EP3768079A4 - Transgenic chicken that produces human antibodies - Google Patents
Transgenic chicken that produces human antibodies Download PDFInfo
- Publication number
- EP3768079A4 EP3768079A4 EP19770329.1A EP19770329A EP3768079A4 EP 3768079 A4 EP3768079 A4 EP 3768079A4 EP 19770329 A EP19770329 A EP 19770329A EP 3768079 A4 EP3768079 A4 EP 3768079A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- human antibodies
- produces human
- transgenic chicken
- chicken
- transgenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000287828 Gallus gallus Species 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/30—Bird
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Environmental Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862646319P | 2018-03-21 | 2018-03-21 | |
PCT/US2019/020799 WO2019182751A1 (en) | 2018-03-21 | 2019-03-05 | Transgenic chicken that produces human antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3768079A1 EP3768079A1 (en) | 2021-01-27 |
EP3768079A4 true EP3768079A4 (en) | 2021-12-08 |
Family
ID=67987909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19770329.1A Pending EP3768079A4 (en) | 2018-03-21 | 2019-03-05 | Transgenic chicken that produces human antibodies |
Country Status (8)
Country | Link |
---|---|
US (1) | US20210000088A1 (en) |
EP (1) | EP3768079A4 (en) |
JP (1) | JP2021516954A (en) |
KR (1) | KR20200133339A (en) |
CN (1) | CN112004411B (en) |
AU (1) | AU2019237926A1 (en) |
CA (1) | CA3093060A1 (en) |
WO (1) | WO2019182751A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019236671A1 (en) * | 2018-06-08 | 2019-12-12 | Crystal Bioscience Inc. | Transgenic animal for producing diversified antibodies that have the same light chain ii |
US20200095619A1 (en) * | 2018-09-26 | 2020-03-26 | Kalamazoo Holdings, Inc . | New enzymatic process for production of modified hop products |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040250307A1 (en) * | 2000-06-19 | 2004-12-09 | Sujay Singh | Transgenic avian species for making human and chimeric antibodies |
WO2011019844A1 (en) * | 2009-08-13 | 2011-02-17 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having minimal cdrs |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5694623B2 (en) * | 1999-02-05 | 2015-04-01 | セラピューティック ヒューマン ポリクローナルズ, インコーポレイテッド | Human polyclonal antibodies obtained from genetically engineered animals |
US20070111259A1 (en) * | 1999-10-02 | 2007-05-17 | Medarex, Inc. | Human antibodies |
MXPA03001915A (en) * | 2000-08-03 | 2004-09-10 | Therapeutic Human Polyclonals | Production of humanized antibodies in transgenic animals. |
WO2002043478A2 (en) * | 2000-11-30 | 2002-06-06 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
AU2003230741A1 (en) * | 2002-03-22 | 2003-10-13 | Origen Therapeutics | Transgenic aves producing human polyclonal antibodies |
AU2004257292A1 (en) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
WO2009013620A2 (en) * | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
GB0905023D0 (en) * | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
CA3006800C (en) * | 2010-03-31 | 2022-10-04 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
JP2012050437A (en) * | 2011-09-12 | 2012-03-15 | Janssen Alzheimer Immunotherapy | Humanized antibody recognizing beta amyloid peptide |
WO2013106489A1 (en) * | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
CA2865506C (en) * | 2012-03-15 | 2021-07-06 | Omeros Corporation | Composition and method for diversification of target sequences |
-
2019
- 2019-03-05 CA CA3093060A patent/CA3093060A1/en active Pending
- 2019-03-05 CN CN201980020878.2A patent/CN112004411B/en active Active
- 2019-03-05 KR KR1020207026678A patent/KR20200133339A/en not_active Application Discontinuation
- 2019-03-05 WO PCT/US2019/020799 patent/WO2019182751A1/en unknown
- 2019-03-05 AU AU2019237926A patent/AU2019237926A1/en active Pending
- 2019-03-05 EP EP19770329.1A patent/EP3768079A4/en active Pending
- 2019-03-05 JP JP2020545533A patent/JP2021516954A/en active Pending
- 2019-03-05 US US16/977,430 patent/US20210000088A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040250307A1 (en) * | 2000-06-19 | 2004-12-09 | Sujay Singh | Transgenic avian species for making human and chimeric antibodies |
WO2011019844A1 (en) * | 2009-08-13 | 2011-02-17 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having minimal cdrs |
Non-Patent Citations (6)
Title |
---|
BENJAMIN SCHUSSER ET AL: "Harnessing Gene Conversion in Chicken B Cells to Create a Human Antibody Sequence Repertoire", PLOS ONE, vol. 8, no. 11, 21 November 2013 (2013-11-21), pages 1 - 15, XP055096053, DOI: 10.1371/journal.pone.0080108 * |
KARL ROSNER ET AL: "Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes", IMMUNOLOGY, vol. 103, 1 January 2001 (2001-01-01), pages 179 - 187, XP055516887 * |
KATHRYN H. CHING ET AL: "Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets", MABS, vol. 10, no. 1, 2 November 2017 (2017-11-02), US, pages 71 - 80, XP055525565, ISSN: 1942-0862, DOI: 10.1080/19420862.2017.1386825 * |
PHILIP A. LEIGHTON ET AL: "V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species", FRONTIERS IN IMMUNOLOGY, vol. 9, no. 1317, 11 June 2018 (2018-06-11), pages 1 - 14, XP055669112, DOI: 10.3389/fimmu.2018.01317 * |
See also references of WO2019182751A1 * |
WU LEEYING ET AL: "Fundamental Characteristics of the Immunoglobulin V H Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids", THE JOURNAL OF IMMUNOLOGY, vol. 188, no. 1, 1 January 2012 (2012-01-01), US, pages 322 - 333, XP055854741, ISSN: 0022-1767, Retrieved from the Internet <URL:https://www.jimmunol.org/content/jimmunol/188/1/322.full.pdf> DOI: 10.4049/jimmunol.1102466 * |
Also Published As
Publication number | Publication date |
---|---|
CN112004411A (en) | 2020-11-27 |
KR20200133339A (en) | 2020-11-27 |
JP2021516954A (en) | 2021-07-15 |
WO2019182751A1 (en) | 2019-09-26 |
EP3768079A1 (en) | 2021-01-27 |
US20210000088A1 (en) | 2021-01-07 |
CN112004411B (en) | 2023-05-26 |
CA3093060A1 (en) | 2019-09-26 |
AU2019237926A1 (en) | 2020-09-24 |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20211109 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 16/00 20060101ALI20211103BHEP Ipc: C07K 16/46 20060101ALI20211103BHEP Ipc: A01K 67/027 20060101AFI20211103BHEP |
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