CY1110699T1 - Μεθοδος πισοτοποιησης πεδιων θεσης συνδεσης που διατηρουν την ικανοτητα συνδεσης προς εναν επιτοπο - Google Patents

Μεθοδος πισοτοποιησης πεδιων θεσης συνδεσης που διατηρουν την ικανοτητα συνδεσης προς εναν επιτοπο

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Publication number
CY1110699T1
CY1110699T1 CY20101100054T CY101100054T CY1110699T1 CY 1110699 T1 CY1110699 T1 CY 1110699T1 CY 20101100054 T CY20101100054 T CY 20101100054T CY 101100054 T CY101100054 T CY 101100054T CY 1110699 T1 CY1110699 T1 CY 1110699T1
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CY
Cyprus
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certification
site
capacity
connection
fields containing
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CY20101100054T
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English (en)
Inventor
Peter Kufer
Tobias Raum
Katrin Borschert
Florian Zettl
Ralf LUTTERBÜSE
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Micromet Ag
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Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Publication of CY1110699T1 publication Critical patent/CY1110699T1/el

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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70528—CD58
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Η παρούσα εφεύρεση αφορά μέθοδο πιστοποίησης πεδίων θέσης σύνδεσης που διατηρούν την ικανότητα σύνδεσης προς έναν επίτοπο όταν τοποθετούνται C-τερματικά από τουλάχιστον ένα περαιτέρω πεδίο σε ένα ανασυνδυασμένο δισθενές ή πολυσθενές πολυπεπτίδιο. Η παρούσα εφεύρεση περαιτέρω αφορά ένα KIT που περιλαμβάνει συστατικά, όπως πάνελ ανασυνδυασμένων φορέων βακτηριακών συλλογών, που μορφομετατρέπονται με ένα πάνελ ανασυνδυασμένων φορέων, που είναι χρήσιμο στην διεξαγωγή της μεθόδου της εφεύρεσης. Περαιτέρω, περιγράφονται πεδία θέσης σύνδεσης, πρωτεΐνες σύντηξης που λαμβάνονται με την μέθοδο της εφεύρεσης, καθώς επίσης ομοιάζοντα με αντίσωμα μόρια που περιλαμβάνουν τέτοια πεδία και πρωτεΐνες. Περαιτέρω παρέχονται φαρμακευτικές και διαγνωστικές συνθέσεις που περιέχουν τις ανωτέρω περιγραφείσες πρωτεΐνες σύντηξης και πολυπεπτίδια.
CY20101100054T 1997-11-17 2010-01-19 Μεθοδος πισοτοποιησης πεδιων θεσης συνδεσης που διατηρουν την ικανοτητα συνδεσης προς εναν επιτοπο CY1110699T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97120096 1997-11-17
EP98963460A EP1032660B1 (en) 1997-11-17 1998-11-16 Method of identifying binding site domains that retain the capacity of binding to an epitop

Publications (1)

Publication Number Publication Date
CY1110699T1 true CY1110699T1 (el) 2015-06-10

Family

ID=8227629

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100054T CY1110699T1 (el) 1997-11-17 2010-01-19 Μεθοδος πισοτοποιησης πεδιων θεσης συνδεσης που διατηρουν την ικανοτητα συνδεσης προς εναν επιτοπο

Country Status (13)

Country Link
US (1) US7435549B1 (el)
EP (1) EP1032660B1 (el)
JP (2) JP4327350B2 (el)
AT (1) ATE447613T1 (el)
AU (1) AU1873199A (el)
CA (1) CA2309679C (el)
CY (1) CY1110699T1 (el)
DE (1) DE69841273D1 (el)
DK (1) DK1032660T3 (el)
ES (1) ES2334184T3 (el)
HK (1) HK1031740A1 (el)
PT (1) PT1032660E (el)
WO (1) WO1999025818A1 (el)

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US20020137022A1 (en) * 2000-08-02 2002-09-26 Min Li Methods and compositions for the construction and use of envelope viruses as display particles
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US9758591B2 (en) 2012-08-24 2017-09-12 The Regents Of The University Of California Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis
EP3620470B1 (en) 2013-10-11 2023-07-26 The United States of America, as represented by The Secretary, Department of Health and Human Services Tem8 antibodies and their use
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US20220089694A1 (en) 2018-12-20 2022-03-24 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Ebola virus glycoprotein-specific monoclonal antibodies and uses thereof
US20220227853A1 (en) 2019-05-03 2022-07-21 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use
US20230085439A1 (en) 2019-05-21 2023-03-16 University Of Georgia Research Foundation, Inc. Antibodies that bind human metapneumovirus fusion protein and their use
AU2020299382A1 (en) 2019-07-02 2022-01-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies that bind EGFRvIII and their use
KR20230098334A (ko) 2020-11-06 2023-07-03 암젠 리서치 (뮌헨) 게엠베하 Cldn6 및 cd3에 선택적으로 결합하는 폴리펩디드 작제물
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Also Published As

Publication number Publication date
ATE447613T1 (de) 2009-11-15
JP4327350B2 (ja) 2009-09-09
WO1999025818A1 (en) 1999-05-27
CA2309679C (en) 2010-07-20
CA2309679A1 (en) 1999-05-27
PT1032660E (pt) 2009-12-28
DE69841273D1 (de) 2009-12-17
EP1032660B1 (en) 2009-11-04
JP2009148280A (ja) 2009-07-09
JP2002508924A (ja) 2002-03-26
DK1032660T3 (da) 2010-01-18
ES2334184T3 (es) 2010-03-05
EP1032660A1 (en) 2000-09-06
JP4977156B2 (ja) 2012-07-18
US7435549B1 (en) 2008-10-14
AU1873199A (en) 1999-06-07
HK1031740A1 (en) 2001-06-22

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