SG11201408337PA - Methods of decellularizing bone - Google Patents

Methods of decellularizing bone

Info

Publication number
SG11201408337PA
SG11201408337PA SG11201408337PA SG11201408337PA SG11201408337PA SG 11201408337P A SG11201408337P A SG 11201408337PA SG 11201408337P A SG11201408337P A SG 11201408337PA SG 11201408337P A SG11201408337P A SG 11201408337PA SG 11201408337P A SG11201408337P A SG 11201408337PA
Authority
SG
Singapore
Prior art keywords
international
bone
methods
decellularizing
nesota
Prior art date
Application number
SG11201408337PA
Other languages
English (en)
Inventor
Jeffrey Ross
Blaise Porter
Original Assignee
Miromatrix Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miromatrix Medical Inc filed Critical Miromatrix Medical Inc
Publication of SG11201408337PA publication Critical patent/SG11201408337PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4646—Devices for cleaning bone graft

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Seats For Vehicles (AREA)
  • Pens And Brushes (AREA)
  • Mattresses And Other Support Structures For Chairs And Beds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11201408337PA 2012-06-13 2013-06-12 Methods of decellularizing bone SG11201408337PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261659046P 2012-06-13 2012-06-13
PCT/US2013/045387 WO2013188525A1 (en) 2012-06-13 2013-06-12 Methods of decellularizing bone

Publications (1)

Publication Number Publication Date
SG11201408337PA true SG11201408337PA (en) 2015-01-29

Family

ID=48703894

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201408337PA SG11201408337PA (en) 2012-06-13 2013-06-12 Methods of decellularizing bone

Country Status (13)

Country Link
US (1) US9290738B2 (ko)
EP (1) EP2861721A1 (ko)
JP (2) JP2015524680A (ko)
KR (1) KR20150033644A (ko)
CN (1) CN104937094B (ko)
AU (1) AU2013274322B2 (ko)
BR (1) BR112014031224A2 (ko)
CA (1) CA2876648C (ko)
HK (1) HK1209159A1 (ko)
IN (1) IN2014DN11201A (ko)
MX (1) MX359769B (ko)
SG (1) SG11201408337PA (ko)
WO (1) WO2013188525A1 (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2965769B1 (en) 2005-08-26 2018-12-26 Regents of the University of Minnesota Decellularization and recellularization of organs and tissues
PL2611472T3 (pl) 2010-09-01 2017-02-28 Regents Of The University Of Minnesota Metody recelularyzacji tkanki lub narządu w celu poprawy wszczepialności
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
MX2015013154A (es) 2013-03-15 2016-07-13 Miromatrix Medical Inc Uso de higado desceluralizado por perfusion para receluralizacion de celulas de islote.
GB201310773D0 (en) * 2013-06-17 2013-07-31 Northwick Park Inst For Medcal Res Ltd Implant and method of producing an implant
JP6271298B2 (ja) * 2014-02-28 2018-01-31 国立大学法人 東京医科歯科大学 脱細胞組織の製造方法
JP6302756B2 (ja) * 2014-06-06 2018-03-28 シスメックス株式会社 細胞の回収方法及びその方法に用いられる加工骨
EP3095469B1 (en) 2015-05-22 2019-09-11 Ilyas Inci Process for bone tissue decellularization
CA3225243A1 (en) 2015-09-11 2017-03-16 The General Hospital Corporation Regeneration of a functional pulmonary vascular bed
CN107456603A (zh) * 2016-06-03 2017-12-12 香港大学深圳医院 一种富集镁离子的骨支架材料及制备方法
CN106075583B (zh) * 2016-07-07 2020-07-14 中国人民解放军第二军医大学 一种采用灌注-压差法制备脱细胞基质生物材料的方法
WO2018048899A1 (en) 2016-09-06 2018-03-15 Micromatrix Medical Inc. Use of resected liver serum for whole liver engineering
CN110227182B (zh) * 2019-01-17 2020-12-15 浙江大学医学院附属邵逸夫医院 一种梯度矿化骨细胞外基质材料的制备方法
JP7336242B2 (ja) * 2019-04-05 2023-08-31 株式会社三共 スロットマシン
CN110237303B (zh) * 2019-06-27 2021-06-29 浙江大学医学院附属邵逸夫医院 天然组织来源的脱细胞骨膜基质凝胶材料的制备方法
KR20230015192A (ko) * 2021-07-22 2023-01-31 한스바이오메드 주식회사 무세포 진피층 이식재의 제조 방법

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545221A (en) 1967-05-22 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining organs in vitro in a completely viable state
US3639084A (en) 1970-04-06 1972-02-01 Baxter Laboratories Inc Mechanism for control pulsatile fluid flow
DE2453363B2 (de) 1974-11-11 1976-08-26 Solco Basel AG, Birsfelden (Schweiz) Verfahren zur herstellung heterologer arterientransplantate
JPS5516016A (en) 1978-07-18 1980-02-04 Dai Ichi Kogyo Seiyaku Co Ltd Improved salt-resistant water-absorbing material
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
FR2699408B1 (fr) * 1992-12-21 1995-03-24 Bioland Procédé de traitement de tissus osseux et biomatériaux implantables correspondants.
US5976104A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Recirculation method for cleaning essentially intact bone grafts using pressure mediated flow of solutions and bone grafts produced thereby
US5556379A (en) * 1994-08-19 1996-09-17 Lifenet Research Foundation Process for cleaning large bone grafts and bone grafts produced thereby
KR970705951A (ko) 1994-09-12 1997-11-03 가일 케이. 노우톤 심장 판막 구조에서 3차원 사람 세포 배양물과 이의 용도(three-dimensional human cell cultures on cardiac valve franeworks and their uses)
US5846484A (en) * 1997-03-20 1998-12-08 Osteotech, Inc. Pressure flow system and method for treating a fluid permeable workpiece such as a bone
US6734018B2 (en) 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US6448076B2 (en) 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
US6432712B1 (en) 1999-11-22 2002-08-13 Bioscience Consultants, Llc Transplantable recellularized and reendothelialized vascular tissue graft
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US20050249816A1 (en) 1999-12-29 2005-11-10 Wake Forest University Health Services Tissue engineered liver constructs
JP2003531685A (ja) 2000-04-28 2003-10-28 エモリー ユニバーシテイ 脱細胞化脈管補綴物
DE10021627B4 (de) 2000-05-04 2009-11-19 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Verfahren zur Herstellung eines vaskularisierten bioartifiziellen Gewebes und zugehöriger Versuchsreaktor
US6962814B2 (en) 2000-08-16 2005-11-08 Duke University Decellularized tissue engineered constructs and tissues
US6749064B1 (en) 2000-08-25 2004-06-15 Sanita L. Alrey Bag with article display aperture and support surface
AU2001292917A1 (en) 2000-09-20 2002-04-02 Regeneration Technologies, Inc. Method of preparing and processing transplant tissue
IL139708A0 (en) 2000-11-15 2002-02-10 Amiel Gilad Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering
DE10064948C1 (de) 2000-12-20 2002-07-11 Auto Tissue Gmbh Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens
ES2558626T3 (es) 2001-02-14 2016-02-05 Anthrogenesis Corporation Placenta post-parto de mamíferos, su uso y células madre placentarias de la misma
EP1387885A1 (en) 2001-05-01 2004-02-11 Universite Du Quebec A Montreal Tridimensional biocompatible support structure for bioartificial organs and uses thereof
GB2375771A (en) 2001-05-24 2002-11-27 Univ Leeds Decellularisation of tissue implant material
EP1317934A1 (de) 2001-11-08 2003-06-11 Artiss GmbH Verfahren zur Herstellung einer azellularisierten Gewebematrix und damit erhältliche Gewebematrix
US7049057B2 (en) 2001-11-16 2006-05-23 Children's Medical Center Corporation Tissue engineered uterus
ATE526047T1 (de) 2001-11-16 2011-10-15 Childrens Medical Center Verbesserung der funktion von organen
US20030180268A1 (en) 2002-02-05 2003-09-25 Anthony Atala Tissue engineered construct for supplementing or replacing a damaged organ
JP4149897B2 (ja) 2002-11-07 2008-09-17 学校法人 聖マリアンナ医科大学 気管移植片の調製方法および気管移植片
US20040187877A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
MXPA05006210A (es) 2002-12-13 2005-08-19 Cilag Ag Preparaciones de liberacion controlada que comprenden tramadol y topiramato.
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
JP2006223101A (ja) 2003-05-15 2006-08-31 Univ Waseda 生体組織の保持装置及びこれを用いた生体組織処理装置
WO2005118014A2 (en) 2004-06-01 2005-12-15 Medtronic, Inc. Decellurisation processes for making bioprotheses
JP3773943B2 (ja) 2004-09-24 2006-05-10 国立大学法人 東京大学 把持状態判定システム及び方法
DE102005023599A1 (de) 2005-05-18 2006-11-23 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Bioartifizielles Herzgewebetransplantat und Verfahren zu seiner Herstellung
US20100093066A1 (en) 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
EP2965769B1 (en) 2005-08-26 2018-12-26 Regents of the University of Minnesota Decellularization and recellularization of organs and tissues
CN101066477B (zh) 2007-05-17 2010-10-06 中国人民解放军第三军医大学 能在体捕获内皮祖细胞的生物人工血管
AU2008334036B2 (en) 2007-11-30 2014-05-29 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
JP2009207700A (ja) * 2008-03-04 2009-09-17 Cell Remover:Kk 脱細胞化処理装置
WO2010120539A2 (en) 2009-03-31 2010-10-21 Regents Of The University Of Minnesota Decellularization and recellularization of organs and tissues
PL2611472T3 (pl) 2010-09-01 2017-02-28 Regents Of The University Of Minnesota Metody recelularyzacji tkanki lub narządu w celu poprawy wszczepialności
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone

Also Published As

Publication number Publication date
BR112014031224A2 (pt) 2017-06-27
JP2019072524A (ja) 2019-05-16
IN2014DN11201A (ko) 2015-10-02
CA2876648A1 (en) 2013-12-19
HK1209159A1 (en) 2016-03-24
JP2015524680A (ja) 2015-08-27
EP2861721A1 (en) 2015-04-22
KR20150033644A (ko) 2015-04-01
US9290738B2 (en) 2016-03-22
MX359769B (es) 2018-10-10
CN104937094B (zh) 2018-06-01
CN104937094A (zh) 2015-09-23
CA2876648C (en) 2020-09-22
WO2013188525A1 (en) 2013-12-19
MX2014015270A (es) 2015-08-12
AU2013274322A1 (en) 2015-01-29
US20130337560A1 (en) 2013-12-19
AU2013274322B2 (en) 2017-03-09

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