SI20149B - Pharmaceutical compositions of tizoxanide and nitazoxanide - Google Patents
Pharmaceutical compositions of tizoxanide and nitazoxanide Download PDFInfo
- Publication number
- SI20149B SI20149B SI9820037A SI9820037A SI20149B SI 20149 B SI20149 B SI 20149B SI 9820037 A SI9820037 A SI 9820037A SI 9820037 A SI9820037 A SI 9820037A SI 20149 B SI20149 B SI 20149B
- Authority
- SI
- Slovenia
- Prior art keywords
- active ingredient
- composition according
- particle size
- pharmaceutical composition
- formula
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 27
- YQNQNVDNTFHQSW-UHFFFAOYSA-N acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester Chemical compound CC(=O)OC1=CC=CC=C1C(=O)NC1=NC=C([N+]([O-])=O)S1 YQNQNVDNTFHQSW-UHFFFAOYSA-N 0.000 title claims 2
- 229960002480 nitazoxanide Drugs 0.000 title claims 2
- FDTZUTSGGSRHQF-UHFFFAOYSA-N Desacetyl-nitazoxanide Chemical group OC1=CC=CC=C1C(=O)NC1=NC=C([N+]([O-])=O)S1 FDTZUTSGGSRHQF-UHFFFAOYSA-N 0.000 title 1
- 239000002245 particle Substances 0.000 claims abstract 39
- 239000002253 acid Substances 0.000 claims abstract 16
- 150000001875 compounds Chemical class 0.000 claims abstract 14
- 239000013543 active substance Substances 0.000 claims abstract 3
- 239000004480 active ingredient Substances 0.000 claims 32
- 239000000203 mixture Substances 0.000 claims 21
- 239000003979 granulating agent Substances 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 5
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 4
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- 239000001630 malic acid Substances 0.000 claims 4
- 235000011090 malic acid Nutrition 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 241001126309 Fasciolopsis Species 0.000 claims 2
- 241001491880 Heterophyes Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241001660197 Metagonimus Species 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 208000004938 Trematode Infections Diseases 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000003071 parasitic effect Effects 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 241000223936 Cryptosporidium parvum Species 0.000 claims 1
- 241000205707 Cystoisospora belli Species 0.000 claims 1
- 241000577452 Dicrocoelium Species 0.000 claims 1
- 241000577456 Dicrocoelium dendriticum Species 0.000 claims 1
- 241000596569 Encephalitozoon intestinalis Species 0.000 claims 1
- 241000204939 Fasciola gigantica Species 0.000 claims 1
- 241000242711 Fasciola hepatica Species 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 206010023076 Isosporiasis Diseases 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 241000186367 Mycobacterium avium Species 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 241000242678 Schistosoma Species 0.000 claims 1
- 241000242683 Schistosoma haematobium Species 0.000 claims 1
- 241000242687 Schistosoma intercalatum Species 0.000 claims 1
- 241000242677 Schistosoma japonicum Species 0.000 claims 1
- 241000242680 Schistosoma mansoni Species 0.000 claims 1
- 241001520868 Schistosoma mekongi Species 0.000 claims 1
- 241000242541 Trematoda Species 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 229960000541 cetyl alcohol Drugs 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- 239000006194 liquid suspension Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000008253 pharmaceutical paste Substances 0.000 claims 1
- 235000015067 sauces Nutrition 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
- 208000001388 Opportunistic Infections Diseases 0.000 abstract 1
- 241000869417 Trematodes Species 0.000 abstract 1
- 230000001010 compromised effect Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/852,447 US5968961A (en) | 1997-05-07 | 1997-05-07 | Pharmaceutical compositions of tizoxanide and nitazoxanide |
| US08/887,810 US5856348A (en) | 1994-09-08 | 1997-07-03 | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US08/887,809 US5965590A (en) | 1994-09-08 | 1997-07-03 | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
| PCT/US1998/009229 WO1998050035A1 (en) | 1997-05-07 | 1998-05-06 | Pharmaceutical compositions of tizoxanide and nitazoxanide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI20149A SI20149A (sl) | 2000-08-31 |
| SI20149B true SI20149B (en) | 2001-08-31 |
Family
ID=27420362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9820037A SI20149B (en) | 1997-05-07 | 1998-05-06 | Pharmaceutical compositions of tizoxanide and nitazoxanide |
Country Status (34)
| Country | Link |
|---|---|
| EP (2) | EP1222921B1 (cs) |
| JP (1) | JP3739802B2 (cs) |
| KR (2) | KR100426657B1 (cs) |
| CN (2) | CN1158074C (cs) |
| AP (1) | AP1103A (cs) |
| AR (1) | AR057242A2 (cs) |
| AT (2) | ATE228839T1 (cs) |
| AU (1) | AU740022B2 (cs) |
| BG (2) | BG109365A (cs) |
| BR (1) | BR9808722A (cs) |
| CA (2) | CA2418634C (cs) |
| CZ (2) | CZ298269B6 (cs) |
| DE (2) | DE69809928T2 (cs) |
| DK (2) | DK1005342T3 (cs) |
| EA (2) | EA002908B1 (cs) |
| EE (1) | EE04870B1 (cs) |
| ES (2) | ES2150404T3 (cs) |
| GE (1) | GEP20032970B (cs) |
| HU (1) | HU229641B1 (cs) |
| IL (2) | IL132516A (cs) |
| IS (1) | IS2087B (cs) |
| LV (1) | LV12492B (cs) |
| ME (1) | ME00530B (cs) |
| NO (2) | NO313983B1 (cs) |
| NZ (2) | NZ500149A (cs) |
| OA (1) | OA11169A (cs) |
| PL (1) | PL193275B1 (cs) |
| PT (2) | PT1005342E (cs) |
| RO (1) | RO120605B1 (cs) |
| SI (1) | SI20149B (cs) |
| SK (2) | SK283947B6 (cs) |
| TR (1) | TR199902733T2 (cs) |
| UA (2) | UA57079C2 (cs) |
| WO (1) | WO1998050035A1 (cs) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2467321A1 (en) | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
| WO2007081974A2 (en) * | 2006-01-09 | 2007-07-19 | Romark Laboratories, L.C. | Viral hepatitis treatment |
| SI2395840T1 (sl) * | 2009-02-13 | 2020-08-31 | Romark Laboratories, L.C. | Farmacevtske formulacije nitazoksanida z nadzorovanim sproščanjem |
| AP3074A (en) | 2009-05-12 | 2014-12-31 | Romark Lab Lc | Haloalkyl heteroaryl benzamide compounds |
| US9023877B2 (en) | 2009-06-26 | 2015-05-05 | Romark Laboratories L.C. | Compounds and methods for treating influenza |
| EP2808019B1 (en) | 2012-01-27 | 2019-09-25 | Siegfried Rhein S.A. De C.V. | Improved nitazoxanide composition and preparation method thereof |
| KR20170081228A (ko) * | 2014-11-11 | 2017-07-11 | 로마크 레버러토리즈, 엘.씨. | 티족사나이드, 그의 유사체 또는 염의 전구 약물을 이용한 치료 조성물 및 방법 |
| KR20200121816A (ko) | 2018-02-02 | 2020-10-26 | 리플 테라퓨틱스 코포레이션 | 스테로이드 이량체를 포함하는 유리 제제 및 이의 용도 |
| WO2019241376A1 (en) | 2018-06-14 | 2019-12-19 | The Trustees Of Columbia University In The City Of New York | Treatment of cognitive disorders using nitazoxanide (ntz), nitazoxanide (ntz) analogs, and metabolites thereof |
| WO2021220061A2 (en) | 2020-05-01 | 2021-11-04 | Ripple Therapeutics Corporation | Heterodimer compositions and methods for the treatment of ocular disorders |
| WO2022130406A1 (en) * | 2020-12-15 | 2022-06-23 | Cipla Limited | Inhalation composition of nitazoxanide or its derivatives for use in coronavirus disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1437800A (en) * | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| US4315018A (en) * | 1978-12-07 | 1982-02-09 | Rossignol Jean F | Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives |
| US5578621A (en) * | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
| US5387598A (en) * | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
-
1998
- 1998-05-06 SK SK708-2003A patent/SK283947B6/sk unknown
- 1998-05-06 SI SI9820037A patent/SI20149B/sl not_active IP Right Cessation
- 1998-05-06 CN CNB988049007A patent/CN1158074C/zh not_active Expired - Fee Related
- 1998-05-06 BR BR9808722-3A patent/BR9808722A/pt not_active IP Right Cessation
- 1998-05-06 AU AU72895/98A patent/AU740022B2/en not_active Ceased
- 1998-05-06 AT AT98920285T patent/ATE228839T1/de active
- 1998-05-06 DE DE69809928T patent/DE69809928T2/de not_active Expired - Lifetime
- 1998-05-06 DE DE69827417T patent/DE69827417T2/de not_active Expired - Lifetime
- 1998-05-06 PT PT98920285T patent/PT1005342E/pt unknown
- 1998-05-06 JP JP54843798A patent/JP3739802B2/ja not_active Expired - Fee Related
- 1998-05-06 ME MEP-2008-877A patent/ME00530B/me unknown
- 1998-05-06 GE GEAP19985109A patent/GEP20032970B/en unknown
- 1998-05-06 EA EA199901012A patent/EA002908B1/ru not_active IP Right Cessation
- 1998-05-06 KR KR10-1999-7009930A patent/KR100426657B1/ko not_active Expired - Lifetime
- 1998-05-06 WO PCT/US1998/009229 patent/WO1998050035A1/en active IP Right Grant
- 1998-05-06 AP APAP/P/1999/001675A patent/AP1103A/en active
- 1998-05-06 KR KR1020037011334A patent/KR100576646B1/ko not_active Expired - Fee Related
- 1998-05-06 SK SK1511-99A patent/SK283946B6/sk unknown
- 1998-05-06 CA CA002418634A patent/CA2418634C/en not_active Expired - Fee Related
- 1998-05-06 CZ CZ0391199A patent/CZ298269B6/cs not_active IP Right Cessation
- 1998-05-06 IL IL13251698A patent/IL132516A/xx not_active IP Right Cessation
- 1998-05-06 EP EP02002887A patent/EP1222921B1/en not_active Expired - Lifetime
- 1998-05-06 RO RO99-01166A patent/RO120605B1/ro unknown
- 1998-05-06 PL PL336805A patent/PL193275B1/pl not_active IP Right Cessation
- 1998-05-06 EE EEP199900578A patent/EE04870B1/xx unknown
- 1998-05-06 HU HU0003330A patent/HU229641B1/hu not_active IP Right Cessation
- 1998-05-06 ES ES98920285T patent/ES2150404T3/es not_active Expired - Lifetime
- 1998-05-06 CN CNB2004100459536A patent/CN100515420C/zh not_active Expired - Fee Related
- 1998-05-06 TR TR1999/02733T patent/TR199902733T2/xx unknown
- 1998-05-06 DK DK98920285T patent/DK1005342T3/da active
- 1998-05-06 IL IL15579998A patent/IL155799A/en not_active IP Right Cessation
- 1998-05-06 NZ NZ500149A patent/NZ500149A/en not_active IP Right Cessation
- 1998-05-06 CA CA002288003A patent/CA2288003C/en not_active Expired - Fee Related
- 1998-05-06 ES ES02002887T patent/ES2232687T3/es not_active Expired - Lifetime
- 1998-05-06 DK DK02002887T patent/DK1222921T3/da active
- 1998-05-06 AT AT02002887T patent/ATE281166T1/de active
- 1998-05-06 EA EA200100956A patent/EA002920B1/ru not_active IP Right Cessation
- 1998-05-06 NZ NZ513881A patent/NZ513881A/xx not_active IP Right Cessation
- 1998-05-06 CZ CZ20060366A patent/CZ298270B6/cs not_active IP Right Cessation
- 1998-05-06 EP EP98920285A patent/EP1005342B1/en not_active Expired - Lifetime
- 1998-05-06 PT PT02002887T patent/PT1222921E/pt unknown
- 1998-06-05 UA UA99126626A patent/UA57079C2/uk unknown
- 1998-12-06 BG BG109365A patent/BG109365A/en unknown
-
1999
- 1999-10-19 IS IS5223A patent/IS2087B/is unknown
- 1999-10-29 OA OA9900239A patent/OA11169A/en unknown
- 1999-11-04 NO NO19995406A patent/NO313983B1/no not_active IP Right Cessation
- 1999-12-01 LV LVP-99-170A patent/LV12492B/en unknown
- 1999-12-06 BG BG103958A patent/BG64973B1/bg unknown
-
2002
- 2002-04-18 NO NO20021832A patent/NO335781B1/no not_active IP Right Cessation
-
2003
- 2003-04-04 UA UA2003042974A patent/UA74388C2/uk unknown
-
2006
- 2006-12-14 AR ARP060105534A patent/AR057242A2/es not_active Application Discontinuation
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