SG11202104417UA - Cell culture process by intensified perfusion with continuous harvest and without cell bleeding - Google Patents
Cell culture process by intensified perfusion with continuous harvest and without cell bleedingInfo
- Publication number
- SG11202104417UA SG11202104417UA SG11202104417UA SG11202104417UA SG11202104417UA SG 11202104417U A SG11202104417U A SG 11202104417UA SG 11202104417U A SG11202104417U A SG 11202104417UA SG 11202104417U A SG11202104417U A SG 11202104417UA SG 11202104417U A SG11202104417U A SG 11202104417UA
- Authority
- SG
- Singapore
- Prior art keywords
- cell
- culture process
- bleeding
- cell culture
- continuous harvest
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Sustainable Development (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2018113776 | 2018-11-02 | ||
CN2019089993 | 2019-06-04 | ||
PCT/CN2019/108921 WO2020088180A1 (en) | 2018-11-02 | 2019-09-29 | Cell culture process by intensified perfusion with continuous harvest and without cell bleeding |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202104417UA true SG11202104417UA (en) | 2021-05-28 |
Family
ID=70463469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202104417UA SG11202104417UA (en) | 2018-11-02 | 2019-09-29 | Cell culture process by intensified perfusion with continuous harvest and without cell bleeding |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220364034A1 (ko) |
EP (1) | EP3874023A4 (ko) |
JP (2) | JP2022506413A (ko) |
KR (1) | KR102597919B1 (ko) |
CN (1) | CN111406105B (ko) |
CA (1) | CA3118398A1 (ko) |
MA (1) | MA54093A (ko) |
SG (1) | SG11202104417UA (ko) |
TW (1) | TW202035681A (ko) |
WO (1) | WO2020088180A1 (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230330055A1 (en) * | 2020-07-10 | 2023-10-19 | Tsingtao A-Smart Medical Technology Co., Ltd. | Method for activating follicles by means of using small-molecule compound, and preparation thereof |
EP4228794A1 (en) * | 2020-10-15 | 2023-08-23 | AGC Biologics, Inc. | Continuous high cell-density culture with dual-vessel tangential flow filtration |
CN112592948B (zh) * | 2020-12-16 | 2023-05-09 | 广州汉腾生物科技有限公司 | 动物细胞的灌流培养方法 |
WO2022180260A1 (en) * | 2021-02-25 | 2022-09-01 | Securecell Ag | Fluid sampling system for biotechnological applications, operating method and use thereof |
CN114230669B (zh) * | 2021-12-24 | 2024-01-30 | 天士力生物医药股份有限公司 | 一种双特异性抗体的生产方法 |
WO2024006893A1 (en) * | 2022-06-30 | 2024-01-04 | Genentech, Inc. | Systems, apparatus, and methods for cell culture |
WO2024040519A1 (en) * | 2022-08-25 | 2024-02-29 | Wuxi Biologics Co., Ltd. | Intermittent perfusion fed-batch culture |
CN115747055A (zh) * | 2022-11-16 | 2023-03-07 | 四川至善唯新生物科技有限公司 | 一种细胞灌流培养的方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2507552B2 (ja) * | 1988-08-29 | 1996-06-12 | 株式会社ニッショー | 細胞培養産生物の取出しおよび培地の交換方法 |
MX340242B (es) * | 2006-07-14 | 2016-07-01 | Dpx Holdings Bv | Proceso mejorado para el cultivo de celulas. |
TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
EP2188371B1 (en) * | 2007-08-09 | 2017-12-20 | Wyeth LLC | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
DE102008064279A1 (de) * | 2008-12-20 | 2010-06-24 | Bayer Technology Services Gmbh | Bioreaktor |
CN103305417A (zh) * | 2012-03-07 | 2013-09-18 | 无锡药明康德生物技术有限公司 | 进行蛋白生产的高产量反应器及其生产方法和应用 |
SG11201601899TA (en) * | 2013-09-16 | 2016-04-28 | Genzyme Corp | Methods and systems for processing a cell culture |
EP3071682A1 (en) * | 2013-11-20 | 2016-09-28 | CMC Biologics A/S | A bioreactor system and method for producing a biopolymer |
US20160312168A1 (en) * | 2013-12-30 | 2016-10-27 | Ge Healthcare Bio-Sciences Corp. | Apparatus for cell cultivation |
US10106829B2 (en) * | 2014-01-29 | 2018-10-23 | Amgen Inc. | Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins |
ES2909630T3 (es) * | 2014-06-04 | 2022-05-09 | Amgen Inc | Métodos de recolección en cultivos de células de mamífero |
TW202340452A (zh) * | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
KR102613876B1 (ko) * | 2015-11-10 | 2023-12-15 | 리플리겐 코포레이션 | 일회용 교번 접방향 유동 여과 유닛 |
HRP20221071T1 (hr) * | 2016-12-23 | 2022-11-11 | Serum Institute Of India Private Limited | Postupci za povećanje produktivnosti antitijela u kulturi stanica sisavaca i smanjenje agregacije tokom nizvodne obrade, postupci formulacije i rezultirajuće stabilne formulacije antitijela |
CN106987559A (zh) * | 2017-03-22 | 2017-07-28 | 上海药明生物技术有限公司 | 一种重组chok1细胞株的构建方法及其应用 |
KR102604988B1 (ko) * | 2017-03-31 | 2023-11-24 | 베링거 인겔하임 인터내셔날 게엠베하 | 관류 배지 |
EP3601584A1 (en) * | 2017-03-31 | 2020-02-05 | Boehringer Ingelheim International GmbH | Perfusion medium |
CN108504562A (zh) * | 2018-06-21 | 2018-09-07 | 江苏澳创生物科技有限公司 | 一种发酵生产l-苏氨酸的系统及其应用 |
-
2019
- 2019-09-29 JP JP2021523777A patent/JP2022506413A/ja active Pending
- 2019-09-29 CN CN201980002230.2A patent/CN111406105B/zh active Active
- 2019-09-29 KR KR1020217015264A patent/KR102597919B1/ko active IP Right Grant
- 2019-09-29 SG SG11202104417UA patent/SG11202104417UA/en unknown
- 2019-09-29 WO PCT/CN2019/108921 patent/WO2020088180A1/en unknown
- 2019-09-29 EP EP19878905.9A patent/EP3874023A4/en active Pending
- 2019-09-29 CA CA3118398A patent/CA3118398A1/en active Pending
- 2019-09-29 US US17/289,332 patent/US20220364034A1/en active Pending
- 2019-09-29 MA MA054093A patent/MA54093A/fr unknown
- 2019-10-31 TW TW108139590A patent/TW202035681A/zh unknown
-
2023
- 2023-05-09 JP JP2023077345A patent/JP2023109835A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN111406105B (zh) | 2024-08-30 |
EP3874023A1 (en) | 2021-09-08 |
MA54093A (fr) | 2021-09-08 |
CA3118398A1 (en) | 2020-05-07 |
TW202035681A (zh) | 2020-10-01 |
KR102597919B1 (ko) | 2023-11-06 |
US20220364034A1 (en) | 2022-11-17 |
CN111406105A (zh) | 2020-07-10 |
EP3874023A4 (en) | 2022-08-17 |
KR20210086655A (ko) | 2021-07-08 |
JP2023109835A (ja) | 2023-08-08 |
WO2020088180A1 (en) | 2020-05-07 |
JP2022506413A (ja) | 2022-01-17 |
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