SG11201504318UA - Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity - Google Patents

Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity

Info

Publication number
SG11201504318UA
SG11201504318UA SG11201504318UA SG11201504318UA SG11201504318UA SG 11201504318U A SG11201504318U A SG 11201504318UA SG 11201504318U A SG11201504318U A SG 11201504318UA SG 11201504318U A SG11201504318U A SG 11201504318UA SG 11201504318U A SG11201504318U A SG 11201504318UA
Authority
SG
Singapore
Prior art keywords
compounds
agonist activity
beta2 adrenergic
receptor antagonist
receptor agonist
Prior art date
Application number
SG11201504318UA
Other languages
English (en)
Inventor
Fabio Rancati
Ian Linney
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of SG11201504318UA publication Critical patent/SG11201504318UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/14Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
SG11201504318UA 2012-12-06 2013-12-05 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity SG11201504318UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12195891 2012-12-06
PCT/EP2013/075661 WO2014086924A1 (en) 2012-12-06 2013-12-05 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity

Publications (1)

Publication Number Publication Date
SG11201504318UA true SG11201504318UA (en) 2015-07-30

Family

ID=47323975

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201504318UA SG11201504318UA (en) 2012-12-06 2013-12-05 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
SG10201704032RA SG10201704032RA (en) 2012-12-06 2013-12-05 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201704032RA SG10201704032RA (en) 2012-12-06 2013-12-05 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity

Country Status (38)

Country Link
US (2) US8987299B2 (ko)
EP (2) EP3345904B1 (ko)
JP (1) JP6421989B2 (ko)
KR (2) KR102156443B1 (ko)
CN (1) CN104822678B (ko)
AR (1) AR093825A1 (ko)
AU (1) AU2013354043C1 (ko)
BR (1) BR112015012730B1 (ko)
CA (1) CA2893626C (ko)
CL (1) CL2015001483A1 (ko)
CO (1) CO7400870A2 (ko)
CY (2) CY1120159T1 (ko)
DK (2) DK3345904T3 (ko)
EA (1) EA030552B1 (ko)
ES (2) ES2816210T3 (ko)
GE (1) GEP20186839B (ko)
HK (1) HK1212989A1 (ko)
HR (2) HRP20180915T1 (ko)
HU (2) HUE037944T2 (ko)
IL (1) IL239182B (ko)
LT (2) LT3345904T (ko)
MA (1) MA38147B1 (ko)
MX (1) MX369311B (ko)
NZ (1) NZ708738A (ko)
PE (1) PE20151216A1 (ko)
PH (1) PH12015501247A1 (ko)
PL (2) PL3345904T3 (ko)
PT (2) PT3345904T (ko)
RS (2) RS57232B1 (ko)
SA (1) SA515360514B1 (ko)
SG (2) SG11201504318UA (ko)
SI (2) SI3345904T1 (ko)
TN (1) TN2015000244A1 (ko)
TR (1) TR201808698T4 (ko)
TW (1) TWI637954B (ko)
UA (1) UA118181C2 (ko)
WO (1) WO2014086924A1 (ko)
ZA (1) ZA201503965B (ko)

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ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EA030552B1 (ru) * 2012-12-06 2018-08-31 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Соединения, обладающие активностью антагонистов мускариновых рецепторов и агонистов бета2 адренергических рецепторов
ES2663878T3 (es) * 2012-12-06 2018-04-17 Chiesi Farmaceutici S.P.A. Compuestos que tienen actividad antagonista del receptor muscarínico y actividad agonista del receptor beta-2 adrenérgico
AP2015008573A0 (en) 2012-12-18 2015-07-31 Almirall Sa New cyclohexyl and quinuclidinyl carbamate derivatives having beta 2 adrenergic agonist and M3 muscarinic antagonsit activity
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有maba化合物和皮質類固醇之組合
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β2腎上腺素受體促效劑二者之活性的2-胺基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β2腎上腺素促效劑及M3蕈毒拮抗劑活性之新穎雙環衍生物
TWI703138B (zh) * 2015-02-12 2020-09-01 義大利商吉斯藥品公司 具有蕈毒鹼受體拮抗劑及β2腎上腺素受體促效劑活性之化合物
AR104828A1 (es) * 2015-06-01 2017-08-16 Chiesi Farm Spa COMPUESTOS CON ACTIVIDAD ANTAGONISTA DE LOS RECEPTORES MUSCARÍNICOS Y ACTIVIDAD AGONISTA DEL RECEPTOR b2 ADRENÉRGICO
MY186229A (en) * 2015-11-16 2021-06-30 Chiesi Farm Spa A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic
EP3383867B1 (en) 2015-12-03 2021-04-14 Chiesi Farmaceutici S.p.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
EP3484879B1 (en) 2016-07-13 2020-12-30 Chiesi Farmaceutici S.p.A. Hydroxyquinolinone compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
CA2994290C (en) 2017-11-06 2024-01-23 Entech Solution As Method and stimulation sleeve for well completion in a subterranean wellbore

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KR20050047552A (ko) 2002-10-11 2005-05-20 화이자 인코포레이티드 베타-2 작용제로서의 인돌 유도체
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
ES2329586T3 (es) 2003-11-21 2009-11-27 Theravance, Inc. Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino.
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ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
WO2006023460A2 (en) 2004-08-16 2006-03-02 Theravance, Inc. COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
EP1778626A1 (en) 2004-08-16 2007-05-02 Theravance, Inc. Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
FR2898640B1 (fr) 2006-03-20 2008-04-25 Siemens Vdo Automotive Sas Procede de transmission d'information relatif au fonctionnement d'un moteur a combustion interne
EP2080523A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Compositions comprising an antimuscarinic and a long-acting beta-agonist
TR201903556T4 (tr) 2009-04-23 2019-04-22 Theravance Respiratory Co Llc Muskarinik reseptör antagonisti ve beta 2 adrenerjik reseptör agonisti aktivitesine sahip diamid bileşikleri.
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WO2011048409A1 (en) 2009-10-20 2011-04-28 Astrazeneca Ab Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
BR112013030302B1 (pt) 2011-06-10 2021-08-24 Chiesi Farmaceutici S.P.A. Composto, composição farmacêutica, uso de um composto, combinação de um composto e dispositivo
WO2012168359A1 (en) * 2011-06-10 2012-12-13 Chiesi Farmaceutici S.P.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
ES2663878T3 (es) * 2012-12-06 2018-04-17 Chiesi Farmaceutici S.P.A. Compuestos que tienen actividad antagonista del receptor muscarínico y actividad agonista del receptor beta-2 adrenérgico
EA030552B1 (ru) * 2012-12-06 2018-08-31 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Соединения, обладающие активностью антагонистов мускариновых рецепторов и агонистов бета2 адренергических рецепторов

Also Published As

Publication number Publication date
TR201808698T4 (tr) 2018-07-23
SI3345904T1 (sl) 2020-09-30
CO7400870A2 (es) 2015-09-30
CY1123365T1 (el) 2021-12-31
ZA201503965B (en) 2016-09-28
PE20151216A1 (es) 2015-09-08
TWI637954B (zh) 2018-10-11
NZ708738A (en) 2019-02-22
CA2893626C (en) 2021-08-24
TW201427976A (zh) 2014-07-16
MA38147B1 (fr) 2018-09-28
PL3345904T3 (pl) 2020-12-14
PT3345904T (pt) 2020-09-07
CA2893626A1 (en) 2014-06-12
US9371318B2 (en) 2016-06-21
JP2016502557A (ja) 2016-01-28
IL239182A0 (en) 2015-07-30
EA030552B1 (ru) 2018-08-31
AR093825A1 (es) 2015-06-24
EA201590873A1 (ru) 2015-09-30
TN2015000244A1 (en) 2016-10-03
HUE037944T2 (hu) 2018-09-28
UA118181C2 (uk) 2018-12-10
SA515360514B1 (ar) 2016-08-30
LT2928889T (lt) 2018-06-11
MX369311B (es) 2019-11-05
HRP20201435T1 (hr) 2020-11-27
KR20200027049A (ko) 2020-03-11
MX2015006788A (es) 2015-08-05
PH12015501247B1 (en) 2015-08-17
DK3345904T3 (da) 2020-08-31
EP3345904A1 (en) 2018-07-11
CN104822678A (zh) 2015-08-05
GEP20186839B (en) 2018-04-10
SG10201704032RA (en) 2017-06-29
EP2928889B1 (en) 2018-03-21
HRP20180915T1 (hr) 2018-07-27
KR102156443B1 (ko) 2020-09-17
WO2014086924A1 (en) 2014-06-12
KR20150090108A (ko) 2015-08-05
AU2013354043C1 (en) 2017-08-31
AU2013354043B2 (en) 2017-06-15
CY1120159T1 (el) 2018-12-12
SI2928889T1 (en) 2018-05-31
PT2928889T (pt) 2018-05-29
PH12015501247A1 (en) 2015-08-17
RS60864B1 (sr) 2020-11-30
US20150133491A1 (en) 2015-05-14
CL2015001483A1 (es) 2015-10-23
MA38147A1 (fr) 2018-03-30
US8987299B2 (en) 2015-03-24
DK2928889T3 (en) 2018-05-22
CN104822678B (zh) 2017-03-08
HK1212989A1 (zh) 2016-06-24
IL239182B (en) 2018-12-31
HUE051394T2 (hu) 2021-03-01
PL2928889T3 (pl) 2018-09-28
ES2670686T3 (es) 2018-05-31
KR102240459B1 (ko) 2021-04-16
ES2816210T3 (es) 2021-03-31
RS57232B1 (sr) 2018-07-31
BR112015012730B1 (pt) 2022-07-05
LT3345904T (lt) 2020-09-25
EP2928889A1 (en) 2015-10-14
JP6421989B2 (ja) 2018-11-14
EP3345904B1 (en) 2020-07-29
US20140161736A1 (en) 2014-06-12
BR112015012730A2 (pt) 2017-07-11

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