SG11201706583PA - Anti-pvrig antibodies and methods of use - Google Patents

Anti-pvrig antibodies and methods of use

Info

Publication number
SG11201706583PA
SG11201706583PA SG11201706583PA SG11201706583PA SG11201706583PA SG 11201706583P A SG11201706583P A SG 11201706583PA SG 11201706583P A SG11201706583P A SG 11201706583PA SG 11201706583P A SG11201706583P A SG 11201706583PA SG 11201706583P A SG11201706583P A SG 11201706583PA
Authority
SG
Singapore
Prior art keywords
methods
pvrig antibodies
pvrig
antibodies
Prior art date
Application number
SG11201706583PA
Other languages
English (en)
Inventor
Mark White
Sandeep Kumar
Christopher Chan
Spencer Liang
Lance Stapleton
Andrew W Drake
Yosi Gozlan
Iian Vaknin
Shirley Sameah-Greenwald
Liat Dassa
Zohar Tiran
Gad S Cojocaru
Leonard Presta
Richard Theolis
Original Assignee
Compugen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55453315&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201706583P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Compugen Ltd filed Critical Compugen Ltd
Publication of SG11201706583PA publication Critical patent/SG11201706583PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
SG11201706583PA 2015-02-19 2016-02-19 Anti-pvrig antibodies and methods of use SG11201706583PA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562118208P 2015-02-19 2015-02-19
US201562141120P 2015-03-31 2015-03-31
US201562235823P 2015-10-01 2015-10-01
PCT/US2016/018809 WO2016134333A1 (fr) 2015-02-19 2016-02-19 Anticorps anti-pvrig et méthodes d'utilisation

Publications (1)

Publication Number Publication Date
SG11201706583PA true SG11201706583PA (en) 2017-09-28

Family

ID=55453315

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201706583PA SG11201706583PA (en) 2015-02-19 2016-02-19 Anti-pvrig antibodies and methods of use

Country Status (23)

Country Link
US (7) US10227408B2 (fr)
EP (4) EP3258951B1 (fr)
JP (2) JP7115856B2 (fr)
KR (1) KR102669294B1 (fr)
CN (2) CN107580500B (fr)
AU (3) AU2016219835B2 (fr)
CA (1) CA2976926A1 (fr)
CY (2) CY1122970T1 (fr)
DK (3) DK3653221T3 (fr)
ES (3) ES2806800T3 (fr)
HK (2) HK1247569A1 (fr)
HR (3) HRP20221284T1 (fr)
HU (3) HUE061084T2 (fr)
IL (2) IL254039B2 (fr)
LT (3) LT3295951T (fr)
MX (2) MX2017010667A (fr)
PL (3) PL3653221T3 (fr)
PT (3) PT3653221T (fr)
RU (2) RU2732042C2 (fr)
SG (1) SG11201706583PA (fr)
SI (2) SI3258951T1 (fr)
WO (1) WO2016134333A1 (fr)
ZA (1) ZA201706323B (fr)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130058957A1 (en) * 2010-02-23 2013-03-07 The University Of Tokyo Dendritic cell immunoreceptor agonist
RS61223B1 (sr) 2013-12-20 2021-01-29 Hutchinson Fred Cancer Res Označeni himerni efektorski molekuli i njihovi receptori
WO2016134333A1 (fr) 2015-02-19 2016-08-25 Compugen Ltd. Anticorps anti-pvrig et méthodes d'utilisation
DK3259597T3 (da) 2015-02-19 2022-05-09 Compugen Ltd Pvrig-polypeptider og fremgangsmåder til behandling
WO2016176652A2 (fr) 2015-04-29 2016-11-03 Fred Hutchinson Cancer Research Center Cellules souches modifiées et leurs utilisations
WO2016196389A1 (fr) * 2015-05-29 2016-12-08 Bristol-Myers Squibb Company Traitement du néphrocarcinome
CN115960235A (zh) * 2015-08-28 2023-04-14 艾利妥 抗siglec-7抗体及其使用方法
AU2016315892B2 (en) * 2015-09-02 2023-06-15 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for modulating T-cell mediated immune response
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
EP3347379B9 (fr) 2016-08-17 2020-03-25 Compugen Ltd. Anticorps anti-tigit, anticorps anti-pvrig et combinaisons associées
AU2017331362A1 (en) 2016-09-23 2019-03-14 Fred Hutchinson Cancer Center TCRs specific for minor histocompatibility (H) antigen HA-1 and uses thereof
CN110582299A (zh) 2017-03-15 2019-12-17 弗雷德哈钦森癌症研究中心 高亲和力mage-a1特异性tcr及其用途
JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
AU2018265856B2 (en) 2017-05-12 2023-04-27 Harpoon Therapeutics, Inc. Mesothelin binding proteins
KR102641269B1 (ko) 2017-05-24 2024-02-26 이펙터 테라퓨틱스, 인크. 개선된 항종양 면역 반응을 위한 조성물 및 방법
CA3064331A1 (fr) * 2017-06-01 2018-12-06 Compugen Ltd. Therapies a base d'anticorps a triple combinaison
MA49652A (fr) 2017-07-17 2020-05-27 Janssen Biotech Inc Régions de liaison à un antigène dirigées contre les domaines de la fibronectine de type iii et leurs procédés d'utilisation
WO2019051128A1 (fr) 2017-09-06 2019-03-14 Fred Hutchinson Cancer Research Center Récepteurs chimériques spécifiques d'étiquette strep et utilisations de ceux-ci
CN111065409A (zh) 2017-09-06 2020-04-24 弗雷德哈钦森癌症研究中心 Strep-tag特异性结合蛋白及其用途
EP3678690A1 (fr) 2017-09-06 2020-07-15 Fred Hutchinson Cancer Research Center Méthodes pour améliorer une thérapie cellulaire adoptive
SG11202003341UA (en) 2017-10-13 2020-05-28 Harpoon Therapeutics Inc B cell maturation antigen binding proteins
WO2019109047A1 (fr) 2017-12-01 2019-06-06 Fred Hutchinson Cancer Research Center Protéines de liaison spécifiques à 5t4 et leurs utilisations
WO2019140278A1 (fr) 2018-01-11 2019-07-18 Fred Hutchinson Cancer Research Center Immunothérapie ciblant des antigènes du facteur de liaison du noyau
KR20200131862A (ko) 2018-03-13 2020-11-24 터스크 테라퓨틱스 리미티드 종양 특이적 세포 고갈에 대한 항-cd25
JP7360401B2 (ja) 2018-05-31 2023-10-12 グリコネックス インコーポレイテッド バイアンテナ型ルイスｂおよびルイスｙ抗原に結合する治療抗体
EP3802605A1 (fr) 2018-06-01 2021-04-14 Compugen Ltd. Anticorps bispécifiques anti-pvrig/anti-tigit et procédés d'utilisation
SG11202100373VA (en) * 2018-07-20 2021-02-25 Surface Oncology Inc Anti-cd112r compositions and methods
WO2020018964A1 (fr) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions et procédés pour réguler l'expression de récepteurs spécifiques à l'antigène
CA3109496A1 (fr) 2018-08-22 2020-02-27 Fred Hutchinson Cancer Research Center Immunotherapie ciblant les antigenes kras ou her2
KR20210057053A (ko) 2018-08-23 2021-05-20 씨젠 인크. 항-tigit 항체
JP2022500037A (ja) * 2018-09-14 2022-01-04 キンドレッド バイオサイエンシズ インコーポレイテッド 獣医学的使用のための抗ｉｌ４受容体抗体
US20240165232A1 (en) 2018-09-24 2024-05-23 Fred Hutchinson Cancer Research Center Chimeric receptor proteins and uses thereof
US10815311B2 (en) 2018-09-25 2020-10-27 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
EA202191012A1 (ru) 2018-11-09 2021-08-17 Фред Хатчинсон Кэнсер Рисерч Сентер T-клеточные рецепторы, специфичные к мезотелину, и их применение в иммунотерапии
CN118108836A (zh) 2018-12-19 2024-05-31 胡默波斯生物医学公司 中和乙型肝炎病毒的抗体和其用途
AR117327A1 (es) 2018-12-20 2021-07-28 23Andme Inc Anticuerpos anti-cd96 y métodos de uso de estos
EP3921344A4 (fr) * 2019-02-06 2022-10-12 Pionyr Immunotherapeutics, Inc. Anticorps anti-trem1 et procédés associés
US10836828B2 (en) 2019-02-06 2020-11-17 Pionyr Immunotherapeutics, Inc. Anti-TREM1 antibodies and related methods
GB2613715B (en) 2019-02-20 2023-12-06 Fred Hutchinson Cancer Center Binding proteins specific for RAS neoantigens and uses thereof
SG11202109745PA (en) 2019-03-11 2021-10-28 Hutchinson Fred Cancer Res High avidity wt1 t cell receptors and uses thereof
BR112022001575A2 (pt) 2019-07-29 2022-04-19 Compugen Ltd Formulações de anticorpos anti-pvrig e usos dos mesmos
WO2021024020A1 (fr) 2019-08-06 2021-02-11 Astellas Pharma Inc. Polythérapie impliquant des anticorps dirigés contre la claudine 18.2 et inhibiteurs de point de contrôle immunitaire pour le traitement du cancer
US20220409661A1 (en) 2019-08-20 2022-12-29 Fred Hutchinson Cancer Research Center T-cell immunotherapy specific for wt-1
EP4021578A1 (fr) 2019-08-29 2022-07-06 VIR Biotechnology, Inc. Compositions d'anticorps et méthodes pour traiter une infection par le virus de l'hépatite b
WO2021091605A1 (fr) 2019-11-04 2021-05-14 Compugen Ltd. Polythérapie avec des formulations d'anticorps anti-pvrig et d'anticorps anti-pd-1
CA3160313A1 (fr) * 2019-11-15 2021-05-20 Surface Oncology, Inc. Compositions et methodes pour l'immunotherapie
US20230057899A1 (en) 2019-12-05 2023-02-23 Compugen Ltd. Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing
KR20220154140A (ko) * 2020-03-13 2022-11-21 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Pvrig 결합 단백질 및 이의 의학적 용도
AU2021296848A1 (en) 2020-06-24 2023-02-09 Humabs Biomed Sa Engineered hepatitis B virus neutralizing antibodies and uses thereof
CN116234568A (zh) 2020-07-07 2023-06-06 生物技术公司 用于hpv阳性癌症的治疗性rna
TW202216778A (zh) 2020-07-15 2022-05-01 美商安進公司 Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷
EP4217387A2 (fr) 2020-09-24 2023-08-02 Fred Hutchinson Cancer Center Immunothérapie ciblant des antigènes sox2
WO2022066973A1 (fr) 2020-09-24 2022-03-31 Fred Hutchinson Cancer Research Center Immunothérapie ciblant les antigènes pbk ou oip5
WO2022076353A1 (fr) 2020-10-06 2022-04-14 Fred Hutchinson Cancer Research Center Compositions et procédés de traitement de la maladie associée à l'expression de mage-a1
EP4232822A2 (fr) * 2020-10-26 2023-08-30 Compugen Ltd. Pvrl2 et/ou pvrig en tant que biomarqueurs de traitement
CN112433055A (zh) * 2020-11-04 2021-03-02 上海药明生物技术有限公司 一种基于报告基因方法检测pvrig抗体的生物学活性的方法
WO2022132836A2 (fr) 2020-12-14 2022-06-23 Fred Hutchinson Cancer Research Center Compositions et méthodes pour l'immunothérapie cellulaire
WO2022135666A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Programme de traitement faisant intervenir des protéines cytokines
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性ｒｎａ
WO2022135667A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Arn thérapeutique pour le traitement du cancer
TW202245838A (zh) 2021-01-26 2022-12-01 美商維爾生物科技股份有限公司 用於治療b型肝炎病毒感染的組成物及方法
US20240076373A1 (en) * 2021-01-28 2024-03-07 Compugen Ltd. Combination therapy with anti-pvrig antibodies formulations and anti-pd-1 antibodies
EP4284516A1 (fr) * 2021-01-28 2023-12-06 Compugen Ltd. Formulations d'anticorps anti-pvrig et leurs utilisations
EP4292611A1 (fr) * 2021-02-09 2023-12-20 Shanghai Junshi Biosciences Co., Ltd. Anticorps anti-cd112r et son utilisation
EP4291580A1 (fr) 2021-02-11 2023-12-20 Nectin Therapeutics Ltd. Anticorps dirigés contre cd112r et leurs utilisations
CN115925917A (zh) * 2021-03-08 2023-04-07 合肥天港免疫药物有限公司 抗pvrig蛋白抗体或抗体片段及其用途
EP4314060A1 (fr) 2021-03-31 2024-02-07 GlaxoSmithKline Intellectual Property Development Limited Protéines de liaison à l'antigène et leurs combinaisons
WO2022258049A1 (fr) * 2021-06-10 2022-12-15 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Animal non humain génétiquement modifié comportant des pvrig humains ou chimériques
EP4363450A1 (fr) * 2021-07-01 2024-05-08 Compugen Ltd. Anticorps anti-tigit et anti-pvp en monothérapie et traitements combinés
KR20240046323A (ko) 2021-07-13 2024-04-08 비온테크 에스이 암에 대한 병용 요법에 있어서 cd40 및 cd137에 대한 다중특이 결합제
WO2023288281A2 (fr) 2021-07-15 2023-01-19 Fred Hutchinson Cancer Center Polypeptides chimériques
CN117751143A (zh) 2021-07-30 2024-03-22 山东先声生物制药有限公司 抗pvrig/抗tigit双特异性抗体和应用
TW202327649A (zh) * 2021-09-15 2023-07-16 大陸商江蘇恆瑞醫藥股份有限公司 Ｐｖｒｉｇ／ｔｉｇｉｔ結合蛋白聯合免疫檢查點抑制劑用於治療癌症
CA3231320A1 (fr) 2021-09-15 2023-03-23 Zhiliang CAO Proteine se liant de maniere specifique a pd-1 et son utilisation pharmaceutique
TW202317644A (zh) 2021-09-15 2023-05-01 大陸商江蘇恆瑞醫藥股份有限公司 一種含抗ｐｖｒｉｇ／ｔｉｇｉｔ雙特異性抗體的醫藥組成物
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
WO2023064958A1 (fr) 2021-10-15 2023-04-20 Compugen Ltd. Polythérapie avec des formulations d'anticorps anti-pvrig, d'anticorps anti-tigit et d'anticorps anti-pd-1
WO2023178192A1 (fr) 2022-03-15 2023-09-21 Compugen Ltd. Anticorps antagonistes de l'il-18bp et leur utilisation en monothérapie et polythérapie dans le traitement du cancer
US20240103010A1 (en) 2022-03-18 2024-03-28 Compugen Ltd. Pvrl2 and/or pvrig as biomarkers for treatment
CN116925222A (zh) * 2022-04-02 2023-10-24 普米斯生物技术(珠海)有限公司 抗pvrig抗体、其药物组合物及用途
CN116925233A (zh) * 2022-04-02 2023-10-24 普米斯生物技术(珠海)有限公司 抗tigit-抗pvrig双特异性抗体、其药物组合物及用途
WO2023215725A1 (fr) 2022-05-02 2023-11-09 Fred Hutchinson Cancer Center Compositions et méthodes pour l'immunothérapie cellulaire
WO2023230439A1 (fr) 2022-05-23 2023-11-30 Vir Biotechnology, Inc. Anticorps neutralisants à fc modifié contre le virus de l'hépatite b et utilisations associées
US20240109965A1 (en) * 2022-06-14 2024-04-04 Ablynx N.V. Immunoglobulin single variable domains targeting t cell receptor
WO2024026496A1 (fr) 2022-07-28 2024-02-01 Compugen Ltd. Polythérapie avec des formulations d'anticorps anti-pvrig et des anticorps anti-pd-1
WO2024032700A1 (fr) * 2022-08-10 2024-02-15 Beigene, Ltd. Anticorps anti-pvrig et procédés d'utilisation
CN117957254A (zh) * 2022-08-31 2024-04-30 石药集团巨石生物制药有限公司 抗pvrig抗体及其应用
WO2024098980A1 (fr) * 2022-11-10 2024-05-16 Huahui Health Ltd. Anticorps anti-cd112r et leur utilisation

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
DE3883899T3 (de) 1987-03-18 1999-04-22 Sb2 Inc Geänderte antikörper.
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
CA2006596C (fr) 1988-12-22 2000-09-05 Rika Ishikawa G-csf modifie chimiquement
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
AU4116793A (en) 1992-04-24 1993-11-29 Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
US5837242A (en) 1992-12-04 1998-11-17 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
CA2163345A1 (fr) 1993-06-16 1994-12-22 Susan Adrienne Morgan Anticorps
US6214388B1 (en) 1994-11-09 2001-04-10 The Regents Of The University Of California Immunoliposomes that optimize internalization into target cells
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5922845A (en) 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US7368531B2 (en) 1997-03-07 2008-05-06 Human Genome Sciences, Inc. Human secreted proteins
US20040002117A1 (en) 1998-02-12 2004-01-01 Hogan Patrick G. Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
DK2180007T4 (da) 1998-04-20 2017-11-27 Roche Glycart Ag Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
KR101077001B1 (ko) 1999-01-15 2011-10-26 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
WO2000052151A2 (fr) 1999-03-05 2000-09-08 Incyte Pharmaceuticals, Inc. Proteines de secretion humaines
PT1176195E (pt) 1999-04-09 2013-07-18 Kyowa Hakko Kirin Co Ltd Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico
US20030224379A1 (en) 2000-01-21 2003-12-04 Tang Y. Tom Novel nucleic acids and polypeptides
WO2002090520A2 (fr) 2001-05-09 2002-11-14 Yale University Proteine adaptatrice receptrice de la toll/interleukine-1 (tirap)
KR100988949B1 (ko) 2001-10-25 2010-10-20 제넨테크, 인크. 당단백질 조성물
PL373256A1 (en) 2002-04-09 2005-08-22 Kyowa Hakko Kogyo Co, Ltd. Cells with modified genome
EP1539228B1 (fr) 2002-09-11 2010-12-29 Genentech, Inc. Nouvelles composition et methodes servant au traitement de maladies associees au systeme immunitaire
US20070224201A1 (en) 2002-10-02 2007-09-27 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2004058805A2 (fr) 2002-12-26 2004-07-15 Asahi Kasei Pharma Corporation Gene d'activation des lymphocytes t
ZA200507757B (en) 2003-04-04 2007-01-31 Genentech Inc High concentration antibody and protein formulations
WO2005019258A2 (fr) 2003-08-11 2005-03-03 Genentech, Inc. Compositions et methodes de traitement de maladies relatives au systeme immunitaire
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
US7622265B2 (en) 2005-02-22 2009-11-24 Genentech, Inc. Methods and compositions for modulating prostasin
WO2006124667A2 (fr) 2005-05-12 2006-11-23 Zymogenetics, Inc. Compositions et procedes permettant de moduler des reponses immunitaires
EP2007806A2 (fr) 2006-04-13 2008-12-31 ZymoGenetics, Inc. Polypeptides tetramerisants et procedes d'utilisation
WO2007124283A2 (fr) 2006-04-13 2007-11-01 Zymogenetics, Inc. tetramerisation de polypeptides et procedes d'utilisation
US20090318376A1 (en) 2006-06-15 2009-12-24 Korea Research Institute Of Bioscience And Biotechnology High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby
EP2520935A3 (fr) 2006-08-09 2013-02-13 Homestead Clinical Corporation Protéines spécifiques d'organes et leurs procédés d'utilisation
JPWO2008044754A1 (ja) * 2006-10-06 2010-02-18 武田薬品工業株式会社 癌の予防・治療剤
AU2008282863A1 (en) * 2007-07-31 2009-02-05 Merck Sharp & Dohme Corp. IGF-1R specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
US20120082659A1 (en) 2007-10-02 2012-04-05 Hartmut Land Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
US20090258013A1 (en) 2008-04-09 2009-10-15 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
CA2745961A1 (fr) 2008-12-04 2010-06-10 The Regents Of The University Of California Materiels et methodes de diagnostic et de pronostic d'un cancer de la prostate
JP5725508B2 (ja) 2009-03-25 2015-05-27 国立大学法人東北大学 Ｌｈ型二重特異性抗体
TW201132813A (en) 2010-03-03 2011-10-01 Koo Foundation Sun Yat Sen Cancer Ct Methods for classifying and treating breast cancers
WO2012031008A2 (fr) 2010-08-31 2012-03-08 The General Hospital Corporation Matières biologiques liées au cancer dans des microvésicules
WO2012129488A2 (fr) 2011-03-23 2012-09-27 Virginia Commonwealth University Signatures géniques associées au rejet ou à la récurrence du cancer
EP2710147A1 (fr) 2011-05-18 2014-03-26 Rheinische Friedrich-Wilhelms-Universität Bonn Analyse moléculaire de la leucémie myéloïde aiguë
WO2012178128A1 (fr) * 2011-06-22 2012-12-27 Oncocyte Corporation Procédés et compositions permettant le traitement et le diagnostic du cancer
AU2013271515A1 (en) 2012-06-06 2015-01-15 Oncomed Pharmaceuticals, Inc. Binding agents that modulate the Hippo pathway and uses thereof
CN103073644B (zh) 2012-12-31 2014-03-12 中国科学技术大学 特异性抗小鼠tigit的单克隆抗体及其制备方法、鉴定及应用
RS60826B1 (sr) 2013-07-16 2020-10-30 Hoffmann La Roche Postupci lečenja kancera upotrebom antagonista vezivanja pd-1 ose i tigit inhibitora
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JP6920194B2 (ja) 2014-08-19 2021-08-18 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗ｔｉｇｉｔ抗体
PT3221346T (pt) 2014-11-21 2020-10-23 Bristol Myers Squibb Co Anticorpos compreendendo regiões constantes de cadeia pesada modificadas
MA40662B1 (fr) 2014-12-23 2020-12-31 Bristol Myers Squibb Co Anticorps contre tigit
WO2016134333A1 (fr) 2015-02-19 2016-08-25 Compugen Ltd. Anticorps anti-pvrig et méthodes d'utilisation
DK3259597T3 (da) 2015-02-19 2022-05-09 Compugen Ltd Pvrig-polypeptider og fremgangsmåder til behandling
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Ｔｉｇｉｔ結合劑和彼之用途
WO2016196389A1 (fr) 2015-05-29 2016-12-08 Bristol-Myers Squibb Company Traitement du néphrocarcinome
JO3620B1 (ar) * 2015-08-05 2020-08-27 Amgen Res Munich Gmbh مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم
AU2016315892B2 (en) * 2015-09-02 2023-06-15 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for modulating T-cell mediated immune response
RU2732591C2 (ru) 2015-09-25 2020-09-21 Дженентек, Инк. Анти-tigit антитела и способы применения
CN108368176B (zh) 2015-10-01 2022-06-07 波滕扎治疗公司 抗tigit抗原结合蛋白及其使用方法
WO2018017864A2 (fr) 2016-07-20 2018-01-25 Oncomed Pharmaceuticals, Inc. Agents de liaison à pvrig et leurs utilisations
EP3347379B9 (fr) 2016-08-17 2020-03-25 Compugen Ltd. Anticorps anti-tigit, anticorps anti-pvrig et combinaisons associées

Also Published As

Publication number Publication date
US20210188974A1 (en) 2021-06-24
HUE049032T2 (hu) 2020-08-28
CA2976926A1 (fr) 2016-08-25
HK1247569A1 (zh) 2018-09-28
IL254039B1 (en) 2023-08-01
US20160244521A1 (en) 2016-08-25
PL3653221T3 (pl) 2022-12-19
EP3295951A1 (fr) 2018-03-21
RU2017132214A (ru) 2019-03-19
AU2020264349A1 (en) 2020-12-03
PT3653221T (pt) 2022-11-08
JP7115856B2 (ja) 2022-08-09
KR102669294B1 (ko) 2024-05-23
US10351625B2 (en) 2019-07-16
HUE061084T2 (hu) 2023-05-28
EP3258951B1 (fr) 2020-01-29
PT3258951T (pt) 2020-08-18
CN107580500B (zh) 2023-05-30
DK3653221T3 (da) 2022-10-24
US20200148769A1 (en) 2020-05-14
US11795220B2 (en) 2023-10-24
EP3258951A1 (fr) 2017-12-27
HRP20221284T1 (hr) 2022-12-23
JP2022106783A (ja) 2022-07-20
HK1247568A1 (zh) 2018-09-28
PL3258951T3 (pl) 2020-07-27
DK3295951T3 (da) 2020-07-20
DK3258951T3 (da) 2020-04-06
PT3295951T (pt) 2020-07-21
IL254039A0 (en) 2017-10-31
LT3295951T (lt) 2020-09-25
HRP20200572T1 (hr) 2020-08-21
CN107580500A (zh) 2018-01-12
HUE049791T2 (hu) 2020-10-28
AU2024202336A1 (en) 2024-05-16
RU2017132214A3 (fr) 2019-08-28
LT3258951T (lt) 2020-05-11
SI3258951T1 (sl) 2020-07-31
EP4129320A1 (fr) 2023-02-08
US11623955B2 (en) 2023-04-11
EP3653221A1 (fr) 2020-05-20
HRP20201066T1 (hr) 2021-02-05
US20180244774A1 (en) 2018-08-30
MX2020009461A (es) 2021-02-17
RU2020128686A (ru) 2020-10-13
CN115350275A (zh) 2022-11-18
WO2016134333A1 (fr) 2016-08-25
WO2016134333A9 (fr) 2017-02-02
ES2786651T3 (es) 2020-10-13
US11220542B2 (en) 2022-01-11
CY1123259T1 (el) 2021-12-31
US10227408B2 (en) 2019-03-12
US9714289B2 (en) 2017-07-25
EP3653221B1 (fr) 2022-08-03
EP3295951B1 (fr) 2020-04-22
US20170081408A1 (en) 2017-03-23
KR20170137067A (ko) 2017-12-12
MX2017010667A (es) 2018-08-15
ZA201706323B (en) 2020-05-27
JP2018512443A (ja) 2018-05-17
AU2016219835A1 (en) 2017-09-14
IL254039B2 (en) 2023-12-01
AU2016219835B2 (en) 2020-12-03
SI3295951T1 (sl) 2020-10-30
AU2020264349B2 (en) 2024-05-02
CY1122970T1 (el) 2021-10-29
ES2806800T3 (es) 2021-02-18
RU2732042C2 (ru) 2020-09-10
LT3653221T (lt) 2022-11-10
ES2929293T3 (es) 2022-11-28
US20170029504A1 (en) 2017-02-02
PL3295951T3 (pl) 2020-10-05
IL304117A (en) 2023-09-01
US20240101669A1 (en) 2024-03-28

Similar Documents

Publication Publication Date Title
IL304117A (en) Anti-pvrig antibodies and methods of use
HK1258058A1 (zh) 抗tigit抗體和使用方法
HK1252858A1 (zh) 抗cll-1抗體和使用方法
HK1249445A1 (zh) 抗分揀蛋白抗體和其使用方法
IL259495A (en) Antibodies and methods for using them
HK1252698A1 (zh) 抗siglec-9抗體及其使用方法
HK1252696A1 (zh) 抗siglec-7抗體及其使用方法
SG10201912150TA (en) Anti-trem2 antibodies and methods of use thereof
IL270793A (en) Anti-HTRA1 antibodies and methods of using them
HK1258850A1 (zh) 抗tpbg抗體及使用方法