BR112017006232A2 - processos e intermediários na preparação de antagonistas de c5ar - Google Patents
processos e intermediários na preparação de antagonistas de c5arInfo
- Publication number
- BR112017006232A2 BR112017006232A2 BR112017006232A BR112017006232A BR112017006232A2 BR 112017006232 A2 BR112017006232 A2 BR 112017006232A2 BR 112017006232 A BR112017006232 A BR 112017006232A BR 112017006232 A BR112017006232 A BR 112017006232A BR 112017006232 A2 BR112017006232 A2 BR 112017006232A2
- Authority
- BR
- Brazil
- Prior art keywords
- intermediates
- preparation
- processes
- c5ar antagonists
- c5ar
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 229940126681 complement 5a receptor antagonist Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
são fornecidos métodos e intermediários para a preparação de compostos antagonistas de c5ar selecionados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462057107P | 2014-09-29 | 2014-09-29 | |
US62/057,107 | 2014-09-29 | ||
PCT/US2015/052697 WO2016053890A1 (en) | 2014-09-29 | 2015-09-28 | PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017006232A2 true BR112017006232A2 (pt) | 2017-12-12 |
BR112017006232B1 BR112017006232B1 (pt) | 2022-10-11 |
Family
ID=55583729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017006232-1A BR112017006232B1 (pt) | 2014-09-29 | 2015-09-28 | Processos e intermediários na preparação de antagonistas de c5ar |
Country Status (19)
Country | Link |
---|---|
US (5) | US9745268B2 (pt) |
EP (2) | EP3682879B1 (pt) |
JP (1) | JP6898229B6 (pt) |
KR (2) | KR20230149873A (pt) |
CN (2) | CN113121415A (pt) |
AU (2) | AU2015324111B2 (pt) |
BR (1) | BR112017006232B1 (pt) |
CA (2) | CA3220371A1 (pt) |
DK (1) | DK3200791T3 (pt) |
ES (2) | ES2802428T3 (pt) |
IL (1) | IL251061B (pt) |
MA (1) | MA52308A (pt) |
MX (2) | MX368492B (pt) |
NZ (2) | NZ767823A (pt) |
PL (1) | PL3200791T3 (pt) |
PT (1) | PT3200791T (pt) |
RU (1) | RU2712233C2 (pt) |
SG (1) | SG11201702185UA (pt) |
WO (1) | WO2016053890A1 (pt) |
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SG172338A1 (en) | 2008-12-22 | 2011-07-28 | Chemocentryx Inc | C5ar antagonists |
US9126939B2 (en) * | 2010-06-24 | 2015-09-08 | Pingchen Fan | C5AR antagonists |
MA52308A (fr) * | 2014-09-29 | 2021-02-24 | Chemocentryx Inc | Procédés et intermédiaires pour la préparation d'antagonistes c5ar |
MX2022006069A (es) | 2016-01-14 | 2023-01-12 | Chemocentryx Inc | Metodo para tratar glomerulopatia c3. |
JP2021501175A (ja) | 2017-10-30 | 2021-01-14 | ケモセントリックス,インコーポレイティド | 免疫調節剤としての重水素化化合物 |
WO2019236820A1 (en) | 2018-06-07 | 2019-12-12 | Chemocentryx, Inc. | Dosing and effect of c5a antagonist with anca-associated vasculitis |
IL283450B1 (en) | 2018-11-30 | 2024-02-01 | Chemocentryx Inc | Solid solution capsule formulations containing (3S,2R)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl) Piperidine-3-carboxamide, methods for their preparation and their medical uses |
KR102207333B1 (ko) * | 2019-09-09 | 2021-01-27 | 성균관대학교산학협력단 | 4중 연속 고리 화합물의 신규한 제조방법 |
CN114641289A (zh) * | 2019-11-08 | 2022-06-17 | 凯莫森特里克斯股份有限公司 | 补体成分C5a受体的游离碱晶型 |
TW202128623A (zh) | 2019-11-08 | 2021-08-01 | 美商卡默森屈有限公司 | 補體成分C5a受體之鹽形式 |
WO2021092286A1 (en) | 2019-11-08 | 2021-05-14 | Chemocentryx, Inc. | Amorphous form of a complement component c5a receptor |
WO2022078269A1 (zh) * | 2020-10-16 | 2022-04-21 | 苏州科睿思制药有限公司 | Avacopan的晶型及其制备方法和用途 |
WO2022263263A1 (en) | 2021-06-16 | 2022-12-22 | Sandoz Ag | Crystalline form of avacopan |
EP4137133A1 (en) | 2021-08-19 | 2023-02-22 | Sandoz AG | Crystalline form of avacopan |
CN113957106B (zh) * | 2021-11-03 | 2024-04-19 | 暨明医药科技(苏州)有限公司 | 一种Avacopan及其中间体的制备方法 |
CN114262291B (zh) * | 2022-01-04 | 2023-05-19 | 重庆医科大学 | 一种阿伐可泮的合成方法 |
WO2023158722A2 (en) | 2022-02-16 | 2023-08-24 | Teva Pharmaceuticals International Gmbh | Processes for preparation of avacopan and intermediates thereof |
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RU2197288C2 (ru) | 1999-08-03 | 2003-01-27 | Тверская медицинская академия | Способ лечения больных хроническим гломерулонефритом |
AU2001259511A1 (en) | 2000-05-05 | 2001-11-20 | Smith Kline Beecham Corporation | Novel anti-infectives |
ES2353077T3 (es) | 2000-08-10 | 2011-02-25 | Mitsubishi Tanabe Pharma Corporation | Derivados de urea con sustitución en posición 3 y uso medicinal de los mismos. |
US7855297B2 (en) | 2000-09-14 | 2010-12-21 | Mitsubishi Tanabe Pharma Corporation | Amide derivatives and medicinal use thereof |
YU23503A (sh) | 2000-09-29 | 2006-03-03 | Neurogen Corporation | Mali molekuli kao modulatori receptora c5a visokog afiniteta |
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MA52308A (fr) * | 2014-09-29 | 2021-02-24 | Chemocentryx Inc | Procédés et intermédiaires pour la préparation d'antagonistes c5ar |
MX2022006069A (es) | 2016-01-14 | 2023-01-12 | Chemocentryx Inc | Metodo para tratar glomerulopatia c3. |
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CN116635075A (zh) | 2020-12-21 | 2023-08-22 | 坎莫森特里克斯公司 | 使用c5a抑制剂治疗c3肾小球病 |
-
2015
- 2015-09-28 MA MA052308A patent/MA52308A/fr unknown
- 2015-09-28 PT PT158456103T patent/PT3200791T/pt unknown
- 2015-09-28 US US14/867,669 patent/US9745268B2/en active Active
- 2015-09-28 EP EP20160995.5A patent/EP3682879B1/en active Active
- 2015-09-28 BR BR112017006232-1A patent/BR112017006232B1/pt active IP Right Grant
- 2015-09-28 KR KR1020237035689A patent/KR20230149873A/ko active Application Filing
- 2015-09-28 PL PL15845610T patent/PL3200791T3/pl unknown
- 2015-09-28 AU AU2015324111A patent/AU2015324111B2/en active Active
- 2015-09-28 NZ NZ767823A patent/NZ767823A/en unknown
- 2015-09-28 CA CA3220371A patent/CA3220371A1/en active Pending
- 2015-09-28 KR KR1020177011789A patent/KR102593431B1/ko active IP Right Grant
- 2015-09-28 WO PCT/US2015/052697 patent/WO2016053890A1/en active Application Filing
- 2015-09-28 NZ NZ730123A patent/NZ730123A/en unknown
- 2015-09-28 ES ES15845610T patent/ES2802428T3/es active Active
- 2015-09-28 RU RU2017114960A patent/RU2712233C2/ru active
- 2015-09-28 CA CA2960733A patent/CA2960733C/en active Active
- 2015-09-28 CN CN202110432100.1A patent/CN113121415A/zh active Pending
- 2015-09-28 JP JP2017516679A patent/JP6898229B6/ja active Active
- 2015-09-28 ES ES20160995T patent/ES2926828T3/es active Active
- 2015-09-28 SG SG11201702185UA patent/SG11201702185UA/en unknown
- 2015-09-28 DK DK15845610.3T patent/DK3200791T3/da active
- 2015-09-28 EP EP15845610.3A patent/EP3200791B1/en active Active
- 2015-09-28 MX MX2017003789A patent/MX368492B/es active IP Right Grant
- 2015-09-28 CN CN201580052937.6A patent/CN106999481B/zh active Active
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2017
- 2017-03-09 IL IL251061A patent/IL251061B/en active IP Right Grant
- 2017-03-23 MX MX2019011911A patent/MX2019011911A/es unknown
- 2017-07-25 US US15/659,468 patent/US10266492B2/en active Active
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2019
- 2019-03-21 US US16/360,195 patent/US10532982B2/en active Active
- 2019-12-06 US US16/706,296 patent/US20200354320A1/en not_active Abandoned
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2021
- 2021-06-22 AU AU2021204209A patent/AU2021204209B2/en active Active
-
2022
- 2022-02-08 US US17/667,289 patent/US11845729B2/en active Active
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