SG165998A1 - 4-tetrazolyl-4phenylpiperidine derivatives for treating pain - Google Patents

4-tetrazolyl-4phenylpiperidine derivatives for treating pain

Info

Publication number
SG165998A1
SG165998A1 SG200703631-2A SG2007036312A SG165998A1 SG 165998 A1 SG165998 A1 SG 165998A1 SG 2007036312 A SG2007036312 A SG 2007036312A SG 165998 A1 SG165998 A1 SG 165998A1
Authority
SG
Singapore
Prior art keywords
tetrazolyl
derivatives
effective amount
treating pain
phenylpiperidine
Prior art date
Application number
SG200703631-2A
Other languages
English (en)
Inventor
Zhengming Chen
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of SG165998A1 publication Critical patent/SG165998A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG200703631-2A 2002-11-18 2003-11-17 4-tetrazolyl-4phenylpiperidine derivatives for treating pain SG165998A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42738102P 2002-11-18 2002-11-18
US46027803P 2003-04-03 2003-04-03
US48848803P 2003-07-17 2003-07-17
US10/714,066 US7202259B2 (en) 2002-11-18 2003-11-13 Therapeutic agents useful for treating pain

Publications (1)

Publication Number Publication Date
SG165998A1 true SG165998A1 (en) 2010-11-29

Family

ID=32777221

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200703631-2A SG165998A1 (en) 2002-11-18 2003-11-17 4-tetrazolyl-4phenylpiperidine derivatives for treating pain

Country Status (37)

Country Link
US (3) US7202259B2 (ru)
EP (2) EP1803718B1 (ru)
JP (2) JP4601429B2 (ru)
KR (1) KR20050115221A (ru)
CN (2) CN101648941A (ru)
AP (1) AP2210A (ru)
AR (1) AR047008A1 (ru)
AT (2) ATE358674T1 (ru)
AU (2) AU2003294313B2 (ru)
BR (1) BR0316305A (ru)
CA (1) CA2506242C (ru)
CO (1) CO5690588A2 (ru)
CR (2) CR7877A (ru)
CY (2) CY1107682T1 (ru)
DE (2) DE60322451D1 (ru)
DK (2) DK1803718T3 (ru)
EA (1) EA008621B1 (ru)
EC (1) ECSP055840A (ru)
ES (2) ES2312150T3 (ru)
GE (1) GEP20084539B (ru)
HK (1) HK1086829A1 (ru)
IL (1) IL209352A0 (ru)
IS (2) IS2720B (ru)
MA (1) MA27565A1 (ru)
ME (1) MEP48108A (ru)
MX (1) MXPA05004669A (ru)
MY (1) MY135647A (ru)
NI (1) NI200500087A (ru)
NO (1) NO20052894D0 (ru)
NZ (2) NZ540068A (ru)
OA (1) OA13010A (ru)
PT (2) PT1562932E (ru)
RS (1) RS51047B (ru)
SG (1) SG165998A1 (ru)
SI (2) SI1803718T1 (ru)
TW (2) TW200819436A (ru)
WO (1) WO2004046132A1 (ru)

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US8790689B2 (en) * 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
WO2005075455A2 (en) 2004-01-30 2005-08-18 Euro-Celtique S.A. Methods for making 4-tetrazolyl-4-phenylpiperidine compounds
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JP5977240B2 (ja) 2010-09-21 2016-08-24 パーデュー、ファーマ、リミテッド、パートナーシップ ブプレノルフィン類似体
CN102648915B (zh) * 2011-02-28 2015-04-15 鲁南制药集团股份有限公司 一种治疗或预防神经病理性疼痛的药物组合物
WO2012149334A2 (en) 2011-04-27 2012-11-01 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
US10138207B2 (en) 2012-11-09 2018-11-27 Purdue Pharma, L.P. Benzomorphan analogs and the use thereof
AR094641A1 (es) 2012-12-07 2015-08-19 Purdue Pharma Lp Análogos de buprenorfina
US8980906B2 (en) 2012-12-14 2015-03-17 Purdue Pharma L.P. Pyridonemorphinan analogs and biological activity on opioid receptors
JP6141444B2 (ja) 2012-12-14 2017-06-07 パーデュー、ファーマ、リミテッド、パートナーシップ スピロ環式モルフィナンおよびこれらの使用
JP6182620B2 (ja) 2013-01-31 2017-08-16 パーデュー、ファーマ、リミテッド、パートナーシップ ベンゾモルファン類似体およびその使用
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
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US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
US9656962B2 (en) 2013-12-26 2017-05-23 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
WO2015097547A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 10-substituted morphinan hydantoins
US9340542B2 (en) 2013-12-26 2016-05-17 Purdue Pharma L.P. Propellane-based compounds and the use thereof
WO2015099863A1 (en) 2013-12-27 2015-07-02 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
JP2017521373A (ja) 2014-05-27 2017-08-03 パーデュー、ファーマ、リミテッド、パートナーシップ スピロ環モルフィナン及びその使用
WO2015192053A1 (en) 2014-06-13 2015-12-17 Purdue Pharma L.P. Azamophinan derivatives and use thereof
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
US11529340B2 (en) 2016-03-22 2022-12-20 Regents Of The University Of Minnesota Combination for treating pain
CA3031705A1 (en) 2016-07-29 2018-02-01 Janssen Pharmaceutica Nv Treatment of prostate cancer with niraparib
WO2018125716A1 (en) 2017-01-02 2018-07-05 Purdue Pharma L.P. Morphinan derivatives and use thereof
IL308315A (en) * 2021-05-21 2024-01-01 Purdue Pharma Lp Treatment methods for cystitis/bladder pain syndrome
WO2023250190A1 (en) * 2022-06-24 2023-12-28 Purdue Pharma L.P. Methods of treating or preventing overactive bladder syndrome

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US4076717A (en) * 1971-12-15 1978-02-28 G. D. Searle & Co. Derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid
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Also Published As

Publication number Publication date
AU2003294313B2 (en) 2010-08-26
CA2506242A1 (en) 2004-06-03
MY135647A (en) 2008-06-30
US20100069437A1 (en) 2010-03-18
MXPA05004669A (es) 2005-06-08
KR20050115221A (ko) 2005-12-07
DE60322451D1 (de) 2008-09-04
NZ540068A (en) 2007-07-27
SI1562932T1 (sl) 2007-08-31
MA27565A1 (fr) 2005-10-03
GEP20084539B (en) 2008-11-25
IS8913A (is) 2010-07-21
SI1803718T1 (sl) 2008-12-31
US20040152689A1 (en) 2004-08-05
TWI343917B (en) 2011-06-21
ES2312150T3 (es) 2009-02-16
US7687518B2 (en) 2010-03-30
RS20050375A (en) 2007-11-15
CN100567288C (zh) 2009-12-09
BR0316305A (pt) 2005-09-27
CR7877A (es) 2005-11-30
DK1803718T3 (da) 2008-10-27
JP2010163452A (ja) 2010-07-29
NI200500087A (es) 2007-07-24
US8026254B2 (en) 2011-09-27
PT1803718E (pt) 2008-09-26
TW200819436A (en) 2008-05-01
EP1562932A1 (en) 2005-08-17
DE60313021D1 (de) 2007-05-16
TW200418828A (en) 2004-10-01
EP1803718A1 (en) 2007-07-04
HK1086829A1 (en) 2006-09-29
CA2506242C (en) 2011-07-05
EP1562932B9 (en) 2007-09-12
IS2720B (is) 2011-02-15
MEP48108A (en) 2011-02-10
NO20052894L (no) 2005-06-14
CN1711256A (zh) 2005-12-21
AU2010246411A1 (en) 2010-12-16
ECSP055840A (es) 2005-08-11
JP2006525944A (ja) 2006-11-16
AR047008A1 (es) 2006-01-04
NZ572685A (en) 2010-06-25
CR11037A (es) 2009-10-29
US20070179141A1 (en) 2007-08-02
CY1108422T1 (el) 2014-04-09
US7202259B2 (en) 2007-04-10
DK1562932T3 (da) 2007-08-13
AU2003294313A1 (en) 2004-06-15
OA13010A (en) 2006-11-10
RS51047B (sr) 2010-10-31
AP2210A (en) 2011-02-25
EA200500726A1 (ru) 2005-10-27
AP2005003297A0 (en) 2005-06-30
CN101648941A (zh) 2010-02-17
IL209352A0 (en) 2011-01-31
DE60313021T2 (de) 2007-12-13
EP1562932B1 (en) 2007-04-04
WO2004046132A1 (en) 2004-06-03
CO5690588A2 (es) 2006-10-31
EP1803718B1 (en) 2008-07-23
ATE358674T1 (de) 2007-04-15
IS7812A (is) 2005-04-19
ATE402167T1 (de) 2008-08-15
CY1107682T1 (el) 2013-04-18
PT1562932E (pt) 2007-07-02
ES2285235T3 (es) 2007-11-16
EA008621B1 (ru) 2007-06-29
NO20052894D0 (no) 2005-06-14
JP4601429B2 (ja) 2010-12-22

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