SG11202001353PA - Pyruvate kinase modulators and use thereof - Google Patents
Pyruvate kinase modulators and use thereofInfo
- Publication number
- SG11202001353PA SG11202001353PA SG11202001353PA SG11202001353PA SG11202001353PA SG 11202001353P A SG11202001353P A SG 11202001353PA SG 11202001353P A SG11202001353P A SG 11202001353PA SG 11202001353P A SG11202001353P A SG 11202001353PA SG 11202001353P A SG11202001353P A SG 11202001353PA
- Authority
- SG
- Singapore
- Prior art keywords
- pyruvate kinase
- kinase modulators
- modulators
- pyruvate
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017097496 | 2017-08-15 | ||
| US201862673533P | 2018-05-18 | 2018-05-18 | |
| US201862673526P | 2018-05-18 | 2018-05-18 | |
| PCT/US2018/000129 WO2019035865A1 (en) | 2017-08-15 | 2018-08-15 | MODULATORS OF PYRUVATE KINASE AND THEIR USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202001353PA true SG11202001353PA (en) | 2020-03-30 |
Family
ID=63524352
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202001353PA SG11202001353PA (en) | 2017-08-15 | 2018-08-15 | Pyruvate kinase modulators and use thereof |
| SG11202001262QA SG11202001262QA (en) | 2017-08-15 | 2018-08-15 | Pyruvate kinase activators for use in treating blood disorders |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202001262QA SG11202001262QA (en) | 2017-08-15 | 2018-08-15 | Pyruvate kinase activators for use in treating blood disorders |
Country Status (32)
| Country | Link |
|---|---|
| US (7) | US11364240B2 (pt) |
| EP (4) | EP4026838A1 (pt) |
| JP (4) | JP7301040B2 (pt) |
| KR (3) | KR20230127364A (pt) |
| CN (3) | CN111032046B (pt) |
| AU (3) | AU2018316587B2 (pt) |
| BR (2) | BR112020003254A2 (pt) |
| CA (2) | CA3071993A1 (pt) |
| CL (1) | CL2020000375A1 (pt) |
| CO (2) | CO2020002959A2 (pt) |
| CR (1) | CR20200123A (pt) |
| CY (1) | CY1124953T1 (pt) |
| DK (2) | DK3668512T3 (pt) |
| EC (1) | ECSP20018487A (pt) |
| ES (3) | ES2966825T3 (pt) |
| FI (1) | FI3668512T3 (pt) |
| HR (2) | HRP20230452T1 (pt) |
| HU (2) | HUE061910T2 (pt) |
| IL (3) | IL272599B (pt) |
| LT (2) | LT3668513T (pt) |
| MD (1) | MD3668513T2 (pt) |
| MX (2) | MX2020001833A (pt) |
| PE (1) | PE20200724A1 (pt) |
| PH (1) | PH12020500343A1 (pt) |
| PL (2) | PL3668513T3 (pt) |
| PT (2) | PT3668512T (pt) |
| RS (2) | RS64221B1 (pt) |
| SG (2) | SG11202001353PA (pt) |
| SI (2) | SI3668513T1 (pt) |
| TW (3) | TWI790271B (pt) |
| UA (1) | UA126292C2 (pt) |
| WO (3) | WO2019035863A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202244048A (zh) | 2017-03-20 | 2022-11-16 | 美商佛瑪治療公司 | 作為丙酮酸激酶（ｐｋｒ）活化劑之吡咯并吡咯組成物 |
| JP7301040B2 (ja) | 2017-08-15 | 2023-06-30 | アジオス ファーマシューティカルズ， インコーポレイテッド | ピルビン酸キナーゼ調節因子およびその使用 |
| EP3853206B1 (en) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Treating sickle cell disease with a pyruvate kinase r activating compound |
| CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
| EP3924056A1 (en) * | 2019-02-13 | 2021-12-22 | Agios Pharmaceuticals, Inc. | Thieno[3,2-b] pyrrole[3,2-d]pyridazinone derivatives and their use as pkm2 derivatives for the treatment of cancer, obesity and diabetes related disorders |
| WO2020262419A1 (ja) * | 2019-06-26 | 2020-12-30 | 日産化学株式会社 | 電荷輸送性ワニス |
| AU2021311597A1 (en) * | 2020-07-21 | 2023-02-02 | The Regents Of The University Of Michigan | Compositions and methods for activating pyruvate kinase |
| CN112490502B (zh) * | 2020-12-04 | 2022-01-21 | 广州天赐高新材料股份有限公司 | 一种电解液及锂二次电池 |
| TW202245758A (zh) | 2021-02-08 | 2022-12-01 | 美商全球血液治療公司 | 作為丙酮酸激酶活化劑之吡咯啶-吡唑 |
| CA3231728A1 (en) * | 2021-09-30 | 2023-04-06 | Sitryx Therapeutics Limited | Novel compounds |
| CA3236880A1 (en) * | 2021-11-16 | 2023-05-25 | Agios Pharmaceuticals, Inc. | Compounds for treating mds-associated anemias and other conditions |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4405635A (en) | 1979-06-18 | 1983-09-20 | Merrell Dow Pharmaceuticals Inc. | 4-Aroylimidazol-2-ones and their use as pharmaceuticals |
| US4883914A (en) | 1987-08-17 | 1989-11-28 | American Cyanamid Company | Benzenesulfonyl carboxamide compounds useful as herbicidal agents |
| TR200200928T2 (tr) | 1999-07-30 | 2002-09-23 | Abbott Gmbh & Co.Kg | 2-pirazolin-5-on terkipleri |
| ES2216940T3 (es) | 1999-09-04 | 2004-11-01 | Astrazeneca Ab | Derivados n-fenilicos de 2-hidroxi-2-metil-3,3,3-trifluoropropanamida sustituidos que elevan la actividad de piruvato deshidrogenasa. |
| EP1972629A1 (en) * | 2007-03-23 | 2008-09-24 | Mutabilis SA | New imidazolo-heteroaryl derivatives with antibacterial properties |
| FR2933983B1 (fr) * | 2008-07-15 | 2010-08-27 | Servier Lab | Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| EP2318408B1 (en) * | 2008-07-23 | 2016-02-17 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| EP2334673A1 (en) * | 2008-08-29 | 2011-06-22 | Amgen Inc. | PYRIDO[3,2-d]PYRIDAZINE-2(1H)-ONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF |
| AU2009303335B2 (en) | 2008-10-09 | 2016-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
| JP5756457B2 (ja) * | 2009-04-06 | 2015-07-29 | アジオス ファーマシューティカルズ， インコーポレイテッド | ピルビン酸キナーゼｍ２調節剤、治療組成物および関連する使用方法 |
| SG10201403696UA (en) | 2009-06-29 | 2014-10-30 | Agios Pharmaceuticals Inc | Therapeutic compounds and compositions |
| JP2013525438A (ja) | 2010-04-29 | 2013-06-20 | アメリカ合衆国 | ヒトピルビン酸キナーゼ活性剤 |
| TW201307324A (zh) | 2010-12-06 | 2013-02-16 | Glaxo Group Ltd | 化合物 |
| TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
| WO2012151448A1 (en) * | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in therapy |
| WO2012151450A1 (en) | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| US9404081B2 (en) * | 2011-05-03 | 2016-08-02 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in therapy |
| BR112013028422B8 (pt) | 2011-05-03 | 2022-01-11 | Agios Pharmaceuticals Inc | Ativadores de piruvato cinase para uso em terapia |
| JP6027610B2 (ja) * | 2011-07-19 | 2016-11-16 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環式化合物及びその使用 |
| WO2013056153A1 (en) * | 2011-10-13 | 2013-04-18 | Kung Charles | Activators of pyruvate kinase m2 and methods of treating disease |
| EP2877214B1 (en) | 2012-07-26 | 2019-04-24 | Joslin Diabetes Center, Inc. | Predicting diabetic complications |
| CA2890664A1 (en) * | 2012-11-08 | 2014-05-15 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions and their use as pkm2 modulators |
| CN105008363A (zh) * | 2013-01-30 | 2015-10-28 | 拜耳医药股份公司 | 作为mknk-1激酶抑制剂的酰氨基咪唑并哒嗪 |
| CN105307655B (zh) | 2013-03-13 | 2019-05-03 | 弗拉特利发现实验室有限责任公司 | 哒嗪酮化合物及其用于制备治疗囊肿状纤维化的药物的应用 |
| WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| AR097543A1 (es) * | 2013-09-06 | 2016-03-23 | Lexicon Pharmaceuticals Inc | COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO |
| SG11201913636WA (en) | 2017-07-07 | 2020-01-30 | Inflazome Ltd | Novel sulfonamide carboxamide compounds |
| CN111093773A (zh) | 2017-08-15 | 2020-05-01 | 英夫拉索姆有限公司 | 作为nlrp3抑制剂的磺酰脲和磺酰硫脲 |
| BR112020003180A2 (pt) | 2017-08-15 | 2020-09-15 | AbbVie Deutschland GmbH & Co. KG | inibidores macrocíclicos de mcl-1 e métodos de uso |
| AR112690A1 (es) | 2017-08-15 | 2019-11-27 | Agios Pharmaceuticals Inc | Activadores de piruvato quinasas para usar en el tratamiento de trastornos en la sangre |
| JP7301040B2 (ja) * | 2017-08-15 | 2023-06-30 | アジオス ファーマシューティカルズ， インコーポレイテッド | ピルビン酸キナーゼ調節因子およびその使用 |
| EP3924056A1 (en) * | 2019-02-13 | 2021-12-22 | Agios Pharmaceuticals, Inc. | Thieno[3,2-b] pyrrole[3,2-d]pyridazinone derivatives and their use as pkm2 derivatives for the treatment of cancer, obesity and diabetes related disorders |
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2018
- 2018-08-15 JP JP2020508455A patent/JP7301040B2/ja active Active
- 2018-08-15 WO PCT/US2018/000127 patent/WO2019035863A1/en unknown
- 2018-08-15 MX MX2020001833A patent/MX2020001833A/es unknown
- 2018-08-15 SG SG11202001353PA patent/SG11202001353PA/en unknown
- 2018-08-15 CN CN201880053325.2A patent/CN111032046B/zh active Active
- 2018-08-15 PE PE2020000245A patent/PE20200724A1/es unknown
- 2018-08-15 WO PCT/US2018/000129 patent/WO2019035865A1/en unknown
- 2018-08-15 KR KR1020237028222A patent/KR20230127364A/ko not_active Application Discontinuation
- 2018-08-15 PL PL18779068T patent/PL3668513T3/pl unknown
- 2018-08-15 US US16/639,075 patent/US11364240B2/en active Active
- 2018-08-15 TW TW107128429A patent/TWI790271B/zh active
- 2018-08-15 EP EP21207073.4A patent/EP4026838A1/en active Pending
- 2018-08-15 HU HUE18766400A patent/HUE061910T2/hu unknown
- 2018-08-15 PT PT187664008T patent/PT3668512T/pt unknown
- 2018-08-15 ES ES18766063T patent/ES2966825T3/es active Active
- 2018-08-15 CN CN202310962497.4A patent/CN117186119A/zh active Pending
- 2018-08-15 UA UAA202001747A patent/UA126292C2/uk unknown
- 2018-08-15 MX MX2020001832A patent/MX2020001832A/es unknown
- 2018-08-15 TW TW111135803A patent/TWI823580B/zh active
- 2018-08-15 EP EP18766400.8A patent/EP3668512B1/en active Active
- 2018-08-15 MD MDE20200663T patent/MD3668513T2/ro unknown
- 2018-08-15 RS RS20230354A patent/RS64221B1/sr unknown
- 2018-08-15 HR HRP20230452TT patent/HRP20230452T1/hr unknown
- 2018-08-15 ES ES18766400T patent/ES2944545T3/es active Active
- 2018-08-15 PL PL18766400.8T patent/PL3668512T3/pl unknown
- 2018-08-15 SI SI201830558T patent/SI3668513T1/sl unknown
- 2018-08-15 US US16/639,086 patent/US11464775B2/en active Active
- 2018-08-15 EP EP18766063.4A patent/EP3668881B1/en active Active
- 2018-08-15 CA CA3071993A patent/CA3071993A1/en active Pending
- 2018-08-15 DK DK18766400.8T patent/DK3668512T3/da active
- 2018-08-15 ES ES18779068T patent/ES2905100T3/es active Active
- 2018-08-15 BR BR112020003254-9A patent/BR112020003254A2/pt unknown
- 2018-08-15 TW TW107128431A patent/TWI796353B/zh active
- 2018-08-15 FI FIEP18766400.8T patent/FI3668512T3/fi active
- 2018-08-15 RS RS20220003A patent/RS62871B1/sr unknown
- 2018-08-15 KR KR1020207007346A patent/KR102642408B1/ko active IP Right Grant
- 2018-08-15 LT LTEPPCT/US2018/000128T patent/LT3668513T/lt unknown
- 2018-08-15 BR BR112020003262-0A patent/BR112020003262A2/pt unknown
- 2018-08-15 CR CR20200123A patent/CR20200123A/es unknown
- 2018-08-15 KR KR1020207007344A patent/KR20200054199A/ko not_active Application Discontinuation
- 2018-08-15 IL IL272599A patent/IL272599B/en unknown
- 2018-08-15 US US16/639,081 patent/US11590132B2/en active Active
- 2018-08-15 CN CN201880053315.9A patent/CN111032045B/zh active Active
- 2018-08-15 SI SI201830914T patent/SI3668512T1/sl unknown
- 2018-08-15 EP EP18779068.8A patent/EP3668513B1/en active Active
- 2018-08-15 AU AU2018316587A patent/AU2018316587B2/en active Active
- 2018-08-15 SG SG11202001262QA patent/SG11202001262QA/en unknown
- 2018-08-15 AU AU2018316588A patent/AU2018316588B2/en active Active
- 2018-08-15 WO PCT/US2018/000128 patent/WO2019035864A1/en active Application Filing
- 2018-08-15 LT LTEPPCT/US2018/000129T patent/LT3668512T/lt unknown
- 2018-08-15 DK DK18779068.8T patent/DK3668513T3/da active
- 2018-08-15 HU HUE18779068A patent/HUE057178T2/hu unknown
- 2018-08-15 PT PT187790688T patent/PT3668513T/pt unknown
- 2018-08-15 HR HRP20220039TT patent/HRP20220039T1/hr unknown
- 2018-08-15 CA CA3072455A patent/CA3072455A1/en active Pending
- 2018-08-15 JP JP2020508498A patent/JP7275107B2/ja active Active
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2020
- 2020-02-11 IL IL272597A patent/IL272597B/en unknown
- 2020-02-13 CL CL2020000375A patent/CL2020000375A1/es unknown
- 2020-02-14 PH PH12020500343A patent/PH12020500343A1/en unknown
- 2020-03-12 CO CONC2020/0002959A patent/CO2020002959A2/es unknown
- 2020-03-12 CO CONC2020/0002961A patent/CO2020002961A2/es unknown
- 2020-03-13 EC ECSENADI202018487A patent/ECSP20018487A/es unknown
- 2020-11-19 US US16/952,257 patent/US11040036B2/en active Active
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2022
- 2022-01-18 CY CY20221100039T patent/CY1124953T1/el unknown
- 2022-01-27 US US17/586,777 patent/US11872225B2/en active Active
- 2022-04-26 IL IL292530A patent/IL292530B2/en unknown
- 2022-05-16 US US17/744,806 patent/US11957680B2/en active Active
- 2022-12-14 JP JP2022199462A patent/JP2023027276A/ja active Pending
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2023
- 2023-01-18 JP JP2023005925A patent/JP2023052478A/ja active Pending
- 2023-01-20 US US18/099,311 patent/US20230226055A1/en active Pending
- 2023-05-03 AU AU2023202772A patent/AU2023202772B2/en active Active
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