SG165995A1 - Phenol derivatives and their use as rotamase inhibitors - Google Patents

Phenol derivatives and their use as rotamase inhibitors

Info

Publication number
SG165995A1
SG165995A1 SG200702382-3A SG2007023823A SG165995A1 SG 165995 A1 SG165995 A1 SG 165995A1 SG 2007023823 A SG2007023823 A SG 2007023823A SG 165995 A1 SG165995 A1 SG 165995A1
Authority
SG
Singapore
Prior art keywords
substituted
alkyl
straight
poly
mono
Prior art date
Application number
SG200702382-3A
Other languages
English (en)
Inventor
Jochen Knolle
Mike Schutkowski
Gerd Hummel
Thomas Tradler
Laurence Jobron
Claudia Christner
Dirk Scharn
Roland Stragies
Christoph Gibson
Frank Osterkamp
Original Assignee
Jerini Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jerini Ag filed Critical Jerini Ag
Publication of SG165995A1 publication Critical patent/SG165995A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Tropical Medicine & Parasitology (AREA)
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  • Cardiology (AREA)
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SG200702382-3A 2002-09-18 2003-09-18 Phenol derivatives and their use as rotamase inhibitors SG165995A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20020020987 EP1402888A1 (fr) 2002-09-18 2002-09-18 Utilisation des composés carbocycliques substitués comme inhibiteurs de Rotamases

Publications (1)

Publication Number Publication Date
SG165995A1 true SG165995A1 (en) 2010-11-29

Family

ID=31970282

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200702382-3A SG165995A1 (en) 2002-09-18 2003-09-18 Phenol derivatives and their use as rotamase inhibitors

Country Status (14)

Country Link
US (2) US20070054904A1 (fr)
EP (3) EP1402888A1 (fr)
JP (2) JP2005539072A (fr)
KR (1) KR20050053673A (fr)
CN (1) CN100546977C (fr)
AU (1) AU2003271619A1 (fr)
BR (1) BR0314544A (fr)
CA (1) CA2498662A1 (fr)
MX (1) MXPA05003084A (fr)
PL (1) PL374846A1 (fr)
RU (2) RU2005111256A (fr)
SG (1) SG165995A1 (fr)
WO (1) WO2004026815A2 (fr)
ZA (1) ZA200501913B (fr)

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* Cited by examiner, † Cited by third party
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WO2004071447A2 (fr) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Utilisation de derives d'azoles substitues en tant qu'agents therapeutiques
EP1608319A4 (fr) * 2003-04-03 2007-02-28 Univ California Inhibiteurs ameliores pour hydrolase epoxyde soluble
WO2005061455A1 (fr) * 2003-12-23 2005-07-07 H. Lundbeck A/S Utilisation de derives de 2-(1h-indolylsulfanyl)-benzylamine comme irs
EP1713780B1 (fr) * 2004-02-05 2012-01-18 Probiodrug AG Nouveaux inhibiteurs de la glutaminyl-cyclase
JP2007532484A (ja) 2004-03-16 2007-11-15 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 可溶性エポキシド加水分解酵素の阻害剤およびエポキシエイコサノイドを用いて腎症を緩和する方法
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
CN1984899B (zh) * 2004-05-12 2011-07-27 先灵公司 Cxcr1和cxcr2趋化因子拮抗剂
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
ZA200703613B (en) * 2004-10-20 2009-05-27 Univ California Improved inhibitors for the soluble epoxide hydrolase
AU2006206611A1 (en) 2005-01-19 2006-07-27 Bristol-Myers Squibb Company 2-phenoxy-N- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as P2Y1 receptor inhibitors for the treatment of thromboembolic disorders
US7417072B2 (en) * 2005-05-12 2008-08-26 Wisconsin Alumni Research Foundation Blockade of Pin1 prevents cytokine production by activated immune cells
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