SG11201504813XA - Mannose derivatives for treating bacterial infections - Google Patents

Mannose derivatives for treating bacterial infections

Info

Publication number
SG11201504813XA
SG11201504813XA SG11201504813XA SG11201504813XA SG11201504813XA SG 11201504813X A SG11201504813X A SG 11201504813XA SG 11201504813X A SG11201504813X A SG 11201504813XA SG 11201504813X A SG11201504813X A SG 11201504813XA SG 11201504813X A SG11201504813X A SG 11201504813XA
Authority
SG
Singapore
Prior art keywords
bacterial infections
treating bacterial
mannose derivatives
mannose
derivatives
Prior art date
Application number
SG11201504813XA
Other languages
English (en)
Inventor
Yeeman K Ramtohul
Sanjoy Kumar Das
Caroline Cadilhac
Thumkunta Jagadeeswar Reddy
Louis Vaillancourt
Michel Gallant
Bingcan Liu
Evelyne Dietrich
Frederic Vallee
Julien Martel
Carl Poisson
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of SG11201504813XA publication Critical patent/SG11201504813XA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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SG11201504813XA 2012-12-18 2013-12-18 Mannose derivatives for treating bacterial infections SG11201504813XA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261738620P 2012-12-18 2012-12-18
US201361788241P 2013-03-15 2013-03-15
US201361874501P 2013-09-06 2013-09-06
PCT/US2013/076086 WO2014100158A1 (en) 2012-12-18 2013-12-18 Mannose derivatives for treating bacterial infections

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JP (1) JP6412506B2 (pt)
KR (1) KR102075885B1 (pt)
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AU (1) AU2013361602B2 (pt)
BR (1) BR112015014458B1 (pt)
CA (1) CA2894536C (pt)
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RU (1) RU2667060C2 (pt)
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Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
WO2014110574A1 (en) 2013-01-14 2014-07-17 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
SG10201705662WA (en) 2013-01-15 2017-08-30 Incyte Corp Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
AU2014248717B2 (en) * 2013-03-12 2018-03-29 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
PE20160532A1 (es) 2013-08-23 2016-05-21 Incyte Corp Compuesto de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
EP3307733B1 (en) * 2015-06-12 2021-10-20 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
TW201718546A (zh) 2015-10-02 2017-06-01 英塞特公司 適用作pim激酶抑制劑之雜環化合物
WO2018009861A1 (en) 2016-07-08 2018-01-11 Biolegend Substituted polyfluorene compounds
EP3658648B1 (en) 2017-07-28 2021-10-27 BioLegend, Inc. Conjugated polymers and methods of use
US11898210B2 (en) * 2017-10-16 2024-02-13 Enterome Tools for assessing FimH blockers therapeutic efficiency
US10596161B2 (en) 2017-12-08 2020-03-24 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
ES2928634T3 (es) 2018-07-10 2022-11-21 Glaxosmithkline Ip Dev Ltd Compuestos de C-manósido útiles para el tratamiento de infecciones de las vías urinarias
CN112771035A (zh) * 2018-07-26 2021-05-07 恩特姆生物科学公司 用于制备甘露糖衍生物的方法
CN110698467B (zh) * 2019-10-31 2023-05-23 黄冈鲁班药业股份有限公司 恩格列净的合成方法
CN111269205B (zh) * 2020-02-19 2023-05-26 华侨大学 一种c-芳基糖苷化合物的制备方法
CN116023273A (zh) * 2023-03-29 2023-04-28 思合基因(北京)生物科技有限公司 一种新型碳糖苷及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0619317A1 (en) 1993-04-07 1994-10-12 Centre National De La Recherche Scientifique An expeditious synthesis of C-disaccharides using a temporary ketal connection
TW457246B (en) * 1996-12-19 2001-10-01 Texas Biotechnology Corp Dimeric small molecule selectin inhibitors comprising of (mannopyranosyloxy)biphenyl-substituted carboxylic acid
WO1998031697A1 (en) 1997-01-15 1998-07-23 Sankyo Company, Limited Aryl c-glycoside compounds and sulfated esters thereof
GB2355457A (en) * 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
AUPQ872300A0 (en) 2000-07-11 2000-08-03 Praxis Pharmaceuticals Pty Ltd Compounds and methods
RU2197499C2 (ru) * 2001-08-23 2003-01-27 Бокованов Владимир Евгеньевич Металлоценовые производные сахаров и содержащее их средство для активации киллинга микроорганизмов, локализованных внутриклеточно
US7691603B2 (en) 2003-04-09 2010-04-06 Novo Nordisk A/S Intracellular formation of peptide conjugates
US20080171706A1 (en) * 2004-03-23 2008-07-17 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Anti-Adhesive Compounds to Prevent and Treat Bacterial Infections
FR2876798A1 (fr) 2004-10-14 2006-04-21 Univ Clermont Auvergne Diagnostic et traitement de la maladie de crohn
WO2006077365A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
JP2008527027A (ja) 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なインドール類
JP2008527030A (ja) 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なインドール類
US8097623B2 (en) 2005-01-19 2012-01-17 Biolipox Ab Indoles useful in the treatment of inflammation
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
WO2007095124A2 (en) 2006-02-10 2007-08-23 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
JP5255559B2 (ja) 2006-03-31 2013-08-07 アボット・ラボラトリーズ インダゾール化合物
EP3492483A1 (en) * 2009-10-22 2019-06-05 The Washington University Compounds and methods for treating bacterial infections
EP2960247A1 (en) 2009-12-14 2015-12-30 University of Basel Phenyl-alpha-d-mannosides for use in the treatment of bacterial infections caused by escherichia coli
EP2377883A1 (en) 2010-04-15 2011-10-19 Universite d'Auvergne Clermont I Antagonists for the prevention or treatment of inflammatory bowel disease, and more particularly of Crohn's disease
EP2672820B1 (en) 2011-02-07 2019-04-17 The Washington University Mannoside compounds and methods of use thereof
WO2012163478A1 (de) 2011-05-27 2012-12-06 Merck Patent Gmbh Polymerisierbare verbindungen und ihre verwendung in flüssigkristallmedien und flüssigkristallanzeigen
WO2012164074A1 (en) * 2011-06-03 2012-12-06 University Of Basel Mannose phosphate derivatives as antagonists of bacterial adhesion
WO2013134415A1 (en) 2012-03-07 2013-09-12 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
TW201350498A (zh) * 2012-04-09 2013-12-16 Vertex Pharma 治療細菌感染之甘露糖衍生物
US20140107049A1 (en) 2012-10-04 2014-04-17 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
AU2014248717B2 (en) 2013-03-12 2018-03-29 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections

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