SG11201900947RA - Tlr7/8 antagonists and uses thereof - Google Patents
Tlr7/8 antagonists and uses thereofInfo
- Publication number
- SG11201900947RA SG11201900947RA SG11201900947RA SG11201900947RA SG11201900947RA SG 11201900947R A SG11201900947R A SG 11201900947RA SG 11201900947R A SG11201900947R A SG 11201900947RA SG 11201900947R A SG11201900947R A SG 11201900947RA SG 11201900947R A SG11201900947R A SG 11201900947RA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- massachusetts
- pct
- tlr7
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 3
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 abstract 2
- 102100039390 Toll-like receptor 7 Human genes 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 235000014036 Castanea Nutrition 0.000 abstract 1
- 241001070941 Castanea Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000015244 frankfurter Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 238000012827 research and development Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/47—Quinolines; Isoquinolines
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662371917P | 2016-08-08 | 2016-08-08 | |
PCT/US2017/045671 WO2018031434A1 (en) | 2016-08-08 | 2017-08-07 | Tlr7/8 antagonists and uses thereof |
Publications (1)
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RU2020123151A (ru) | 2017-12-19 | 2022-01-20 | Мерк Патент Гмбх | Антагонисты tlr7/8 и их применение |
AU2018392213B2 (en) | 2017-12-20 | 2021-03-04 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
JP7098748B2 (ja) | 2017-12-20 | 2022-07-11 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. | Stingアダプタータンパク質を活性化するホスホン酸結合を有する2’3’環状ジヌクレオチド |
JP7328977B2 (ja) | 2018-02-12 | 2023-08-17 | エフ. ホフマン-ラ ロシュ アーゲー | ウイルス感染の処置および予防のための新規のスルホン化合物および誘導体 |
TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
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KR20240019867A (ko) | 2024-02-14 |
DK3497094T3 (da) | 2023-05-15 |
MX2019001096A (es) | 2019-07-04 |
RU2758686C2 (ru) | 2021-11-01 |
EP3497094B1 (en) | 2023-02-15 |
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JP7125385B2 (ja) | 2022-08-24 |
WO2018031434A1 (en) | 2018-02-15 |
IL264676B (en) | 2022-04-01 |
CA3033240A1 (en) | 2018-02-15 |
AU2017311047B2 (en) | 2021-07-22 |
CN109563075B (zh) | 2022-09-30 |
BR112019000696A2 (pt) | 2019-04-24 |
KR20190038616A (ko) | 2019-04-08 |
RU2019105719A (ru) | 2020-09-11 |
US20180037570A1 (en) | 2018-02-08 |
ES2944573T3 (es) | 2023-06-22 |
US20210002256A1 (en) | 2021-01-07 |
EP3497094A1 (en) | 2019-06-19 |
US11512069B2 (en) | 2022-11-29 |
KR102635885B1 (ko) | 2024-02-14 |
US10947214B2 (en) | 2021-03-16 |
JP2019527718A (ja) | 2019-10-03 |
RU2019105719A3 (es) | 2020-10-16 |
AU2017311047A1 (en) | 2019-03-21 |
CN109563075A (zh) | 2019-04-02 |
EP4198031A1 (en) | 2023-06-21 |
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