SG11201912342QA - Synthesis of halichondrins - Google Patents
Synthesis of halichondrinsInfo
- Publication number
- SG11201912342QA SG11201912342QA SG11201912342QA SG11201912342QA SG11201912342QA SG 11201912342Q A SG11201912342Q A SG 11201912342QA SG 11201912342Q A SG11201912342Q A SG 11201912342QA SG 11201912342Q A SG11201912342Q A SG 11201912342QA SG 11201912342Q A SG11201912342Q A SG 11201912342QA
- Authority
- SG
- Singapore
- Prior art keywords
- halichondrins
- synthesis
- Prior art date
Links
- 229930195695 Halichondrin Natural products 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Carbon And Carbon Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762529310P | 2017-07-06 | 2017-07-06 | |
| US201762529333P | 2017-07-06 | 2017-07-06 | |
| PCT/US2018/041005 WO2019010363A1 (en) | 2017-07-06 | 2018-07-06 | HALICHONDRINES SYNTHESIS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201912342QA true SG11201912342QA (en) | 2020-01-30 |
Family
ID=63036376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201912342QA SG11201912342QA (en) | 2017-07-06 | 2018-07-06 | Synthesis of halichondrins |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11548898B2 (ja) |
| EP (2) | EP3649135B1 (ja) |
| JP (2) | JP7370313B2 (ja) |
| KR (2) | KR102438417B1 (ja) |
| CN (1) | CN111433211B (ja) |
| AU (2) | AU2018297305B2 (ja) |
| BR (1) | BR112020000141A2 (ja) |
| CA (2) | CA3211559A1 (ja) |
| ES (1) | ES2940688T3 (ja) |
| HU (1) | HUE061306T2 (ja) |
| IL (3) | IL271660B (ja) |
| MX (1) | MX2020000142A (ja) |
| SG (1) | SG11201912342QA (ja) |
| WO (1) | WO2019010363A1 (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017520586A (ja) | 2014-06-30 | 2017-07-27 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ハリコンドリン類似体の合成およびその使用 |
| WO2016176560A1 (en) | 2015-04-30 | 2016-11-03 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| CN115093429A (zh) | 2017-04-05 | 2022-09-23 | 哈佛大学的校长及成员们 | 大环化合物及其用途 |
| BR112020000141A2 (pt) | 2017-07-06 | 2020-07-14 | President And Fellows Of Harvard College | síntese de halicondrinas |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| CN117924310A (zh) | 2017-11-15 | 2024-04-26 | 哈佛大学的校长及成员们 | 大环化合物及其用途 |
| CN111484393A (zh) * | 2019-01-28 | 2020-08-04 | 上海茂晟康慧科技有限公司 | 一种顺,顺-3,5-二甲基-1-环己醇的制备方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61191687A (ja) | 1985-02-20 | 1986-08-26 | Fujisawa Pharmaceut Co Ltd | ハリコンドリンｂ |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| US5352804A (en) | 1993-01-19 | 1994-10-04 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 2 |
| US5426194A (en) | 1993-01-19 | 1995-06-20 | Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 1 |
| JP2818381B2 (ja) | 1994-01-18 | 1998-10-30 | 帝人株式会社 | ７−チアプロスタグランジン類およびその製造法 |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| RU2245335C2 (ru) | 1998-06-17 | 2005-01-27 | Эйсай Ко., Лтд. | Макроциклическое соединение и способ идентификации агента на его основе |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| JP2001305734A (ja) | 2000-04-20 | 2001-11-02 | Fuji Photo Film Co Ltd | 光重合性組成物 |
| JP2003261447A (ja) | 2002-03-07 | 2003-09-16 | Kyosei Seiyaku Kk | 抗腫瘍剤 |
| PL2522663T3 (pl) | 2004-06-03 | 2015-08-31 | Eisai R&D Man Co Ltd | Produkty pośrednie do otrzymywania halichondryny B |
| WO2006076100A2 (en) | 2004-12-09 | 2006-07-20 | Eisai Co. Ltd. | Tubulin isotype screening in cancer therapy using halichondrin b analogs |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| ES2503395T3 (es) | 2007-03-07 | 2014-10-06 | Interdigital Technology Corporation | Método y aparato para generar y tratar una unidad de datos de protocolo MAC-ehs |
| KR20100056438A (ko) | 2007-06-18 | 2010-05-27 | 메디뮨 엘엘씨 | ＥｐｈＡ2 및 ＥｒｂＢ2를 발현하는 세포의 상승적 치료 방법 |
| RU2489437C2 (ru) | 2007-10-03 | 2013-08-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Промежуточные соединения и способы синтеза аналогов галихондрина в |
| EP2220094A1 (en) | 2007-11-16 | 2010-08-25 | Eisai R&D Management Co., Ltd. | Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate |
| MX2010010902A (es) | 2008-04-04 | 2010-12-21 | Eisai R&D Man Co Ltd | Analogos de halicondrina b. |
| CA2787919C (en) | 2010-01-26 | 2018-07-31 | Eisai R&D Management Co., Ltd. | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
| CA2824154A1 (en) | 2011-01-10 | 2012-07-19 | President And Fellows Of Harvard College | Method for delivering agents into cells using bacterial toxins |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| CA2857395A1 (en) | 2011-12-16 | 2013-06-20 | Alphora Research Inc. | Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof |
| AU2012363334B2 (en) | 2011-12-29 | 2017-02-02 | Alphora Research Inc. | 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl) tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
| EP2831082B1 (en) | 2012-03-30 | 2019-02-20 | Sandoz AG | Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein |
| EP2997017B1 (en) | 2013-05-15 | 2017-08-09 | Alphora Research Inc. | 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
| US9850254B2 (en) | 2013-07-03 | 2017-12-26 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups |
| RU2710545C2 (ru) | 2013-11-04 | 2019-12-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, пригодные в получении аналогов халихондрина b |
| SG10201805024YA (en) | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| JP2017520586A (ja) | 2014-06-30 | 2017-07-27 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ハリコンドリン類似体の合成およびその使用 |
| EP3191479B1 (en) | 2014-09-09 | 2020-04-08 | Cipla Limited | "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof" |
| WO2016176560A1 (en) | 2015-04-30 | 2016-11-03 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| MX2021002629A (es) | 2015-05-07 | 2022-05-13 | Eisai R&D Man Co Ltd | Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina. |
| AU2017225982B2 (en) | 2016-03-02 | 2023-10-05 | Eisai R&D Management Co., Ltd. | Eribulin-based antibody-drug conjugates and methods of use |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| CA3053857A1 (en) | 2017-02-20 | 2018-08-23 | Polyphor Ag | Pharmaceutical combinations for treating cancer |
| CN115093429A (zh) | 2017-04-05 | 2022-09-23 | 哈佛大学的校长及成员们 | 大环化合物及其用途 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| WO2019009956A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | SUMMARY OF MEDIUM MEDIATED KETONE |
| BR112020000141A2 (pt) | 2017-07-06 | 2020-07-14 | President And Fellows Of Harvard College | síntese de halicondrinas |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| CN117924310A (zh) | 2017-11-15 | 2024-04-26 | 哈佛大学的校长及成员们 | 大环化合物及其用途 |
-
2018
- 2018-07-06 BR BR112020000141-4A patent/BR112020000141A2/pt active Search and Examination
- 2018-07-06 WO PCT/US2018/041005 patent/WO2019010363A1/en active Application Filing
- 2018-07-06 CA CA3211559A patent/CA3211559A1/en active Pending
- 2018-07-06 ES ES18746401T patent/ES2940688T3/es active Active
- 2018-07-06 MX MX2020000142A patent/MX2020000142A/es unknown
- 2018-07-06 SG SG11201912342QA patent/SG11201912342QA/en unknown
- 2018-07-06 KR KR1020207003432A patent/KR102438417B1/ko active IP Right Grant
- 2018-07-06 CN CN201880058283.1A patent/CN111433211B/zh active Active
- 2018-07-06 CA CA3069160A patent/CA3069160C/en active Active
- 2018-07-06 IL IL271660A patent/IL271660B/en unknown
- 2018-07-06 HU HUE18746401A patent/HUE061306T2/hu unknown
- 2018-07-06 IL IL307273A patent/IL307273A/en unknown
- 2018-07-06 EP EP18746401.1A patent/EP3649135B1/en active Active
- 2018-07-06 IL IL295588A patent/IL295588B2/en unknown
- 2018-07-06 AU AU2018297305A patent/AU2018297305B2/en active Active
- 2018-07-06 EP EP22214189.7A patent/EP4169924A3/en active Pending
- 2018-07-06 US US16/628,504 patent/US11548898B2/en active Active
- 2018-07-06 KR KR1020227029591A patent/KR20220124279A/ko not_active Application Discontinuation
- 2018-07-06 JP JP2020500097A patent/JP7370313B2/ja active Active
-
2022
- 2022-11-23 US US18/058,441 patent/US20230128195A1/en active Pending
-
2023
- 2023-05-15 AU AU2023203013A patent/AU2023203013A1/en active Pending
- 2023-08-07 JP JP2023128422A patent/JP2023166381A/ja active Pending
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