YU23503A - Mali molekuli kao modulatori receptora c5a visokog afiniteta - Google Patents

Mali molekuli kao modulatori receptora c5a visokog afiniteta

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Publication number
YU23503A
YU23503A YU23503A YUP23503A YU23503A YU 23503 A YU23503 A YU 23503A YU 23503 A YU23503 A YU 23503A YU P23503 A YUP23503 A YU P23503A YU 23503 A YU23503 A YU 23503A
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YU
Yugoslavia
Prior art keywords
act
compounds
receptors
small molecule
complement
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YU23503A
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English (en)
Inventor
Andrew Thurkauf
Xiaoyan Zhang
He Zhao
Xia-Shu He
John Peterson
George Maynard
Robert Ohliger
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Neurogen Corporation
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Publication date
Application filed by Neurogen Corporation filed Critical Neurogen Corporation
Publication of YU23503A publication Critical patent/YU23503A/sh

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Abstract

Pronalazak se odnosi na nepeptidne, nepeptidomimeticke oragnske molekule male molekularne tezine, koji mogu da deluju kao modulatori komplemenata rteceptora C5a kod sisara, a prvenstveno na one koji deluju kao ligandireceptora C5a visokog afiniteta i takodje takvi ligandi koji moguda deluju kao antagonisti ili inverzni agonisti komplemenata receptora C5a. Prednosna jedinjenja prema pronalasku poseduju neka ili sva od sledecih svojstava: 1) multi- aril u strukturi; 2) heteroaril u strukturi; 3) farmaceutski prihvatljiva oralna doza moze obezbediti in vivo dejstvo koje se moze detektovati; 4) sadrze manje od cetiri ili prvenstveno ne sadrze amidne veze, i 5) imaju sposobnost da inhibiraju hemotaksiju leukocita pri nanomolarnim ili subnanomolarnim koncentracijama. Pronalazak takodje obuhvata i farmaceutske kompozicije koje sadrze takva jedinjenja i primenu takvih jedinjenja za lecenje razlicitih zapaljenskih poremecaja i poremecaja imunog sistema.
YU23503A 2000-09-29 2000-09-29 Mali molekuli kao modulatori receptora c5a visokog afiniteta YU23503A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/026816 WO2002049993A2 (en) 2000-09-29 2000-09-29 High affinity small molecule c5a receptor modulators

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YU23503A true YU23503A (sh) 2006-03-03

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YU23503A YU23503A (sh) 2000-09-29 2000-09-29 Mali molekuli kao modulatori receptora c5a visokog afiniteta

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EP (1) EP1322309B1 (sh)
JP (1) JP5260818B2 (sh)
KR (1) KR20030060887A (sh)
CN (1) CN1454086A (sh)
AT (1) ATE404553T1 (sh)
AU (1) AU7622500A (sh)
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BR0017338A (pt) 2004-04-27
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AU7622500A (en) 2002-07-01
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ATE404553T1 (de) 2008-08-15
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