SG148179A1 - Benzyltriazolone compounds as non-nucleoside reverse transcriptase inhibitors - Google Patents
Benzyltriazolone compounds as non-nucleoside reverse transcriptase inhibitorsInfo
- Publication number
- SG148179A1 SG148179A1 SG200808471-7A SG2008084717A SG148179A1 SG 148179 A1 SG148179 A1 SG 148179A1 SG 2008084717 A SG2008084717 A SG 2008084717A SG 148179 A1 SG148179 A1 SG 148179A1
- Authority
- SG
- Singapore
- Prior art keywords
- benzyltriazolone
- compounds
- reverse transcriptase
- transcriptase inhibitors
- nucleoside reverse
- Prior art date
Links
- FBMUOYIIXNRNPN-UHFFFAOYSA-N 5-benzyltriazol-4-one Chemical class O=C1N=NN=C1CC1=CC=CC=C1 FBMUOYIIXNRNPN-UHFFFAOYSA-N 0.000 title abstract 2
- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 title abstract 2
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59131104P | 2004-07-27 | 2004-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG148179A1 true SG148179A1 (en) | 2008-12-31 |
Family
ID=35056908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200808471-7A SG148179A1 (en) | 2004-07-27 | 2005-07-20 | Benzyltriazolone compounds as non-nucleoside reverse transcriptase inhibitors |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7666891B2 (ja) |
| EP (1) | EP1773790B1 (ja) |
| JP (1) | JP4675959B2 (ja) |
| CN (1) | CN1993332B (ja) |
| AR (1) | AR050266A1 (ja) |
| AU (1) | AU2005266530B2 (ja) |
| BR (1) | BRPI0513858B8 (ja) |
| CA (1) | CA2574308C (ja) |
| ES (1) | ES2391461T3 (ja) |
| IL (1) | IL180495A (ja) |
| MX (1) | MX2007000788A (ja) |
| NO (1) | NO338376B1 (ja) |
| RU (1) | RU2394028C2 (ja) |
| SG (1) | SG148179A1 (ja) |
| TW (1) | TWI299334B (ja) |
| WO (1) | WO2006010545A1 (ja) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| WO2007045573A1 (en) | 2005-10-19 | 2007-04-26 | F. Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
| CL2007002105A1 (es) * | 2006-07-21 | 2008-02-22 | Hoffmann La Roche | Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u |
| MX2009001198A (es) * | 2006-08-16 | 2009-02-11 | Hoffmann La Roche | Inhibidores no nucleosidicos de la transcriptasa inversa. |
| TW200831085A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| CN101657433A (zh) * | 2007-03-29 | 2010-02-24 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
| BRPI0810496A2 (pt) * | 2007-04-09 | 2018-11-06 | Hoffmann La Roche | inibidores de transcriptase reversa de não-nucleosídeo |
| EP2164835B1 (en) | 2007-05-30 | 2012-12-12 | F. Hoffmann-La Roche AG | Process for preparing triazolones |
| ES2542153T3 (es) * | 2007-05-30 | 2015-07-31 | F. Hoffmann-La Roche Ag | Inhibidores no nucleósidos de la transcriptasa inversa |
| JP2010530863A (ja) * | 2007-06-22 | 2010-09-16 | エフ．ホフマン−ラ ロシュ アーゲー | 非ヌクレオシド逆転写酵素阻害剤としての尿素及びカルバマート誘導体 |
| KR101610607B1 (ko) * | 2007-12-21 | 2016-04-07 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 항바이러스 화합물 |
| US20090181068A1 (en) | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| CN101723909B (zh) * | 2008-10-29 | 2011-12-28 | 天津药物研究院 | 三唑酮类化合物、其制备方法和用途 |
| CN101735023B (zh) * | 2008-11-24 | 2014-07-09 | 联化科技股份有限公司 | 一种3-溴-5-氯苯酚的制备方法 |
| ES2677946T3 (es) | 2009-11-18 | 2018-08-07 | National Research Council Of Canada | Monómeros, oligómeros y polímeros fluorados para su uso en dispositivos electrónicos orgánicos |
| CN102146022B (zh) * | 2010-02-05 | 2013-07-03 | 中国中化股份有限公司 | 3-氯-5-溴苯酚的制备方法 |
| CN103025696B (zh) | 2010-07-15 | 2015-08-12 | 阿尔比马尔公司 | 用于制备4-溴代-2-甲氧基苯甲醛的方法 |
| US9150539B2 (en) * | 2012-09-26 | 2015-10-06 | Merck Sharp & Dohme Corp. | Crystalline form of a reverse transcriptase inhibitor |
| MX2015007433A (es) * | 2012-12-20 | 2015-12-07 | Inception 2 Inc | Compuestos de triazolona y usos de los mismos. |
| WO2015035059A1 (en) | 2013-09-06 | 2015-03-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| GB2598624A (en) * | 2020-09-07 | 2022-03-09 | Lorico Aurelio | Use of triazole analogues for inhibition of a tripartite VOR protein complex in multicellular organisms |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274185A (en) | 1963-10-08 | 1966-09-20 | S E Massengill Company | Phthalazine derivatives |
| US3813384A (en) | 1972-01-17 | 1974-05-28 | Asta Werke Ag Chem Fab | Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof |
| JP2593084B2 (ja) | 1986-12-19 | 1997-03-19 | メレルダウファーマスーティカルズ インコーポレーテッド | ５−アリールー３ｈ−１，２，４−トリアゾールー３−オン類の神経変性障害の処置への用途 |
| US5436252A (en) | 1986-12-19 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders |
| JP2542880B2 (ja) | 1986-12-19 | 1996-10-09 | メレルダウファーマスーティカルズ インコーポレーテッド | ５−アリ―ル−３ｈ−１，２，４，−トリアゾ―ル−３−オン類の抗痙攣剤としての用途 |
| US5103014A (en) | 1987-09-30 | 1992-04-07 | American Home Products Corporation | Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propanoic acid derivatives |
| US4942236A (en) | 1987-09-30 | 1990-07-17 | American Home Products Corporation | 2-aryl substituted pyridyl-containing phenyl sulfonamido compounds as antiallergic and antiinflammatory agents |
| US4826990A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
| US5331002A (en) | 1990-04-19 | 1994-07-19 | Merrell Dow Pharmaceuticals Inc. | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers |
| US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| WO1997040017A2 (en) | 1996-04-19 | 1997-10-30 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| TW467902B (en) | 1996-07-31 | 2001-12-11 | Bristol Myers Squibb Co | Diphenyl heterocycles as potassium channel modulators |
| US6367003B1 (en) * | 1998-03-04 | 2002-04-02 | Micron Technology, Inc. | Digital signal processor having enhanced utilization of multiply accumulate (MAC) stage and method |
| IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
| UA82048C2 (uk) * | 2000-11-10 | 2008-03-11 | Эли Лилли Энд Компани | Агоністи альфа-рецепторів, активованих проліфератором пероксисом |
| CA2428753C (en) * | 2000-11-17 | 2013-05-21 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| TW200505441A (en) * | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
-
2005
- 2005-07-20 WO PCT/EP2005/007893 patent/WO2006010545A1/en active Application Filing
- 2005-07-20 MX MX2007000788A patent/MX2007000788A/es active IP Right Grant
- 2005-07-20 CA CA2574308A patent/CA2574308C/en active Active
- 2005-07-20 RU RU2007106928/04A patent/RU2394028C2/ru active
- 2005-07-20 EP EP05763730A patent/EP1773790B1/en active Active
- 2005-07-20 JP JP2007522983A patent/JP4675959B2/ja active Active
- 2005-07-20 BR BRPI0513858A patent/BRPI0513858B8/pt active IP Right Grant
- 2005-07-20 AU AU2005266530A patent/AU2005266530B2/en active Active
- 2005-07-20 SG SG200808471-7A patent/SG148179A1/en unknown
- 2005-07-20 ES ES05763730T patent/ES2391461T3/es active Active
- 2005-07-20 CN CN2005800255832A patent/CN1993332B/zh active Active
- 2005-07-25 AR ARP050103064A patent/AR050266A1/es not_active Application Discontinuation
- 2005-07-25 TW TW094125051A patent/TWI299334B/zh not_active IP Right Cessation
- 2005-07-27 US US11/190,478 patent/US7666891B2/en active Active
-
2007
- 2007-01-02 IL IL180495A patent/IL180495A/en active IP Right Grant
- 2007-01-15 NO NO20070258A patent/NO338376B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2394028C2 (ru) | 2010-07-10 |
| AU2005266530A1 (en) | 2006-02-02 |
| EP1773790B1 (en) | 2012-08-15 |
| TWI299334B (en) | 2008-08-01 |
| ES2391461T3 (es) | 2012-11-27 |
| WO2006010545A1 (en) | 2006-02-02 |
| IL180495A (en) | 2013-12-31 |
| JP2008508211A (ja) | 2008-03-21 |
| EP1773790A1 (en) | 2007-04-18 |
| BRPI0513858B1 (pt) | 2020-11-10 |
| BRPI0513858B8 (pt) | 2021-05-25 |
| CA2574308C (en) | 2014-03-25 |
| BRPI0513858A (pt) | 2008-05-20 |
| JP4675959B2 (ja) | 2011-04-27 |
| NO338376B1 (no) | 2016-08-15 |
| RU2007106928A (ru) | 2008-09-10 |
| US20060025462A1 (en) | 2006-02-02 |
| NO20070258L (no) | 2007-01-15 |
| AR050266A1 (es) | 2006-10-11 |
| CN1993332A (zh) | 2007-07-04 |
| IL180495A0 (en) | 2007-06-03 |
| AU2005266530B2 (en) | 2012-04-12 |
| CA2574308A1 (en) | 2006-02-02 |
| CN1993332B (zh) | 2011-04-06 |
| MX2007000788A (es) | 2007-03-23 |
| TW200616979A (en) | 2006-06-01 |
| US7666891B2 (en) | 2010-02-23 |
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