SG73962A1 - Organic salts of n, n'-diacetyl cystine - Google Patents
Organic salts of n, n'-diacetyl cystineInfo
- Publication number
- SG73962A1 SG73962A1 SG1996004497A SG1996004497A SG73962A1 SG 73962 A1 SG73962 A1 SG 73962A1 SG 1996004497 A SG1996004497 A SG 1996004497A SG 1996004497 A SG1996004497 A SG 1996004497A SG 73962 A1 SG73962 A1 SG 73962A1
- Authority
- SG
- Singapore
- Prior art keywords
- organic salts
- diacetyl cystine
- cystine
- diacetyl
- salts
- Prior art date
Links
- YTPQSLLEROSACP-YUMQZZPRSA-N (2R)-2-acetamido-3-[[(2R)-2-acetamido-2-carboxyethyl]disulfanyl]propanoic acid Chemical class CC(=O)N[C@H](C(O)=O)CSSC[C@@H](C(O)=O)NC(C)=O YTPQSLLEROSACP-YUMQZZPRSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
- C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9103572A SE9103572D0 (sv) | 1991-11-29 | 1991-11-29 | Organic salts of n,n'-diacetyl cystine |
Publications (1)
Publication Number | Publication Date |
---|---|
SG73962A1 true SG73962A1 (en) | 2000-07-18 |
Family
ID=20384494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996004497A SG73962A1 (en) | 1991-11-29 | 1992-11-25 | Organic salts of n, n'-diacetyl cystine |
Country Status (38)
Country | Link |
---|---|
US (5) | US5385904A (xx) |
EP (1) | EP0621862B1 (xx) |
JP (1) | JP3302018B2 (xx) |
KR (1) | KR100256185B1 (xx) |
CN (1) | CN1039586C (xx) |
AP (1) | AP350A (xx) |
AT (1) | ATE141913T1 (xx) |
AU (1) | AU657827B2 (xx) |
CA (1) | CA2123516A1 (xx) |
CZ (1) | CZ282085B6 (xx) |
DE (1) | DE69213256T2 (xx) |
DK (1) | DK0621862T3 (xx) |
DZ (1) | DZ1637A1 (xx) |
EE (1) | EE03025B1 (xx) |
ES (1) | ES2090713T3 (xx) |
FI (1) | FI942504A0 (xx) |
GR (1) | GR3021546T3 (xx) |
HK (1) | HK62297A (xx) |
HR (1) | HRP921322B1 (xx) |
HU (1) | HU215390B (xx) |
IL (1) | IL103778A (xx) |
IS (1) | IS1645B (xx) |
LV (1) | LV11949B (xx) |
MA (1) | MA22716A1 (xx) |
MX (1) | MX9206851A (xx) |
MY (1) | MY110523A (xx) |
NO (1) | NO301325B1 (xx) |
NZ (1) | NZ245077A (xx) |
PL (2) | PL170787B1 (xx) |
RU (1) | RU2135468C1 (xx) |
SE (1) | SE9103572D0 (xx) |
SG (1) | SG73962A1 (xx) |
SI (1) | SI9200351A (xx) |
SK (1) | SK281697B6 (xx) |
TN (1) | TNSN92108A1 (xx) |
WO (1) | WO1993011104A1 (xx) |
YU (1) | YU48594B (xx) |
ZA (1) | ZA928739B (xx) |
Families Citing this family (47)
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US3865463A (en) * | 1973-11-12 | 1975-02-11 | Busch & Co Inc Ag | Electrical adapter plug |
EP0494405B2 (en) * | 1991-01-10 | 2000-04-19 | Transcend Therapeutics, Inc. | Use of L-2-oxo thiazolidine-4-carboxylate for the treatment of pulmonary diseases |
US5747459A (en) * | 1991-02-04 | 1998-05-05 | Nestec, Ltd. | Method for insuring adequate intracellular glutathione in tissue |
US5430045A (en) * | 1992-04-23 | 1995-07-04 | Free Radical Sciences, Inc. | Method of reducing or preventing bone marrow hypoplasia |
US5447712A (en) * | 1993-12-09 | 1995-09-05 | Free Radical Sciences | Method of reducing cyclophosphamide induced hemorrhagic cystitis |
SE9500897D0 (sv) * | 1995-03-14 | 1995-03-14 | Astra Ab | The pharmacological use of certain cystine derivatives |
SE9602262D0 (sv) * | 1996-06-06 | 1996-06-06 | Astra Ab | New use of derivatives of cystine |
AR007398A1 (es) * | 1996-06-18 | 1999-10-27 | Astrazeneca Ab | Proceso para preparar sales inorganicas de n-n'-diacetilcistina |
SE9602416D0 (sv) * | 1996-06-18 | 1996-06-18 | Astra Ab | New forms of an organic salt of N'N-diacetylcystine |
US6017959A (en) * | 1996-06-18 | 2000-01-25 | Astra Aktiebolag | Forms of organic salts of N,N'-diacetylcystine |
CN1059907C (zh) * | 1997-05-23 | 2000-12-27 | 中国石油化工集团公司巴陵石化岳阳石油化工总厂 | 一种含共轭二烯轻聚合物的选择氢化方法 |
US6197749B1 (en) * | 1997-10-29 | 2001-03-06 | Ajinomoto Co., Inc. | Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes |
US20030203006A1 (en) * | 1997-10-29 | 2003-10-30 | Ajinomoto Co. Inc. | Immunomodulator |
SE9800932D0 (sv) * | 1998-03-20 | 1998-03-20 | Astra Ab | New compunds |
EP1004302A3 (en) * | 1998-10-29 | 2003-06-04 | Ajinomoto Co., Inc. | Immunomodulator |
SE9900438D0 (sv) * | 1999-02-10 | 1999-02-10 | Astra Ab | The pharmacological use of certian cystine derivatives |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
SE518784C2 (sv) * | 2000-12-27 | 2002-11-19 | Nactilus Ab | "N-Acetyl-L-cystein med kompositioner för behandling av neoplasier" |
KR20040021589A (ko) * | 2001-03-13 | 2004-03-10 | 아지노모토 가부시키가이샤 | 화장품 또는 피부 외용제 |
EP1494732B1 (en) | 2002-03-20 | 2008-01-30 | MannKind Corporation | Inhalation apparatus |
KR101273120B1 (ko) | 2004-08-20 | 2013-06-13 | 맨카인드 코포레이션 | 다이케토피페라진 합성의 촉매 작용 |
KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
IN2014DN09128A (xx) | 2005-09-14 | 2015-07-10 | Mannkind Corp | |
BRPI0707991B8 (pt) | 2006-02-22 | 2021-05-25 | Mannkind Corp | métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco |
US8438729B2 (en) * | 2006-03-09 | 2013-05-14 | Canon Kabushiki Kaisha | Method of producing liquid discharge head |
US8485180B2 (en) * | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
CN109568740B (zh) | 2008-06-13 | 2022-05-27 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
ES2904623T3 (es) * | 2008-06-20 | 2022-04-05 | Mannkind Corp | Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
PL2405963T3 (pl) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Urządzenie, układ i sposób pomiaru oporu inhalatora |
KR101875969B1 (ko) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
EP2496295A1 (en) | 2009-11-03 | 2012-09-12 | MannKind Corporation | An apparatus and method for simulating inhalation efforts |
KR20130117755A (ko) | 2010-06-21 | 2013-10-28 | 맨카인드 코포레이션 | 건조 분말 약물 운반 시스템 및 방법 |
JP6133270B2 (ja) | 2011-04-01 | 2017-05-24 | マンカインド コーポレイション | 薬剤カートリッジのためのブリスター包装 |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
BR112014009686A2 (pt) | 2011-10-24 | 2018-08-07 | Mannkind Corp | composição analgésica inalável, pó seco e método para tratar dor |
CN102491926B (zh) * | 2011-12-15 | 2013-09-25 | 青岛市药品检验所 | 一种硫普罗宁二硫化物的制备和纯化方法 |
AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
ES2754388T3 (es) | 2013-03-15 | 2020-04-17 | Mannkind Corp | Composiciones y métodos de dicetopiperazina microcristalina |
BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
WO2015021064A1 (en) | 2013-08-05 | 2015-02-12 | Mannkind Corporation | Insufflation apparatus and methods |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
EP4142677A1 (en) * | 2020-04-28 | 2023-03-08 | Unilever IP Holdings B.V. | Personal care compositions with enhanced solubility actives |
US20230372272A1 (en) * | 2020-09-28 | 2023-11-23 | Georgia Tech Research Corporation | Use of cystine and derivatives thereof as anti-thrombotic and thrombolytic agents |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB592631A (en) * | 1945-04-04 | 1947-09-24 | Du Pont | Cysteine and cystine |
GB954268A (en) | 1962-02-26 | 1964-04-02 | Mead Johnson & Co | Decongestant compositions comprising n-acylated sulphydryl compounds |
FR8205M (xx) * | 1968-12-20 | 1970-09-14 | ||
US3647834A (en) | 1969-08-11 | 1972-03-07 | Mead Johnson & Co | Zinc mercaptide n-acetylcysteine carboxylate salts |
US3878305A (en) * | 1972-05-25 | 1975-04-15 | Procter & Gamble | Fortification of foodstuffs with n-acyl derivatives of sulphur-containing l-amino acids |
US3952115A (en) * | 1975-04-02 | 1976-04-20 | The Procter & Gamble Company | Fortification of foodstuffs with N-acyl derivatives of sulfur-containing L-amino acid esters |
US4141734A (en) * | 1975-09-11 | 1979-02-27 | Ciba-Geiby Ag | Photographic developing process |
US4093739A (en) * | 1977-06-15 | 1978-06-06 | Mead Johnson & Company | Mercaptoacylamidobenzoyl glycine and mucolytic process |
JPS6011888B2 (ja) * | 1978-10-11 | 1985-03-28 | 参天製薬株式会社 | リウマチ疾患治療薬 |
JPS56155298A (en) * | 1980-05-02 | 1981-12-01 | Tanabe Seiyaku Co | Shampoo composition |
FR2503151A1 (fr) * | 1981-04-02 | 1982-10-08 | Morelle Jean | Butyryminoacides soufres. mode de preparation. emploi comme element keratogenique chez l'homme et l'animal et comme agent de fertilisation chez les vegetaux |
GB2097256B (en) * | 1981-04-02 | 1985-05-30 | Morelle Jean V | Compositions containing n-butyryl alphaaminoacids |
JPS58164566A (ja) * | 1982-03-09 | 1983-09-29 | Kenji Okawa | シスチン類の製造法 |
US4708965A (en) * | 1985-09-16 | 1987-11-24 | Morgan Lee R | Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives |
US4724239A (en) * | 1985-09-16 | 1988-02-09 | Morgan Lee R | Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine |
US4827016A (en) * | 1985-09-16 | 1989-05-02 | Morgan Lee R | Method and compounds for reducing dermal inflammations |
JPH0660157B2 (ja) * | 1985-11-20 | 1994-08-10 | 三井東圧化学株式会社 | システインからシスチンを製造する方法 |
JPS62195356A (ja) * | 1986-02-20 | 1987-08-28 | Seiwa Kasei:Kk | シスチン誘導体及びその塩 |
AT402931B (de) * | 1986-11-07 | 1997-09-25 | Pharmacia Gmbh | Verfahren zur herstellung von neuen cystinverbindungen und derenverwendung |
SE8704542D0 (sv) * | 1987-11-19 | 1987-11-19 | Draco Ab | New derivatives of cysteine |
IL98310A (en) * | 1990-06-08 | 1996-08-04 | Astra Ab | Medicinal preparations containing a history of cystine |
TW221376B (xx) * | 1990-06-28 | 1994-03-01 | Astra Ab | |
GB9111885D0 (en) * | 1991-06-03 | 1991-07-24 | Erba Carlo Spa | Nerve growth factor for use in the prevention and treatment of viral infections |
-
1991
- 1991-11-29 SE SE9103572A patent/SE9103572D0/xx unknown
-
1992
- 1992-11-10 NZ NZ245077A patent/NZ245077A/en unknown
- 1992-11-12 ZA ZA928739A patent/ZA928739B/xx unknown
- 1992-11-17 IL IL10377892A patent/IL103778A/xx not_active IP Right Cessation
- 1992-11-18 YU YU99092A patent/YU48594B/sh unknown
- 1992-11-20 AP APAP/P/1992/000448A patent/AP350A/en active
- 1992-11-23 TN TNTNSN92108A patent/TNSN92108A1/fr unknown
- 1992-11-23 HR HR9103572-5A patent/HRP921322B1/xx not_active IP Right Cessation
- 1992-11-24 IS IS3949A patent/IS1645B/is unknown
- 1992-11-24 MA MA23006A patent/MA22716A1/fr unknown
- 1992-11-25 KR KR1019940701815A patent/KR100256185B1/ko not_active IP Right Cessation
- 1992-11-25 DK DK92924975.3T patent/DK0621862T3/da active
- 1992-11-25 PL PL92303924A patent/PL170787B1/pl unknown
- 1992-11-25 US US07/981,373 patent/US5385904A/en not_active Expired - Lifetime
- 1992-11-25 AT AT92924975T patent/ATE141913T1/de not_active IP Right Cessation
- 1992-11-25 JP JP51003993A patent/JP3302018B2/ja not_active Expired - Fee Related
- 1992-11-25 MY MYPI92002155A patent/MY110523A/en unknown
- 1992-11-25 PL PL92314567A patent/PL171336B1/pl unknown
- 1992-11-25 SK SK632-94A patent/SK281697B6/sk unknown
- 1992-11-25 AU AU30996/92A patent/AU657827B2/en not_active Ceased
- 1992-11-25 HU HU9401473A patent/HU215390B/hu not_active IP Right Cessation
- 1992-11-25 SG SG1996004497A patent/SG73962A1/en unknown
- 1992-11-25 WO PCT/SE1992/000807 patent/WO1993011104A1/en active IP Right Grant
- 1992-11-25 DE DE69213256T patent/DE69213256T2/de not_active Expired - Fee Related
- 1992-11-25 CZ CZ941297A patent/CZ282085B6/cs not_active IP Right Cessation
- 1992-11-25 ES ES92924975T patent/ES2090713T3/es not_active Expired - Lifetime
- 1992-11-25 CA CA002123516A patent/CA2123516A1/en not_active Abandoned
- 1992-11-25 RU RU94027569/04A patent/RU2135468C1/ru not_active IP Right Cessation
- 1992-11-25 DZ DZ920148A patent/DZ1637A1/fr active
- 1992-11-25 EP EP92924975A patent/EP0621862B1/en not_active Expired - Lifetime
- 1992-11-27 MX MX9206851A patent/MX9206851A/es not_active IP Right Cessation
- 1992-11-28 CN CN92113666A patent/CN1039586C/zh not_active Expired - Fee Related
- 1992-11-30 SI SI19929200351A patent/SI9200351A/sl unknown
-
1994
- 1994-05-26 NO NO941968A patent/NO301325B1/no not_active IP Right Cessation
- 1994-05-27 FI FI942504A patent/FI942504A0/fi unknown
- 1994-11-08 US US08/335,941 patent/US5693858A/en not_active Expired - Fee Related
- 1994-11-17 EE EE9400378A patent/EE03025B1/xx not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/484,143 patent/US5824681A/en not_active Expired - Fee Related
- 1995-06-07 US US08/476,218 patent/US5650538A/en not_active Expired - Lifetime
- 1995-06-07 US US08/477,387 patent/US5804582A/en not_active Expired - Fee Related
-
1996
- 1996-11-06 GR GR960402920T patent/GR3021546T3/el unknown
-
1997
- 1997-05-08 HK HK62297A patent/HK62297A/xx not_active IP Right Cessation
- 1997-08-28 LV LVP-97-158A patent/LV11949B/en unknown
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