BR112019003547A2 - animais transgênicos não humanos que produzem anticorpos modificados somente de cadeia pesada - Google Patents

animais transgênicos não humanos que produzem anticorpos modificados somente de cadeia pesada

Info

Publication number
BR112019003547A2
BR112019003547A2 BR112019003547A BR112019003547A BR112019003547A2 BR 112019003547 A2 BR112019003547 A2 BR 112019003547A2 BR 112019003547 A BR112019003547 A BR 112019003547A BR 112019003547 A BR112019003547 A BR 112019003547A BR 112019003547 A2 BR112019003547 A2 BR 112019003547A2
Authority
BR
Brazil
Prior art keywords
heavy chain
transgenic animals
human transgenic
modified antibodies
chain modified
Prior art date
Application number
BR112019003547A
Other languages
English (en)
Inventor
Bruggemann Marianne
Osborn Michael
Trinklein Nathan
Force-Aldred Shelley
Vanschooten Wim
Original Assignee
Teneobio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teneobio Inc filed Critical Teneobio Inc
Publication of BR112019003547A2 publication Critical patent/BR112019003547A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

são proporcionados anticorpos de cadeia pesada somente humanos ou quiméricos no resíduo de aminoácido nativo na primeira posição da quarta região de estrutura (fr4) do referido hcab é substituído por um resíduo de aminoácido diferente que é capaz de interromper um emplastro hidrofóbico exposto à superfície compreendendo ou associado com o resíduo de aminoácido nativo nessa posição.
BR112019003547A 2016-08-24 2017-08-22 animais transgênicos não humanos que produzem anticorpos modificados somente de cadeia pesada BR112019003547A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662379075P 2016-08-24 2016-08-24
PCT/US2017/047928 WO2018039180A1 (en) 2016-08-24 2017-08-22 Transgenic non-human animals producing modified heavy chain-only antibodies

Publications (1)

Publication Number Publication Date
BR112019003547A2 true BR112019003547A2 (pt) 2019-05-28

Family

ID=59772725

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019003547A BR112019003547A2 (pt) 2016-08-24 2017-08-22 animais transgênicos não humanos que produzem anticorpos modificados somente de cadeia pesada

Country Status (11)

Country Link
US (1) US20190225671A1 (pt)
EP (1) EP3503722A1 (pt)
JP (2) JP7229153B2 (pt)
KR (2) KR20230039773A (pt)
CN (1) CN109862784A (pt)
AU (1) AU2017316604A1 (pt)
BR (1) BR112019003547A2 (pt)
CA (1) CA3034706A1 (pt)
MX (1) MX2019002256A (pt)
RU (2) RU2762835C2 (pt)
WO (1) WO2018039180A1 (pt)

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KR20190053835A (ko) 2016-06-21 2019-05-20 테네오바이오, 인코포레이티드 Cd3 결합 항체
UA126384C2 (uk) 2016-09-14 2022-09-28 Тенеобіо, Інк. Антитіло, яке зв'язує cd3
CN110431151B (zh) 2016-12-21 2023-07-18 特尼奥生物股份有限公司 仅有重链的抗bcma抗体
EP3642237A2 (en) * 2017-06-20 2020-04-29 Teneobio, Inc. Anti-bcma heavy chain-only antibodies
EP3642236A1 (en) 2017-06-20 2020-04-29 TeneoOne, Inc. Anti-bcma heavy chain-only antibodies
SG11202005880XA (en) 2017-12-22 2020-07-29 Teneobio Inc Heavy chain antibodies binding to cd22
CN116769032A (zh) * 2018-07-20 2023-09-19 坦尼奥第二公司 与cd19结合的重链抗体
GB2576914A (en) 2018-09-06 2020-03-11 Kymab Ltd Antigen-binding molecules comprising unpaired variable domains produced in mammals
JP2022505445A (ja) 2018-10-26 2022-01-14 テネオバイオ， インコーポレイテッド Ｃｄ３８に結合する重鎖抗体
AR119746A1 (es) 2019-06-14 2022-01-05 Teneobio Inc Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3
EP4021941A4 (en) * 2019-08-29 2023-08-30 National Institute for Biotechnology in the Negev Ltd. SINGLE-DOMAIN ANTIBODY FOR TARGETING PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)
AU2020405183A1 (en) 2019-12-18 2022-06-09 TeneoFour, Inc. Heavy chain antibodies binding to CD38
JP2023532129A (ja) 2020-06-30 2023-07-26 テネオバイオ， インコーポレイテッド Ｂｃｍａに結合する多重特異性抗体
IL301137A (en) 2020-09-11 2023-05-01 Regeneron Pharma Identification and production of antigen-specific antibodies
TW202233684A (zh) 2020-11-18 2022-09-01 美商泰尼歐生物公司 結合於葉酸受體α之重鏈抗體
US20240065239A1 (en) 2020-12-16 2024-02-29 Regeneron Pharmaceuticals, Inc. Mice expressing humanized fc alpha receptors
EP4298130A2 (en) 2021-02-25 2024-01-03 Teneobio, Inc. Anti-psma antibodies and car-t structures
KR20230150825A (ko) 2021-02-26 2023-10-31 테네오바이오, 인코포레이티드 항-muc1-c 항체 및 car-t 구조
TW202304994A (zh) 2021-04-02 2023-02-01 美商泰尼歐生物公司 促效性抗ｉｌ－２ｒ抗體及使用方法
JP2024514107A (ja) 2021-04-06 2024-03-28 テネオバイオ， インコーポレイテッド 抗ｃｄ１９抗体及びｃａｒ－ｔ構造体
AU2022259688A1 (en) 2021-04-16 2023-10-05 Teneobio, Inc. Anti-cd20 antibodies and car-t structures
WO2022271987A1 (en) 2021-06-23 2022-12-29 TeneoFour, Inc. Anti-cd38 antibodies and epitopes of same
WO2023004197A1 (en) 2021-07-23 2023-01-26 Teneoten, Inc. Heavy chain antibodies binding to hepatitis b surface antigen
TW202323281A (zh) 2021-10-14 2023-06-16 美商泰尼歐生物公司 間皮素結合蛋白及其用途
WO2024026358A1 (en) 2022-07-27 2024-02-01 Teneobio, Inc. Mesothelin binding proteins and uses thereof
WO2024049684A1 (en) 2022-08-30 2024-03-07 Amgen Inc. Live cell profiling assay
WO2024077044A1 (en) 2022-10-05 2024-04-11 Amgen Inc. Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof

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GB0110029D0 (en) * 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
GB0115256D0 (en) 2001-06-21 2001-08-15 Babraham Inst Mouse light chain locus
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
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Also Published As

Publication number Publication date
RU2019108240A (ru) 2020-10-02
JP7229153B2 (ja) 2023-02-27
EP3503722A1 (en) 2019-07-03
KR20230039773A (ko) 2023-03-21
MX2019002256A (es) 2019-10-09
US20190225671A1 (en) 2019-07-25
RU2762835C2 (ru) 2021-12-23
CN109862784A (zh) 2019-06-07
KR20190052006A (ko) 2019-05-15
RU2021137547A (ru) 2022-01-11
JP2021183648A (ja) 2021-12-02
CA3034706A1 (en) 2018-03-01
RU2019108240A3 (pt) 2020-10-16
AU2017316604A1 (en) 2019-04-11
JP2019528295A (ja) 2019-10-10
WO2018039180A1 (en) 2018-03-01

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]