SG151072A1 - Stabilization of macrolides - Google Patents
Stabilization of macrolidesInfo
- Publication number
- SG151072A1 SG151072A1 SG200302502-0A SG2003025020A SG151072A1 SG 151072 A1 SG151072 A1 SG 151072A1 SG 2003025020 A SG2003025020 A SG 2003025020A SG 151072 A1 SG151072 A1 SG 151072A1
- Authority
- SG
- Singapore
- Prior art keywords
- stabilization
- macrolides
- poly
- relates
- crystalline form
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9826882.4A GB9826882D0 (en) | 1998-12-07 | 1998-12-07 | Organic compounds |
GBGB9904934.8A GB9904934D0 (en) | 1998-12-07 | 1999-03-04 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SG151072A1 true SG151072A1 (en) | 2009-06-29 |
Family
ID=26314797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200302502-0A SG151072A1 (en) | 1998-12-07 | 1999-12-06 | Stabilization of macrolides |
Country Status (38)
Country | Link |
---|---|
US (5) | US6605613B2 (pl) |
EP (4) | EP2279751A3 (pl) |
JP (3) | JP3805625B2 (pl) |
KR (2) | KR20060096477A (pl) |
CN (2) | CN1876657B (pl) |
AR (3) | AR026102A1 (pl) |
AT (1) | ATE365051T1 (pl) |
AU (1) | AU759219B2 (pl) |
BE (1) | BE1012869A3 (pl) |
BR (1) | BR9915986A (pl) |
CA (3) | CA2351580C (pl) |
CO (1) | CO4980847A1 (pl) |
CY (1) | CY1106870T1 (pl) |
CZ (2) | CZ302210B6 (pl) |
DE (1) | DE69936352T3 (pl) |
DK (1) | DK1137439T4 (pl) |
ES (1) | ES2288033T5 (pl) |
FR (1) | FR2786771B1 (pl) |
GB (2) | GB9826882D0 (pl) |
HK (1) | HK1038889B (pl) |
HU (2) | HU228939B1 (pl) |
ID (1) | ID29250A (pl) |
IL (1) | IL143092A0 (pl) |
IT (1) | IT1319701B1 (pl) |
MY (2) | MY120594A (pl) |
NO (2) | NO332698B1 (pl) |
NZ (2) | NZ511936A (pl) |
PE (1) | PE20001333A1 (pl) |
PL (2) | PL196627B1 (pl) |
PT (1) | PT1137439E (pl) |
RU (1) | RU2243769C2 (pl) |
SG (1) | SG151072A1 (pl) |
SI (1) | SI1137439T2 (pl) |
SK (2) | SK286688B6 (pl) |
TR (2) | TR200201428T2 (pl) |
TW (2) | TWI248938B (pl) |
WO (1) | WO2000033878A2 (pl) |
ZA (1) | ZA200104360B (pl) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US7452692B2 (en) | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
PL374059A1 (pl) | 2002-02-13 | 2005-09-19 | Teva Gyogyszergyar Reszvenytarsasag | Sposób ekstrakcji makrolidu z materiału biologicznego |
KR101131794B1 (ko) | 2002-07-30 | 2012-03-30 | 와이어쓰 엘엘씨 | Cci-779 공용매 농축액, 비경구 cci-779 제형 및 비경구 cci-779 제형의 제조방법 |
US7232486B2 (en) | 2003-03-31 | 2007-06-19 | TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság | Crystallization and purification of macrolides |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
KR20060052874A (ko) | 2003-07-24 | 2006-05-19 | 테바 기오기스제르갸르 레스즈베니타르사사그 | 마크로라이드의 정제 방법 |
US9114198B2 (en) * | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
BRPI0417437A (pt) * | 2003-12-10 | 2007-03-06 | Acrux Dds Pty Ltd | dispositivo para inibição da absorção, dispositivo para remoção de agente fisiologicamente ativo e dispositivo para redução do efeito de overdose |
US8551512B2 (en) | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
KR20070083839A (ko) * | 2004-09-29 | 2007-08-24 | 코디스 코포레이션 | 안정한 무정형 라파마이신 유사 화합물의 약학적 투약 형태 |
DK1848431T3 (en) | 2005-02-09 | 2016-04-18 | Santen Pharmaceutical Co Ltd | LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS |
JP2009518648A (ja) * | 2005-12-07 | 2009-05-07 | ワイス | 結晶性ラパマイシンを調製するための方法およびを示差走査熱量測定使用してラパマイシン化合物の結晶化度を測定するための方法 |
US7700614B2 (en) * | 2005-12-14 | 2010-04-20 | Abbott Laboratories | One pot synthesis of tetrazole derivatives of rapamycin |
CA2632239A1 (en) * | 2005-12-20 | 2007-07-05 | Wyeth | Control of cci-779 dosage form stability through control of drug substance impurities |
JP5528708B2 (ja) * | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | 安定な製剤ならびにそれらを調製および使用する方法 |
CN103127100A (zh) | 2006-03-23 | 2013-06-05 | 参天制药株式会社 | 用于与血管通透性有关的疾病或病症的制剂和方法 |
WO2011151704A2 (en) | 2010-06-02 | 2011-12-08 | Fresenius Kabi Oncology Ltd. | Stable pharmaceutical compositions of rapamycin esters |
CN103025753A (zh) * | 2010-06-07 | 2013-04-03 | 泰立克公司 | 晶体盐酸依泽替米贝非溶剂化物 |
WO2012017449A1 (en) * | 2010-08-04 | 2012-02-09 | Meril Life Sciences Pvt. Ltd | Process for preparation of novel 42-0-(heteroalkoxyalkyl) rapamycin compounds with anti-proliferative properties" |
WO2012066502A1 (en) | 2010-11-19 | 2012-05-24 | Biocon Limited | Processes for preparation of everolimus and intermediates thereof |
WO2012170384A1 (en) | 2011-06-06 | 2012-12-13 | Chevron Phillips Chemical Company Lp | Use of metallocene compounds for cancer treatment |
WO2013022201A1 (en) * | 2011-08-11 | 2013-02-14 | Dong-A Pharm. Co., Ltd. | Process of preparing a stabilized and solubilized formulation of sirolimus derivatives |
US9610385B2 (en) | 2013-03-07 | 2017-04-04 | Abbott Cardiovascular Systems Inc. | Method of fabricating an implantable medical device comprising a rapamycin derivative |
IN2013MU02532A (pl) | 2013-07-31 | 2015-06-26 | Sahajanand Medical Technologies Pvt Ltd | |
CN104721158B (zh) * | 2013-12-24 | 2018-01-30 | 正大天晴药业集团股份有限公司 | 一种稳定的依维莫司片剂 |
CN104892632B (zh) * | 2015-06-03 | 2017-12-26 | 道中道(菏泽)制药有限公司 | 一种晶体形式的依维莫司及其制备方法 |
US10383860B2 (en) | 2015-07-28 | 2019-08-20 | Nippon Kayaku Kabushiki Kaisha | Pharmaceutical composition comprising rapamycin or derivative thereof, and method for producing the same |
JP6793651B2 (ja) * | 2015-08-28 | 2020-12-02 | 日本化薬株式会社 | ラパマイシン又はその誘導体を含有する医薬組成物 |
WO2017047618A1 (ja) * | 2015-09-18 | 2017-03-23 | 日本化薬株式会社 | ラパマイシン又はその誘導体を含有する医薬組成物 |
WO2017129772A1 (en) | 2016-01-29 | 2017-08-03 | Xellia Phamaceuticals Aps | Stable pharmaceutical compositions of temsirolimus |
US20190290631A1 (en) | 2016-05-27 | 2019-09-26 | Nippon Kayaku Kabushiki Kaisha | Pharmaceutical composition comprising rapamycin or derivative thereof |
KR102051806B1 (ko) * | 2018-01-12 | 2019-12-04 | 주식회사 종근당 | 에베로리무스를 포함하는 안정화된 약제학적 제제 |
CN115667271A (zh) * | 2020-03-27 | 2023-01-31 | 波士顿科学国际有限公司 | 用于使药物结晶的方法 |
JP2023028473A (ja) * | 2021-08-19 | 2023-03-03 | 日本マイクロバイオファーマ株式会社 | エベロリムスの製造方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US3996355A (en) | 1975-01-02 | 1976-12-07 | American Home Products Corporation | Permanent suspension pharmaceutical dosage form |
US4049128A (en) | 1976-11-18 | 1977-09-20 | Westinghouse Air Brake Company | Control system for automatic railway car coupler |
AU543727B2 (en) * | 1980-06-02 | 1985-05-02 | Ayerst Mckenna & Harrison Inc. | Injectable composition of rapamycin |
JPH01249651A (ja) † | 1988-02-18 | 1989-10-04 | E I Du Pont De Nemours & Co | セラミツク/蒸留可能な結合剤組成物 |
GB8803836D0 (en) | 1988-02-18 | 1988-03-16 | Glaxo Group Ltd | Compositions |
KR0159766B1 (ko) * | 1989-10-16 | 1998-12-01 | 후지사와 토모키치로 | 양모제 조성물 |
JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
JP3108192B2 (ja) | 1991-05-07 | 2000-11-13 | アメリカン・ホーム・プロダクツ・コーポレイション | 免疫抑制剤、抗炎症剤または抗真菌剤用ラパマイシンの還元生成物 |
GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
ATE321053T1 (de) | 1992-10-13 | 2006-04-15 | Wyeth Corp | Carbamate von rapamycin |
US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
CA2219659C (en) | 1995-06-09 | 2008-03-18 | Novartis Ag | Rapamycin derivatives |
BE1009856A5 (fr) * | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
CA2261666C (en) * | 1996-07-30 | 2010-09-14 | Novartis Ag | Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin |
US6362264B1 (en) * | 1996-12-20 | 2002-03-26 | Ck Witco Corporation | Stabilizer for food contact and medical grade PVC |
EP0975330A1 (en) | 1997-02-04 | 2000-02-02 | Abbott Laboratories | Pain reducing parenteral liposome formulation |
-
1998
- 1998-12-07 GB GBGB9826882.4A patent/GB9826882D0/en not_active Ceased
-
1999
- 1999-03-04 GB GBGB9904934.8A patent/GB9904934D0/en not_active Ceased
- 1999-11-29 CO CO99074905A patent/CO4980847A1/es unknown
- 1999-12-02 IT IT1999MI002520A patent/IT1319701B1/it active
- 1999-12-03 AR ARP990106171A patent/AR026102A1/es active IP Right Grant
- 1999-12-03 FR FR9915256A patent/FR2786771B1/fr not_active Expired - Lifetime
- 1999-12-03 PE PE1999001209A patent/PE20001333A1/es not_active IP Right Cessation
- 1999-12-04 TW TW088121250A patent/TWI248938B/zh not_active IP Right Cessation
- 1999-12-04 TW TW094104943A patent/TWI270550B/zh not_active IP Right Cessation
- 1999-12-06 CZ CZ20050170A patent/CZ302210B6/cs not_active IP Right Cessation
- 1999-12-06 CZ CZ20012001A patent/CZ303006B6/cs not_active IP Right Cessation
- 1999-12-06 IL IL14309299A patent/IL143092A0/xx not_active IP Right Cessation
- 1999-12-06 PL PL348333A patent/PL196627B1/pl unknown
- 1999-12-06 EP EP10179096A patent/EP2279751A3/en not_active Withdrawn
- 1999-12-06 CA CA2351580A patent/CA2351580C/en not_active Expired - Lifetime
- 1999-12-06 ES ES99959381T patent/ES2288033T5/es not_active Expired - Lifetime
- 1999-12-06 AU AU16573/00A patent/AU759219B2/en not_active Expired
- 1999-12-06 DK DK99959381.7T patent/DK1137439T4/da active
- 1999-12-06 KR KR1020067017352A patent/KR20060096477A/ko not_active Application Discontinuation
- 1999-12-06 WO PCT/EP1999/009521 patent/WO2000033878A2/en active Application Filing
- 1999-12-06 EP EP06122628A patent/EP1743657A3/en not_active Ceased
- 1999-12-06 TR TR2002/01428T patent/TR200201428T2/xx unknown
- 1999-12-06 BR BR9915986-4A patent/BR9915986A/pt not_active Application Discontinuation
- 1999-12-06 CA CA002651609A patent/CA2651609A1/en not_active Abandoned
- 1999-12-06 NZ NZ511936A patent/NZ511936A/en not_active IP Right Cessation
- 1999-12-06 PT PT99959381T patent/PT1137439E/pt unknown
- 1999-12-06 DE DE69936352T patent/DE69936352T3/de not_active Expired - Lifetime
- 1999-12-06 EP EP99959381A patent/EP1137439B2/en not_active Expired - Lifetime
- 1999-12-06 SK SK766-2001A patent/SK286688B6/sk not_active IP Right Cessation
- 1999-12-06 SG SG200302502-0A patent/SG151072A1/en unknown
- 1999-12-06 HU HU0104489A patent/HU228939B1/hu unknown
- 1999-12-06 CN CN2006100798040A patent/CN1876657B/zh not_active Expired - Lifetime
- 1999-12-06 TR TR2001/01416T patent/TR200101416T2/xx unknown
- 1999-12-06 JP JP2000586368A patent/JP3805625B2/ja not_active Expired - Lifetime
- 1999-12-06 KR KR1020017007009A patent/KR100695834B1/ko active IP Right Grant
- 1999-12-06 SI SI9930985T patent/SI1137439T2/sl unknown
- 1999-12-06 CA CA2732620A patent/CA2732620C/en not_active Expired - Lifetime
- 1999-12-06 PL PL380082A patent/PL208854B1/pl unknown
- 1999-12-06 EP EP10179099A patent/EP2269651A3/en not_active Withdrawn
- 1999-12-06 SK SK5032-2008A patent/SK287325B6/sk not_active IP Right Cessation
- 1999-12-06 CN CNB998141240A patent/CN1261163C/zh not_active Expired - Lifetime
- 1999-12-06 AT AT99959381T patent/ATE365051T1/de active
- 1999-12-06 RU RU2001118266/15A patent/RU2243769C2/ru active
- 1999-12-06 ID IDW00200101156A patent/ID29250A/id unknown
- 1999-12-06 HU HU1300289A patent/HU230174B1/hu unknown
- 1999-12-07 MY MYPI99005309A patent/MY120594A/en unknown
- 1999-12-07 BE BE9900799A patent/BE1012869A3/fr not_active IP Right Cessation
- 1999-12-07 MY MYPI20043386A patent/MY127579A/en unknown
-
2001
- 2001-05-16 NO NO20012424A patent/NO332698B1/no not_active IP Right Cessation
- 2001-05-28 ZA ZA200104360A patent/ZA200104360B/en unknown
- 2001-05-29 US US09/866,977 patent/US6605613B2/en not_active Expired - Lifetime
-
2002
- 2002-01-28 HK HK02100663.4A patent/HK1038889B/zh not_active IP Right Cessation
-
2003
- 2003-03-21 US US10/393,795 patent/US6852729B2/en not_active Expired - Lifetime
- 2003-08-25 NZ NZ527781A patent/NZ527781A/en not_active IP Right Cessation
-
2004
- 2004-12-23 US US11/020,860 patent/US7297703B2/en not_active Expired - Lifetime
-
2005
- 2005-02-28 AR ARP050100744A patent/AR048073A2/es active IP Right Grant
- 2005-04-01 JP JP2005106512A patent/JP5043308B2/ja not_active Expired - Lifetime
- 2005-12-28 JP JP2005378514A patent/JP5165199B2/ja not_active Expired - Lifetime
-
2006
- 2006-05-04 AR ARP060101807A patent/AR054444A2/es active IP Right Grant
-
2007
- 2007-09-14 CY CY20071101192T patent/CY1106870T1/el unknown
- 2007-10-11 US US11/973,927 patent/US7572804B2/en not_active Expired - Fee Related
-
2009
- 2009-07-06 US US12/497,728 patent/US7741338B2/en not_active Expired - Fee Related
-
2012
- 2012-10-01 NO NO20121113A patent/NO334612B1/no not_active IP Right Cessation
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