SI1077941T1 - Spojine, ki imajo lastnost sproščanja rastnega hormona - Google Patents

Spojine, ki imajo lastnost sproščanja rastnega hormona

Info

Publication number
SI1077941T1
SI1077941T1 SI9931036T SI9931036T SI1077941T1 SI 1077941 T1 SI1077941 T1 SI 1077941T1 SI 9931036 T SI9931036 T SI 9931036T SI 9931036 T SI9931036 T SI 9931036T SI 1077941 T1 SI1077941 T1 SI 1077941T1
Authority
SI
Slovenia
Prior art keywords
compounds
growth hormone
hormone releasing
releasing properties
disubstituted
Prior art date
Application number
SI9931036T
Other languages
English (en)
Inventor
Thomas Kruse Hansen
Michael Ankersen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of SI1077941T1 publication Critical patent/SI1077941T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
SI9931036T 1998-05-11 1999-05-10 Spojine, ki imajo lastnost sproščanja rastnega hormona SI1077941T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK63698 1998-05-11
DKPA199800875 1998-07-01
PCT/DK1999/000260 WO1999058501A1 (en) 1998-05-11 1999-05-10 Compounds with growth hormone releasing properties
EP99919125A EP1077941B1 (en) 1998-05-11 1999-05-10 Compounds with growth hormone releasing properties

Publications (1)

Publication Number Publication Date
SI1077941T1 true SI1077941T1 (sl) 2010-01-29

Family

ID=26064372

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9931036T SI1077941T1 (sl) 1998-05-11 1999-05-10 Spojine, ki imajo lastnost sproščanja rastnega hormona

Country Status (23)

Country Link
EP (1) EP1077941B1 (sl)
JP (2) JP4142253B2 (sl)
KR (1) KR100593601B1 (sl)
CN (1) CN1142911C (sl)
AT (1) ATE439346T1 (sl)
AU (1) AU757217B2 (sl)
BR (1) BR9910329A (sl)
CA (1) CA2329881C (sl)
CY (1) CY1109626T1 (sl)
CZ (1) CZ301276B6 (sl)
DE (1) DE69941255D1 (sl)
DK (1) DK1077941T3 (sl)
ES (1) ES2331102T3 (sl)
HU (1) HUP0102071A3 (sl)
IL (2) IL139090A0 (sl)
NO (1) NO318080B1 (sl)
PL (1) PL194560B1 (sl)
PT (1) PT1077941E (sl)
RU (1) RU2243215C2 (sl)
SI (1) SI1077941T1 (sl)
TW (1) TWI222969B (sl)
UA (1) UA72210C2 (sl)
WO (1) WO1999058501A1 (sl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2001114518A (ru) 1999-09-29 2003-04-20 Орто-Макнейл Фармасьютикал, Инк. (Us) Изонипекотамиды для лечения опосредованных интегринами нарушений
UA73530C2 (uk) * 1999-11-10 2005-08-15 Ново Нордіск А/С Сполука з властивостями вивільнювати гормон росту
US20010020012A1 (en) * 2000-02-01 2001-09-06 Andersen Maibritt Bansholm Use of compounds for the regulation of food intake
WO2002046156A2 (en) 2000-12-06 2002-06-13 Sepracor, Inc. 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands
WO2002079146A2 (en) 2001-03-02 2002-10-10 Bristol-Myers Squibb Company Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same
DE10113604A1 (de) * 2001-03-20 2002-10-24 Ibfb Gmbh Privates Inst Fuer B Verfahren zur Spaltung des humanen Wachstumshormons GH
US7081460B2 (en) 2001-04-09 2006-07-25 Ortho-Mcneil Pharmaceutical, Inc. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
US6911447B2 (en) 2001-04-25 2005-06-28 The Procter & Gamble Company Melanocortin receptor ligands
EP1425029A4 (en) 2001-08-10 2006-06-07 Palatin Technologies Inc PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
US7026335B2 (en) 2002-04-30 2006-04-11 The Procter & Gamble Co. Melanocortin receptor ligands
EP1407779A1 (en) 2002-10-10 2004-04-14 Gastrotech A/S Use of ghrelin for treating low body weight and body fat in gastrectomized individuals
TW200504033A (en) 2002-10-23 2005-02-01 Procter & Gamble Melanocortin receptor ligands
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
KR20070010151A (ko) * 2004-03-30 2007-01-22 사파이어 세라퓨틱스, 인크. 성장 호르몬 분비촉진제를 이용하여 ｃ-반응성 단백질을감소시키는 방법
CN103772483A (zh) * 2004-06-29 2014-05-07 赫尔辛医疗股份公司 （3r）－1－（2－甲基丙氨酰－d－色氨酰）－3－（苯甲基）－3－哌啶羧酸1,2,2－三甲基酰肼的晶形
SI1789067T1 (sl) * 2004-08-12 2012-09-28 Helsinn Healthcare Sa Uporaba spojine rastnega hormona sekretagoga za stimulacijo dejavnosti gastrointestinalnega sistema
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
JP2009542666A (ja) * 2006-06-30 2009-12-03 シェーリング コーポレイション Ｐ５３活性を増加させる置換ピペリジンおよびその使用
ES2604943T3 (es) 2007-02-09 2017-03-10 Ocera Therapeutics, Inc. Moduladores macrocíclicos del receptor de la grelina y procedimientos de uso de los mismos
WO2012131090A1 (en) 2011-03-31 2012-10-04 Galderma Research & Development Method for treatment of xeroderma pigmentosum
CN114805305B (zh) * 2022-04-20 2024-04-26 成都诺和晟泰生物科技有限公司 一种化合物及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492916A (en) * 1993-12-23 1996-02-20 Merck & Co., Inc. Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
AU1172995A (en) * 1993-11-09 1995-05-29 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US5721250A (en) * 1993-12-23 1998-02-24 Merck & Co. Inc. Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
US5559128A (en) * 1995-04-18 1996-09-24 Merck & Co., Inc. 3-substituted piperidines promote release of growth hormone
WO1996035713A1 (en) * 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
EP0828754B1 (en) * 1995-05-29 2005-02-02 Pfizer Inc. Dipeptides which promote release of growth hormone
GB2308064A (en) * 1995-10-31 1997-06-18 Merck & Co Inc Treatment of congestive heart failure with a growth hormone secretagogue
AU2722297A (en) * 1996-04-03 1997-10-22 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
JP4425992B2 (ja) * 1996-07-22 2010-03-03 サファイア セラピューティクス，インコーポレイティド 成長ホルモン放出特性を有する化合物
AU4342097A (en) * 1996-09-13 1998-04-02 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
WO1998016527A1 (en) * 1996-10-15 1998-04-23 Fujisawa Pharmaceutical Co., Ltd. Benzoxepine derivatives which promote release of growth hormone

Also Published As

Publication number Publication date
JP4938708B2 (ja) 2012-05-23
KR100593601B1 (ko) 2006-06-28
WO1999058501A1 (en) 1999-11-18
NO20005668D0 (no) 2000-11-10
IL139090A0 (en) 2001-11-25
PL194560B1 (pl) 2007-06-29
PL344042A1 (en) 2001-09-24
CN1300281A (zh) 2001-06-20
CA2329881C (en) 2010-03-16
NO20005668L (no) 2001-01-10
EP1077941B1 (en) 2009-08-12
JP2008156372A (ja) 2008-07-10
RU2243215C2 (ru) 2004-12-27
NO318080B1 (no) 2005-01-31
EP1077941A1 (en) 2001-02-28
BR9910329A (pt) 2001-01-30
JP4142253B2 (ja) 2008-09-03
PT1077941E (pt) 2010-07-01
DE69941255D1 (de) 2009-09-24
JP2004500312A (ja) 2004-01-08
DK1077941T3 (da) 2009-12-07
HUP0102071A2 (hu) 2002-03-28
ATE439346T1 (de) 2009-08-15
AU3701099A (en) 1999-11-29
IL139090A (en) 2007-03-08
CZ20004129A3 (en) 2001-06-13
CA2329881A1 (en) 1999-11-18
ES2331102T3 (es) 2009-12-21
CN1142911C (zh) 2004-03-24
TWI222969B (en) 2004-11-01
CY1109626T1 (el) 2014-08-13
KR20010043422A (ko) 2001-05-25
CZ301276B6 (cs) 2009-12-30
AU757217B2 (en) 2003-02-06
HUP0102071A3 (en) 2002-06-28
UA72210C2 (uk) 2005-02-15

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