HUP0102071A3 - 3,3- and 4,4-disubstituted piperidine derivatives with growth hormone releasing properties and pharmaceutical compositions containing them - Google Patents
3,3- and 4,4-disubstituted piperidine derivatives with growth hormone releasing properties and pharmaceutical compositions containing themInfo
- Publication number
- HUP0102071A3 HUP0102071A3 HU0102071A HUP0102071A HUP0102071A3 HU P0102071 A3 HUP0102071 A3 HU P0102071A3 HU 0102071 A HU0102071 A HU 0102071A HU P0102071 A HUP0102071 A HU P0102071A HU P0102071 A3 HUP0102071 A3 HU P0102071A3
- Authority
- HU
- Hungary
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- growth hormone
- hormone releasing
- piperidine derivatives
- Prior art date
Links
- -1 4,4-disubstituted piperidine Chemical class 0.000 title 1
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000003578 releasing effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK63698 | 1998-05-11 | ||
| DKPA199800875 | 1998-07-01 | ||
| PCT/DK1999/000260 WO1999058501A1 (en) | 1998-05-11 | 1999-05-10 | Compounds with growth hormone releasing properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0102071A2 HUP0102071A2 (hu) | 2002-03-28 |
| HUP0102071A3 true HUP0102071A3 (en) | 2002-06-28 |
Family
ID=26064372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102071A HUP0102071A3 (en) | 1998-05-11 | 1999-05-10 | 3,3- and 4,4-disubstituted piperidine derivatives with growth hormone releasing properties and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1077941B1 (hu) |
| JP (2) | JP4142253B2 (hu) |
| KR (1) | KR100593601B1 (hu) |
| CN (1) | CN1142911C (hu) |
| AT (1) | ATE439346T1 (hu) |
| AU (1) | AU757217B2 (hu) |
| BR (1) | BR9910329A (hu) |
| CA (1) | CA2329881C (hu) |
| CY (1) | CY1109626T1 (hu) |
| CZ (1) | CZ301276B6 (hu) |
| DE (1) | DE69941255D1 (hu) |
| DK (1) | DK1077941T3 (hu) |
| ES (1) | ES2331102T3 (hu) |
| HU (1) | HUP0102071A3 (hu) |
| IL (2) | IL139090A0 (hu) |
| NO (1) | NO318080B1 (hu) |
| PL (1) | PL194560B1 (hu) |
| PT (1) | PT1077941E (hu) |
| RU (1) | RU2243215C2 (hu) |
| SI (1) | SI1077941T1 (hu) |
| TW (1) | TWI222969B (hu) |
| UA (1) | UA72210C2 (hu) |
| WO (1) | WO1999058501A1 (hu) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0007183A (pt) | 1999-09-29 | 2002-02-05 | Ortho Mcneil Pharm Inc | Isonipectoamidas para o tratamento de distúrbios mediados por integrina |
| UA73530C2 (uk) * | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| US20010020012A1 (en) * | 2000-02-01 | 2001-09-06 | Andersen Maibritt Bansholm | Use of compounds for the regulation of food intake |
| WO2002046156A2 (en) | 2000-12-06 | 2002-06-13 | Sepracor, Inc. | 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands |
| CA2438272A1 (en) | 2001-03-02 | 2002-10-10 | John Macor | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
| DE10113604A1 (de) * | 2001-03-20 | 2002-10-24 | Ibfb Gmbh Privates Inst Fuer B | Verfahren zur Spaltung des humanen Wachstumshormons GH |
| DE60208186T2 (de) | 2001-04-09 | 2006-08-24 | Ortho-Mcneil Pharmaceutical Research Inc. | Chinazolin- und chinazolinähnliche verbindungen zur behandlung von integrin-vermittelten erkrankungen |
| US6911447B2 (en) | 2001-04-25 | 2005-06-28 | The Procter & Gamble Company | Melanocortin receptor ligands |
| WO2003013571A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7026335B2 (en) | 2002-04-30 | 2006-04-11 | The Procter & Gamble Co. | Melanocortin receptor ligands |
| EP1407779A1 (en) | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Use of ghrelin for treating low body weight and body fat in gastrectomized individuals |
| TW200504033A (en) | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| US20050261201A1 (en) * | 2004-03-30 | 2005-11-24 | Rejuvenon Corporation | Method of reducing C-reactive protein using growth hormone secretagogues |
| CN1976921B (zh) * | 2004-06-29 | 2013-08-21 | 蓝宝石治疗公司 | (3r)-1-(2-甲基丙氨酰-d-色氨酰)-3-(苯甲基)-3-哌啶羧酸1,2,2-三甲基酰肼的晶形 |
| WO2006020930A2 (en) * | 2004-08-12 | 2006-02-23 | Sapphire Therapeutics, Inc. | Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| KR20090042779A (ko) * | 2006-06-30 | 2009-04-30 | 쉐링 코포레이션 | Ｐ53 활성을 증가시키는 치환된 피페리딘 및 이의 사용 |
| BRPI0807046A2 (pt) | 2007-02-09 | 2015-05-26 | Tranzyme Pharma Inc | Composto, composição farmacêutica, métodos de tratar um distúrbio, uma doença cardiovascular e um paciente que sofre de motilidade gastrointestinal reduzida ou disfuncional e, kit. |
| WO2012131090A1 (en) | 2011-03-31 | 2012-10-04 | Galderma Research & Development | Method for treatment of xeroderma pigmentosum |
| CN114805305B (zh) * | 2022-04-20 | 2024-04-26 | 成都诺和晟泰生物科技有限公司 | 一种化合物及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1172995A (en) * | 1993-11-09 | 1995-05-29 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| US5492916A (en) * | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5721250A (en) * | 1993-12-23 | 1998-02-24 | Merck & Co. Inc. | Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5559128A (en) * | 1995-04-18 | 1996-09-24 | Merck & Co., Inc. | 3-substituted piperidines promote release of growth hormone |
| WO1996035713A1 (en) * | 1995-05-08 | 1996-11-14 | Pfizer, Inc. | Dipeptides which promote release of growth hormone |
| EP0828754B1 (en) * | 1995-05-29 | 2005-02-02 | Pfizer Inc. | Dipeptides which promote release of growth hormone |
| GB2308064A (en) * | 1995-10-31 | 1997-06-18 | Merck & Co Inc | Treatment of congestive heart failure with a growth hormone secretagogue |
| WO1997036873A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| AU3434697A (en) * | 1996-07-22 | 1998-02-10 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| WO1998010653A1 (en) * | 1996-09-13 | 1998-03-19 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| JP2001502319A (ja) * | 1996-10-15 | 2001-02-20 | 藤沢薬品工業株式会社 | 成長ホルモンの放出を促進するベンズオキセピン誘導体 |
-
1999
- 1999-05-10 PL PL344042A patent/PL194560B1/pl unknown
- 1999-05-10 AU AU37010/99A patent/AU757217B2/en not_active Expired
- 1999-05-10 BR BR9910329-0A patent/BR9910329A/pt not_active Application Discontinuation
- 1999-05-10 KR KR1020007012458A patent/KR100593601B1/ko not_active IP Right Cessation
- 1999-05-10 IL IL13909099A patent/IL139090A0/xx active IP Right Grant
- 1999-05-10 ES ES99919125T patent/ES2331102T3/es not_active Expired - Lifetime
- 1999-05-10 WO PCT/DK1999/000260 patent/WO1999058501A1/en active IP Right Grant
- 1999-05-10 DK DK99919125T patent/DK1077941T3/da active
- 1999-05-10 CZ CZ20004129A patent/CZ301276B6/cs not_active IP Right Cessation
- 1999-05-10 RU RU2000131184/04A patent/RU2243215C2/ru active
- 1999-05-10 CA CA2329881A patent/CA2329881C/en not_active Expired - Lifetime
- 1999-05-10 CN CNB998060100A patent/CN1142911C/zh not_active Expired - Lifetime
- 1999-05-10 JP JP2000548305A patent/JP4142253B2/ja not_active Expired - Lifetime
- 1999-05-10 HU HU0102071A patent/HUP0102071A3/hu unknown
- 1999-05-10 SI SI9931036T patent/SI1077941T1/sl unknown
- 1999-05-10 EP EP99919125A patent/EP1077941B1/en not_active Expired - Lifetime
- 1999-05-10 DE DE69941255T patent/DE69941255D1/de not_active Expired - Lifetime
- 1999-05-10 PT PT99919125T patent/PT1077941E/pt unknown
- 1999-05-10 AT AT99919125T patent/ATE439346T1/de active
- 1999-05-24 TW TW088108436A patent/TWI222969B/zh not_active IP Right Cessation
- 1999-10-05 UA UA2000116293A patent/UA72210C2/uk unknown
-
2000
- 2000-10-17 IL IL139090A patent/IL139090A/en not_active IP Right Cessation
- 2000-11-10 NO NO20005668A patent/NO318080B1/no not_active IP Right Cessation
-
2008
- 2008-03-12 JP JP2008062381A patent/JP4938708B2/ja not_active Expired - Lifetime
-
2009
- 2009-11-12 CY CY20091101195T patent/CY1109626T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: HELSINN HEALTHCARE SA, CH Free format text: FORMER OWNER(S): NOVO NORDISK A/S, DK |