OA10303A - Antifungal sordaridin derivatives - Google Patents

Antifungal sordaridin derivatives Download PDF

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Publication number
OA10303A
OA10303A OA60855A OA60855A OA10303A OA 10303 A OA10303 A OA 10303A OA 60855 A OA60855 A OA 60855A OA 60855 A OA60855 A OA 60855A OA 10303 A OA10303 A OA 10303A
Authority
OA
OAPI
Prior art keywords
compound
group
methyl
formula
solution
Prior art date
Application number
OA60855A
Other languages
English (en)
Inventor
Jose Ramon Ruiz Gomez
Jose Maria Bueno Calderon
Viola Domingo Gargallo
Zurita Juan Carlos Cuevas
Diaz Jose Luis Lavandera
Sophie Huss
Dorado Silvestre Garcia-Ochoa
Gabaldon Maria Teresa Fraile
Julia Castro Pichel
Roman Jose Fiandor
Original Assignee
Glaxo Wellcome Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94500173A external-priority patent/EP0712859A1/fr
Priority claimed from EP94500175A external-priority patent/EP0711784A1/fr
Application filed by Glaxo Wellcome Sa filed Critical Glaxo Wellcome Sa
Publication of OA10303A publication Critical patent/OA10303A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
OA60855A 1994-11-08 1996-07-03 Antifungal sordaridin derivatives OA10303A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94500173A EP0712859A1 (fr) 1994-11-08 1994-11-08 Dérivés de Sordarin antifongiques
EP94500175A EP0711784A1 (fr) 1994-11-08 1994-11-08 Dérivés de Sordarin antifongiques

Publications (1)

Publication Number Publication Date
OA10303A true OA10303A (en) 1997-10-07

Family

ID=26137608

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60855A OA10303A (en) 1994-11-08 1996-07-03 Antifungal sordaridin derivatives

Country Status (35)

Country Link
US (2) US5854280A (fr)
EP (1) EP0753001B1 (fr)
JP (1) JPH09508144A (fr)
KR (1) KR100391401B1 (fr)
CN (1) CN1056849C (fr)
AP (1) AP614A (fr)
AR (1) AR013815A1 (fr)
AT (1) ATE184284T1 (fr)
AU (1) AU704405B2 (fr)
BG (1) BG62620B1 (fr)
BR (1) BR9506473A (fr)
CA (1) CA2179403A1 (fr)
CO (1) CO4520226A1 (fr)
CZ (1) CZ202796A3 (fr)
DE (1) DE69512041T2 (fr)
DK (1) DK0753001T3 (fr)
EE (1) EE9600117A (fr)
ES (1) ES2137549T3 (fr)
FI (1) FI962773A (fr)
GR (1) GR3031677T3 (fr)
HK (1) HK1004222A1 (fr)
HU (1) HU218611B (fr)
IL (1) IL115905A0 (fr)
IS (1) IS4352A (fr)
MX (1) MX9602563A (fr)
NO (1) NO307092B1 (fr)
NZ (1) NZ296091A (fr)
OA (1) OA10303A (fr)
PE (1) PE49696A1 (fr)
RU (1) RU2152398C1 (fr)
SI (1) SI0753001T1 (fr)
SK (1) SK88496A3 (fr)
TW (1) TW321644B (fr)
WO (1) WO1996014326A1 (fr)
ZA (1) ZA959362B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0901493A1 (fr) * 1996-05-08 1999-03-17 Glaxo Wellcome S.A. Procede de preparation d'un compose d'indacene
US6436395B1 (en) 1996-09-18 2002-08-20 Merck & Co., Inc. Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) * 1996-10-07 2000-03-21 Merck & Co., Inc. Sordarin derivatives
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
CA2300407C (fr) * 1997-08-22 2010-01-26 Merck & Co., Inc. Derives de 4-cyano-4-deformylsordarine
US6136853A (en) * 1997-10-03 2000-10-24 Merck & Co., Inc. Sordarin derivatives
FI974385A0 (fi) * 1997-12-01 1997-12-01 Xyrofin Oy Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) * 1998-04-14 2006-07-04 Zhenhua Yang Small molecule anticancer compounds and related production process
MA26628A1 (fr) * 1998-05-11 2004-12-20 Glaxo Wellcome Sa Morpholino ethers
WO2000024728A1 (fr) 1998-10-26 2000-05-04 Merck & Co., Inc. Produit de transformation microbienne
JP2003501488A (ja) 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6645960B1 (en) 1999-11-11 2003-11-11 Glaxo Wellcome S.A. Antifungal sordaricin derivatives
AU2001289063A1 (en) * 2000-09-15 2002-03-26 Bristol-Myers Squibb Company Novel thio derivatives of sordarin as antifungal agents
AU2002249935A1 (en) * 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
WO2003007878A2 (fr) 2001-07-18 2003-01-30 Merck & Co., Inc. Agents antifongiques de derives de sordarine
US7045116B2 (en) 2001-12-13 2006-05-16 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
AU2002351340A1 (en) * 2001-12-14 2003-06-30 Merck & Co., Inc. A novel sordarin derivative isolated from culture fermentations and functions as an antifungal agent
JP2006513235A (ja) * 2002-12-31 2006-04-20 ネクター セラピューティクス 真菌感染症療法のためのエアゾール化可能な医薬製剤
US9314524B2 (en) 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US8419948B2 (en) * 2009-11-22 2013-04-16 United Laboratories International, Llc Wastewater treatment
WO2012033427A1 (fr) * 2010-09-08 2012-03-15 Dalin Mikhail Viktorovich Procédé de traitement des infections mycosiques et produit pour sa mise en oeuvre
RU2630403C2 (ru) * 2016-02-25 2017-09-07 Жанна Владимировна Вараткова Абразивная масса для изготовления инструмента с высокими номерами структуры

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH465771A (de) * 1965-12-06 1968-11-30 Sandoz Ag Verfahren zur Herstellung eines neuen Antibioticums
JPH0615555B2 (ja) * 1985-08-14 1994-03-02 三共株式会社 抗生物質ゾフイマリン
JP3189443B2 (ja) * 1992-11-20 2001-07-16 萬有製薬株式会社 抗真菌性物質ｂｅ−３１４０５
EA002469B1 (ru) * 1996-09-12 2002-06-27 Мерк Энд Ко., Инк. Способ лечения грибковой инфекции

Also Published As

Publication number Publication date
NO962856L (no) 1996-09-05
SI0753001T1 (en) 1999-12-31
HK1004222A1 (en) 1998-11-20
CN1143965A (zh) 1997-02-26
AU704405B2 (en) 1999-04-22
ZA959362B (en) 1996-05-08
MX9602563A (es) 1997-05-31
EE9600117A (et) 1997-04-15
CO4520226A1 (es) 1997-10-15
AP9600824A0 (en) 1996-07-31
CA2179403A1 (fr) 1996-05-17
EP0753001B1 (fr) 1999-09-08
PE49696A1 (es) 1996-12-05
IS4352A (is) 1996-06-10
US5952334A (en) 1999-09-14
DK0753001T3 (da) 2000-05-08
DE69512041T2 (de) 2000-02-03
EP0753001A1 (fr) 1997-01-15
IL115905A0 (en) 1996-01-31
NZ296091A (en) 1998-06-26
BR9506473A (pt) 1997-10-07
NO307092B1 (no) 2000-02-07
BG100699A (bg) 1997-02-28
CN1056849C (zh) 2000-09-27
CZ202796A3 (en) 1997-02-12
ES2137549T3 (es) 1999-12-16
AP614A (en) 1997-09-05
FI962773A0 (fi) 1996-07-05
RU2152398C1 (ru) 2000-07-10
JPH09508144A (ja) 1997-08-19
DE69512041D1 (de) 1999-10-14
WO1996014326A1 (fr) 1996-05-17
HUT76292A (en) 1997-07-28
ATE184284T1 (de) 1999-09-15
HU218611B (hu) 2000-10-28
AR013815A1 (es) 2001-01-31
GR3031677T3 (en) 2000-02-29
FI962773A (fi) 1996-08-26
NO962856D0 (no) 1996-07-05
KR100391401B1 (ko) 2003-12-31
TW321644B (fr) 1997-12-01
BG62620B1 (en) 2000-03-31
HU9601865D0 (en) 1996-11-28
AU3980995A (en) 1996-05-31
SK88496A3 (en) 1997-04-09
US5854280A (en) 1998-12-29

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