CA2131776A1 - Process for producing cis-3-hydroxy-l-proline - Google Patents

Process for producing cis-3-hydroxy-l-proline

Info

Publication number
CA2131776A1
CA2131776A1 CA002131776A CA2131776A CA2131776A1 CA 2131776 A1 CA2131776 A1 CA 2131776A1 CA 002131776 A CA002131776 A CA 002131776A CA 2131776 A CA2131776 A CA 2131776A CA 2131776 A1 CA2131776 A1 CA 2131776A1
Authority
CA
Canada
Prior art keywords
proline
hydroxy
cis
useful
aqueous medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002131776A
Other languages
French (fr)
Other versions
CA2131776C (en
Inventor
Akio Ozaki
Hideo Mori
Takeshi Shibasaki
Katsuhiko Ando
Keiko Ochiai
Shigeru Chiba
Yoichi Uosaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of CA2131776A1 publication Critical patent/CA2131776A1/en
Application granted granted Critical
Publication of CA2131776C publication Critical patent/CA2131776C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Provided is a process for industrially producing cis-3-hydroxy-L-proline useful as a raw material for medicines or as an additive to foods. L-proline is converted into cis-3-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Streptomyces or Bacillus and which catalyzes hydroxylation of L-proline into cis-3-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced cis-3-hydroxy-L-proline is recovered from the aqueous medium. Also provided is a novel enzyme L-proline-3-hydroxylase, which is useful for the process.
CA002131776A 1994-04-05 1994-09-09 Process for producing cis-3-hydroxy-l-proline Expired - Fee Related CA2131776C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP67315/94 1994-04-05
JP6731594 1994-04-05

Publications (2)

Publication Number Publication Date
CA2131776A1 true CA2131776A1 (en) 1995-10-06
CA2131776C CA2131776C (en) 2002-04-23

Family

ID=13341473

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002131776A Expired - Fee Related CA2131776C (en) 1994-04-05 1994-09-09 Process for producing cis-3-hydroxy-l-proline

Country Status (1)

Country Link
CA (1) CA2131776C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0771876A4 (en) * 1995-03-07 1999-06-02 Kyowa Hakko Kogyo Kk PROCESS FOR PRODUCING cis-3-HYDROXY-L-PROLINE
CN105177026A (en) * 2015-09-22 2015-12-23 河北师范大学 Cis-3-hydroxy-L-proline hydroxylase modified gene and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0771876A4 (en) * 1995-03-07 1999-06-02 Kyowa Hakko Kogyo Kk PROCESS FOR PRODUCING cis-3-HYDROXY-L-PROLINE
CN105177026A (en) * 2015-09-22 2015-12-23 河北师范大学 Cis-3-hydroxy-L-proline hydroxylase modified gene and application thereof

Also Published As

Publication number Publication date
CA2131776C (en) 2002-04-23

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Legal Events

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