MX2019002256A - Animales transgenicos no humanos que producen anticuerpos modificados solo de cadena pesada. - Google Patents
Animales transgenicos no humanos que producen anticuerpos modificados solo de cadena pesada.Info
- Publication number
- MX2019002256A MX2019002256A MX2019002256A MX2019002256A MX2019002256A MX 2019002256 A MX2019002256 A MX 2019002256A MX 2019002256 A MX2019002256 A MX 2019002256A MX 2019002256 A MX2019002256 A MX 2019002256A MX 2019002256 A MX2019002256 A MX 2019002256A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- heavy chain
- human animals
- transgenic non
- modified heavy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
Abstract
Se proporcionan anticuerpos sólo de cadena pesada humanos o quiméricos, en el residuo de aminoácido nativo en la primera posición de la cuarta región de estructura (FR4) de dicho HCAb está sustituido por un residuo de aminoácido diferente que es capaz de alterar un parche hidrofóbico expuesto a la superficie que comprende o está asociado con el residuo de aminoácido nativo en tal posición.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662379075P | 2016-08-24 | 2016-08-24 | |
PCT/US2017/047928 WO2018039180A1 (en) | 2016-08-24 | 2017-08-22 | Transgenic non-human animals producing modified heavy chain-only antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019002256A true MX2019002256A (es) | 2019-10-09 |
Family
ID=59772725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019002256A MX2019002256A (es) | 2016-08-24 | 2017-08-22 | Animales transgenicos no humanos que producen anticuerpos modificados solo de cadena pesada. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20190225671A1 (es) |
EP (1) | EP3503722A1 (es) |
JP (2) | JP7229153B2 (es) |
KR (2) | KR20230039773A (es) |
CN (1) | CN109862784A (es) |
AU (1) | AU2017316604A1 (es) |
BR (1) | BR112019003547A2 (es) |
CA (1) | CA3034706A1 (es) |
MX (1) | MX2019002256A (es) |
RU (2) | RU2762835C2 (es) |
WO (1) | WO2018039180A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190053835A (ko) | 2016-06-21 | 2019-05-20 | 테네오바이오, 인코포레이티드 | Cd3 결합 항체 |
UA126384C2 (uk) | 2016-09-14 | 2022-09-28 | Тенеобіо, Інк. | Антитіло, яке зв'язує cd3 |
CN110431151B (zh) | 2016-12-21 | 2023-07-18 | 特尼奥生物股份有限公司 | 仅有重链的抗bcma抗体 |
EP3642237A2 (en) * | 2017-06-20 | 2020-04-29 | Teneobio, Inc. | Anti-bcma heavy chain-only antibodies |
EP3642236A1 (en) | 2017-06-20 | 2020-04-29 | TeneoOne, Inc. | Anti-bcma heavy chain-only antibodies |
SG11202005880XA (en) | 2017-12-22 | 2020-07-29 | Teneobio Inc | Heavy chain antibodies binding to cd22 |
CN116769032A (zh) * | 2018-07-20 | 2023-09-19 | 坦尼奥第二公司 | 与cd19结合的重链抗体 |
GB2576914A (en) | 2018-09-06 | 2020-03-11 | Kymab Ltd | Antigen-binding molecules comprising unpaired variable domains produced in mammals |
JP2022505445A (ja) | 2018-10-26 | 2022-01-14 | テネオバイオ, インコーポレイテッド | Cd38に結合する重鎖抗体 |
AR119746A1 (es) | 2019-06-14 | 2022-01-05 | Teneobio Inc | Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3 |
EP4021941A4 (en) * | 2019-08-29 | 2023-08-30 | National Institute for Biotechnology in the Negev Ltd. | SINGLE-DOMAIN ANTIBODY FOR TARGETING PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) |
AU2020405183A1 (en) | 2019-12-18 | 2022-06-09 | TeneoFour, Inc. | Heavy chain antibodies binding to CD38 |
JP2023532129A (ja) | 2020-06-30 | 2023-07-26 | テネオバイオ, インコーポレイテッド | Bcmaに結合する多重特異性抗体 |
IL301137A (en) | 2020-09-11 | 2023-05-01 | Regeneron Pharma | Identification and production of antigen-specific antibodies |
TW202233684A (zh) | 2020-11-18 | 2022-09-01 | 美商泰尼歐生物公司 | 結合於葉酸受體α之重鏈抗體 |
US20240065239A1 (en) | 2020-12-16 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
EP4298130A2 (en) | 2021-02-25 | 2024-01-03 | Teneobio, Inc. | Anti-psma antibodies and car-t structures |
KR20230150825A (ko) | 2021-02-26 | 2023-10-31 | 테네오바이오, 인코포레이티드 | 항-muc1-c 항체 및 car-t 구조 |
TW202304994A (zh) | 2021-04-02 | 2023-02-01 | 美商泰尼歐生物公司 | 促效性抗il-2r抗體及使用方法 |
JP2024514107A (ja) | 2021-04-06 | 2024-03-28 | テネオバイオ, インコーポレイテッド | 抗cd19抗体及びcar-t構造体 |
AU2022259688A1 (en) | 2021-04-16 | 2023-10-05 | Teneobio, Inc. | Anti-cd20 antibodies and car-t structures |
WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
WO2023004197A1 (en) | 2021-07-23 | 2023-01-26 | Teneoten, Inc. | Heavy chain antibodies binding to hepatitis b surface antigen |
TW202323281A (zh) | 2021-10-14 | 2023-06-16 | 美商泰尼歐生物公司 | 間皮素結合蛋白及其用途 |
WO2024026358A1 (en) | 2022-07-27 | 2024-02-01 | Teneobio, Inc. | Mesothelin binding proteins and uses thereof |
WO2024049684A1 (en) | 2022-08-30 | 2024-03-07 | Amgen Inc. | Live cell profiling assay |
WO2024077044A1 (en) | 2022-10-05 | 2024-04-11 | Amgen Inc. | Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0110029D0 (en) * | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
EP2390270A1 (en) | 2003-01-10 | 2011-11-30 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation |
CN101001874B (zh) | 2004-04-21 | 2012-12-19 | 布赖汉姆妇女医院 | 聚-n-乙酰葡萄糖胺(pnag/dpnag)结合肽及其应用方法 |
JP2008512987A (ja) | 2004-07-22 | 2008-05-01 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | 結合分子 |
US20100062004A1 (en) * | 2006-12-19 | 2010-03-11 | Ablynx N.V. | Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders |
US20100122358A1 (en) | 2008-06-06 | 2010-05-13 | Crescendo Biologics Limited | H-Chain-only antibodies |
GB0905023D0 (en) * | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
-
2017
- 2017-08-22 CA CA3034706A patent/CA3034706A1/en active Pending
- 2017-08-22 RU RU2019108240A patent/RU2762835C2/ru active
- 2017-08-22 RU RU2021137547A patent/RU2021137547A/ru unknown
- 2017-08-22 AU AU2017316604A patent/AU2017316604A1/en active Pending
- 2017-08-22 BR BR112019003547A patent/BR112019003547A2/pt unknown
- 2017-08-22 KR KR1020237008743A patent/KR20230039773A/ko not_active Application Discontinuation
- 2017-08-22 EP EP17761656.2A patent/EP3503722A1/en active Pending
- 2017-08-22 CN CN201780058419.4A patent/CN109862784A/zh active Pending
- 2017-08-22 KR KR1020197008454A patent/KR20190052006A/ko active Application Filing
- 2017-08-22 WO PCT/US2017/047928 patent/WO2018039180A1/en unknown
- 2017-08-22 JP JP2019510837A patent/JP7229153B2/ja active Active
- 2017-08-22 US US16/327,299 patent/US20190225671A1/en active Pending
- 2017-08-22 MX MX2019002256A patent/MX2019002256A/es unknown
-
2021
- 2021-09-02 JP JP2021143168A patent/JP2021183648A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112019003547A2 (pt) | 2019-05-28 |
RU2019108240A (ru) | 2020-10-02 |
JP7229153B2 (ja) | 2023-02-27 |
EP3503722A1 (en) | 2019-07-03 |
KR20230039773A (ko) | 2023-03-21 |
US20190225671A1 (en) | 2019-07-25 |
RU2762835C2 (ru) | 2021-12-23 |
CN109862784A (zh) | 2019-06-07 |
KR20190052006A (ko) | 2019-05-15 |
RU2021137547A (ru) | 2022-01-11 |
JP2021183648A (ja) | 2021-12-02 |
CA3034706A1 (en) | 2018-03-01 |
RU2019108240A3 (es) | 2020-10-16 |
AU2017316604A1 (en) | 2019-04-11 |
JP2019528295A (ja) | 2019-10-10 |
WO2018039180A1 (en) | 2018-03-01 |
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