SG170763A1 - Ras mutation and compositions and methods related thereto - Google Patents
Ras mutation and compositions and methods related theretoInfo
- Publication number
- SG170763A1 SG170763A1 SG201102095-5A SG2011020955A SG170763A1 SG 170763 A1 SG170763 A1 SG 170763A1 SG 2011020955 A SG2011020955 A SG 2011020955A SG 170763 A1 SG170763 A1 SG 170763A1
- Authority
- SG
- Singapore
- Prior art keywords
- mutations
- compositions
- methods related
- ras mutation
- proteins
- Prior art date
Links
- 230000035772 mutation Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001162—Kinases, e.g. Raf or Src
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78656806P | 2006-03-27 | 2006-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG170763A1 true SG170763A1 (en) | 2011-05-30 |
Family
ID=38694572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG201102095-5A SG170763A1 (en) | 2006-03-27 | 2007-03-09 | Ras mutation and compositions and methods related thereto |
Country Status (12)
Country | Link |
---|---|
US (3) | US7745128B2 (zh) |
EP (1) | EP2004666B1 (zh) |
JP (2) | JP2009531068A (zh) |
KR (1) | KR20090008290A (zh) |
CN (1) | CN101448848B (zh) |
AU (1) | AU2007249639B2 (zh) |
BR (1) | BRPI0709340A2 (zh) |
CA (1) | CA2647102A1 (zh) |
MX (1) | MX2008012392A (zh) |
SG (1) | SG170763A1 (zh) |
TW (1) | TW200806789A (zh) |
WO (1) | WO2007133835A2 (zh) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002225681A1 (en) * | 2000-11-15 | 2002-05-27 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
US8343502B2 (en) * | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
AU2003301021C1 (en) * | 2002-12-16 | 2010-02-18 | Globelmmune, Inc. | Yeast-based vaccines as immunotherapy |
AU2006268333B2 (en) * | 2005-07-11 | 2012-06-14 | Globeimmune, Inc. | Compositions and methods for eliciting an immune response to escape mutants of targeted therapies |
US20070172503A1 (en) | 2005-12-13 | 2007-07-26 | Mycologics,Inc. | Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines |
TW200806789A (en) * | 2006-03-27 | 2008-02-01 | Globeimmune Inc | RAS mutation and compositions and methods related thereto |
RU2008146868A (ru) | 2006-05-18 | 2010-06-27 | Кэрис МПИ, Инк.445 Норт Фифс Стрит, 3-ий Флор, Феникс, Аризона 85004, США (US) | Система и способ определения персонализированого медицинского вмешательства при болезненном состоянии |
US8768629B2 (en) * | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
AU2008214029B2 (en) * | 2007-02-02 | 2014-01-30 | Globelmmune, Inc. | Methods for producing yeast-based vaccines |
BRPI0809247A2 (pt) * | 2007-03-19 | 2014-09-09 | Globeimmune Inc | Composições e métodos para a ablação do escape mutacional de terapias marcadas para câncer. |
EP3034095B1 (en) * | 2007-06-29 | 2018-08-08 | Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. | Method of fixing and expressing physiologically active substance |
KR100957555B1 (ko) | 2007-12-28 | 2010-05-11 | 덕성여자대학교 산학협력단 | Ras 융합 단백질 |
WO2009099991A2 (en) * | 2008-01-31 | 2009-08-13 | The Brigham And Women's Hospital, Inc. | Treatment of cancer |
EP3216874A1 (en) | 2008-09-05 | 2017-09-13 | TOMA Biosciences, Inc. | Methods for stratifying and annotating cancer drug treatment options |
US20100075326A1 (en) * | 2008-09-12 | 2010-03-25 | Cornell University | Yeast surface two-hybrid system for quantitative detection of protein-protein interactions |
KR101153845B1 (ko) | 2008-11-10 | 2012-07-09 | 단국대학교 산학협력단 | Kras G12V RNA를 특이적으로 인지할 수 있는 트랜스-스플라이싱 그룹 I 리보자임 |
CN102301002A (zh) | 2008-11-12 | 2011-12-28 | 卡里斯生命科学卢森堡控股有限责任公司 | 使用外来体来确定表现型的方法和系统 |
DK2756845T3 (en) | 2009-04-03 | 2017-06-12 | Dicerna Pharmaceuticals Inc | Methods and compositions for specific inhibition of KRAS with asymmetric double stranded RNA |
JP5759980B2 (ja) | 2009-04-17 | 2015-08-05 | グローブイミューン,インコーポレイテッド | 癌および感染症に対する免疫療法組成物の組み合わせ |
EP2477647B1 (en) | 2009-09-14 | 2016-01-13 | The Regents of the University of Colorado | Modulation of yeast-based immunotherapy products and responses |
CA2786696C (en) * | 2010-01-12 | 2021-05-25 | Jill Detmer | Oligonucleotides and methods for detecting pik3ca mutations |
JP5808349B2 (ja) | 2010-03-01 | 2015-11-10 | カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー | セラノーシスのためのバイオマーカー |
US9469876B2 (en) | 2010-04-06 | 2016-10-18 | Caris Life Sciences Switzerland Holdings Gmbh | Circulating biomarkers for metastatic prostate cancer |
CN102869790B (zh) * | 2010-04-12 | 2014-11-26 | 反应遗传有限公司 | Kras引物和探针 |
EP3572528A1 (en) | 2010-09-24 | 2019-11-27 | The Board of Trustees of the Leland Stanford Junior University | Direct capture, amplification and sequencing of target dna using immobilized primers |
ES2696551T3 (es) | 2010-12-17 | 2019-01-16 | Globeimmune Inc | Composiciones y métodos para el tratamiento o la prevención de la infección por adenovirus-36 humano |
EA028659B1 (ru) | 2011-02-12 | 2017-12-29 | Глоубиммьюн, Инк. | Терапевтическое средство на основе дрожжей для лечения хронического гепатита b |
US9556473B2 (en) | 2011-02-15 | 2017-01-31 | Leica Biosystems Newcastle Ltd | Methods for identifying nucleic acid sequences |
CA2827497C (en) | 2011-02-15 | 2014-12-02 | Leica Biosystems Newcastle Ltd. | Method for localized in situ detection of mrna |
EP2685995B1 (en) * | 2011-03-17 | 2017-05-03 | Globeimmune, Inc. | Yeast-brachyury immunotherapeutic compositions |
WO2012149259A1 (en) | 2011-04-29 | 2012-11-01 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers to reduce antibody responses |
CN102796811B (zh) * | 2011-05-26 | 2013-12-18 | 上海赛安生物医药科技有限公司 | 检测kras突变的试剂及方法 |
AU2012271625B2 (en) | 2011-06-14 | 2017-05-18 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
WO2013025972A1 (en) | 2011-08-17 | 2013-02-21 | Globeimmune, Inc. | Yeast-muc1 immunotherapeutic compositions and uses thereof |
JP6286358B2 (ja) * | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤に応答するバイオマーカー |
US9260714B2 (en) * | 2011-12-02 | 2016-02-16 | Roche Molecular Systems, Inc. | Suppression of non-specific amplification with high-homology oligonucleotides |
KR101153844B1 (ko) | 2012-04-17 | 2012-06-20 | 단국대학교 산학협력단 | Kras G12V RNA를 특이적으로 인지할 수 있는 트랜스-스플라이싱 그룹 I 리보자임 |
BR112014029338A2 (pt) * | 2012-05-31 | 2017-06-27 | Bayer Pharma AG | biomarcadores para determinação da resposta eficaz dos tratamentos de pacientes com carcinoma hepatocelular (hcc) |
EP2864792A1 (en) * | 2012-06-26 | 2015-04-29 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
US11105802B2 (en) * | 2012-12-10 | 2021-08-31 | Seattle Children's Hospital | Cell-free biofragment compositions and related systems, devices, and methods |
TWI674108B (zh) | 2013-03-19 | 2019-10-11 | 美商環球免疫公司 | 索脊瘤之以酵母菌爲基礎之免疫療法 |
EP2978449B1 (en) | 2013-03-26 | 2021-09-08 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human immunodeficiency virus infection |
EA201592103A3 (ru) | 2013-05-03 | 2016-08-31 | Селекта Байосайенсиз, Инк. | Способы и композиции для усиления cd4+ регуляторных t-клеток |
US10226522B2 (en) | 2013-08-30 | 2019-03-12 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of tuberculosis |
WO2015059677A1 (en) | 2013-10-26 | 2015-04-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Methods of treating cancer |
EP3369432A1 (en) * | 2013-12-09 | 2018-09-05 | Targovax Asa | A peptide mixture |
WO2015123532A1 (en) * | 2014-02-16 | 2015-08-20 | Globeimmune, Inc. | Ras g12r immunotherapy for ras mutation-positive cancers |
CN106456677A (zh) * | 2014-04-11 | 2017-02-22 | 全球免疫股份有限公司 | 基于酵母的免疫疗法和i型干扰素敏感性 |
CA2946759A1 (en) * | 2014-04-25 | 2015-10-29 | Memorial Sloan-Kettering Cancer Center | Treatment of h-ras-driven tumors |
KR101602870B1 (ko) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
KR101602876B1 (ko) | 2014-07-22 | 2016-03-11 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
US10829752B2 (en) * | 2014-08-01 | 2020-11-10 | Northwestern University | Bacterial toxins and uses thereof as Ras specific proteases for treating cell proliferation diseases and disorders |
WO2016025804A1 (en) * | 2014-08-15 | 2016-02-18 | Medimmune, Llc | Detecting residual host cell proteins in recombinant protein preparations |
CN106714826A (zh) | 2014-09-07 | 2017-05-24 | 西莱克塔生物科技公司 | 用于减弱基因表达调节抗病毒转移载体免疫应答的方法和组合物 |
US20190374628A1 (en) * | 2015-06-16 | 2019-12-12 | Targovax Asa | Mutated fragments of the ras protein |
EP3331552B1 (en) | 2015-08-03 | 2021-01-27 | Globeimmune, Inc. | Modified yeast-brachyury immunotherapeutic compositions |
US10612032B2 (en) | 2016-03-24 | 2020-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inducible production-phase promoters for coordinated heterologous expression in yeast |
US11155641B2 (en) | 2016-05-27 | 2021-10-26 | Orum Therapeutics Inc. | Cytosol-penetrating antibody and use thereof |
US20190351039A1 (en) * | 2017-02-01 | 2019-11-21 | Modernatx, Inc. | Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides |
WO2018145020A1 (en) * | 2017-02-03 | 2018-08-09 | The Medical College Of Wisconsin, Inc. | Kras peptide vaccine compositions and method of use |
WO2018146253A1 (en) | 2017-02-10 | 2018-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway |
CN110612122A (zh) | 2017-03-11 | 2019-12-24 | 西莱克塔生物科技公司 | 与用抗炎剂和包含免疫抑制剂之合成纳米载体进行的组合治疗相关的方法和组合物 |
WO2019008001A1 (en) * | 2017-07-04 | 2019-01-10 | Curevac Ag | NEW NUCLEIC ACID MOLECULES |
CN108250269A (zh) * | 2018-04-02 | 2018-07-06 | 天津亨佳生物科技发展有限公司 | 一种治疗肿瘤的抗原肽链组及其在药物中的应用 |
CN108440647A (zh) * | 2018-04-02 | 2018-08-24 | 天津亨佳生物科技发展有限公司 | 一种治疗肿瘤的抗原肽链组及其在药物中的应用 |
CN108440646A (zh) * | 2018-04-02 | 2018-08-24 | 天津亨佳生物科技发展有限公司 | 一种治疗肿瘤的抗原肽链组及其在药物中的应用 |
CN108484731A (zh) * | 2018-04-02 | 2018-09-04 | 天津亨佳生物科技发展有限公司 | 一种治疗肿瘤的抗原肽链组及其在药物中的应用 |
CN108484730A (zh) * | 2018-04-02 | 2018-09-04 | 天津亨佳生物科技发展有限公司 | 一种治疗肿瘤的抗原肽链组及其在药物中的应用 |
CN108440648A (zh) * | 2018-04-02 | 2018-08-24 | 天津亨佳生物科技发展有限公司 | 一种治疗肿瘤的抗原肽链组及其在药物中的应用 |
US20210154250A1 (en) | 2018-05-15 | 2021-05-27 | Globeimmune, Inc. | Lysates of recombinant yeast for inducing cellular immune responses |
WO2019244086A1 (en) | 2018-06-21 | 2019-12-26 | Orum Therapeutics Inc. | Cell/tissue-specific cell-penetrating antibodies |
EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021211691A1 (en) | 2020-04-14 | 2021-10-21 | Immunitybio, Inc. | Yeast lysate covid-19 vaccine |
CN116438308A (zh) * | 2020-08-06 | 2023-07-14 | 磨石生物公司 | 多表位疫苗盒 |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2377188A (en) * | 1941-08-07 | 1945-05-29 | Schering Corp | Stabilized filter preparations |
US2376884A (en) * | 1941-08-07 | 1945-05-29 | Schering Corp | Hydroquinone composition |
US3856934A (en) * | 1970-06-24 | 1974-12-24 | A Kligman | Skin depigmentation |
US3755560A (en) * | 1971-06-30 | 1973-08-28 | Dow Chemical Co | Nongreasy cosmetic lotions |
US4136166A (en) * | 1977-04-18 | 1979-01-23 | Helena Rubinstein, Inc. | Skin lightening composition |
US4229427A (en) * | 1978-06-28 | 1980-10-21 | The Procter & Gamble Company | Radioactive scanning agents with hydroquinone stabilizer |
FR2486400B1 (fr) | 1980-07-09 | 1986-05-30 | Univablot | Medicaments a base de levures ou de leurs extraits insolubles |
NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
JPS57145803A (en) * | 1981-03-05 | 1982-09-09 | Sunstar Inc | External decoloring agent for skin |
US4421769A (en) * | 1981-09-29 | 1983-12-20 | The Procter & Gamble Company | Skin conditioning composition |
US4775622A (en) | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
US4466955A (en) * | 1982-06-09 | 1984-08-21 | Germaine Monteil Cosmetiques Corporation | Skin bleaching stick containing hydroquinone |
US4725550A (en) | 1984-01-19 | 1988-02-16 | Research Foundation Of State University Of New York | Novel mutation of the c-K-ras oncogene activated in a human lung carcinoma |
US4871838A (en) | 1985-07-23 | 1989-10-03 | The Board Of Rijks Universiteit Leiden | Probes and methods for detecting activated ras oncogenes |
US5591582A (en) | 1985-07-23 | 1997-01-07 | The Board Of Rijks Universiteit Leiden | Methods for detecting activated RAS oncogenes |
US4792443A (en) * | 1985-12-20 | 1988-12-20 | Warner-Lambert Company | Skin bleaching preparations |
US5389677B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of treating wrinkles using glycalic acid |
JPH0474515A (ja) * | 1990-07-13 | 1992-03-09 | Toray Ind Inc | 酸素吸収体 |
GB9103974D0 (en) | 1991-02-26 | 1991-04-10 | Norsk Hydro As | Therapeutically useful peptides or peptide fragments |
US5523077A (en) * | 1992-02-06 | 1996-06-04 | Yale University | Composition and method for whitening skin |
US5830463A (en) | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
JPH09500650A (ja) * | 1993-07-26 | 1997-01-21 | ケイ.オー.テクノロジー インコーポレイテッド | ガン治療薬の主薬としての遺伝子の異なる対立遺伝子の阻害剤 |
GB9422814D0 (en) | 1994-11-11 | 1995-01-04 | Medinnova Sf | Chemical method |
US5858378A (en) | 1996-05-02 | 1999-01-12 | Galagen, Inc. | Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen |
US6497860B1 (en) * | 1996-11-04 | 2002-12-24 | Children's Hospital Medical Center | Skin lightening compositions |
US6060297A (en) * | 1997-04-17 | 2000-05-09 | Incyte Pharmaceuticals, Inc. | Rho protein |
US5945306A (en) * | 1997-12-16 | 1999-08-31 | Incyte Pharmaceuticals, Inc. | Ras protein |
US6207450B1 (en) * | 1998-04-15 | 2001-03-27 | University Of Iowa Research Foundation | Glaucoma therapeutics and diagnostics based on a novel human transcription factor |
US6017710A (en) * | 1998-05-13 | 2000-01-25 | Axys Pharmaceuticals, Inc. | RAQ genes and their uses |
NO309798B1 (no) | 1999-04-30 | 2001-04-02 | Targovax As | Peptidblanding, samt farmasoytisk sammensetning og kreftvaksine som innbefatter peptidblandingen |
AU7686100A (en) * | 1999-10-15 | 2001-04-23 | Yaeta Endo | Template molecule having broad applicability and highly efficient function meansof cell-free synthesis of proteins by using the same |
AUPQ495700A0 (en) * | 2000-01-05 | 2000-02-03 | Johnson & Johnson Research Pty. Limited | Method for concurrent amplification and real time detection of polymorphic nucleic acid sequences |
US20020044948A1 (en) | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
DK1272213T3 (da) | 2000-04-06 | 2006-07-10 | Seer Pharmaceuticals Llc | Mikrobielt afgivelsessystem |
WO2002020841A2 (en) * | 2000-09-06 | 2002-03-14 | Glaxo Group Limited | 5-hydroxytryptamine receptor gene polymorphisms and response to treatment |
AU2002225681A1 (en) | 2000-11-15 | 2002-05-27 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
US7189759B2 (en) * | 2001-05-23 | 2007-03-13 | Medicis Pharmaceutical Corporation | Compositions for the treatment of pigmentation disorders and methods for their manufacture |
US6699464B1 (en) * | 2001-07-30 | 2004-03-02 | Stiefel Laboratories, Inc. | Compositions for treatment of hyperpigmentation and methods for making and using such compositions |
GB0130955D0 (en) * | 2001-12-24 | 2002-02-13 | Cancer Res Ventures | Expression system |
US20040185016A1 (en) * | 2002-07-30 | 2004-09-23 | Popp Karl F | Compositions for treatment of hyperpigmentation and methods for making and using such compositions |
GB0229139D0 (en) * | 2002-12-13 | 2003-01-15 | Glaxo Group Ltd | Gene polymorphisms |
AU2003301021C1 (en) * | 2002-12-16 | 2010-02-18 | Globelmmune, Inc. | Yeast-based vaccines as immunotherapy |
AU2006268333B2 (en) | 2005-07-11 | 2012-06-14 | Globeimmune, Inc. | Compositions and methods for eliciting an immune response to escape mutants of targeted therapies |
TW200806789A (en) * | 2006-03-27 | 2008-02-01 | Globeimmune Inc | RAS mutation and compositions and methods related thereto |
AU2008214029B2 (en) | 2007-02-02 | 2014-01-30 | Globelmmune, Inc. | Methods for producing yeast-based vaccines |
BRPI0809247A2 (pt) | 2007-03-19 | 2014-09-09 | Globeimmune Inc | Composições e métodos para a ablação do escape mutacional de terapias marcadas para câncer. |
-
2007
- 2007-03-09 TW TW096108338A patent/TW200806789A/zh unknown
- 2007-03-09 AU AU2007249639A patent/AU2007249639B2/en not_active Ceased
- 2007-03-09 JP JP2009503126A patent/JP2009531068A/ja active Pending
- 2007-03-09 CN CN2007800183814A patent/CN101448848B/zh not_active Expired - Fee Related
- 2007-03-09 US US11/684,290 patent/US7745128B2/en active Active
- 2007-03-09 MX MX2008012392A patent/MX2008012392A/es active IP Right Grant
- 2007-03-09 KR KR1020087026290A patent/KR20090008290A/ko not_active Application Discontinuation
- 2007-03-09 WO PCT/US2007/063711 patent/WO2007133835A2/en active Application Filing
- 2007-03-09 SG SG201102095-5A patent/SG170763A1/en unknown
- 2007-03-09 EP EP07797163.8A patent/EP2004666B1/en not_active Not-in-force
- 2007-03-09 BR BRPI0709340-3A patent/BRPI0709340A2/pt not_active IP Right Cessation
- 2007-03-09 CA CA002647102A patent/CA2647102A1/en not_active Abandoned
-
2010
- 2010-05-06 US US12/775,267 patent/US8470313B2/en active Active
-
2013
- 2013-03-13 US US13/799,496 patent/US20130344097A1/en not_active Abandoned
-
2014
- 2014-09-29 JP JP2014198353A patent/JP2015043773A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2009531068A (ja) | 2009-09-03 |
WO2007133835A3 (en) | 2008-11-13 |
AU2007249639A1 (en) | 2007-11-22 |
US20130344097A1 (en) | 2013-12-26 |
US20100215678A1 (en) | 2010-08-26 |
CN101448848B (zh) | 2013-12-04 |
MX2008012392A (es) | 2008-12-17 |
JP2015043773A (ja) | 2015-03-12 |
EP2004666A4 (en) | 2009-11-18 |
AU2007249639B2 (en) | 2012-05-31 |
CN101448848A (zh) | 2009-06-03 |
US20070224208A1 (en) | 2007-09-27 |
WO2007133835A8 (en) | 2010-11-11 |
BRPI0709340A2 (pt) | 2013-04-16 |
KR20090008290A (ko) | 2009-01-21 |
US8470313B2 (en) | 2013-06-25 |
EP2004666A2 (en) | 2008-12-24 |
WO2007133835A2 (en) | 2007-11-22 |
US7745128B2 (en) | 2010-06-29 |
EP2004666B1 (en) | 2014-09-03 |
TW200806789A (en) | 2008-02-01 |
CA2647102A1 (en) | 2007-11-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG170763A1 (en) | Ras mutation and compositions and methods related thereto | |
JOP20190083A1 (ar) | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها | |
TNSN08064A1 (en) | Albumin fusion proteins | |
MX2009002816A (es) | Proteinas de fusion de albumina. | |
WO2008065372A3 (en) | Modified erythropoietin polypeptides and uses thereof for treatment | |
WO2003104418A3 (en) | RECONSTITUTED POLYPEPTIDES | |
PH12015502433B1 (en) | Fgf21 mutants and uses thereof | |
TN2011000161A1 (en) | Fgf21 mutants and uses thereof | |
EP2441829A3 (en) | Heparan sulfate glycosaminoglycan lyase and uses thereof | |
DE602006019598D1 (de) | Neuartige phagenanzeigetechnologien | |
EA019476B9 (ru) | АНТИТЕЛА ПРОТИВ IL-23p19 И ИХ ПРИМЕНЕНИЕ | |
WO2007146038A3 (en) | Albumin fusion proteins | |
EP2332970A3 (en) | Mutated pseudomonas exotoxins with reduced antigenicity | |
WO2004065603A3 (en) | Methods for increasing neisseria protein expression | |
EA200800667A1 (ru) | Аптамеры, связывающие тромбин с высокой аффинностью | |
BRPI0714844B8 (pt) | molécula de ácido nucleico e seus usos, composição farmaceutica e complexo | |
WO2003104425A3 (en) | NEW STABLE ANTI-CD22 ANTIBODIES | |
WO2008040190A8 (en) | Small peptides for anti-angiogenesis and use thereof | |
MX2010000232A (es) | Metodos mejorados para la formacion de enlaces disulfuro. | |
PL374550A1 (en) | Il-17 like molecules and uses thereof | |
WO2007011765A3 (en) | Methods of identifying and treating individuals exhibiting mutant src kinase polypeptides | |
WO2005079316A3 (en) | Nucleic acid molecules encoding novel murine low-voltage activated calcium channel proteins, designated-alpha 1h, encoded proteins and methods of use thereof | |
WO2005023979A3 (en) | Isolated s. mansoni nucleic acid molecules and uses thereof | |
WO2010078469A3 (en) | Sand fly salivary proteins as novel factor xa inhibitors and methods of use | |
WO2006065981A3 (en) | Nucleic acid molecules for optimized cab-2 expression and their use |