SG11201702185UA - PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS - Google Patents

PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS

Info

Publication number
SG11201702185UA
SG11201702185UA SG11201702185UA SG11201702185UA SG11201702185UA SG 11201702185U A SG11201702185U A SG 11201702185UA SG 11201702185U A SG11201702185U A SG 11201702185UA SG 11201702185U A SG11201702185U A SG 11201702185UA SG 11201702185U A SG11201702185U A SG 11201702185UA
Authority
SG
Singapore
Prior art keywords
intermediates
processes
preparation
c5ar antagonists
c5ar
Prior art date
Application number
SG11201702185UA
Other languages
English (en)
Inventor
Pingchen Fan
Jaroslaw Kalisiak
Antoni Krasinski
Rebecca Lui
Jay Powers
Sreenivas Punna
Hiroko Tanaka
Penglie Zhang
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of SG11201702185UA publication Critical patent/SG11201702185UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG11201702185UA 2014-09-29 2015-09-28 PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS SG11201702185UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462057107P 2014-09-29 2014-09-29
PCT/US2015/052697 WO2016053890A1 (fr) 2014-09-29 2015-09-28 Procédés et intermédiaires utilisés dans la préparation d'antagonistes de c5ar

Publications (1)

Publication Number Publication Date
SG11201702185UA true SG11201702185UA (en) 2017-04-27

Family

ID=55583729

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201702185UA SG11201702185UA (en) 2014-09-29 2015-09-28 PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS

Country Status (19)

Country Link
US (5) US9745268B2 (fr)
EP (2) EP3200791B1 (fr)
JP (1) JP6898229B6 (fr)
KR (2) KR102593431B1 (fr)
CN (2) CN113121415A (fr)
AU (2) AU2015324111B2 (fr)
BR (1) BR112017006232B1 (fr)
CA (2) CA2960733C (fr)
DK (1) DK3200791T3 (fr)
ES (2) ES2802428T3 (fr)
IL (1) IL251061B (fr)
MA (1) MA52308A (fr)
MX (2) MX368492B (fr)
NZ (2) NZ767823A (fr)
PL (1) PL3200791T3 (fr)
PT (1) PT3200791T (fr)
RU (1) RU2712233C2 (fr)
SG (1) SG11201702185UA (fr)
WO (1) WO2016053890A1 (fr)

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WO2016053890A1 (fr) 2014-09-29 2016-04-07 Chemocentryx, Inc. Procédés et intermédiaires utilisés dans la préparation d'antagonistes de c5ar
RU2742888C2 (ru) 2016-01-14 2021-02-11 Кемосентрикс, Инк. Способ лечения с3-гломерулопатии
AU2018359214A1 (en) * 2017-10-30 2020-04-16 Chemocentryx, Inc. Deuterated compounds as immunomodulators
MX2020013166A (es) 2018-06-07 2021-03-29 Chemocentryx Inc Dosificación y efecto del antagonista de c5a con la vasculitis asociada con anca.
IL283450B1 (en) 2018-11-30 2024-02-01 Chemocentryx Inc Solid solution capsule formulations containing (3S,2R)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl) Piperidine-3-carboxamide, methods for their preparation and their medical uses
KR102207333B1 (ko) * 2019-09-09 2021-01-27 성균관대학교산학협력단 4중 연속 고리 화합물의 신규한 제조방법
KR20220098179A (ko) 2019-11-08 2022-07-11 케모센트릭스, 인크. 보체 성분 C5a 수용체의 유리 염기 결정질 형태
JP2023501789A (ja) 2019-11-08 2023-01-19 ケモセントリックス,インコーポレイティド 補体成分C5a受容体の非晶質形態
AU2020380367A1 (en) * 2019-11-08 2022-05-12 Chemocentryx, Inc. Salt forms of a complement component C5a receptor
WO2022078269A1 (fr) * 2020-10-16 2022-04-21 苏州科睿思制药有限公司 Forme cristalline d'avacopan, son procédé de préparation et son utilisation
EP4137133A1 (fr) 2021-08-19 2023-02-22 Sandoz AG Forme cristalline d'avacopan
WO2022263263A1 (fr) 2021-06-16 2022-12-22 Sandoz Ag Forme cristalline d'avacopan
CN113957106B (zh) * 2021-11-03 2024-04-19 暨明医药科技(苏州)有限公司 一种Avacopan及其中间体的制备方法
CN114262291B (zh) * 2022-01-04 2023-05-19 重庆医科大学 一种阿伐可泮的合成方法
WO2023158722A2 (fr) 2022-02-16 2023-08-24 Teva Pharmaceuticals International Gmbh Processus de préparation d'avacopan et de ses intermédiaires

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Also Published As

Publication number Publication date
CA3220371A1 (fr) 2016-04-07
EP3682879A1 (fr) 2020-07-22
IL251061A0 (en) 2017-04-30
BR112017006232A2 (pt) 2017-12-12
MX2017003789A (es) 2017-08-02
RU2017114960A3 (fr) 2019-04-10
US10532982B2 (en) 2020-01-14
CN106999481A (zh) 2017-08-01
KR20230149873A (ko) 2023-10-27
EP3682879B1 (fr) 2022-08-03
AU2021204209B2 (en) 2022-10-06
MX368492B (es) 2019-10-04
ES2926828T3 (es) 2022-10-28
ES2802428T3 (es) 2021-01-19
BR112017006232B1 (pt) 2022-10-11
AU2015324111A1 (en) 2017-04-06
RU2712233C2 (ru) 2020-01-27
KR102593431B1 (ko) 2023-10-23
US10266492B2 (en) 2019-04-23
EP3200791A4 (fr) 2018-06-13
RU2017114960A (ru) 2018-11-07
US20200354320A1 (en) 2020-11-12
NZ730123A (en) 2023-05-26
PT3200791T (pt) 2020-05-06
KR20170085492A (ko) 2017-07-24
IL251061B (en) 2019-09-26
US11845729B2 (en) 2023-12-19
DK3200791T3 (da) 2020-05-25
WO2016053890A1 (fr) 2016-04-07
CA2960733A1 (fr) 2016-04-07
CA2960733C (fr) 2024-01-09
US20230008966A1 (en) 2023-01-12
PL3200791T3 (pl) 2020-08-10
CN113121415A (zh) 2021-07-16
EP3200791B1 (fr) 2020-04-22
AU2015324111B2 (en) 2021-04-01
MA52308A (fr) 2021-02-24
US9745268B2 (en) 2017-08-29
US20160090357A1 (en) 2016-03-31
JP6898229B6 (ja) 2021-07-28
US20190276402A1 (en) 2019-09-12
NZ767823A (en) 2023-05-26
CN106999481B (zh) 2021-04-16
AU2021204209A1 (en) 2021-07-15
EP3200791A1 (fr) 2017-08-09
MX2019011911A (es) 2019-11-25
JP6898229B2 (ja) 2021-07-07
JP2017529378A (ja) 2017-10-05
US20180072668A1 (en) 2018-03-15

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