SG11201702185UA - PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS - Google Patents
PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTSInfo
- Publication number
- SG11201702185UA SG11201702185UA SG11201702185UA SG11201702185UA SG11201702185UA SG 11201702185U A SG11201702185U A SG 11201702185UA SG 11201702185U A SG11201702185U A SG 11201702185UA SG 11201702185U A SG11201702185U A SG 11201702185UA SG 11201702185U A SG11201702185U A SG 11201702185UA
- Authority
- SG
- Singapore
- Prior art keywords
- intermediates
- processes
- preparation
- c5ar antagonists
- c5ar
- Prior art date
Links
- 102100032957 C5a anaphylatoxin chemotactic receptor 1 Human genes 0.000 title 1
- 101710098483 C5a anaphylatoxin chemotactic receptor 1 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462057107P | 2014-09-29 | 2014-09-29 | |
| PCT/US2015/052697 WO2016053890A1 (fr) | 2014-09-29 | 2015-09-28 | Procédés et intermédiaires utilisés dans la préparation d'antagonistes de c5ar |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201702185UA true SG11201702185UA (en) | 2017-04-27 |
Family
ID=55583729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201702185UA SG11201702185UA (en) | 2014-09-29 | 2015-09-28 | PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US9745268B2 (fr) |
| EP (2) | EP3200791B1 (fr) |
| JP (1) | JP6898229B6 (fr) |
| KR (2) | KR20230149873A (fr) |
| CN (2) | CN106999481B (fr) |
| AU (2) | AU2015324111B2 (fr) |
| BR (1) | BR112017006232B1 (fr) |
| CA (2) | CA2960733C (fr) |
| DK (1) | DK3200791T3 (fr) |
| ES (2) | ES2802428T3 (fr) |
| IL (1) | IL251061B (fr) |
| MA (1) | MA52308A (fr) |
| MX (2) | MX368492B (fr) |
| NZ (2) | NZ767823A (fr) |
| PL (1) | PL3200791T3 (fr) |
| PT (1) | PT3200791T (fr) |
| RU (1) | RU2712233C2 (fr) |
| SG (1) | SG11201702185UA (fr) |
| WO (1) | WO2016053890A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA32975B1 (fr) | 2008-12-22 | 2012-01-02 | Chemocentryx Inc | Antagonistes de c5ar |
| SI2585064T1 (sl) * | 2010-06-24 | 2017-08-31 | Chemocentryx, Inc. | Antagonisti C5AR |
| ES2802428T3 (es) * | 2014-09-29 | 2021-01-19 | Chemocentryx Inc | Procesos e intermedios en la preparación de antagonistas de C5aR |
| BR112018014222A2 (pt) | 2016-01-14 | 2018-12-11 | Chemocentryx, Inc. | método de tratamento da glomerulopatia c3 |
| EP3703687A4 (fr) | 2017-10-30 | 2021-04-07 | ChemoCentryx, Inc. | Composés deutérés utilisés comme immunomodulateurs |
| MX2020013166A (es) | 2018-06-07 | 2021-03-29 | Chemocentryx Inc | Dosificación y efecto del antagonista de c5a con la vasculitis asociada con anca. |
| ES2943492T3 (es) | 2018-11-30 | 2023-06-13 | Chemocentryx Inc | Formulación de cápsulas |
| KR102207333B1 (ko) * | 2019-09-09 | 2021-01-27 | 성균관대학교산학협력단 | 4중 연속 고리 화합물의 신규한 제조방법 |
| AU2020378061A1 (en) | 2019-11-08 | 2022-05-26 | Chemocentryx, Inc. | Free base crystalline form of a complement component C5a receptor |
| TW202128622A (zh) * | 2019-11-08 | 2021-08-01 | 美商卡默森屈有限公司 | 補體成分C5a受體之非晶型 |
| KR20220099989A (ko) * | 2019-11-08 | 2022-07-14 | 케모센트릭스, 인크. | 보체 성분 c5a 수용체의 염 형태 |
| WO2022078269A1 (fr) * | 2020-10-16 | 2022-04-21 | 苏州科睿思制药有限公司 | Forme cristalline d'avacopan, son procédé de préparation et son utilisation |
| EP4137133A1 (fr) | 2021-08-19 | 2023-02-22 | Sandoz AG | Forme cristalline d'avacopan |
| WO2022263263A1 (fr) | 2021-06-16 | 2022-12-22 | Sandoz Ag | Forme cristalline d'avacopan |
| CN113957106B (zh) * | 2021-11-03 | 2024-04-19 | 暨明医药科技（苏州）有限公司 | 一种Avacopan及其中间体的制备方法 |
| CN114262291B (zh) * | 2022-01-04 | 2023-05-19 | 重庆医科大学 | 一种阿伐可泮的合成方法 |
| WO2023158722A2 (fr) | 2022-02-16 | 2023-08-24 | Teva Pharmaceuticals International Gmbh | Processus de préparation d'avacopan et de ses intermédiaires |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686100A (en) | 1985-04-02 | 1987-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Method for the treatment of adult respiratory distress syndrome |
| WO2000012074A2 (fr) | 1998-08-28 | 2000-03-09 | Scios Inc. | INHIBITEURS DE p38-α KINASE |
| RU2197288C2 (ru) | 1999-08-03 | 2003-01-27 | Тверская медицинская академия | Способ лечения больных хроническим гломерулонефритом |
| EP1278743A4 (fr) | 2000-05-05 | 2003-05-14 | Smithkline Beecham Corp | Nouveaux anti-infectieux |
| AU2001277751A1 (en) | 2000-08-10 | 2002-02-25 | Mitsubishi Pharma Corporation | Novel 3-substituted urea derivatives and medicinal use thereof |
| AU2001288045A1 (en) | 2000-09-14 | 2002-03-26 | Mitsubishi Pharma Corporation | Novel amide derivatives and medicinal use thereof ugs |
| BR0017338A (pt) | 2000-09-29 | 2004-04-27 | Neurogen Corp | Composto, processo para preparar um composto, composição farmacêutica, e métodos para tratar um paciente, para inibir quimiotaxia celular promovida com c5a, para localizar receptores de c5a em um tecido, e para reduzir a gravidade ou frequência de uma ou mais sequelas inflamatórias de transplante de órgão |
| SE524438C2 (sv) | 2000-10-05 | 2004-08-10 | Magnus Georg Goertz | Fjärrstyrt dörrelaterat låsarrangemang, första och andra datorpogramprodukt, bärande medium och ett datorlösbart medium |
| DE10231786B4 (de) | 2001-07-19 | 2014-09-11 | Schaeffler Technologies Gmbh & Co. Kg | Ausrücksystem zum Ansteuern einer zugedrückten Kupplung |
| US7432356B2 (en) | 2001-08-17 | 2008-10-07 | Genentech, Inc. | Complement pathway inhibitors binding to C5 and C5a without preventing formation of C5b |
| PT1427720E (pt) | 2001-09-21 | 2009-04-27 | Sanofi Aventis | Derivados de 4-pirimidona substituídos em 3 posições |
| ITMI20012025A1 (it) | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
| US20030195192A1 (en) | 2002-04-05 | 2003-10-16 | Fortuna Haviv | Nicotinamides having antiangiogenic activity |
| CA2479928A1 (fr) | 2002-03-28 | 2003-10-09 | Neurogen Corporation | Biarylamides substitues en tant que modulateurs du recepteur c5a |
| WO2003082828A1 (fr) | 2002-03-28 | 2003-10-09 | Neurogen Corporation | Tetrahydroisoquinoleines substituees servant de modulateurs du recepteur c5a |
| US20040014782A1 (en) | 2002-03-29 | 2004-01-22 | Krause James E. | Combination therapy for the treatment of diseases involving inflammatory components |
| US20040014744A1 (en) | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
| WO2004014905A1 (fr) | 2002-08-08 | 2004-02-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Composes benzimidazole substitues |
| WO2004018460A1 (fr) | 2002-08-21 | 2004-03-04 | Neurogen Corporation | Aminomethyl imidazoles en tant que modulateurs de recepteurs c5a |
| WO2004043223A2 (fr) | 2002-11-05 | 2004-05-27 | The Regents Of The University Of Michigan | Compositions et methodes de diagnostic et traitement de la sepsie |
| FR2846654A1 (fr) | 2002-11-05 | 2004-05-07 | Servier Lab | Nouveaux derives de la 2,3-dihydro-4(1h)-pyridinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| ATE552253T1 (de) | 2002-11-08 | 2012-04-15 | Novartis Int Pharm Ltd | 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren |
| AU2003902354A0 (en) | 2003-05-15 | 2003-05-29 | Harkin, Denis W. | Treatment of haemorrhagic shock |
| CA2528652A1 (fr) | 2003-06-19 | 2004-12-23 | Pfizer Products Inc. | Antagoniste de nk1 |
| US20060154917A1 (en) | 2003-07-03 | 2006-07-13 | Neurogen Corporation | Substituted (heterocycloalkyl)methyl azole derivatives as c5a receptor modulators |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| US8071624B2 (en) | 2004-06-24 | 2011-12-06 | Incyte Corporation | N-substituted piperidines and their use as pharmaceuticals |
| EP1621536A1 (fr) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Dérivés d'urées cycliques aminés, leur préparation et utilisation pharmaceutique en tant qu'inhibiteurs de Kinase |
| US7635698B2 (en) | 2004-12-29 | 2009-12-22 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| UA94901C2 (ru) | 2005-02-18 | 2011-06-25 | Астразенека Аб | Антибактериальные производные пиперидина |
| WO2007035428A1 (fr) | 2005-09-15 | 2007-03-29 | Bristol-Myers Squibb Company | Inhibiteurs de la kinase met |
| WO2007051062A2 (fr) | 2005-10-28 | 2007-05-03 | Chemocentryx, Inc. | Dihydropyridines substituees et leurs methodes d'utilisation |
| AU2006316452B2 (en) | 2005-11-24 | 2013-01-10 | Dompe' Farmaceutici S.P.A. | (R)-arylalkylamino derivatives and pharmaceutical compositions containing them |
| SI2359834T1 (sl) | 2006-03-15 | 2017-02-28 | Alexion Pharmaceuticals, Inc. | Zdravljenje pacientov,ki imajo paroksizmalno nočno hemoglobinurijo, z zaviralcem komplementa |
| WO2008022060A2 (fr) | 2006-08-14 | 2008-02-21 | Novartis Ag | composés organiques et leurs utilisations |
| US8198266B2 (en) | 2006-10-31 | 2012-06-12 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Use of an EGFR antagonist for the treatment of glomerolonephritis |
| US20100190824A1 (en) | 2007-06-29 | 2010-07-29 | Prabhat Kumar | Novel Substituted Piperidones as HSP Inducers |
| JP2011530596A (ja) | 2008-08-11 | 2011-12-22 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | ｔＲＮＡ合成酵素の阻害のためのハロフジノン類似体およびそれらの使用 |
| US20110172126A1 (en) | 2008-09-03 | 2011-07-14 | Xenome Ltd | Libraries of peptide conjugates and methods for making them |
| US20100074863A1 (en) | 2008-09-17 | 2010-03-25 | Yat Sun Or | Anti-infective pyrrolidine derivatives and analogs |
| RS64039B1 (sr) | 2008-11-10 | 2023-04-28 | Alexion Pharma Inc | Metode i kompozicije za lečenje poremećaja povezanih sa komplementom |
| MA32975B1 (fr) * | 2008-12-22 | 2012-01-02 | Chemocentryx Inc | Antagonistes de c5ar |
| US20110275639A1 (en) * | 2008-12-22 | 2011-11-10 | Chemocentryx, Inc. | C5aR ANTAGONISTS |
| WO2011035143A2 (fr) | 2009-09-17 | 2011-03-24 | The Regents Of The University Of Michigan | Procédés et compositions pour inhiber des maladies et des états à médiation par rho |
| SI2585064T1 (sl) | 2010-06-24 | 2017-08-31 | Chemocentryx, Inc. | Antagonisti C5AR |
| CN104662015B (zh) | 2012-06-20 | 2017-03-29 | 诺华股份有限公司 | 补体途径调节剂及其用途 |
| DK2994488T3 (da) | 2013-05-08 | 2022-10-03 | Novo Nordisk As | Anvendelse af c5ar-antagonister |
| ES2802428T3 (es) | 2014-09-29 | 2021-01-19 | Chemocentryx Inc | Procesos e intermedios en la preparación de antagonistas de C5aR |
| BR112018014222A2 (pt) | 2016-01-14 | 2018-12-11 | Chemocentryx, Inc. | método de tratamento da glomerulopatia c3 |
| NZ747259A (en) | 2016-04-04 | 2022-11-25 | Chemocentryx Inc | Soluble c5ar antagonists |
| MX2023007420A (es) | 2020-12-21 | 2023-06-29 | Chemocentryx Inc | Tratamiento de glomerulopatia c3 usando un inhibidor de c5a. |
-
2015
- 2015-09-28 ES ES15845610T patent/ES2802428T3/es active Active
- 2015-09-28 AU AU2015324111A patent/AU2015324111B2/en active Active
- 2015-09-28 US US14/867,669 patent/US9745268B2/en active Active
- 2015-09-28 MA MA052308A patent/MA52308A/fr unknown
- 2015-09-28 BR BR112017006232-1A patent/BR112017006232B1/pt active IP Right Grant
- 2015-09-28 CN CN201580052937.6A patent/CN106999481B/zh active Active
- 2015-09-28 WO PCT/US2015/052697 patent/WO2016053890A1/fr active Application Filing
- 2015-09-28 PL PL15845610T patent/PL3200791T3/pl unknown
- 2015-09-28 PT PT158456103T patent/PT3200791T/pt unknown
- 2015-09-28 CN CN202110432100.1A patent/CN113121415A/zh active Pending
- 2015-09-28 KR KR1020237035689A patent/KR20230149873A/ko active Application Filing
- 2015-09-28 EP EP15845610.3A patent/EP3200791B1/fr active Active
- 2015-09-28 NZ NZ767823A patent/NZ767823A/en unknown
- 2015-09-28 EP EP20160995.5A patent/EP3682879B1/fr active Active
- 2015-09-28 CA CA2960733A patent/CA2960733C/fr active Active
- 2015-09-28 DK DK15845610.3T patent/DK3200791T3/da active
- 2015-09-28 ES ES20160995T patent/ES2926828T3/es active Active
- 2015-09-28 KR KR1020177011789A patent/KR102593431B1/ko active IP Right Grant
- 2015-09-28 NZ NZ730123A patent/NZ730123A/en unknown
- 2015-09-28 SG SG11201702185UA patent/SG11201702185UA/en unknown
- 2015-09-28 JP JP2017516679A patent/JP6898229B6/ja active Active
- 2015-09-28 RU RU2017114960A patent/RU2712233C2/ru active
- 2015-09-28 MX MX2017003789A patent/MX368492B/es active IP Right Grant
- 2015-09-28 CA CA3220371A patent/CA3220371A1/fr active Pending
-
2017
- 2017-03-09 IL IL251061A patent/IL251061B/en active IP Right Grant
- 2017-03-23 MX MX2019011911A patent/MX2019011911A/es unknown
- 2017-07-25 US US15/659,468 patent/US10266492B2/en active Active
-
2019
- 2019-03-21 US US16/360,195 patent/US10532982B2/en active Active
- 2019-12-06 US US16/706,296 patent/US20200354320A1/en not_active Abandoned
-
2021
- 2021-06-22 AU AU2021204209A patent/AU2021204209B2/en active Active
-
2022
- 2022-02-08 US US17/667,289 patent/US11845729B2/en active Active
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