SI0753001T1 - Antifungal sordaridin derivatives - Google Patents

Antifungal sordaridin derivatives

Info

Publication number
SI0753001T1
SI0753001T1 SI9530311T SI9530311T SI0753001T1 SI 0753001 T1 SI0753001 T1 SI 0753001T1 SI 9530311 T SI9530311 T SI 9530311T SI 9530311 T SI9530311 T SI 9530311T SI 0753001 T1 SI0753001 T1 SI 0753001T1
Authority
SI
Slovenia
Prior art keywords
antifungal
sordaridin
derivatives
sordaridin derivatives
antifungal sordaridin
Prior art date
Application number
SI9530311T
Other languages
English (en)
Slovenian (sl)
Inventor
Jose Ramon Ruiz Glaxo Wellcome S.A. GOMEZ
Jose Maria Bueno Glaxo Wellcome S.A. CALDERON
DORADO Silvestre Glaxo Wellcome S.A. GARCIA-OCHOA
GABALDON Maria Teresa Glaxo Wellcome S.A. FRAILE
Julia Castro Glaxo Wellcome S.A. PICHEL
ROMAN Jose Glaxo Wellcome S.A. FIANDOR
VIOLA Domingo Glaxo Wellcome S.A. GARSALLO
ZURITA Juan Carlos Glaxo Wellcome S.A. CUEVA
DIAZ Jose Luis Glaxo Wellcome S.A. LAVANDERA
Sophie Glaxo Wellcome S.A. HUSS
Original Assignee
Glaxo Wellcome S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94500175A external-priority patent/EP0711784A1/fr
Priority claimed from EP94500173A external-priority patent/EP0712859A1/fr
Application filed by Glaxo Wellcome S.A. filed Critical Glaxo Wellcome S.A.
Publication of SI0753001T1 publication Critical patent/SI0753001T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI9530311T 1994-11-08 1995-11-06 Antifungal sordaridin derivatives SI0753001T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP94500175A EP0711784A1 (fr) 1994-11-08 1994-11-08 Dérivés de Sordarin antifongiques
EP94500173A EP0712859A1 (fr) 1994-11-08 1994-11-08 Dérivés de Sordarin antifongiques
EP95938406A EP0753001B1 (fr) 1994-11-08 1995-11-06 Derives de sordaridine a action antifongique
PCT/EP1995/004331 WO1996014326A1 (fr) 1994-11-08 1995-11-06 Derives de sordaridine a action antifongique

Publications (1)

Publication Number Publication Date
SI0753001T1 true SI0753001T1 (en) 1999-12-31

Family

ID=26137608

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530311T SI0753001T1 (en) 1994-11-08 1995-11-06 Antifungal sordaridin derivatives

Country Status (35)

Country Link
US (2) US5854280A (fr)
EP (1) EP0753001B1 (fr)
JP (1) JPH09508144A (fr)
KR (1) KR100391401B1 (fr)
CN (1) CN1056849C (fr)
AP (1) AP614A (fr)
AR (1) AR013815A1 (fr)
AT (1) ATE184284T1 (fr)
AU (1) AU704405B2 (fr)
BG (1) BG62620B1 (fr)
BR (1) BR9506473A (fr)
CA (1) CA2179403A1 (fr)
CO (1) CO4520226A1 (fr)
CZ (1) CZ202796A3 (fr)
DE (1) DE69512041T2 (fr)
DK (1) DK0753001T3 (fr)
EE (1) EE9600117A (fr)
ES (1) ES2137549T3 (fr)
FI (1) FI962773A (fr)
GR (1) GR3031677T3 (fr)
HK (1) HK1004222A1 (fr)
HU (1) HU218611B (fr)
IL (1) IL115905A0 (fr)
IS (1) IS4352A (fr)
MX (1) MX9602563A (fr)
NO (1) NO307092B1 (fr)
NZ (1) NZ296091A (fr)
OA (1) OA10303A (fr)
PE (1) PE49696A1 (fr)
RU (1) RU2152398C1 (fr)
SI (1) SI0753001T1 (fr)
SK (1) SK88496A3 (fr)
TW (1) TW321644B (fr)
WO (1) WO1996014326A1 (fr)
ZA (1) ZA959362B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177457B1 (en) * 1996-05-08 2001-01-23 Glaxo Wellcome S.A. Process for the preparation of indacene compound
US6436395B1 (en) 1996-09-18 2002-08-20 Merck & Co., Inc. Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) * 1996-10-07 2000-03-21 Merck & Co., Inc. Sordarin derivatives
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
AU740477B2 (en) * 1997-08-22 2001-11-08 Merck Sharp & Dohme Corp. 4-cyano-4-deformylsordarin derivatives
US6136853A (en) * 1997-10-03 2000-10-24 Merck & Co., Inc. Sordarin derivatives
FI974385A0 (fi) 1997-12-01 1997-12-01 Xyrofin Oy Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) * 1998-04-14 2006-07-04 Zhenhua Yang Small molecule anticancer compounds and related production process
MA26628A1 (fr) * 1998-05-11 2004-12-20 Glaxo Wellcome Sa Morpholino ethers
JP2002528444A (ja) 1998-10-26 2002-09-03 メルク エンド カムパニー インコーポレーテッド 微生物変換産物
WO2000076556A2 (fr) 1999-06-11 2000-12-21 Neorx Corporation Complexe a forte dose de radionucleides destine a la suppression de la moelle osseuse
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
JP2003513964A (ja) * 1999-11-11 2003-04-15 グラクソ、ウェルカム、ソシエダッド、アノニマ 抗真菌性ソルダリシン誘導体
US6436930B1 (en) * 2000-09-15 2002-08-20 Bristol-Myers Squibb Company Thio derivatives of sordarin as antifungal agents
WO2002062398A2 (fr) 2001-01-08 2002-08-15 Neorx Corporation Composes, compositions et methodes therapeutiques et diagnostiques
WO2003007878A2 (fr) 2001-07-18 2003-01-30 Merck & Co., Inc. Agents antifongiques de derives de sordarine
JP2005516933A (ja) 2001-12-13 2005-06-09 ダウ グローバル テクノロジーズ インコーポレイティド 放射性医薬による骨髄炎の治療
JP2005519039A (ja) * 2001-12-14 2005-06-30 メルク　エンド　カムパニー　インコーポレーテッド 培養株の発酵産物から単離された新規ソルダリン誘導体及び抗真菌剤としての機能
MXPA05007156A (es) * 2002-12-31 2005-09-21 Nektar Therapeutics Formulacion farmaceuticas aerosolizable para terapia para infecciones fungicas.
US9314524B2 (en) 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US8419948B2 (en) * 2009-11-22 2013-04-16 United Laboratories International, Llc Wastewater treatment
WO2012033427A1 (fr) * 2010-09-08 2012-03-15 Dalin Mikhail Viktorovich Procédé de traitement des infections mycosiques et produit pour sa mise en oeuvre
RU2630403C2 (ru) * 2016-02-25 2017-09-07 Жанна Владимировна Вараткова Абразивная масса для изготовления инструмента с высокими номерами структуры

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH465771A (de) * 1965-12-06 1968-11-30 Sandoz Ag Verfahren zur Herstellung eines neuen Antibioticums
JPH0615555B2 (ja) * 1985-08-14 1994-03-02 三共株式会社 抗生物質ゾフイマリン
JP3189443B2 (ja) * 1992-11-20 2001-07-16 萬有製薬株式会社 抗真菌性物質ｂｅ−３１４０５
ES2203819T3 (es) * 1996-09-12 2004-04-16 MERCK & CO., INC. Terapia antifungica combinada.

Also Published As

Publication number Publication date
NO307092B1 (no) 2000-02-07
BR9506473A (pt) 1997-10-07
HUT76292A (en) 1997-07-28
CZ202796A3 (en) 1997-02-12
BG62620B1 (en) 2000-03-31
MX9602563A (es) 1997-05-31
HU9601865D0 (en) 1996-11-28
ZA959362B (en) 1996-05-08
OA10303A (en) 1997-10-07
IS4352A (is) 1996-06-10
CN1056849C (zh) 2000-09-27
AP9600824A0 (en) 1996-07-31
FI962773A0 (fi) 1996-07-05
WO1996014326A1 (fr) 1996-05-17
ES2137549T3 (es) 1999-12-16
GR3031677T3 (en) 2000-02-29
HU218611B (hu) 2000-10-28
CA2179403A1 (fr) 1996-05-17
NO962856L (no) 1996-09-05
DE69512041D1 (de) 1999-10-14
CN1143965A (zh) 1997-02-26
FI962773A (fi) 1996-08-26
HK1004222A1 (en) 1998-11-20
IL115905A0 (en) 1996-01-31
AP614A (en) 1997-09-05
KR100391401B1 (ko) 2003-12-31
NZ296091A (en) 1998-06-26
EE9600117A (et) 1997-04-15
ATE184284T1 (de) 1999-09-15
US5854280A (en) 1998-12-29
RU2152398C1 (ru) 2000-07-10
CO4520226A1 (es) 1997-10-15
AU704405B2 (en) 1999-04-22
EP0753001B1 (fr) 1999-09-08
SK88496A3 (en) 1997-04-09
AR013815A1 (es) 2001-01-31
TW321644B (fr) 1997-12-01
DK0753001T3 (da) 2000-05-08
NO962856D0 (no) 1996-07-05
US5952334A (en) 1999-09-14
JPH09508144A (ja) 1997-08-19
EP0753001A1 (fr) 1997-01-15
DE69512041T2 (de) 2000-02-03
PE49696A1 (es) 1996-12-05
BG100699A (bg) 1997-02-28
AU3980995A (en) 1996-05-31

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Effective date: 20060718