SG11201811559WA - Cancer treatment combinations - Google Patents

Cancer treatment combinations

Info

Publication number
SG11201811559WA
SG11201811559WA SG11201811559WA SG11201811559WA SG11201811559WA SG 11201811559W A SG11201811559W A SG 11201811559WA SG 11201811559W A SG11201811559W A SG 11201811559WA SG 11201811559W A SG11201811559W A SG 11201811559WA SG 11201811559W A SG11201811559W A SG 11201811559WA
Authority
SG
Singapore
Prior art keywords
international
antagonist
ror
pct
publication
Prior art date
Application number
SG11201811559WA
Other languages
English (en)
Inventor
Thomas Kipps
Liguang Chen
Bing Cui
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of SG11201811559WA publication Critical patent/SG11201811559WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/804—Blood cells [leukemia, lymphoma]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201811559WA 2016-06-27 2017-06-27 Cancer treatment combinations SG11201811559WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662355171P 2016-06-27 2016-06-27
PCT/US2017/039536 WO2018005519A2 (fr) 2016-06-27 2017-06-27 Associations médicamenteuses pour le traitement du cancer

Publications (1)

Publication Number Publication Date
SG11201811559WA true SG11201811559WA (en) 2019-01-30

Family

ID=60675188

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201811559WA SG11201811559WA (en) 2016-06-27 2017-06-27 Cancer treatment combinations

Country Status (15)

Country Link
US (3) US10688181B2 (fr)
EP (1) EP3474854A4 (fr)
JP (2) JP7109007B2 (fr)
KR (2) KR20230047507A (fr)
CN (1) CN109996544A (fr)
AR (1) AR108889A1 (fr)
AU (1) AU2017289270B2 (fr)
CA (1) CA3029003A1 (fr)
IL (2) IL299099A (fr)
MX (1) MX2018016330A (fr)
MY (1) MY196869A (fr)
PH (1) PH12019500025A1 (fr)
SG (1) SG11201811559WA (fr)
TW (1) TWI767915B (fr)
WO (1) WO2018005519A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109996544A (zh) 2016-06-27 2019-07-09 加利福尼亚大学董事会 癌症治疗组合
CA3067829A1 (fr) 2017-06-23 2018-12-27 VelosBio Inc. Immunoconjugues d'anticorps ror1
WO2019173843A1 (fr) * 2018-03-09 2019-09-12 The Regents Of The University Of California Polythérapie de cancers chimiorésistants
US20210121466A1 (en) 2018-05-03 2021-04-29 Juno Therapeutics, Inc. Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
WO2020006273A1 (fr) 2018-06-27 2020-01-02 Juvena Therapeutics, Inc. Polypeptides associés à l'héparine et leurs utilisations
CN110922409A (zh) * 2019-12-19 2020-03-27 武汉九州钰民医药科技有限公司 制备btk抑制剂泽布替尼的方法
EP4233866A1 (fr) * 2020-11-24 2023-08-30 Geneheal Biotechnology Co., Ltd. Application d'un composé dans la préparation d'un réactif pour la régulation négative de l'expression de runx2
WO2023133444A1 (fr) * 2022-01-07 2023-07-13 University Of Florida Research Foundation, Incorporated Inhibiteurs de tyrosine kinase de bruton en tant qu'agents antiviraux
WO2023220655A1 (fr) 2022-05-11 2023-11-16 Celgene Corporation Méthodes pour surmonter la résistance aux médicaments par ré-sensibilisation de cellules cancéreuses à un traitement avec une thérapie antérieure par l'intermédiaire d'un traitement avec une thérapie par lymphocytes t
WO2024039925A1 (fr) * 2022-08-19 2024-02-22 Oncternal Therapeutics, Inc. Méthodes de traitement associées pour cancer à mutation tp53

Family Cites Families (195)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219837A (en) 1990-06-21 1993-06-15 Trustees Of The University Of Pennsylvania Method of stimulating myelination of cells
US5858725A (en) 1990-10-10 1999-01-12 Glaxo Wellcome Inc. Preparation of chimaeric antibodies using the recombinant PCR strategy
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
US5843749A (en) 1991-07-26 1998-12-01 Regeneron Pharmaceuticals, Inc. Ehk and Ror tyrosine kinases
US5855885A (en) 1993-01-22 1999-01-05 Smith; Rodger Isolation and production of catalytic antibodies using phage technology
US7473423B2 (en) 1994-04-29 2009-01-06 Mayo Foundation For Medical Education And Research Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
ES2292173T3 (es) 1994-12-30 2008-03-01 Planet Biotechnology, Inc. Procedimiento para producir inmunoglobulinas que contienen proteinas de proteccion en plantas y sus usos.
JP4423680B2 (ja) 1995-06-07 2010-03-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Ｃｄｒ−グラフト化抗組織因子抗体及びその使用
US6037454A (en) 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
US6133426A (en) 1997-02-21 2000-10-17 Genentech, Inc. Humanized anti-IL-8 monoclonal antibodies
WO1998041541A1 (fr) 1997-03-19 1998-09-24 Johns Hopkins University Utilisations therapeutiques de molecules de proteines grip et apparentees a grip
DK1032660T3 (da) 1997-11-17 2010-01-18 Micromet Ag Fremgangsmåde til identivicering af bindingsstedsdominans som bevarer evnen til at binde til en epitop
PL343322A1 (en) 1998-04-03 2001-08-13 Chugai Pharmaceutical Co Ltd Humanized antibody against human tissue factor (tf) and process for constructing humanized antibody
US6605709B1 (en) 1999-04-09 2003-08-12 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Proteus mirabilis for diagnostics and therapeutics
EP1267926A2 (fr) 2000-03-17 2003-01-02 Millennium Pharmaceuticals, Inc. Methode d'inhibition de la stenose et de la restenose
PT2281843T (pt) 2000-06-16 2017-01-02 Human Genome Sciences Inc Anticorpos que se ligam imunoespecificamente a blys
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7214786B2 (en) 2000-12-14 2007-05-08 Kovalic David K Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
US20140072980A1 (en) 2001-01-16 2014-03-13 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
US20140072979A1 (en) 2001-01-16 2014-03-13 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
AU2002245272B2 (en) 2001-01-16 2006-06-29 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
JP2004538324A (ja) 2001-08-03 2004-12-24 メディカル リサーチ カウンシル 細胞内抗体
ES2466377T3 (es) 2001-08-23 2014-06-10 Rsr Limited Regiones epitópicas de un receptor de tirotropina (TSH), usos de las mismas y anticuerpos para las mismas
US7226594B2 (en) 2001-11-07 2007-06-05 Agensys, Inc. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
JP4063769B2 (ja) 2001-12-28 2008-03-19 中外製薬株式会社 タンパク質安定化方法
ATE509032T1 (de) 2002-02-13 2011-05-15 Ludwig Inst For Cancer Res Ltd Chimerizierte gm-csf antikörper
US7314974B2 (en) 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
US20060234226A1 (en) 2002-04-26 2006-10-19 Fahner Robert L Non-affinity purification of proteins
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
EP1544291A4 (fr) 2002-07-19 2006-08-02 Towa Kagaku Co Ltd Nouveau procede de production d'une enzyme d'anticorps, nouvelle enzyme d'anticorps et utilisation correspondante
EP2298806A1 (fr) 2002-10-16 2011-03-23 Purdue Pharma L.P. Anticorps se fixant sur des polypeptides CA 125/0722P associés à des cellules et leurs procédés d'utilisation
CA2515081A1 (fr) 2003-02-07 2004-08-19 Protein Design Labs, Inc. Anticorps anti-amphireguline (ar) et leur utilisation dans le traitement du cancer et du psoriasis
US7605235B2 (en) 2003-05-30 2009-10-20 Centocor, Inc. Anti-tissue factor antibodies and compositions
NZ543202A (en) 2003-05-31 2008-04-30 Micromet Ag Pharmaceutical composition comprising a bispecific antibody for epcam
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
AU2003271174A1 (en) 2003-10-10 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
DK1673398T3 (da) 2003-10-16 2011-04-18 Micromet Ag Multispecifikke, deimmuniserede CD3-bindere
US7612179B2 (en) 2003-11-28 2009-11-03 Astrazeneca Ab antibodies binding to a C-terminal fragment of apoliopoprotein E
KR20130133302A (ko) 2003-12-10 2013-12-06 메다렉스, 인코포레이티드 Ｉｐ―１０ 항체 및 그의 용도
US8298532B2 (en) 2004-01-16 2012-10-30 Regeneron Pharmaceuticals, Inc. Fusion polypeptides capable of activating receptors
WO2005070966A2 (fr) 2004-01-16 2005-08-04 Regeneron Pharmaceuticals, Inc. Polypeptides hybrides capables d'activer des recepteurs
SI1716178T1 (sl) 2004-02-16 2010-11-30 Micromet Ag Manj imunogene vezne molekule
EP3653641A1 (fr) 2004-02-19 2020-05-20 Genentech, Inc. Anticorps à regions hypervariables réparées
US7504086B2 (en) 2004-03-31 2009-03-17 Canon Kabushiki Kaisha Structure and method for releasing substance therefrom
WO2005100605A1 (fr) 2004-04-06 2005-10-27 The Regents Of The University Of California Recepteur a activite tyrosine kinase orphelin en tant que cible dans le cancer du sein
US7625561B2 (en) 2004-04-22 2009-12-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Diabody which specifically binds Streptococcus surface antigen I/II and methods of use thereof
JPWO2005105998A1 (ja) 2004-04-27 2008-07-31 財団法人化学及血清療法研究所 ヒト抗アミロイドβペプチド抗体およびその抗体フラグメント
UY28886A1 (es) 2004-05-10 2005-12-30 Boehringer Ingelheim Int Anticuerpos que consisten en polipéptidos y derivados conprendiendo tres secuencias conteniendo respectivamente los siguientes números de seq. id: 1-3 y 4-6; 7-9 y 10-12 y 13-15 ó 16-18
WO2005123777A2 (fr) 2004-06-09 2005-12-29 Genentech, Inc. Procede de traitement du granulome annulaire ou sarcoide
EP1778845A2 (fr) 2004-08-16 2007-05-02 CropDesign N.V. Plantes possedant des caracteristiques de croissance ameliorees et leur methode de fabrication
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
AU2005291486A1 (en) 2004-10-01 2006-04-13 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Novel antibodies directed to the mammalian EAG1 ion channel protein
WO2006067122A2 (fr) 2004-12-20 2006-06-29 Crucell Holland B.V. Molecules de liaison capables de neutraliser le virus du nil occidental et utilisations correspondantes
PT1848744E (pt) 2005-01-27 2012-04-24 Novimmune Sa Anticorpos anti-interferão gama e os seus processos de utilização
US8088976B2 (en) 2005-02-24 2012-01-03 Monsanto Technology Llc Methods for genetic control of plant pest infestation and compositions thereof
BRPI0609543B1 (pt) 2005-03-31 2021-11-09 Biomedics Inc Anticorpo monoclonal anti-cd20, hibridoma, anticorpo monoclonal anti-cd20 quimérico, anticorpo monoclonal anti-cd20 humanizado, agente de diagnóstico, e, agente terapêutico
JP5004154B2 (ja) 2005-04-06 2012-08-22 一般財団法人化学及血清療法研究所 組換え抗ボツリヌス神経毒素抗体
PL1874818T3 (pl) 2005-04-22 2011-09-30 Lilly Co Eli Przeciwciała swoiste wobec TGF-beta 1
EP1882392A4 (fr) 2005-05-10 2009-07-01 Monsanto Technology Llc Genes et leurs utilisations pour l'ameliorations de plantes
US7736647B2 (en) 2005-06-15 2010-06-15 Monoclonal Antibodies Therapeutics Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells
SG10201402712QA (en) 2005-08-31 2014-08-28 Merck Sharp & Dohme Engineered anti-il-23 antibodies
EP1948680A4 (fr) 2005-10-28 2010-01-13 Univ California Methodes et composes de detection et d'isolement de cellules lymphomatiques
WO2008103849A2 (fr) 2007-02-21 2008-08-28 The Regents Of The University Of California Méthodes et composés pour la détection et l'isolement de cellules de lymphomes
CA2627075A1 (fr) 2005-11-14 2007-05-18 Bioren, Inc. Ultra-humanisation d'anticorps par production et analyse de librairies cdr matures predites de type blast et cohorte
USRE45660E1 (en) 2006-02-14 2015-09-01 Bp Corporation North America Inc. Xylanases, nucleic acids encoding them and methods for making and using them
JPWO2007102200A1 (ja) 2006-03-07 2009-07-23 国立大学法人大阪大学 抗ｃｄ２０モノクローナル抗体
WO2007146957A2 (fr) 2006-06-13 2007-12-21 Irm Llc Procédés et compositions destinés au traitement du cancer
WO2008021290A2 (fr) 2006-08-09 2008-02-21 Homestead Clinical Corporation Protéines spécifiques d'organes et procédés d'utilisation
ES2444065T3 (es) 2006-08-18 2014-02-24 Novartis Ag Anticuerpo específico para PRLR y usos del mismo
CA2664738C (fr) 2006-09-29 2017-03-07 Oncomed Pharmaceuticals, Inc. Compositions et procedes permettant de diagnostiquer et de traiter le cancer
US7718774B2 (en) 2006-11-08 2010-05-18 Macrogenics, Inc. TES7 and antibodies that bind thereto
FR2909092B1 (fr) 2006-11-24 2012-10-19 Pf Medicament Nouveaux anticorps anti-proliferation
WO2008076868A2 (fr) 2006-12-18 2008-06-26 Abbott Laboratories Méthodes et compositions associées à la modulation du récepteur tyrosine kinase orphelin de type 1 (ror-1)
AR064610A1 (es) 2006-12-22 2009-04-15 Schering Corp Anticuerpos contra el cd200r
US8298545B2 (en) 2007-02-07 2012-10-30 The Trustees Of The University Of Pennsylvania Anti-autoimmune antibodies for treatment of pemphigus
US9745367B2 (en) 2007-03-23 2017-08-29 Novelmed Theraputics, Inc. Alternative pathway specific antibodies for treating arthritis
WO2008127735A1 (fr) 2007-04-13 2008-10-23 Stemline Therapeutics, Inc. Conjugués d'anticorps il3ralpha et leurs utilisations
EP2142640B1 (fr) 2007-05-03 2012-01-04 Regeneron Pharmaceuticals, Inc. Identification de cellules souches embryonnaires à compétence germinale
US8318163B2 (en) 2007-05-17 2012-11-27 Genentech, Inc. Anti-pan neuropilin antibody and binding fragments thereof
CN101687924A (zh) 2007-07-04 2010-03-31 株式会社未来创药研究所 抗Muc17抗体
US8299318B2 (en) 2007-07-05 2012-10-30 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
AU2008278803A1 (en) 2007-07-25 2009-01-29 Astrazeneca Ab Targeted binging agents directed to KDR and uses thereof - 035
CN101848999A (zh) 2007-09-06 2010-09-29 国立大学法人大阪大学 抗-cd20单克隆抗体
US8362325B2 (en) 2007-10-03 2013-01-29 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
US7968687B2 (en) 2007-10-19 2011-06-28 Seattle Genetics, Inc. CD19 binding agents and uses thereof
EP3211011A1 (fr) 2007-11-16 2017-08-30 Nuvelo, Inc. Anticorps pour lrp6
DK2236604T3 (en) 2007-12-05 2016-10-03 Chugai Pharmaceutical Co Ltd The anti-NR10 antibody and use thereof
PT2851374T (pt) 2007-12-14 2017-06-20 Pfizer Moléculas de ligação ao recetor humano ox40
CA2707637A1 (fr) 2007-12-17 2009-06-25 Dyax Corp. Compositions et procedes pour traiter des troubles osteolytiques comprenant des proteines de liaison a mmp-14
CA2709354C (fr) 2007-12-21 2014-06-17 Amgen Inc. Anticorps anti-amyloide et utilisations de ceux-ci
JP5690593B2 (ja) 2007-12-26 2015-03-25 ヴァクシネックス， インコーポレイテッド 抗ｃ３５抗体併用療法および方法
US8603474B2 (en) 2008-01-29 2013-12-10 Ludwig Institute For Cancer Research, Ltd. Membrane transporter NaPi2b (SCL34A1) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy
US9029636B2 (en) 2008-02-05 2015-05-12 Monsanto Technology Llc Isolated novel nucleic acid and protein molecules from soy and methods of using those molecules to generate transgenic plants with enhanced agronomic traits
AR070316A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
WO2009101611A1 (fr) 2008-02-11 2009-08-20 Curetech Ltd. Anticorps monoclonaux pour le traitement de tumeurs
JP2011517662A (ja) 2008-03-03 2011-06-16 ダイアックス コーポレーション メタロプロテアーゼ９結合タンパク質
EP2262837A4 (fr) 2008-03-12 2011-04-06 Merck Sharp & Dohme Protéines de liaison avec pd-1
CA2720614A1 (fr) 2008-04-07 2009-10-15 Kalobios Pharmaceuticals, Inc. Neutralisation de gm-csf pour le traitement d'une insuffisance cardiaque
EP2280997A2 (fr) 2008-04-18 2011-02-09 Xencor, Inc. Anticorps monoclonaux d équivalent humain conçus à partir de régions variables non humaines
US9029508B2 (en) 2008-04-29 2015-05-12 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
US8410251B2 (en) 2008-06-20 2013-04-02 National University Corporation Okayama University Antibody against calcified globule and use of the same
EP2313435A4 (fr) 2008-07-01 2012-08-08 Aveo Pharmaceuticals Inc Protéines se liant au récepteur 3 du facteur de croissance des fibroblastes (fgfr3)
MX2011000071A (es) 2008-07-02 2011-05-03 Emergent Product Dev Seattle Inmunoterapeuticos de interleucina-6 (il6).
MX2011000543A (es) 2008-07-16 2011-04-27 Inst Research In Biomedicine Anticuerpos neutralizantes de citomegalovirus humano y uso de los mismos.
US8710022B2 (en) 2008-07-18 2014-04-29 National University Corporation Nagoya University Cell proliferation inhibitor
MX2011000778A (es) 2008-07-31 2011-03-15 Basf Plant Science Gmbh Plantas con caracteristicas modificadas de crecimiento y un metodo para obtenerlas.
US8399630B2 (en) 2008-08-20 2013-03-19 Centocor Ortho Biotech Inc. Engineered anti-IL-13 antibodies, compositions, methods and uses
CA3050455A1 (fr) 2008-11-03 2010-06-03 Adc Therapeutics Sa Anticorps qui bloquent specifiquement l'activite biologique d'un antigene tumoral
US8183346B2 (en) 2008-12-05 2012-05-22 Eli Lilly And Company Anti-ferroportin 1 monoclonal antibodies and uses thereof
WO2010083179A2 (fr) 2009-01-16 2010-07-22 Monsanto Technology Llc Nouvelles molécules de protéine et d'acide nucléique isolées obtenues à partir de soja et procédés d'utilisation desdites molécules pour générer des plantes transgéniques présentant des caractéristiques agronomiques améliorées
US8673307B1 (en) 2009-03-09 2014-03-18 The Rockefeller University HIV-1 anti-core neutralizing antibodies that target a conformational epitope within the ALPHA5-helix of GP120
CN102388068B (zh) 2009-03-20 2015-05-20 安姆根有限公司 α-4-β-7异二聚体特异性拮抗剂抗体
RU2542394C2 (ru) 2009-03-24 2015-02-20 ТЕВА БИОФАРМАСЬЮТИКАЛЗ ЮЭсЭй, ИНК. Гуманизированные антитела против light и их применение
HUE025726T2 (en) 2009-03-25 2016-04-28 Genentech Inc Anti-FGFR3 antibodies and their use
WO2010117455A2 (fr) 2009-04-08 2010-10-14 U.S. Army Medical Research Institute Of Infectious Diseases Anticorps monoclonaux humains protecteurs contre la peste bubonique
DK2419447T3 (en) 2009-04-17 2017-09-25 Immunas Pharma Inc ANTIBODIES THAT SPECIFICALLY BIND TO A BETA OLIGOMER AND USE THEREOF
WO2010124188A1 (fr) 2009-04-23 2010-10-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps anti-ror1 humain
WO2010129304A2 (fr) 2009-04-27 2010-11-11 Oncomed Pharmaceuticals, Inc. Procédé de fabrication de molécules hétéromultimères
EA023179B1 (ru) 2009-08-13 2016-05-31 Круселл Холланд Б.В. Антитела против респираторного синцитиального вируса (pcb) и способы их применения
PL2470671T3 (pl) 2009-08-28 2015-05-29 Regeneron Pharma Przeciwciała antykinowe wiążące się z wieloma chemokinami CC
US8926976B2 (en) 2009-09-25 2015-01-06 Xoma Technology Ltd. Modulators
CN103403026B (zh) 2009-09-25 2016-05-11 美国政府(由卫生和人类服务部的部长所代表) Hiv-1中和抗体及其用途
DK2488867T3 (da) 2009-10-14 2020-11-09 Janssen Biotech Inc Fremgangsmåder til affinitetsmodning af antistoffer
JP5756757B2 (ja) 2009-10-30 2015-07-29 東レ株式会社 Ｃ型肝炎ウイルス（ｈｃｖ）に対して感染阻害活性を有する抗体及びその用途
US20120282177A1 (en) 2009-11-02 2012-11-08 Christian Rohlff ROR1 as Therapeutic and Diagnostic Target
CA2775373C (fr) 2009-11-11 2019-10-29 Ganymed Pharmaceuticals Ag Anticorps specifiques pour la claudine 6 (cldn6)
EP2513148B1 (fr) 2009-12-16 2016-08-31 AbbVie Biotherapeutics Inc. Anticorps anti-her2 et leurs utilisations
DK2513146T3 (en) 2009-12-18 2017-07-31 Kancera Ab Antibodies against ROR1 capable of inducing cell death by CLL
EP2534257B1 (fr) 2010-02-12 2017-09-27 Oncomed Pharmaceuticals, Inc. Procédés d'identification et d'isolement de cellules exprimant un polypeptide
US8609095B2 (en) 2010-03-04 2013-12-17 Symphogen A/S Anti-HER2 antibodies and compositions
JP6039428B2 (ja) 2010-03-04 2016-12-07 シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ 抗ｈｅｒ２抗体および組成物
CA2789071C (fr) 2010-03-05 2018-03-27 F. Hoffmann-La Roche Ag Anticorps contre le csf-1r humain et leurs utilisations
US8468130B2 (en) 2010-04-02 2013-06-18 Skyfire Labs, Inc. Assisted hybrid mobile browser
WO2011125015A2 (fr) 2010-04-05 2011-10-13 Bar-Ilan University Polypeptides formant des pores pouvant être activés par une protéase
CA2799746C (fr) 2010-05-17 2020-11-24 Sai Reddy Isolement rapide d'anticorps monoclonaux a partir d'animaux
AR081434A1 (es) 2010-06-10 2012-08-29 Lilly Co Eli Anticuerpo del peptido relacionado con el gen calcitonina (cgrp), composicion farmaceutica que lo comprende, uso de dicho anticuerpo para preparar un medicamento util para tratar dolor de osteoartritis o migranas y fragmento de union a antigeno de dicho anticuerpo
JP2012021943A (ja) 2010-07-16 2012-02-02 National Cancer Center 子宮体がんの検査方法、子宮体がんの検査薬、並びに子宮体がん抗原に対する抗体
US9163258B2 (en) 2010-07-23 2015-10-20 Fred Hutchinson Cancer Research Center Method for the treatment of obesity
CN103221429A (zh) 2010-09-22 2013-07-24 诺沃—诺迪斯克有限公司 治疗因子viii抗体
EP3828205A1 (fr) 2010-10-01 2021-06-02 Oxford BioTherapeutics Ltd Anticorps anti-ror1
BR112013010544A2 (pt) 2010-10-29 2016-08-02 Immunogen Inc moléculas de ligação ao egfr e imunoconjugados das mesmas
JO3756B1 (ar) 2010-11-23 2021-01-31 Regeneron Pharma اجسام مضادة بشرية لمستقبلات الجلوكاجون
EP2455403A1 (fr) 2010-11-23 2012-05-23 Pierre Fabre Medicament Anticorps humanisés homogènes contre JAM-A qui inhibitent la prolifération
WO2012075158A1 (fr) 2010-12-01 2012-06-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps ror1 chimériques lapin/humain
GB201020995D0 (en) 2010-12-10 2011-01-26 Bioinvent Int Ab Biological materials and uses thereof
JP2014506257A (ja) 2011-01-06 2014-03-13 ダイアックス コーポレーション 血漿カリクレイン結合タンパク質
ES2865068T3 (es) 2011-01-14 2021-10-14 Univ California Anticuerpos terapéuticos contra la proteína ROR-1 y métodos para usarlos
AU2012217867A1 (en) 2011-02-14 2013-09-05 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of influenza
WO2012118693A1 (fr) 2011-02-28 2012-09-07 Northshore University Healthsystem Méthodes de diagnostic d'infection par clostridium difficile
RU2592686C2 (ru) 2011-04-22 2016-07-27 ВАЙЕТ ЭлЭлСи Композиции, относящиеся к мутантному токсину clostridium difficile, и способы их применения
CN107090043B (zh) 2011-05-13 2021-12-07 加尼梅德药物公司 用于治疗表达密蛋白6之癌症的抗体
WO2013019730A1 (fr) 2011-07-29 2013-02-07 The Washington University Anticorps dirigés contre la tip-1 et la grp78
EP2742067A4 (fr) 2011-08-12 2015-03-04 Omeros Corp Anticorps monoclonaux anti-fzd10 et leurs procédés d'utilisation
CN107722122B (zh) 2011-09-23 2022-05-27 昂考梅德药品有限公司 Vegf/dll4结合剂及其应用
PT2766395T (pt) 2011-10-13 2020-02-04 Domantis Ltd Polipéptidos de anticorpo que antagonizam cd40l
AU2012325804B2 (en) 2011-10-19 2017-09-07 Pharmacyclics Llc Use of inhibitors of Bruton's tyrosine kinase (Btk)
EP2589609A1 (fr) 2011-11-03 2013-05-08 Pierre Fabre Medicament Protéine se liant à un antigène et son utilisation pour l'adressage d'un produit pour le traitement du cancer
US20130131139A1 (en) * 2011-11-17 2013-05-23 Oregon Health & Science University Ror1 as a gene target in acute lymphoblastic leukemia
EP2617319A1 (fr) 2012-01-17 2013-07-24 Braun GmbH Portion de tête et portion de poignée d'un dispositif de soins oraux
PL2818483T3 (pl) 2012-02-21 2018-01-31 Toray Industries Kompozycja lecznicza do leczenia i/lub zapobiegania nowotworowi
PL2818482T3 (pl) 2012-02-21 2019-11-29 Toray Industries Kompozycja farmaceutyczna do leczenia nowotworu
RU2014138474A (ru) 2012-02-24 2016-04-10 СтемСентРкс, Инк. Новые модуляторы и способы применения
EP2832856A4 (fr) 2012-03-29 2016-01-27 Chugai Pharmaceutical Co Ltd Anticorps anti-lamp5 et son utilisation
CN104203281B (zh) 2012-03-30 2019-07-26 东丽株式会社 胆囊癌的治疗和/或预防用药物组合物
EP2832365B1 (fr) 2012-03-30 2017-11-01 Toray Industries, Inc. Composition pharmaceutique pour le traitement et/ou la prévention du cancer du foie
EP2834271B1 (fr) 2012-04-03 2019-01-16 NovelMed Therapeutics, Inc. Anticorps anti-facteur bb humanisés et chimériques, et leurs utilisations
EP2844300B1 (fr) 2012-05-01 2018-10-17 Genentech, Inc. Anticorps anti-pmel17 et immunoconjugués
RU2014145633A (ru) 2012-05-14 2016-07-10 Дженентек, Инк. Композиции и способы для диагностики и лечения опухолей
CN103421113B (zh) 2012-05-22 2018-01-19 武汉华鑫康源生物医药有限公司 抗BLyS抗体
JO3462B1 (ar) 2012-08-22 2020-07-05 Regeneron Pharma أجسام مضادة بشرية تجاه gfr?3 وطرق لاستخدامها
KR102312856B1 (ko) 2012-08-24 2021-10-13 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신
CN103792364B (zh) 2012-10-31 2016-06-08 张宝弘 用于检测外周血中循环肿瘤细胞ror1蛋白的试剂及其应用
TW202206465A (zh) 2012-11-14 2022-02-16 美商再生元醫藥公司 重組細胞表面捕捉蛋白質
SG11201506650PA (en) 2013-02-22 2015-09-29 Stemcentrx Inc Novel antibody conjugates and uses thereof
EP2789630A1 (fr) 2013-04-09 2014-10-15 EngMab AG Anticorps bispécifiques contre le CD3e et ROR1
JP2016518382A (ja) 2013-04-26 2016-06-23 ピエール、ファーブル、メディカマン Ａｘｌ抗体薬物複合体および癌の治療のためのその使用
MA38632B1 (fr) 2013-05-20 2019-10-31 Genentech Inc Anticorps anti-récepteur de transferrine et procédés d'utilisation
WO2015014376A1 (fr) 2013-07-31 2015-02-05 Biontech Ag Diagnostic et thérapie du cancer impliquant des cellules souches cancéreuses
EP3038659A4 (fr) 2013-08-28 2017-07-26 AbbVie Stemcentrx LLC Conjugués anti-dll3 modifiés et procédés d'utilisation
MX2016005763A (es) 2013-11-06 2016-08-19 Stemcentrx Inc Anticuerpos anti-claudina novedosos y metodos de uso.
RU2685914C1 (ru) 2013-12-11 2019-04-23 Регенерон Фармасьютикалс, Инк. Способы и композиции для направленной модификации генома
CA2931340A1 (fr) 2013-12-13 2015-06-18 Genentech, Inc. Anticorps et immunoconjugues anti-cd33
UA120753C2 (uk) 2013-12-17 2020-02-10 Дженентек, Інк. Біспецифічне антитіло до сd3 та cd20
US10183989B2 (en) 2013-12-24 2019-01-22 Novelmed Therapeutics, Inc. Methods of treating ocular diseases
US10308721B2 (en) 2014-02-21 2019-06-04 Abbvie Stemcentrx Llc Anti-DLL3 antibodies and drug conjugates for use in melanoma
HUE050355T2 (hu) 2014-04-01 2020-12-28 Biontech Cell & Gene Therapies Gmbh Claudin-6-specifikus immunreceptorok és T-sejt-epitópok
SG10202109752XA (en) * 2014-04-07 2021-10-28 Novartis Ag Treatment of cancer using anti-cd19 chimeric antigen receptor
CN106470708B (zh) 2014-04-25 2019-12-31 皮埃尔法布雷医药公司 抗体-药物-缀合物和其用于治疗癌症的用途
CN109996544A (zh) 2016-06-27 2019-07-09 加利福尼亚大学董事会 癌症治疗组合
CA3067829A1 (fr) * 2017-06-23 2018-12-27 VelosBio Inc. Immunoconjugues d'anticorps ror1

Also Published As

Publication number Publication date
AR108889A1 (es) 2018-10-03
KR20190022752A (ko) 2019-03-06
MX2018016330A (es) 2020-02-17
IL263802B1 (en) 2023-01-01
JP2019520426A (ja) 2019-07-18
MY196869A (en) 2023-05-05
TW201806622A (zh) 2018-03-01
TWI767915B (zh) 2022-06-21
IL263802B2 (en) 2023-05-01
JP7109007B2 (ja) 2022-07-29
JP2022133402A (ja) 2022-09-13
WO2018005519A3 (fr) 2018-02-15
US20240115700A1 (en) 2024-04-11
AU2017289270A1 (en) 2019-01-24
AU2017289270B2 (en) 2023-05-04
KR20230047507A (ko) 2023-04-07
IL263802A (en) 2019-01-31
CN109996544A (zh) 2019-07-09
US11654193B2 (en) 2023-05-23
US20170368173A1 (en) 2017-12-28
EP3474854A4 (fr) 2020-02-19
CA3029003A1 (fr) 2018-01-04
US20210038716A1 (en) 2021-02-11
IL299099A (en) 2023-02-01
US10688181B2 (en) 2020-06-23
WO2018005519A2 (fr) 2018-01-04
EP3474854A2 (fr) 2019-05-01
PH12019500025A1 (en) 2019-10-21

Similar Documents

Publication Publication Date Title
SG11201811559WA (en) Cancer treatment combinations
SG11201908330PA (en) Farnesoid x receptor agonists and uses thereof
SG11201900344YA (en) Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
SG11201811432WA (en) Rna for cancer therapy
SG11201806515RA (en) Eribulin-based antibody-drug conjugates and methods of use
SG11201908517XA (en) Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders
SG11201808990QA (en) Compositions for topical application of compounds
SG11201900163PA (en) Macrocycle kinase inhibitors
SG11201804647TA (en) Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
SG11201809982RA (en) Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents
SG11201900554YA (en) Spiro-lactam nmda modulators and methods of using same
SG11201810280YA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201808676RA (en) Methods of treating pediatric cancers
SG11201806251WA (en) Methods for treating er+, her2-, hrg+ breast cancer using combination therapies comprising an anti-erbb3 antibody
SG11201900558RA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201909155VA (en) Ask1 inhibitor compounds and uses thereof
SG11201900551WA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201808237UA (en) Substituted indole compound derivatives as dengue viral replication inhibitors
SG11201900546UA (en) Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
SG11201809751XA (en) Egfr inhibitor compounds
SG11201808222RA (en) Methods of treatment of cholestatic diseases
SG11201811230RA (en) Compositions and methods for reducing ocular neovascularization
SG11201900443VA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201903312VA (en) Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
SG11202000333UA (en) Bicyclic ketone compounds and methods of use thereof