SG11201808830YA - Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders - Google Patents
Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disordersInfo
- Publication number
- SG11201808830YA SG11201808830YA SG11201808830YA SG11201808830YA SG11201808830YA SG 11201808830Y A SG11201808830Y A SG 11201808830YA SG 11201808830Y A SG11201808830Y A SG 11201808830YA SG 11201808830Y A SG11201808830Y A SG 11201808830YA SG 11201808830Y A SG11201808830Y A SG 11201808830YA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- compounds
- pyrazolo
- pct
- pyrimidinyl carboxamide
- Prior art date
Links
- BCJQJAVVUTUJPF-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical class N1=CC=CN2N=C(C(=O)N)C=C21 BCJQJAVVUTUJPF-UHFFFAOYSA-N 0.000 title abstract 4
- 102220240796 rs553605556 Human genes 0.000 abstract 10
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000009829 Lewy Body Disease Diseases 0.000 abstract 2
- 201000002832 Lewy body dementia Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000015872 Gaucher disease Diseases 0.000 abstract 1
- 208000001089 Multiple system atrophy Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002132 lysosomal effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662318929P | 2016-04-06 | 2016-04-06 | |
| PCT/US2017/026280 WO2017176960A1 (en) | 2016-04-06 | 2017-04-06 | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201808830YA true SG11201808830YA (en) | 2018-11-29 |
Family
ID=60001526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201808830YA SG11201808830YA (en) | 2016-04-06 | 2017-04-06 | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US11192892B2 (enExample) |
| EP (1) | EP3440080A4 (enExample) |
| JP (1) | JP7038063B2 (enExample) |
| KR (2) | KR20230104752A9 (enExample) |
| CN (1) | CN109311887B (enExample) |
| AU (1) | AU2017246455B2 (enExample) |
| BR (1) | BR112018070586A8 (enExample) |
| CA (1) | CA3020287A1 (enExample) |
| IL (1) | IL262177B (enExample) |
| MX (1) | MX2018012211A (enExample) |
| SG (1) | SG11201808830YA (enExample) |
| WO (1) | WO2017176960A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202400187T1 (it) | 2014-11-06 | 2024-07-09 | Bial R&D Investments S A | Pirazolo(1,5-a)pirimidine sostituite e loro utilizzo nel trattamento di disturbi medici |
| ES2958391T3 (es) | 2014-11-06 | 2024-02-08 | Bial R&D Invest S A | Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos |
| EP3215509B1 (en) | 2014-11-06 | 2020-02-26 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| US10787454B2 (en) | 2016-04-06 | 2020-09-29 | BIAL—BioTech Investments, Inc. | Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| AU2017246455B2 (en) | 2016-04-06 | 2021-09-30 | Bial - R&D Investments, S.A. | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| WO2017176962A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics, Inc. | Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| US11345698B2 (en) | 2016-05-05 | 2022-05-31 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders |
| BR112018072552A8 (pt) | 2016-05-05 | 2023-03-14 | Lysosomal Therapeutics Inc | Compostos de imidazo [1,2-b]piridazinas e imidazo [1,5-b] piridazinas substituídas, composição farmacêutica que os compreende e seu uso no tratamento de distúrbios médicos |
| CN110698484B (zh) * | 2019-06-05 | 2021-11-05 | 陕西理工大学 | 含吡唑并[1,5-a]嘧啶的衍生物、药用组合物及应用 |
| CN115108972A (zh) * | 2022-08-29 | 2022-09-27 | 北京迪泰医药科技有限公司 | 一种2-甲基-3-氟-5-溴吡啶的合成方法 |
| WO2025014639A2 (en) * | 2023-07-07 | 2025-01-16 | The Johns Hopkins University | Neutral sphingomyelinase inhibitors |
| WO2025146216A1 (zh) * | 2024-01-05 | 2025-07-10 | 成都赜灵生物医药科技有限公司 | 六并五氮杂环酰胺类化合物及其用途 |
| CN118184599A (zh) * | 2024-02-29 | 2024-06-14 | 重庆药友制药有限责任公司 | 一种阿莫奈韦中间体的制备方法 |
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-
2017
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- 2017-04-06 US US16/091,311 patent/US11192892B2/en active Active
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- 2017-04-06 SG SG11201808830YA patent/SG11201808830YA/en unknown
- 2017-04-06 KR KR1020187032153A patent/KR20180133461A/ko not_active Ceased
- 2017-04-06 BR BR112018070586A patent/BR112018070586A8/pt not_active Application Discontinuation
- 2017-04-06 MX MX2018012211A patent/MX2018012211A/es unknown
- 2017-04-06 WO PCT/US2017/026280 patent/WO2017176960A1/en not_active Ceased
- 2017-04-06 CN CN201780034861.3A patent/CN109311887B/zh not_active Expired - Fee Related
- 2017-04-06 CA CA3020287A patent/CA3020287A1/en active Pending
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2019
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| JP2019510790A (ja) | 2019-04-18 |
| CN109311887A (zh) | 2019-02-05 |
| RU2018138688A3 (enExample) | 2020-08-31 |
| CN109311887B (zh) | 2022-09-13 |
| RU2018138688A (ru) | 2020-05-19 |
| US9840510B1 (en) | 2017-12-12 |
| KR20180133461A (ko) | 2018-12-14 |
| EP3440080A1 (en) | 2019-02-13 |
| IL262177B (en) | 2022-06-01 |
| KR20230104752A (ko) | 2023-07-10 |
| WO2017176960A1 (en) | 2017-10-12 |
| AU2017246455A1 (en) | 2018-10-25 |
| MX2018012211A (es) | 2019-03-28 |
| CA3020287A1 (en) | 2017-10-12 |
| US11192892B2 (en) | 2021-12-07 |
| IL262177A (en) | 2018-11-29 |
| BR112018070586A2 (pt) | 2019-02-05 |
| US20190330213A1 (en) | 2019-10-31 |
| KR20230104752A9 (ko) | 2024-11-15 |
| US20200017507A1 (en) | 2020-01-16 |
| US20230098494A1 (en) | 2023-03-30 |
| US20170349598A1 (en) | 2017-12-07 |
| US12116369B2 (en) | 2024-10-15 |
| US10934298B2 (en) | 2021-03-02 |
| BR112018070586A8 (pt) | 2023-03-14 |
| EP3440080A4 (en) | 2020-01-22 |
| JP7038063B2 (ja) | 2022-03-17 |
| AU2017246455B2 (en) | 2021-09-30 |
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