HK1209755A1 - Mannose derivatives for treating bacterial infections - Google Patents

Mannose derivatives for treating bacterial infections

Info

Publication number
HK1209755A1
HK1209755A1 HK15110630.8A HK15110630A HK1209755A1 HK 1209755 A1 HK1209755 A1 HK 1209755A1 HK 15110630 A HK15110630 A HK 15110630A HK 1209755 A1 HK1209755 A1 HK 1209755A1
Authority
HK
Hong Kong
Prior art keywords
bacterial infections
treating bacterial
mannose derivatives
mannose
derivatives
Prior art date
Application number
HK15110630.8A
Other languages
English (en)
Chinese (zh)
Inventor
．拉姆托爾
．達斯
．卡迪萊克
．雷迪
．瓦揚古
．格蘭特
．劉
．迪特裡希
．沃裡
．馬特爾
．普瓦松
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of HK1209755A1 publication Critical patent/HK1209755A1/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
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    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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HK15110630.8A 2012-12-18 2015-10-28 Mannose derivatives for treating bacterial infections HK1209755A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261738620P 2012-12-18 2012-12-18
US201361788241P 2013-03-15 2013-03-15
US201361874501P 2013-09-06 2013-09-06
PCT/US2013/076086 WO2014100158A1 (en) 2012-12-18 2013-12-18 Mannose derivatives for treating bacterial infections

Publications (1)

Publication Number Publication Date
HK1209755A1 true HK1209755A1 (en) 2016-04-08

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HK15110630.8A HK1209755A1 (en) 2012-12-18 2015-10-28 Mannose derivatives for treating bacterial infections

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US (5) US9598454B2 (xx)
EP (2) EP3388441A1 (xx)
JP (1) JP6412506B2 (xx)
KR (1) KR102075885B1 (xx)
CN (1) CN104936969B (xx)
AU (1) AU2013361602B2 (xx)
BR (1) BR112015014458B1 (xx)
CA (1) CA2894536C (xx)
CL (1) CL2015001667A1 (xx)
DK (1) DK2935302T3 (xx)
ES (1) ES2685975T3 (xx)
HK (1) HK1209755A1 (xx)
IL (1) IL239481A0 (xx)
MX (1) MX2015007556A (xx)
NZ (1) NZ708928A (xx)
PL (1) PL2935302T3 (xx)
RU (1) RU2667060C2 (xx)
SG (1) SG11201504813XA (xx)
TW (1) TWI626247B (xx)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
KR102403306B1 (ko) 2013-01-15 2022-06-02 인사이트 홀딩스 코포레이션 Pim 키나제 저해제로서 유용한 티아졸카복스아마이드 및 피리딘카복스아마이드 화합물
US9890176B2 (en) * 2013-03-12 2018-02-13 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
JP2016528298A (ja) 2013-08-23 2016-09-15 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用なフロピリジン及びチエノピリジンカルボキシアミド化合物
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
JP6856550B2 (ja) * 2015-06-12 2021-04-07 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 細菌感染症の処置のためのマンノース誘導体
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
WO2018009861A1 (en) 2016-07-08 2018-01-11 Biolegend Substituted polyfluorene compounds
WO2019023463A1 (en) 2017-07-28 2019-01-31 Biolegend CONJUGATED POLYMERS AND METHODS OF USE
US11898210B2 (en) * 2017-10-16 2024-02-13 Enterome Tools for assessing FimH blockers therapeutic efficiency
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
CA3105940A1 (en) 2018-07-10 2020-01-16 Glaxosmithkline Intellectual Property Development Limited C-mannoside compounds useful for the treatment of urinary tract infections
WO2020021113A1 (en) 2018-07-26 2020-01-30 Enterome Process for preparing mannose derivatives
CN110698467B (zh) * 2019-10-31 2023-05-23 黄冈鲁班药业股份有限公司 恩格列净的合成方法
CN111269205B (zh) * 2020-02-19 2023-05-26 华侨大学 一种c-芳基糖苷化合物的制备方法
WO2024118503A1 (en) 2022-11-28 2024-06-06 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs
CN116023273A (zh) * 2023-03-29 2023-04-28 思合基因(北京)生物科技有限公司 一种新型碳糖苷及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0619317A1 (en) 1993-04-07 1994-10-12 Centre National De La Recherche Scientifique An expeditious synthesis of C-disaccharides using a temporary ketal connection
TW457246B (en) * 1996-12-19 2001-10-01 Texas Biotechnology Corp Dimeric small molecule selectin inhibitors comprising of (mannopyranosyloxy)biphenyl-substituted carboxylic acid
AU6024998A (en) * 1997-01-15 1998-08-07 Glycomed Incorporated Aryl c-glycoside compounds and sulfated esters thereof
GB2355457A (en) * 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
AUPQ872300A0 (en) 2000-07-11 2000-08-03 Praxis Pharmaceuticals Pty Ltd Compounds and methods
RU2197499C2 (ru) * 2001-08-23 2003-01-27 Бокованов Владимир Евгеньевич Металлоценовые производные сахаров и содержащее их средство для активации киллинга микроорганизмов, локализованных внутриклеточно
EP1613261A4 (en) 2003-04-09 2011-01-26 Novo Nordisk As INTRA-CELLULAR FORMATION OF PEPTIDE CONJUGATES
EP1755619A2 (en) * 2004-03-23 2007-02-28 VIB vzw Anti-adhesive compounds to prevent and treat bacterial infections
FR2876798A1 (fr) 2004-10-14 2006-04-21 Univ Clermont Auvergne Diagnostic et traitement de la maladie de crohn
JP2008527030A (ja) 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なインドール類
KR20070114123A (ko) 2005-01-19 2007-11-29 바이올리폭스 에이비 염증 치료에 유용한 인돌
JP2008527027A (ja) 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なインドール類
WO2006077365A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
EP2295432A1 (en) 2006-02-10 2011-03-16 TransTech Pharma Inc. Process for the preparation of aminobenzimidazole derivatives
EP2001480A4 (en) 2006-03-31 2011-06-15 Abbott Lab Indazole CONNECTIONS
WO2012109263A1 (en) 2011-02-07 2012-08-16 The Washington University Mannoside compounds and methods of use thereof
EP3492483A1 (en) * 2009-10-22 2019-06-05 The Washington University Compounds and methods for treating bacterial infections
NZ616764A (en) 2009-12-14 2014-11-28 Univ Basel Mannose derivatives as antagonists of bacterial adhesion
EP2377883A1 (en) 2010-04-15 2011-10-19 Universite d'Auvergne Clermont I Antagonists for the prevention or treatment of inflammatory bowel disease, and more particularly of Crohn's disease
WO2012163478A1 (de) 2011-05-27 2012-12-06 Merck Patent Gmbh Polymerisierbare verbindungen und ihre verwendung in flüssigkristallmedien und flüssigkristallanzeigen
WO2012164074A1 (en) * 2011-06-03 2012-12-06 University Of Basel Mannose phosphate derivatives as antagonists of bacterial adhesion
CA2869416A1 (en) 2012-03-07 2013-09-12 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
TW201350498A (zh) * 2012-04-09 2013-12-16 Vertex Pharma 治療細菌感染之甘露糖衍生物
US20140107049A1 (en) 2012-10-04 2014-04-17 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
US9890176B2 (en) 2013-03-12 2018-02-13 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections

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US11634447B2 (en) 2023-04-25
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