方法 |
WO2009148709A1 (en) * | 2008-04-16 | 2009-12-10 | University Of Utah Research Foundation | Pharmacological targeting of vascular malformations |
CN101348476B (zh) * | 2008-09-05 | 2011-05-11 | 丽珠集团新北江制药股份有限公司 | 一种制备4,5,6,7-四氢普伐他汀及其钠盐的方法和固体结晶形式 |
CN101648867B (zh) * | 2009-09-04 | 2012-07-11 | 天津大学 | 一种普伐他汀钠晶型及其制备方法和应用 |
EP2343054A1 (en) | 2010-01-04 | 2011-07-13 | LEK Pharmaceuticals d.d. | Pellets and microparticles of pravastatin sodium and a process of making them |
CN102533893A (zh) * | 2010-12-09 | 2012-07-04 | 浙江海正药业股份有限公司 | 一种制备莫那可林j的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS572240A (en) * | 1980-06-06 | 1982-01-07 | Sankyo Co Ltd | Ml-236b derivative |
DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
JPS5889191A (ja) * | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | 3−ヒドロキシ−ml−236b誘導体の製造法 |
CA2040865C (en) | 1990-05-15 | 2002-07-23 | James L. Bergey | Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor |
KR100210482B1 (ko) * | 1997-04-10 | 1999-07-15 | 김종인 | 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법 |
US6098031A (en) | 1998-03-05 | 2000-08-01 | Gsi Lumonics, Inc. | Versatile method and system for high speed, 3D imaging of microscopic targets |
SI20070A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
US6682913B1 (en) * | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
CA2361701C (en) † | 1999-02-03 | 2007-04-10 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
-
1999
- 1999-08-06 SI SI9900191A patent/SI20305A/sl not_active IP Right Cessation
-
2000
- 2000-08-04 YU YU5402A patent/YU5402A/sh unknown
- 2000-08-04 SK SK174-2002A patent/SK1742002A3/sk not_active Application Discontinuation
- 2000-08-04 RU RU2002102862/04A patent/RU2247711C2/ru not_active IP Right Cessation
- 2000-08-04 CA CA002379335A patent/CA2379335A1/en not_active Abandoned
- 2000-08-04 IL IL14805000A patent/IL148050A0/xx unknown
- 2000-08-04 KR KR1020077015051A patent/KR20070086847A/ko not_active Application Discontinuation
- 2000-08-04 CZ CZ2002414A patent/CZ2002414A3/cs unknown
- 2000-08-04 NZ NZ516685A patent/NZ516685A/en not_active IP Right Cessation
- 2000-08-04 KR KR1020027001231A patent/KR100766928B1/ko not_active IP Right Cessation
- 2000-08-04 EP EP00946239A patent/EP1200385B2/en not_active Expired - Lifetime
- 2000-08-04 JP JP2001515281A patent/JP2003506424A/ja active Pending
- 2000-08-04 DE DE60017568T patent/DE60017568T2/de not_active Expired - Lifetime
- 2000-08-04 DK DK00946239T patent/DK1200385T3/da active
- 2000-08-04 CN CNB008113653A patent/CN1205172C/zh not_active Expired - Fee Related
- 2000-08-04 WO PCT/IB2000/001103 patent/WO2001010813A1/en active Application Filing
- 2000-08-04 PL PL00365850A patent/PL365850A1/xx not_active Application Discontinuation
- 2000-08-04 ES ES00946239T patent/ES2235911T5/es not_active Expired - Lifetime
- 2000-08-04 US US10/049,093 patent/US7078558B1/en not_active Expired - Fee Related
- 2000-08-04 PT PT00946239T patent/PT1200385E/pt unknown
- 2000-08-04 HU HU0202536A patent/HUP0202536A3/hu unknown
- 2000-08-04 AT AT00946239T patent/ATE287389T1/de not_active IP Right Cessation
- 2000-08-04 SI SI200030653T patent/SI1200385T2/sl unknown
-
2002
- 2002-01-17 ZA ZA200200437A patent/ZA200200437B/en unknown
- 2002-02-04 HR HR20020106A patent/HRP20020106A2/hr not_active Application Discontinuation
- 2002-02-05 BG BG106389A patent/BG65368B1/bg unknown
- 2002-02-06 IL IL148050A patent/IL148050A/en not_active IP Right Cessation
-
2003
- 2003-04-04 US US10/408,012 patent/US6740775B1/en not_active Expired - Fee Related
-
2006
- 2006-04-10 US US11/400,872 patent/US20060183929A1/en not_active Abandoned
-
2007
- 2007-11-08 IL IL187261A patent/IL187261A0/en unknown
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Legal Events
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IF | Valid on the event date | ||
KO00 | Lapse of patent |
Effective date: 20090827 |