EA202091557A1 - Антитела, содержащие только тяжелые цепи, которые связываются с cd22 - Google Patents

Антитела, содержащие только тяжелые цепи, которые связываются с cd22

Info

Publication number
EA202091557A1
EA202091557A1 EA202091557A EA202091557A EA202091557A1 EA 202091557 A1 EA202091557 A1 EA 202091557A1 EA 202091557 A EA202091557 A EA 202091557A EA 202091557 A EA202091557 A EA 202091557A EA 202091557 A1 EA202091557 A1 EA 202091557A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bind
heavy chains
antibodies
antibodies containing
uniabs
Prior art date
Application number
EA202091557A
Other languages
English (en)
Inventor
Шелли Форс АЛЬДРЕД
Вим ВАН СХОТЕН
Хизер Энн Н. Огана
Лора Мэри Дэйвисон
Кэтрин ХАРРИС
Удая Рангасвами
Нейтан Д. Тринклейн
Original Assignee
Тенеобио, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тенеобио, Инк. filed Critical Тенеобио, Инк.
Publication of EA202091557A1 publication Critical patent/EA202091557A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

В данном документе раскрыты антитела к CD22, содержащие только тяжелые цепи (UniAbs), наряду со способами получения таких антител, композиции, включая фармацевтические композиции, содержащие такие антитела, и их применение для лечения В-клеточных расстройств, характеризующихся экспрессией CD22.
EA202091557A 2017-12-22 2018-12-21 Антитела, содержащие только тяжелые цепи, которые связываются с cd22 EA202091557A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762609759P 2017-12-22 2017-12-22
PCT/US2018/067299 WO2019126756A1 (en) 2017-12-22 2018-12-21 Heavy chain antibodies binding to cd22

Publications (1)

Publication Number Publication Date
EA202091557A1 true EA202091557A1 (ru) 2020-11-18

Family

ID=65041936

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091557A EA202091557A1 (ru) 2017-12-22 2018-12-21 Антитела, содержащие только тяжелые цепи, которые связываются с cd22

Country Status (21)

Country Link
US (2) US11873336B2 (ru)
EP (1) EP3728319A1 (ru)
JP (2) JP7486421B2 (ru)
KR (1) KR20200104342A (ru)
CN (1) CN111683966B (ru)
AU (1) AU2018392088A1 (ru)
BR (1) BR112020012554A2 (ru)
CA (1) CA3086665A1 (ru)
CL (2) CL2020001703A1 (ru)
CO (1) CO2020008925A2 (ru)
CR (1) CR20200322A (ru)
EA (1) EA202091557A1 (ru)
EC (1) ECSP20042489A (ru)
IL (1) IL275498A (ru)
JO (1) JOP20200157A1 (ru)
MX (1) MX2020006494A (ru)
NI (1) NI202000050A (ru)
PE (1) PE20201171A1 (ru)
PH (1) PH12020550964A1 (ru)
SG (1) SG11202005880XA (ru)
WO (1) WO2019126756A1 (ru)

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Also Published As

Publication number Publication date
SG11202005880XA (en) 2020-07-29
NI202000050A (es) 2020-12-04
CA3086665A1 (en) 2019-06-27
IL275498A (en) 2020-08-31
AU2018392088A1 (en) 2020-08-13
RU2020124188A (ru) 2022-01-24
US11873336B2 (en) 2024-01-16
ECSP20042489A (es) 2020-11-30
WO2019126756A9 (en) 2019-10-17
JP2024062992A (ja) 2024-05-10
BR112020012554A2 (pt) 2020-11-24
CN111683966B (zh) 2023-07-11
WO2019126756A1 (en) 2019-06-27
PH12020550964A1 (en) 2021-03-22
CN111683966A (zh) 2020-09-18
CO2020008925A2 (es) 2020-10-30
KR20200104342A (ko) 2020-09-03
PE20201171A1 (es) 2020-10-28
JP2021506325A (ja) 2021-02-22
AU2018392088A2 (en) 2020-08-27
EP3728319A1 (en) 2020-10-28
CL2020001703A1 (es) 2020-11-06
MX2020006494A (es) 2020-11-24
CR20200322A (es) 2021-01-12
US20240117046A1 (en) 2024-04-11
JP7486421B2 (ja) 2024-05-17
JOP20200157A1 (ar) 2022-10-30
US20210095022A1 (en) 2021-04-01
CL2022002247A1 (es) 2023-02-24

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