DK1032660T3 - Fremgangsmåde til identivicering af bindingsstedsdominans som bevarer evnen til at binde til en epitop - Google Patents
Fremgangsmåde til identivicering af bindingsstedsdominans som bevarer evnen til at binde til en epitopInfo
- Publication number
- DK1032660T3 DK1032660T3 DK98963460.5T DK98963460T DK1032660T3 DK 1032660 T3 DK1032660 T3 DK 1032660T3 DK 98963460 T DK98963460 T DK 98963460T DK 1032660 T3 DK1032660 T3 DK 1032660T3
- Authority
- DK
- Denmark
- Prior art keywords
- binding site
- epitope
- dominance
- retains
- bind
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70528—CD58
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97120096 | 1997-11-17 | ||
PCT/EP1998/007313 WO1999025818A1 (en) | 1997-11-17 | 1998-11-16 | Method of identifying binding site domains that retain the capacity of binding to an epitope |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1032660T3 true DK1032660T3 (da) | 2010-01-18 |
Family
ID=8227629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98963460.5T DK1032660T3 (da) | 1997-11-17 | 1998-11-16 | Fremgangsmåde til identivicering af bindingsstedsdominans som bevarer evnen til at binde til en epitop |
Country Status (13)
Country | Link |
---|---|
US (1) | US7435549B1 (da) |
EP (1) | EP1032660B1 (da) |
JP (2) | JP4327350B2 (da) |
AT (1) | ATE447613T1 (da) |
AU (1) | AU1873199A (da) |
CA (1) | CA2309679C (da) |
CY (1) | CY1110699T1 (da) |
DE (1) | DE69841273D1 (da) |
DK (1) | DK1032660T3 (da) |
ES (1) | ES2334184T3 (da) |
HK (1) | HK1031740A1 (da) |
PT (1) | PT1032660E (da) |
WO (1) | WO1999025818A1 (da) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6420110B1 (en) | 1998-10-19 | 2002-07-16 | Gpc Biotech, Inc. | Methods and reagents for isolating biologically active peptides |
GB9917027D0 (en) * | 1999-07-20 | 1999-09-22 | Affibody Technology Sweeden Ab | In vitro selection and optional identification of polypeptides using solid support carriers |
PL358215A1 (en) * | 2000-03-24 | 2004-08-09 | Micromet Ag | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
US20020137022A1 (en) * | 2000-08-02 | 2002-09-26 | Min Li | Methods and compositions for the construction and use of envelope viruses as display particles |
RU2005137325A (ru) | 2003-05-31 | 2006-09-10 | Микромет Аг (De) | Фармацевтическая композиция, содержащая конструкт, специфичный к ерсам |
EP1673398B1 (en) | 2003-10-16 | 2010-12-29 | Micromet AG | Multispecific deimmunized cd3-binders |
EP2102239B1 (en) * | 2006-11-30 | 2012-04-25 | Research Development Foundation | Improved immunoglobulin libraries |
TWI653333B (zh) | 2010-04-01 | 2019-03-11 | 安進研究(慕尼黑)有限責任公司 | 跨物種專一性之PSMAxCD3雙專一性單鏈抗體 |
US9255595B2 (en) * | 2011-04-29 | 2016-02-09 | Bae Systems Information And Electronic Systems Integration Inc. | Optical dome bezel |
KR102134088B1 (ko) | 2012-08-24 | 2020-07-14 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신 |
CA2925393C (en) | 2013-10-11 | 2023-03-07 | Dimiter Dimitrov | Tem8 antibodies and their use |
WO2015103549A1 (en) | 2014-01-03 | 2015-07-09 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
EP3218397B8 (en) | 2014-11-14 | 2021-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to ebola virus glycoprotein and their use |
KR20170140180A (ko) | 2015-02-24 | 2017-12-20 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 중동 호흡기 증후군 코로나 바이러스 면역원, 항체 및 그 용도 |
PL3271389T3 (pl) | 2015-03-20 | 2020-08-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizujące przeciwciała wiążące się z gp120 i ich stosowanie |
CA2997809A1 (en) | 2015-10-07 | 2017-04-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Il-7r-alpha specific antibodies for treating acute lymphoblastic leukemia |
WO2017079479A1 (en) | 2015-11-03 | 2017-05-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human | Neutralizing antibodies to hiv-1 gp41 and their use |
WO2017192589A1 (en) | 2016-05-02 | 2017-11-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to influenza ha and their use and identification |
EP3474854A4 (en) | 2016-06-27 | 2020-02-19 | The Regents of The University of California | DRUG ASSOCIATIONS FOR THE TREATMENT OF CANCER |
WO2018148660A1 (en) | 2017-02-10 | 2018-08-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use |
EP3724223A1 (en) | 2018-01-02 | 2020-10-21 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Neutralizing antibodies to ebola virus glycoprotein and their use |
CN111971299A (zh) | 2018-02-21 | 2020-11-20 | 美国政府(由卫生和人类服务部的部长所代表) | HIV-1 Env的中和抗体及其用途 |
EP3883609A2 (en) | 2018-12-20 | 2021-09-29 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Ebola virus glycoprotein-specific monoclonal antibodies and uses thereof |
US20220227853A1 (en) | 2019-05-03 | 2022-07-21 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use |
US20230085439A1 (en) | 2019-05-21 | 2023-03-16 | University Of Georgia Research Foundation, Inc. | Antibodies that bind human metapneumovirus fusion protein and their use |
CN114269783B (zh) | 2019-07-02 | 2024-03-26 | 美国政府(由卫生和人类服务部的部长所代表) | 结合egfrviii的单克隆抗体及其应用 |
AU2021374036A1 (en) | 2020-11-06 | 2023-06-08 | Amgen Inc. | Polypeptide constructs selectively binding to cldn6 and cd3 |
WO2022132904A1 (en) | 2020-12-17 | 2022-06-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies targeting sars-cov-2 |
AU2021414400A1 (en) | 2020-12-31 | 2023-08-17 | Innate Pharma | Multifunctional natural killer (nk) cell engagers binding to nkp46 and cd123 |
CN117642178A (zh) | 2021-02-09 | 2024-03-01 | 美国政府(由卫生和人类服务部的部长所代表) | 靶向冠状病毒刺突蛋白的抗体 |
CN117396502A (zh) | 2021-02-09 | 2024-01-12 | 佐治亚大学研究基金会有限公司 | 针对肺炎球菌抗原的人类单克隆抗体 |
WO2023044272A1 (en) | 2021-09-17 | 2023-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies |
WO2023154824A1 (en) | 2022-02-10 | 2023-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that broadly target coronaviruses |
WO2023192881A1 (en) | 2022-03-28 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
WO2024030829A1 (en) | 2022-08-01 | 2024-02-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies that bind to the underside of influenza viral neuraminidase |
WO2024054822A1 (en) | 2022-09-07 | 2024-03-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Engineered sars-cov-2 antibodies with increased neutralization breadth |
WO2024064826A1 (en) | 2022-09-22 | 2024-03-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
DK1471142T3 (da) * | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
US5637481A (en) * | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
JPH08502645A (ja) * | 1992-09-04 | 1996-03-26 | ザ スクリップス リサーチ インスティテュート | 表面レセプター及び表面異種タンパク質を同時発現するファージミド |
EP0672142B1 (en) * | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
RU2170257C2 (ru) | 1994-03-17 | 2001-07-10 | Мерк Патент Гмбх | Анти-эфрр одноцепочечный fv, химерное анти-эфрр антитело и способ его получения, фармацевтическая композиция для лечения опухолей, средство для диагностики локализации или оценки роста опухоли |
GB9500851D0 (en) * | 1995-01-17 | 1995-03-08 | Bionvent International Ab | Method of selecting specific bacteriophages |
ES2176574T3 (es) * | 1996-09-03 | 2002-12-01 | Gsf Forschungszentrum Umwelt | Utilizacion de anticuerpos bi y triespecificos para la induccion de inmunidad tumoral. |
WO1999006587A2 (en) * | 1997-08-01 | 1999-02-11 | Morphosys Ag | Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex |
-
1998
- 1998-11-16 EP EP98963460A patent/EP1032660B1/en not_active Expired - Lifetime
- 1998-11-16 AU AU18731/99A patent/AU1873199A/en not_active Abandoned
- 1998-11-16 AT AT98963460T patent/ATE447613T1/de active
- 1998-11-16 DE DE69841273T patent/DE69841273D1/de not_active Expired - Lifetime
- 1998-11-16 ES ES98963460T patent/ES2334184T3/es not_active Expired - Lifetime
- 1998-11-16 WO PCT/EP1998/007313 patent/WO1999025818A1/en active Application Filing
- 1998-11-16 CA CA2309679A patent/CA2309679C/en not_active Expired - Lifetime
- 1998-11-16 JP JP2000521184A patent/JP4327350B2/ja not_active Expired - Lifetime
- 1998-11-16 PT PT98963460T patent/PT1032660E/pt unknown
- 1998-11-16 US US09/554,465 patent/US7435549B1/en not_active Expired - Fee Related
- 1998-11-16 DK DK98963460.5T patent/DK1032660T3/da active
-
2001
- 2001-02-23 HK HK01101344.0A patent/HK1031740A1/xx not_active IP Right Cessation
-
2009
- 2009-02-18 JP JP2009034882A patent/JP4977156B2/ja not_active Expired - Lifetime
-
2010
- 2010-01-19 CY CY20101100054T patent/CY1110699T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE447613T1 (de) | 2009-11-15 |
PT1032660E (pt) | 2009-12-28 |
HK1031740A1 (en) | 2001-06-22 |
CY1110699T1 (el) | 2015-06-10 |
AU1873199A (en) | 1999-06-07 |
CA2309679A1 (en) | 1999-05-27 |
EP1032660A1 (en) | 2000-09-06 |
JP4327350B2 (ja) | 2009-09-09 |
JP4977156B2 (ja) | 2012-07-18 |
ES2334184T3 (es) | 2010-03-05 |
US7435549B1 (en) | 2008-10-14 |
WO1999025818A1 (en) | 1999-05-27 |
DE69841273D1 (de) | 2009-12-17 |
EP1032660B1 (en) | 2009-11-04 |
CA2309679C (en) | 2010-07-20 |
JP2009148280A (ja) | 2009-07-09 |
JP2002508924A (ja) | 2002-03-26 |
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