SG47504A1 - Enzymatic hydroxylation process for the preparation of hmgcoa reductase inhibitors and intermediates thereof - Google Patents

Enzymatic hydroxylation process for the preparation of hmgcoa reductase inhibitors and intermediates thereof

Info

Publication number
SG47504A1
SG47504A1 SG1996002486A SG1996002486A SG47504A1 SG 47504 A1 SG47504 A1 SG 47504A1 SG 1996002486 A SG1996002486 A SG 1996002486A SG 1996002486 A SG1996002486 A SG 1996002486A SG 47504 A1 SG47504 A1 SG 47504A1
Authority
SG
Singapore
Prior art keywords
preparation
reductase inhibitors
intermediates
hydroxylation process
hmgcoa reductase
Prior art date
Application number
SG1996002486A
Other languages
English (en)
Inventor
Brian L Davis
Laszlo Szarka
Paul M Cino
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG47504A1 publication Critical patent/SG47504A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG1996002486A 1993-10-22 1994-10-18 Enzymatic hydroxylation process for the preparation of hmgcoa reductase inhibitors and intermediates thereof SG47504A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/141,316 US6043064A (en) 1993-10-22 1993-10-22 Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof

Publications (1)

Publication Number Publication Date
SG47504A1 true SG47504A1 (en) 1998-04-17

Family

ID=22495167

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996002486A SG47504A1 (en) 1993-10-22 1994-10-18 Enzymatic hydroxylation process for the preparation of hmgcoa reductase inhibitors and intermediates thereof

Country Status (20)

Country Link
US (1) US6043064A (de)
EP (1) EP0649907B1 (de)
JP (1) JP3683606B2 (de)
KR (1) KR100342627B1 (de)
CN (1) CN1085250C (de)
AT (1) ATE196166T1 (de)
AU (1) AU679113B2 (de)
CA (1) CA2134025A1 (de)
CY (1) CY2216B1 (de)
DE (1) DE69425801T2 (de)
DK (1) DK0649907T3 (de)
ES (1) ES2150459T3 (de)
FI (1) FI113279B (de)
GR (1) GR3034835T3 (de)
HK (1) HK1014740A1 (de)
HU (1) HU217104B (de)
IL (1) IL111084A (de)
PT (1) PT649907E (de)
SG (1) SG47504A1 (de)
TW (1) TW438888B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245535B1 (en) 1997-08-07 2001-06-12 Kyowa Hakko Kogyo Co., Ltd. Process for the preparation of HMG-COA reductase inhibitors
WO1999010499A1 (en) * 1997-08-22 1999-03-04 Dsm N.V. Statin production by fermentation
SI9800144A (sl) * 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
KR100633867B1 (ko) * 1999-01-20 2006-10-16 교와 핫꼬 고교 가부시끼가이샤 히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법
CZ20012728A3 (cs) * 1999-01-29 2002-02-13 Kyowa Hakko Kogyo Co., Ltd. Způsob výroby inhibitorů HMG-CoA reduktasy
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
JP2003093045A (ja) * 2001-09-26 2003-04-02 Godo Shusei Co Ltd 有用変換微生物
CA2461951C (en) * 2001-09-27 2011-08-09 Biocon Limited Process for producing pravastatin sodium salt using streptomyces flavidovirens dsm 14455
EP1452602A1 (de) * 2003-02-25 2004-09-01 Antibiotic Co., Fermentatives Verfahren zur Herstellung von Pravastatin
TWI252253B (en) * 2004-01-09 2006-04-01 Chinese Petroleum Corp A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same
CN101351551A (zh) 2005-11-29 2009-01-21 协和发酵工业株式会社 新型蛋白质和编码该蛋白质的dna
WO2007137816A1 (en) * 2006-05-30 2007-12-06 Dsm Ip Assets B.V. Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP1953233A1 (de) * 2007-02-02 2008-08-06 LEK Pharmaceuticals d.d. Fermentationsverfahren zur Herstellung von Pravastatin
KR20200015606A (ko) 2017-06-06 2020-02-12 지머젠 인코포레이티드 사카로폴리스포라 스피노사를 개량하기 위한 고 처리량(htp) 게놈 공학 플랫폼

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (de) * 1974-06-07 1981-03-18
US4206206A (en) * 1977-03-24 1980-06-03 Kowa Company, Ltd. Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0069442B1 (de) * 1981-06-06 1985-02-20 Pfizer Limited Fungizide Mittel, Verfahren zu deren Herstellung, und diese enthaltende pharmazeutische Zusammenstellungen
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS60176595A (ja) * 1984-02-21 1985-09-10 Akira Endo 生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
PT85109A (en) * 1986-06-23 1987-07-01 Merck & Co Inc Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
EP0337548A3 (de) * 1988-04-15 1991-08-14 Merck & Co. Inc. Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695)
EP0381478A1 (de) * 1989-02-01 1990-08-08 Merck & Co. Inc. Verfahren zur Herstellung von 6-alpha-Hydroxymethyl-Lovastatin-Derivaten
EP0408806A1 (de) * 1989-07-19 1991-01-23 Merck & Co. Inc. Antihypercholesterolemische Mittel
MY106564A (en) * 1990-07-06 1995-06-30 Squibb & Sons Inc Sulfur-substituted mevinic acid derivatives.
CA2053000C (en) * 1990-10-15 1995-08-29 Michael J. Conder Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
HK1014740A1 (en) 1999-09-30
CN1106067A (zh) 1995-08-02
JPH07184670A (ja) 1995-07-25
CN1085250C (zh) 2002-05-22
DE69425801T2 (de) 2001-05-03
FI113279B (fi) 2004-03-31
KR950011616A (ko) 1995-05-15
DK0649907T3 (da) 2000-10-09
TW438888B (en) 2001-06-07
EP0649907A1 (de) 1995-04-26
DE69425801D1 (de) 2000-10-12
AU679113B2 (en) 1997-06-19
JP3683606B2 (ja) 2005-08-17
KR100342627B1 (ko) 2002-11-18
ATE196166T1 (de) 2000-09-15
EP0649907B1 (de) 2000-09-06
CY2216B1 (en) 2003-04-18
FI944926A (fi) 1995-04-23
IL111084A (en) 1998-01-04
HUT69959A (en) 1995-09-28
GR3034835T3 (en) 2001-02-28
HU217104B (hu) 1999-11-29
AU7597294A (en) 1995-05-11
FI944926A0 (fi) 1994-10-20
US6043064A (en) 2000-03-28
CA2134025A1 (en) 1995-04-23
IL111084A0 (en) 1994-11-28
HU9403061D0 (en) 1994-12-28
ES2150459T3 (es) 2000-12-01
PT649907E (pt) 2000-12-29

Similar Documents

Publication Publication Date Title
SG47504A1 (en) Enzymatic hydroxylation process for the preparation of hmgcoa reductase inhibitors and intermediates thereof
AU3075697A (en) Enzymatic process for the manufacture of ascorbic acid, 2-keto-l-gulonic acid and esters of 2-keto-l-gulonic acid
MX9702724A (es) Lipasa, microorganismo que la produce, procedimiento para la preparacion de dicha lipasa y su uso.
CA2311756A1 (en) Reduction of hair growth
AU7610200A (en) Improved fermentation process
EP0826773A3 (de) Verfahren zur Herstellung von trans-4-Hydroxy-L-Prolin
EP0896057A3 (de) D-Aminoacylase
EP0927755A3 (de) Haloacetoacetatreductase,Verfahren zur Herstellung und Verfahren zur Herstellung von Alcoholen damit
AU1273000A (en) Process for preparing optically active-3-hydroxy-pyrrolidine derivatives by enzymatic hydroxylation
HK1075063A1 (en) Microorganisms
AU8978398A (en) Process for preparing amides
AU2818392A (en) Method for enhancing enzyme activities and the synthetic performance of organisms
EP0950706A3 (de) D-Aminoacylase
ATE161584T1 (de) Esterase und ihre verwendung in bioumwandlung
CA2131776A1 (en) Process for producing cis-3-hydroxy-l-proline
AU2001265994A1 (en) Method for microbial production of difructose anhydride iii, micro-organism usedtherefor and enzyme with inulase ii activity and dna sequences coding therefor
EP0909757A3 (de) Verfahren zur Herstellung optisch aktiver Pentatetraole
WO1999007199A3 (de) Verfahren zur herstellung von l-alaninol und gamma-glutamylisopropylamid und mikroorganismusstamm des genus pseudomonas
IT1255470B (it) Composti attivi come inibitori dell'enzima hmg-coa reduttasi
CA2131775A1 (en) Process for producing trans-4-hydroxy-l-proline