SG11202005880XA - Heavy chain antibodies binding to cd22 - Google Patents

Heavy chain antibodies binding to cd22

Info

Publication number
SG11202005880XA
SG11202005880XA SG11202005880XA SG11202005880XA SG11202005880XA SG 11202005880X A SG11202005880X A SG 11202005880XA SG 11202005880X A SG11202005880X A SG 11202005880XA SG 11202005880X A SG11202005880X A SG 11202005880XA SG 11202005880X A SG11202005880X A SG 11202005880XA
Authority
SG
Singapore
Prior art keywords
heavy chain
chain antibodies
antibodies binding
binding
heavy
Prior art date
Application number
SG11202005880XA
Other languages
English (en)
Inventor
Shelley Force Aldred
Schooten Wim Van
Heather Anne N Ogana
Laura Marie Davison
Katherine Harris
Udaya Rangaswamy
Nathan D Trinklein
Original Assignee
Teneobio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teneobio Inc filed Critical Teneobio Inc
Publication of SG11202005880XA publication Critical patent/SG11202005880XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/522CH1 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202005880XA 2017-12-22 2018-12-21 Heavy chain antibodies binding to cd22 SG11202005880XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762609759P 2017-12-22 2017-12-22
PCT/US2018/067299 WO2019126756A1 (en) 2017-12-22 2018-12-21 Heavy chain antibodies binding to cd22

Publications (1)

Publication Number Publication Date
SG11202005880XA true SG11202005880XA (en) 2020-07-29

Family

ID=65041936

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005880XA SG11202005880XA (en) 2017-12-22 2018-12-21 Heavy chain antibodies binding to cd22

Country Status (21)

Country Link
US (2) US11873336B2 (es)
EP (1) EP3728319A1 (es)
JP (2) JP7486421B2 (es)
KR (1) KR20200104342A (es)
CN (1) CN111683966B (es)
AU (1) AU2018392088A1 (es)
BR (1) BR112020012554A2 (es)
CA (1) CA3086665A1 (es)
CL (2) CL2020001703A1 (es)
CO (1) CO2020008925A2 (es)
CR (1) CR20200322A (es)
EA (1) EA202091557A1 (es)
EC (1) ECSP20042489A (es)
IL (1) IL275498A (es)
JO (1) JOP20200157A1 (es)
MX (1) MX2020006494A (es)
NI (1) NI202000050A (es)
PE (1) PE20201171A1 (es)
PH (1) PH12020550964A1 (es)
SG (1) SG11202005880XA (es)
WO (1) WO2019126756A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230129583A (ko) 2016-06-21 2023-09-08 테네오바이오, 인코포레이티드 Cd3 결합 항체
CN109843325B (zh) 2016-09-14 2023-10-03 特尼奥生物股份有限公司 Cd3结合抗体
EP3642236A1 (en) 2017-06-20 2020-04-29 TeneoOne, Inc. Anti-bcma heavy chain-only antibodies
JP7486421B2 (ja) 2017-12-22 2024-05-17 テネオバイオ, インコーポレイテッド Cd22に結合する重鎖抗体
JOP20210323A1 (ar) * 2019-06-14 2023-01-30 Teneobio Inc ارتباط أجسام مضادة ثقيلة السلسلة ومتعددة النوعية بـ cd22 وcd3
KR20210143097A (ko) * 2020-05-19 2021-11-26 (주)이노베이션바이오 Cd22에 특이적인 항체 및 이의 용도
CN116323948A (zh) * 2020-07-16 2023-06-23 南京传奇生物科技有限公司 Cd22结合分子及其用途

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
ATE255131T1 (de) 1991-06-14 2003-12-15 Genentech Inc Humanisierter heregulin antikörper
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
WO1997034631A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
CN100390288C (zh) 2000-04-11 2008-05-28 杰南技术公司 多价抗体及其应用
GB0115256D0 (en) 2001-06-21 2001-08-15 Babraham Inst Mouse light chain locus
NZ538996A (en) 2002-10-31 2008-04-30 Genentech Inc Methods and compositions for increasing antibody production
EP1585768A2 (en) 2003-01-23 2005-10-19 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
MX2007000921A (es) 2004-07-22 2007-11-09 Univ Erasmus Medical Ct Moleculas de union.
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP3461842A1 (en) 2007-04-03 2019-04-03 Amgen Research (Munich) GmbH Cross-species-specific binding domain
US8703485B2 (en) 2007-06-01 2014-04-22 Omt, Inc. Germ cells having inactivated endogenous immunoglobulin genes, and transgenic animals derived therefrom
US20100122358A1 (en) 2008-06-06 2010-05-13 Crescendo Biologics Limited H-Chain-only antibodies
US8207306B2 (en) 2008-09-19 2012-06-26 Medimmune, Llc Targeted binding agents directed to sonic hedgehog homolog and uses thereof
RS54900B1 (sr) 2008-10-01 2016-10-31 Amgen Res (Munich) Gmbh Interspecijski specifično psmaxcd3 bispecifično jednolančano antitelo
WO2010104949A2 (en) 2009-03-10 2010-09-16 Biogen Idec Ma Inc. Anti-bcma antibodies
GB0905023D0 (en) 2009-03-24 2009-05-06 Univ Erasmus Medical Ct Binding molecules
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
HUE029785T2 (en) 2010-02-08 2017-04-28 Regeneron Pharma Common mouse light chain
TWI653333B (zh) 2010-04-01 2019-03-11 安進研究(慕尼黑)有限責任公司 跨物種專一性之PSMAxCD3雙專一性單鏈抗體
JP2014500879A (ja) 2010-11-16 2014-01-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Bcma発現に相関性を有する疾患を治療する因子及び方法
CN103619876A (zh) 2011-03-10 2014-03-05 Hco抗体股份有限公司 双特异性三链抗体样分子
WO2012122512A1 (en) 2011-03-10 2012-09-13 Hco Antibody, Inc. Recombinant production of mixtures of single chain antibodies
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對bcma之e3以及cd3的結合分子
MX366813B (es) 2012-04-20 2019-07-25 Aptevo Res & Development Llc Polipeptidos de enlace cd3.
AU2013251482B2 (en) 2012-04-26 2018-01-04 Bioatla Llc Anti-CD22 antibodies
US20150203591A1 (en) 2012-08-02 2015-07-23 Regeneron Pharmaceuticals, Inc. Mutivalent antigen-binding proteins
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
LT2931030T (lt) 2012-12-14 2020-11-10 Open Monoclonal Technology, Inc. Polinukleotidai, koduojantys graužikų antikūnus su žmogaus idiotipais, ir juos apimantys gyvūnai
WO2014122144A1 (en) 2013-02-05 2014-08-14 Engmab Ag BISPECIFIC ANTIBODIES AGAINST CD3ε AND BCMA
AR095374A1 (es) 2013-03-15 2015-10-14 Amgen Res (Munich) Gmbh Moléculas de unión para bcma y cd3
WO2015095412A1 (en) 2013-12-19 2015-06-25 Zhong Wang Bispecific antibody with two single-domain antigen-binding fragments
EP3105252B1 (en) 2014-02-12 2019-07-24 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
US9139649B2 (en) 2014-02-25 2015-09-22 Immunomedics, Inc. Humanized anti-CD22 antibody
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
TWI750110B (zh) 2014-07-21 2021-12-21 瑞士商諾華公司 使用人類化抗-bcma嵌合抗原受體治療癌症
CN107108738A (zh) 2014-07-25 2017-08-29 西托姆克斯治疗公司 抗cd3抗体、可活化抗cd3抗体、多特异性抗cd3抗体、多特异性可活化抗cd3抗体及其使用方法
EP3023437A1 (en) 2014-11-20 2016-05-25 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
JP7164949B2 (ja) 2014-11-20 2022-11-02 エフ.ホフマン-ラ ロシュ アーゲー 共通軽鎖および使用方法
CN104710528B (zh) * 2015-03-13 2019-02-15 西北农林科技大学 一种特异性结合PRRS病毒非结构蛋白Nsp9纳米抗体及其应用
CR20180420A (es) 2016-02-03 2018-12-05 Amgen Inc Constructos de anticuerpo biespecíficos para bcma y cd3 que se ligan a células t
KR20230129583A (ko) 2016-06-21 2023-09-08 테네오바이오, 인코포레이티드 Cd3 결합 항체
MX2019002256A (es) 2016-08-24 2019-10-09 Teneobio Inc Animales transgenicos no humanos que producen anticuerpos modificados solo de cadena pesada.
CN109843325B (zh) 2016-09-14 2023-10-03 特尼奥生物股份有限公司 Cd3结合抗体
KR102633423B1 (ko) 2016-12-21 2024-02-06 테네오바이오, 인코포레이티드 항-bcma 중쇄-단독 항체
EP3642236A1 (en) 2017-06-20 2020-04-29 TeneoOne, Inc. Anti-bcma heavy chain-only antibodies
CN117866097A (zh) 2017-06-20 2024-04-12 特尼奥生物股份有限公司 仅有重链的抗bcma抗体
AU2018291128A1 (en) 2017-06-30 2020-01-23 Teneobio, Inc. Anti-B-cell maturation antigen chimeric antigen receptors with human domains
EP3681908A1 (en) 2017-09-13 2020-07-22 Teneobio, Inc. Heavy chain antibodies binding to ectoenzymes
JP7486421B2 (ja) 2017-12-22 2024-05-17 テネオバイオ, インコーポレイテッド Cd22に結合する重鎖抗体
JP2021508479A (ja) 2017-12-27 2021-03-11 テネオバイオ, インコーポレイテッド ヘテロ二量体特異的抗体上のcd3デルタ及びcd3イプシロン
SG11202011597RA (en) 2018-07-20 2020-12-30 Teneobio Inc Heavy chain antibodies binding to cd19
SG11202102713TA (en) 2018-09-21 2021-04-29 Teneobio Inc Methods for purifying heterodimeric, multispecific antibodies
CA3100232A1 (en) 2018-10-26 2020-04-30 Teneobio, Inc. Heavy chain antibodies binding to cd38
AU2020252556A1 (en) 2019-04-05 2021-10-21 Teneobio, Inc. Heavy chain antibodies binding to PSMA
JOP20210323A1 (ar) 2019-06-14 2023-01-30 Teneobio Inc ارتباط أجسام مضادة ثقيلة السلسلة ومتعددة النوعية بـ cd22 وcd3
IL293751A (en) 2019-12-18 2022-08-01 Teneofour Inc Heavy chain antibodies that bind to cd38
UY39191A (es) 2020-04-29 2021-11-30 Teneobio Inc Anticuerpos de cadena pesada multiespecíficos con regiones constantes de cadena pesada modificadas
WO2021222616A1 (en) 2020-04-29 2021-11-04 Teneobio, Inc. Methods of treating multiple myeloma
CN116472049A (zh) 2020-06-30 2023-07-21 特尼奥生物股份有限公司 与bcma结合的多特异性抗体
TW202233684A (zh) 2020-11-18 2022-09-01 美商泰尼歐生物公司 結合於葉酸受體α之重鏈抗體
KR20230148828A (ko) 2021-02-25 2023-10-25 테네오바이오, 인코포레이티드 항-psma 항체 및 car-t 구조
CN116917327A (zh) 2021-02-26 2023-10-20 特尼奥生物股份有限公司 抗muc1-c抗体及car-t结构
TW202304994A (zh) 2021-04-02 2023-02-01 美商泰尼歐生物公司 促效性抗il-2r抗體及使用方法
WO2022216864A1 (en) 2021-04-06 2022-10-13 Teneobio, Inc. Anti-cd19 antibodies and car-t structures
WO2022221698A1 (en) 2021-04-16 2022-10-20 Teneobio, Inc. Anti-cd20 antibodies and car-t structures
WO2022271987A1 (en) 2021-06-23 2022-12-29 TeneoFour, Inc. Anti-cd38 antibodies and epitopes of same
WO2023004197A1 (en) 2021-07-23 2023-01-26 Teneoten, Inc. Heavy chain antibodies binding to hepatitis b surface antigen

Also Published As

Publication number Publication date
RU2020124188A (ru) 2022-01-24
EA202091557A1 (ru) 2020-11-18
PE20201171A1 (es) 2020-10-28
US20210095022A1 (en) 2021-04-01
CO2020008925A2 (es) 2020-10-30
CN111683966B (zh) 2023-07-11
US20240117046A1 (en) 2024-04-11
JP7486421B2 (ja) 2024-05-17
CA3086665A1 (en) 2019-06-27
CL2020001703A1 (es) 2020-11-06
US11873336B2 (en) 2024-01-16
KR20200104342A (ko) 2020-09-03
WO2019126756A1 (en) 2019-06-27
EP3728319A1 (en) 2020-10-28
CR20200322A (es) 2021-01-12
IL275498A (en) 2020-08-31
CL2022002247A1 (es) 2023-02-24
JOP20200157A1 (ar) 2022-10-30
NI202000050A (es) 2020-12-04
JP2024062992A (ja) 2024-05-10
MX2020006494A (es) 2020-11-24
CN111683966A (zh) 2020-09-18
AU2018392088A2 (en) 2020-08-27
JP2021506325A (ja) 2021-02-22
BR112020012554A2 (pt) 2020-11-24
WO2019126756A9 (en) 2019-10-17
ECSP20042489A (es) 2020-11-30
AU2018392088A1 (en) 2020-08-13
PH12020550964A1 (en) 2021-03-22

Similar Documents

Publication Publication Date Title
IL276537A (en) Antibodies bind to GPRC5D
HK1252863A1 (zh) 結合cd22的抗體分子
IL261188A (en) Antibodies against tigit
ZA201803669B (en) Antibodies specifically binding pd-1 and their uses
IL274370A (en) Single-region antibodies that bind CD137
IL275498A (en) Heavy chain antibodies that bind CD22
IL287613A (en) Antibodies that bind gprc5d
IL271194A (en) Antibodies against bcma containing only heavy chains
IL279010A (en) Heavy chain antibodies that bind to CD19
HK1256300A1 (zh) 特異性地結合至tl1a的抗體
IL286398A (en) Heavy chain antibodies that bind to psma
ZA201905341B (en) Antibodies specifically binding to human il-1r7
IL282590A (en) Heavy chain antibodies that bind to CD38
IL273235A (en) Heavy chain antibodies that bind to ectoenzymes
IL269394A (en) Antibodies bind to STEAP-1
HK1253947A1 (zh) 僅有重鏈的抗ang-2抗體
HK1254093A1 (zh) 僅有重鏈的pdgf抗體
GB201709379D0 (en) Humanised ADAMTS13 binding antibodies
GB201715149D0 (en) IL-ß binding antibody
GB201718734D0 (en) Single domain antibodies that bind to CD137