SG10202007937SA - PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF - Google Patents

PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

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Publication number
SG10202007937SA
SG10202007937SA SG10202007937SA SG10202007937SA SG10202007937SA SG 10202007937S A SG10202007937S A SG 10202007937SA SG 10202007937S A SG10202007937S A SG 10202007937SA SG 10202007937S A SG10202007937S A SG 10202007937SA SG 10202007937S A SG10202007937S A SG 10202007937SA
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Singapore
Prior art keywords
ligand
methods
cell death
programmed cell
irna compositions
Prior art date
Application number
SG10202007937SA
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English (en)
Inventor
Gregory Hinkle
Original Assignee
Alnylam Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of SG10202007937SA publication Critical patent/SG10202007937SA/en

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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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SG10202007937SA 2015-09-02 2016-08-22 PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF SG10202007937SA (en)

Applications Claiming Priority (1)

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US201562213224P 2015-09-02 2015-09-02

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SG10202007937SA true SG10202007937SA (en) 2020-09-29

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Country Status (13)

Country Link
US (2) US10889813B2 (fr)
EP (2) EP4393495A2 (fr)
JP (3) JP7028764B2 (fr)
KR (1) KR20180051550A (fr)
CN (2) CN108368507B (fr)
AU (1) AU2016315584B2 (fr)
CA (1) CA2996873A1 (fr)
EA (1) EA201890619A1 (fr)
HK (2) HK1255138A1 (fr)
PE (1) PE20181131A1 (fr)
SA (1) SA518391045B1 (fr)
SG (1) SG10202007937SA (fr)
WO (1) WO2017040078A1 (fr)

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AU2018360697A1 (en) 2017-11-01 2020-05-14 Alnylam Pharmaceuticals, Inc. Complement component C3 iRNA compositions and methods of use thereof
US20200385719A1 (en) * 2017-11-16 2020-12-10 Alnylam Pharmaceuticals, Inc. Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
CN108359667B (zh) * 2018-01-06 2021-01-05 武汉泽智生物医药有限公司 沉默程序性死亡受体-配体表达的siRNA序列及其应用
US20210332359A1 (en) * 2018-09-07 2021-10-28 The General Hospital Corporation Compositions and methods for immune checkpoint inhibition
US20240182900A1 (en) * 2019-11-07 2024-06-06 Yale University Microrna blockade for the treatment of disease
JP2023515218A (ja) 2020-02-28 2023-04-12 アリゴス セラピューティクス インコーポレイテッド Ｐｄ－ｌ１を標的とするための方法及び組成物
CN112180005B (zh) * 2020-09-01 2022-10-04 上海市疾病预防控制中心 一种预测鉴定生物样本中酰基肉碱的方法及其应用
CA3234636A1 (fr) 2021-10-29 2023-05-04 Alnylam Pharmaceuticals, Inc. Compositions d'arni du facteur b du complement (cfb) et leurs procedes d'utilisation
KR20230128690A (ko) * 2022-02-28 2023-09-05 주식회사 시선테라퓨틱스 핵산 복합체를 포함하는 폐암 예방 또는 치료용 조성물
WO2023233290A1 (fr) * 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Agents d'arni ciblant pd-l1
CN117881783A (zh) * 2023-02-17 2024-04-12 苏州时安生物技术有限公司 一种用于抑制细胞程序性死亡-配体1基因表达的siRNA、其缀合物和药物组合物及用途

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EA201890619A1 (ru) 2018-09-28
KR20180051550A (ko) 2018-05-16
HK1255138A1 (zh) 2019-08-09
HK1256303A1 (zh) 2019-09-20
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EP3344769B1 (fr) 2024-04-17
PE20181131A1 (es) 2018-07-17
CN108368507A (zh) 2018-08-03
US20210189391A1 (en) 2021-06-24
EP3344769A1 (fr) 2018-07-11
JP7028764B2 (ja) 2022-03-02
US11685918B2 (en) 2023-06-27
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CN108368507B (zh) 2022-03-22
AU2016315584B2 (en) 2022-07-14
JP2023166601A (ja) 2023-11-21
US20180273947A1 (en) 2018-09-27
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US10889813B2 (en) 2021-01-12
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